JP2003501488A5 - - Google Patents

Info

Publication number

JP2003501488A5

JP2003501488A5 JP2001502887A JP2001502887A JP2003501488A5 JP 2003501488 A5 JP2003501488 A5 JP 2003501488A5 JP 2001502887 A JP2001502887 A JP 2001502887A JP 2001502887 A JP2001502887 A JP 2001502887A JP 2003501488 A5 JP2003501488 A5 JP 2003501488A5

Authority

JP

Japan

Prior art keywords

composition according

pharmaceutical composition

liquid pharmaceutical

complex

bone

Prior art date

2000-06-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000007788 liquid Substances 0.000 description 16
• 239000008194 pharmaceutical composition Substances 0.000 description 13
• 210000000988 bone and bone Anatomy 0.000 description 6
• 230000008685 targeting Effects 0.000 description 6
• 239000003814 drug Substances 0.000 description 5
• 239000000203 mixture Substances 0.000 description 5
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• 206010028980 Neoplasm Diseases 0.000 description 3
• 239000008365 aqueous carrier Substances 0.000 description 3
• 210000001185 bone marrow Anatomy 0.000 description 3
• 201000011510 cancer Diseases 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 229940124553 radioprotectant Drugs 0.000 description 3
• WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 description 2
• 229940120146 EDTMP Drugs 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• 206010031252 Osteomyelitis Diseases 0.000 description 2
• ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 2
• JSTADIGKFYFAIY-GJNDDOAHSA-K [2-[bis[[hydroxy(oxido)phosphoryl]methyl]amino]ethyl-(phosphonomethyl)amino]methyl-hydroxyphosphinate;samarium-153(3+) Chemical compound [H+].[H+].[H+].[H+].[H+].[153Sm+3].[O-]P([O-])(=O)CN(CP([O-])([O-])=O)CCN(CP([O-])([O-])=O)CP([O-])([O-])=O JSTADIGKFYFAIY-GJNDDOAHSA-K 0.000 description 2
• 229960005070 ascorbic acid Drugs 0.000 description 2
• 235000010323 ascorbic acid Nutrition 0.000 description 2
• 239000011668 ascorbic acid Substances 0.000 description 2
• NFDRPXJGHKJRLJ-UHFFFAOYSA-N edtmp Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O NFDRPXJGHKJRLJ-UHFFFAOYSA-N 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 206010055113 Breast cancer metastatic Diseases 0.000 description 1
• 208000006168 Ewing Sarcoma Diseases 0.000 description 1
• 208000034578 Multiple myelomas Diseases 0.000 description 1
• 206010035226 Plasma cell myeloma Diseases 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 229960005219 gentisic acid Drugs 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 208000010658 metastatic prostate carcinoma Diseases 0.000 description 1
• 238000000034 method Methods 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 239000003223 protective agent Substances 0.000 description 1
• 230000002285 radioactive effect Effects 0.000 description 1