DE68908125T2 - Knochenmark unterdrückende Medikamente. - Google Patents

Knochenmark unterdrückende Medikamente.

Info

Publication number
DE68908125T2
DE68908125T2 DE89121564T DE68908125T DE68908125T2 DE 68908125 T2 DE68908125 T2 DE 68908125T2 DE 89121564 T DE89121564 T DE 89121564T DE 68908125 T DE68908125 T DE 68908125T DE 68908125 T2 DE68908125 T2 DE 68908125T2
Authority
DE
Germany
Prior art keywords
bone marrow
suppressing drugs
marrow suppressing
suppressing
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89121564T
Other languages
English (en)
Other versions
DE68908125D1 (de
Inventor
Jaime Simon
Joseph R Garlich
David A Wilson
Kenneth Mcmillan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of DE68908125D1 publication Critical patent/DE68908125D1/de
Application granted granted Critical
Publication of DE68908125T2 publication Critical patent/DE68908125T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
DE89121564T 1988-12-19 1989-11-21 Knochenmark unterdrückende Medikamente. Expired - Lifetime DE68908125T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/284,875 US4882142A (en) 1988-12-19 1988-12-19 Bone marrow suppressing agents

Publications (2)

Publication Number Publication Date
DE68908125D1 DE68908125D1 (de) 1993-09-09
DE68908125T2 true DE68908125T2 (de) 1994-03-03

Family

ID=23091850

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89121564T Expired - Lifetime DE68908125T2 (de) 1988-12-19 1989-11-21 Knochenmark unterdrückende Medikamente.

Country Status (17)

Country Link
US (1) US4882142A (de)
EP (1) EP0374501B1 (de)
JP (1) JP2795934B2 (de)
KR (1) KR0142907B1 (de)
AT (1) ATE92339T1 (de)
AU (1) AU625644B2 (de)
CA (1) CA2003326C (de)
DE (1) DE68908125T2 (de)
DK (1) DK175607B1 (de)
FI (1) FI895516A0 (de)
HK (1) HK152395A (de)
IE (1) IE69049B1 (de)
IL (1) IL92373A (de)
NZ (1) NZ231474A (de)
PH (1) PH26086A (de)
PT (1) PT92362B (de)
ZA (1) ZA898866B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
WO1991016075A1 (en) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Bone marrow treatments
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
US5133956A (en) * 1991-05-30 1992-07-28 The Dow Chemical Company Radiolabeled metal-binding protein for the treatment of arthritis
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
DK2255800T3 (da) * 1997-11-10 2013-02-04 Sloan Kettering Inst Cancer Arsentrioxid til anvendelse ved behandling af leukæmi
AU2652599A (en) * 1998-01-06 1999-07-26 University Of Virginia Patent Foundation Nuclear scintigraphic assessment of mucosal function
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
EP1191948A2 (de) * 1999-06-11 2002-04-03 Neorx Corporation Hochdosierte radionuklide komplexe zur knochenmark-unterdrückung
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6794371B1 (en) * 1999-10-18 2004-09-21 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
AU2002249935A1 (en) 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US20030228256A1 (en) * 2002-06-11 2003-12-11 Inverardi Luca A. Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations
WO2004052408A1 (en) * 2002-12-10 2004-06-24 University Of Miami Radioablation of hemolymphopoietic cell populations
WO2007126730A1 (en) * 2006-03-29 2007-11-08 Isotherapeautics Group Llc Radionuclide therapy for urinary bladder cancer
HUE062439T2 (hu) 2013-10-07 2023-11-28 Igl Pharma Inc Eljárás nagy tisztaságú terápiás csont szerek elõállítására
CN114404427A (zh) 2014-02-13 2022-04-29 配体药物公司 前药化合物及其用途
US9994600B2 (en) 2014-07-02 2018-06-12 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
EP3302496B1 (de) * 2015-05-25 2021-01-06 IGL Pharma, Inc. Dotmp-kitformulierungen für radioisotope
EP3737676B1 (de) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Acetalverbindungen und therapeutische verwendungen davon

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508625A (en) * 1982-10-18 1985-04-02 Graham Marshall D Magnetic separation using chelated magnetic ions
IL74902A (en) * 1984-06-04 1990-12-23 Dow Chemical Co Organic amine phosphonic acid complexes with particle-emitting radionuclides for the treatment of calcific tumors
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents

Also Published As

Publication number Publication date
DE68908125D1 (de) 1993-09-09
CA2003326A1 (en) 1990-06-19
HK152395A (en) 1995-09-29
US4882142A (en) 1989-11-21
IL92373A (en) 1995-08-31
KR900009080A (ko) 1990-07-02
EP0374501B1 (de) 1993-08-04
KR0142907B1 (ko) 1998-07-15
DK582789D0 (da) 1989-11-20
PH26086A (en) 1992-02-06
IE893714L (en) 1990-06-19
CA2003326C (en) 1999-01-19
JPH02237936A (ja) 1990-09-20
PT92362B (pt) 1995-09-12
EP0374501A1 (de) 1990-06-27
DK175607B1 (da) 2004-12-27
ZA898866B (en) 1991-07-31
FI895516A0 (fi) 1989-11-20
PT92362A (pt) 1990-06-29
DK582789A (da) 1990-06-20
JP2795934B2 (ja) 1998-09-10
AU4544089A (en) 1990-06-21
IE69049B1 (en) 1996-08-07
NZ231474A (en) 1992-06-25
AU625644B2 (en) 1992-07-16
ATE92339T1 (de) 1993-08-15

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