KR900009080A - 골수 억제제 - Google Patents

골수 억제제 Download PDF

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Publication number
KR900009080A
KR900009080A KR1019890016866A KR890016866A KR900009080A KR 900009080 A KR900009080 A KR 900009080A KR 1019890016866 A KR1019890016866 A KR 1019890016866A KR 890016866 A KR890016866 A KR 890016866A KR 900009080 A KR900009080 A KR 900009080A
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South Korea
Prior art keywords
radionuclide
composition
bone marrow
holmium
samarium
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KR1019890016866A
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English (en)
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KR0142907B1 (ko
Inventor
시몬 제임
알. 가알리치 조셉
에이. 윌슨 데이비드
맥밀란 케네스
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원본미기재
더 다우 케미칼 캄파니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

내용 없음.

Description

골수 억제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (20)

1,4,7,10-테트라아자시클로도데칸 잔기를 함유하는 하나 이상의 거대환상 아미노포스폰산 리간드(여기에서, 포스폰산 작용기는 알킬렌 그룹을 통해 기대환상 폴리아민의 질소에 부착되어 있다) 또는 생리학적으로 허용되는 그의 염과 착화된, 사마륨-153, 가돌리늄-159, 홀뮴-166 또는 이트륨-90으로부터 선택된 하나이상의 방사성핵종을 포함하는 하나 이상의 골수억제 조성물 골수억제량을 골수억제 치료가 필요한 포유동물에게 투여함을 포함하는 골수억제 방법.
제1항에 있어서, 리간드가 1,4,7,10-테트라아자시클로도데칸테트라 메틸렌포스폰산 또는 그의 생리학적으로 허용되는 염인 골수억제 방법.
제1항 또는 제2항에 있어서, 방사성 핵종이 사마륨-153인 골수억제 방법.
제1항 또는 제2항에 있어서, 방사성 핵종이 가돌리늄-159인 골수억제 방법.
제1항 또는 제2항에 있어서, 방사성 핵종이 홀뮴-166인 골수억제 방법.
제1항 또는 제2항에 있어서, 방사성 핵종이 이트륨-90인 골수억제 방법.
제1항 내지 6항중 어느 한 항에 있어서, 백혈병, 임파종, 골수종 또는 호지킨병의 치료를 위해 하나 이상의 치료적 양생법과 함께 사용되는 골수억제 방법.
제1항 내지 7항중 어느 한 항에 있어서, (a) 하나 이상의 골수억체제, 및/또는 (b) 하나 이상의 화학요법제, 및/또는 (c) 하나 이상의 방사성치료제 또는 방사상 치료방법 중 적어도 하나를 사용하는 추가 치료 양생법과 함께 사용되는 골수억제 방법.
제8항에 있어서, 전신방사 또는 표적에 맞춘 외적 방사와 함께 사용된 골수억제 방법.
제8항 또는 제9항에 있어서, 적어도 하나의 화학요법제를 사용하는 치료법과 함께 사용된 골수억제 방법.
제10항에 있어서, 화학요법제가 디메틸 부술판, 시클로포스파미드, 비스클로로에틸 니트로소우레아, 시토신 아라비노시드 또는 6-티오구아닌 인 골수억제 방법.
제1항 내지 11항중 어느 한 항에 있어서, 충분한 골수억제를 이룩한후 골수이색의 추가단계를 포함하는 골수억제 방법.
1,4,7,10-테트라아자시클로도데칸 잔기를 함유하는 하나 이상의 거대환상 아미노포스폰산 리간드 또는 생리학적으로 허용되는 그의 염과 착화된, 사마륨-153, 가돌리늄-159, 홀뮴-166 또는 이트륨-90 으로부터 선택된 하나 이상의 방사성핵종을 포함하는, 골수억제를 위해 포유동물에게 투여하기에 적합한 멸균 조성물(여기에서, 상기 리간드의 인은 알킬렌 잔기를 통해 아민의 질소에 부착되어 있고, 투약 형태에서 상기 방사성 핵종은 상기 포유동물의 몸무게 ㎏당 18 내지 1850 메가벡쿼렐을 함유하는 양으로 존재한다.
제13항에 있어서, 투약 형태가 상기 포유동물의 몸부게 ㎏당 185 내지 1850 메가벡쿼렐을 함유하는 조성물.
제13항 또는 제14항에 있어서, 방사성핵종이 사마륨-153인 조성물.
제13항 또는 제14항에 있어서, 방사성핵종이 가돌리늄-159인 조성물.
제13항 또는 제14항에 있어서, 방사성핵종이 홀뮴-166인 조성물.
제13항 또는 제14항에 있어서, 방사성핵종이 이트륨-90인 조성물.
제13항 내지 18항 중 어느 한 항에 있어서 리간드 대 방사성 핵종의 비가 1:1 내지 2:1인 조성물.
약학적으로 허용되는 담체에 제13항 내지 제19항중 어느 한 항에서 특허청구된 조성물을 포함하는 약학제제.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016866A 1988-12-19 1989-11-21 골수억제제 KR0142907B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US284,875 1988-12-19
US07/284,875 US4882142A (en) 1988-12-19 1988-12-19 Bone marrow suppressing agents

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KR900009080A true KR900009080A (ko) 1990-07-02
KR0142907B1 KR0142907B1 (ko) 1998-07-15

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US (1) US4882142A (ko)
EP (1) EP0374501B1 (ko)
JP (1) JP2795934B2 (ko)
KR (1) KR0142907B1 (ko)
AT (1) ATE92339T1 (ko)
AU (1) AU625644B2 (ko)
CA (1) CA2003326C (ko)
DE (1) DE68908125T2 (ko)
DK (1) DK175607B1 (ko)
FI (1) FI895516A0 (ko)
HK (1) HK152395A (ko)
IE (1) IE69049B1 (ko)
IL (1) IL92373A (ko)
NZ (1) NZ231474A (ko)
PH (1) PH26086A (ko)
PT (1) PT92362B (ko)
ZA (1) ZA898866B (ko)

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US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
WO1991016075A1 (en) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Bone marrow treatments
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
US5133956A (en) * 1991-05-30 1992-07-28 The Dow Chemical Company Radiolabeled metal-binding protein for the treatment of arthritis
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
DK2255800T3 (da) * 1997-11-10 2013-02-04 Sloan Kettering Inst Cancer Arsentrioxid til anvendelse ved behandling af leukæmi
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US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
EP1191948A2 (en) * 1999-06-11 2002-04-03 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6794371B1 (en) * 1999-10-18 2004-09-21 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
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US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
AU2002249935A1 (en) 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US20030228256A1 (en) * 2002-06-11 2003-12-11 Inverardi Luca A. Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations
WO2004052408A1 (en) * 2002-12-10 2004-06-24 University Of Miami Radioablation of hemolymphopoietic cell populations
WO2007126730A1 (en) * 2006-03-29 2007-11-08 Isotherapeautics Group Llc Radionuclide therapy for urinary bladder cancer
HUE062439T2 (hu) 2013-10-07 2023-11-28 Igl Pharma Inc Eljárás nagy tisztaságú terápiás csont szerek elõállítására
CN114404427A (zh) 2014-02-13 2022-04-29 配体药物公司 前药化合物及其用途
US9994600B2 (en) 2014-07-02 2018-06-12 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
EP3302496B1 (en) * 2015-05-25 2021-01-06 IGL Pharma, Inc. Dotmp kit formulations for radioisotopes
EP3737676B1 (en) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

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US4508625A (en) * 1982-10-18 1985-04-02 Graham Marshall D Magnetic separation using chelated magnetic ions
IL74902A (en) * 1984-06-04 1990-12-23 Dow Chemical Co Organic amine phosphonic acid complexes with particle-emitting radionuclides for the treatment of calcific tumors
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents

Also Published As

Publication number Publication date
DE68908125D1 (de) 1993-09-09
CA2003326A1 (en) 1990-06-19
HK152395A (en) 1995-09-29
US4882142A (en) 1989-11-21
IL92373A (en) 1995-08-31
EP0374501B1 (en) 1993-08-04
KR0142907B1 (ko) 1998-07-15
DK582789D0 (da) 1989-11-20
PH26086A (en) 1992-02-06
IE893714L (en) 1990-06-19
CA2003326C (en) 1999-01-19
JPH02237936A (ja) 1990-09-20
PT92362B (pt) 1995-09-12
EP0374501A1 (en) 1990-06-27
DE68908125T2 (de) 1994-03-03
DK175607B1 (da) 2004-12-27
ZA898866B (en) 1991-07-31
FI895516A0 (fi) 1989-11-20
PT92362A (pt) 1990-06-29
DK582789A (da) 1990-06-20
JP2795934B2 (ja) 1998-09-10
AU4544089A (en) 1990-06-21
IE69049B1 (en) 1996-08-07
NZ231474A (en) 1992-06-25
AU625644B2 (en) 1992-07-16
ATE92339T1 (de) 1993-08-15

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