JP2003503017A5 - - Google Patents

Download PDF

Info

Publication number
JP2003503017A5
JP2003503017A5 JP2001500673A JP2001500673A JP2003503017A5 JP 2003503017 A5 JP2003503017 A5 JP 2003503017A5 JP 2001500673 A JP2001500673 A JP 2001500673A JP 2001500673 A JP2001500673 A JP 2001500673A JP 2003503017 A5 JP2003503017 A5 JP 2003503017A5
Authority
JP
Japan
Prior art keywords
antibody
american type
culture collection
deposited under
type culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001500673A
Other languages
English (en)
Japanese (ja)
Other versions
JP4589586B2 (ja
JP2003503017A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/014599 external-priority patent/WO2000073349A1/en
Publication of JP2003503017A publication Critical patent/JP2003503017A/ja
Publication of JP2003503017A5 publication Critical patent/JP2003503017A5/ja
Application granted granted Critical
Publication of JP4589586B2 publication Critical patent/JP4589586B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2001500673A 1999-05-28 2000-05-25 Ｄｒ４抗体とその利用 Expired - Lifetime JP4589586B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32287599A 1999-05-28 1999-05-28
US09/322,875 1999-05-28
PCT/US2000/014599 WO2000073349A1 (en) 1999-05-28 2000-05-25 Dr4 antibodies and uses thereof

Publications (3)

Publication Number Publication Date
JP2003503017A JP2003503017A (ja) 2003-01-28
JP2003503017A5 true JP2003503017A5 (https=) 2007-07-19
JP4589586B2 JP4589586B2 (ja) 2010-12-01

Family

ID=23256824

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001500673A Expired - Lifetime JP4589586B2 (ja) 1999-05-28 2000-05-25 Ｄｒ４抗体とその利用

Country Status (12)

Country Link
EP (2) EP1181319B1 (https=)
JP (1) JP4589586B2 (https=)
AT (1) ATE429450T1 (https=)
AU (3) AU781952B2 (https=)
CA (1) CA2374599A1 (https=)
CY (1) CY1109151T1 (https=)
DE (1) DE60042066D1 (https=)
DK (1) DK1181319T3 (https=)
ES (1) ES2325305T3 (https=)
IL (1) IL146448A0 (https=)
PT (1) PT1181319E (https=)
WO (1) WO2000073349A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
JP4330180B2 (ja) 1997-03-17 2009-09-16 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 死ドメイン含有レセプター５
JP2002543151A (ja) * 1999-05-04 2002-12-17 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 死ドメイン含有レセプター５
EP1181319B1 (en) * 1999-05-28 2009-04-22 Genentech, Inc. Chimeric dr4 antibodies and uses thereof
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
US7115717B2 (en) * 2001-05-18 2006-10-03 Kirin Beer Kabushiki Kaisha Anti-TRAIL-R antibodies
US7064189B2 (en) 2001-05-25 2006-06-20 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
EP1409544B1 (en) 2001-07-03 2009-06-17 Genentech, Inc. Human dr4 antibodies and uses thereof
WO2003013584A1 (en) * 2001-08-09 2003-02-20 Genset S.A. Xafinix agonists and antagonists for use in the treatment of metabolic disorders
ES2357225T3 (es) * 2001-11-01 2011-04-20 Uab Research Foundation Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos.
US20080199423A1 (en) * 2004-06-18 2008-08-21 Genentech, Inc. Methods of Using Apo2l Receptor Agonists and Ink Cell Activators
CN101061238B (zh) 2004-08-06 2013-11-20 健泰科生物技术公司 使用生物标志的测定法和方法
MX2007001469A (es) 2004-08-06 2007-03-26 Genentech Inc Ensayos y metodos que utilizan biomarcadores.
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
JP5562521B2 (ja) 2005-02-02 2014-07-30 ザ ユーエービー リサーチ ファンデーション アポトーシス誘導デスレセプターアゴニストに対する抵抗性を低減することに関する薬剤及び方法
CN101287990B (zh) 2005-08-16 2012-07-04 健泰科生物技术公司 通过检测细胞/组织中galnac-t14的表达判定对apo2l/trail的凋亡敏感性
WO2008066854A2 (en) * 2006-11-28 2008-06-05 Novartis Ag Methods and compositions for inducing apoptosis in cancer cells
CN101679974B (zh) 2007-03-27 2015-09-30 航道生物技术有限责任公司 包含抗体替代轻链序列的构建体和文库
CA2761681A1 (en) 2009-05-13 2010-11-18 Sea Lane Biotechnologies, Llc Neutralizing molecules to influenza viruses
EP2704735A1 (en) 2011-05-03 2014-03-12 Genentech, Inc. Vascular disruption agents and uses thereof
EP2736928B1 (en) 2011-07-28 2019-01-09 i2 Pharmaceuticals, Inc. Sur-binding proteins against erbb3
US9975956B2 (en) 2011-12-22 2018-05-22 I2 Pharmaceuticals, Inc. Surrogate binding proteins which bind DR4 and/or DR5
CN110305874A (zh) * 2019-06-19 2019-10-08 浙江省肿瘤医院 长爪沙鼠免疫球蛋白IgG1、IgG2重组蛋白、基因及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1993016177A1 (en) 1992-02-11 1993-08-19 Cell Genesys, Inc. Homogenotization of gene-targeting events
PT1012274E (pt) * 1997-01-28 2007-08-14 Craig A Rosen Receptor 4 contendo um domínio de morte (dm4; receptor de morte 4), membro da super-família do ftn e ligação a liart (ap02)
ES2293682T5 (es) * 1997-05-15 2011-11-17 Genentech, Inc. Anticuerpo anti-apo2.
AU2338299A (en) * 1998-01-26 1999-08-09 Genentech Inc. Antibodies to death receptor 4 (dr4) and uses thereof
ATE443723T1 (de) * 1998-06-12 2009-10-15 Genentech Inc Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren
EP1181319B1 (en) * 1999-05-28 2009-04-22 Genentech, Inc. Chimeric dr4 antibodies and uses thereof

Similar Documents

Publication Publication Date Title
JP2003503017A5 (https=)
CN106967172B (zh) 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
RU2571515C2 (ru) Гуманизированные антитела к cxcr5, их производные и их применение
JP7262597B2 (ja) 二重特異性抗体及びその作製方法と使用
RU2486204C2 (ru) Антитела против сd26 и способы их применения
AU2009200269B2 (en) Modulation of NKG2D
CA3099530A1 (en) Anti-interleukin-17a antibody, pharmaceutical composition thereof and use thereof
KR20200143470A (ko) 항-ror 항체 구조체
KR20210100654A (ko) Cd3 항체 및 그의 약제학적 용도
WO1989009621A3 (en) Compounds for diagnosis and/or therapy of tumours
NZ616992A (en) Anti-ilt7 antibody
NO179615B (no) Monoklonale antistoffer eller fragmenter derav som reagerer med kakektin, cellelinjer som produserer dem, prövesett som omfatter dem, samt anvendelse derav in vitro
KR930700662A (ko) 인간화된 단클론성 항체 및 혼성 단클론성 항체
CA2185656A1 (en) Protein tyrosine kinase agonist antibodies
CN101778864A (zh) 排斥性引导分子(rgm)蛋白质家族的蛋白的骨形态发生蛋白(bmp)-结合结构域及其功能片段,和它们的用途
EP3026060A1 (en) Humanized antibody or fragment thereof specific for CD45R0
WO2018092907A1 (ja) エピトープ均質化抗体パネル、ならびにその作製方法および利用
JP2024510811A (ja) Ｕｐａｒ抗体及びその融合タンパク質
Gattei et al. Characterization of anti‐CD138 monoclonal antibodies as tools for investigating the molecular polymorphism of syndecan‐1 in human lymphoma cells
CN120129701A (zh) 抗ccr8的抗体及其用途
CN113929783B (zh) 抗cd99蛋白单克隆抗体、细胞系及其制备方法和应用
WO2014139425A1 (zh) 一种抗Blys的单克隆抗体及含有该抗体的药物组合物
CN118556077A (zh) 一种多特异性抗体及其药物用途
CN118562015A (zh) 一种针对cd20/cd3的双异性抗体及其制备方法和应用
CN121319184A (zh) 一种靶向b细胞cd20的纳米抗体及其应用