DE164843T1 - Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren. - Google Patents

Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.

Info

Publication number
DE164843T1
DE164843T1 DE198585302634T DE85302634T DE164843T1 DE 164843 T1 DE164843 T1 DE 164843T1 DE 198585302634 T DE198585302634 T DE 198585302634T DE 85302634 T DE85302634 T DE 85302634T DE 164843 T1 DE164843 T1 DE 164843T1
Authority
DE
Germany
Prior art keywords
calciuming
aminphosphonic
tumors
organic
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198585302634T
Other languages
English (en)
Inventor
Jaime Angleton Texas 77515 Us Simon
Wynn A. Columbia Missouri 65212 Us Volkert
David A. Richwood Texas 77531 Us Wilson
David E. Columbia Missouri 65201 Us Troutner
William F. Midland Michigan 48640 Us Goeckeler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of DE164843T1 publication Critical patent/DE164843T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE198585302634T 1984-06-04 1985-04-15 Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren. Pending DE164843T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61698584A 1984-06-04 1984-06-04

Publications (1)

Publication Number Publication Date
DE164843T1 true DE164843T1 (de) 1989-12-07

Family

ID=24471820

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585302634T Expired - Lifetime DE3583257D1 (de) 1984-06-04 1985-04-15 Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.
DE198585302634T Pending DE164843T1 (de) 1984-06-04 1985-04-15 Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8585302634T Expired - Lifetime DE3583257D1 (de) 1984-06-04 1985-04-15 Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.

Country Status (10)

Country Link
EP (1) EP0164843B1 (de)
JP (2) JPH0655681B2 (de)
AU (1) AU563671B2 (de)
CA (1) CA1243603A (de)
DE (2) DE3583257D1 (de)
HK (1) HK146895A (de)
IL (1) IL74902A (de)
NL (1) NL980021I2 (de)
NZ (1) NZ211808A (de)
ZA (1) ZA852799B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515767A (en) * 1983-06-20 1985-05-07 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
EP0225409A1 (de) * 1985-12-02 1987-06-16 The Dow Chemical Company Organoaminophosphonische Säurekomplexe für die Behandlung von Kalktumoren
NZ222304A (en) * 1987-05-18 1990-10-26 Dow Chemical Co Suppression of bone marrow using samarium-153, gadolinium-159 or holmium-166 complexes
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
WO1991016075A1 (en) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Bone marrow treatments
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes
EP1191948A2 (de) 1999-06-11 2002-04-03 Neorx Corporation Hochdosierte radionuklide komplexe zur knochenmark-unterdrückung
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
DE19953636A1 (de) * 1999-11-09 2001-05-23 Karlsruhe Forschzent Radioaktive Materialien

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2543349C2 (de) * 1975-09-29 1984-05-10 Henkel KGaA, 4000 Düsseldorf Preaparate zur herstellung von99m technetium-radiagnostica
CA1078731A (en) * 1976-12-16 1980-06-03 Charles E. Frosst And Co. Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
US4504463A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
US4508704A (en) * 1984-02-27 1985-04-02 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of bicycloheptane bis(alkylamines)

Also Published As

Publication number Publication date
NZ211808A (en) 1989-01-06
DE3583257D1 (de) 1991-07-25
ZA852799B (en) 1986-12-30
NL980021I1 (nl) 1998-09-01
IL74902A0 (en) 1985-07-31
CA1243603A (en) 1988-10-25
HK146895A (en) 1995-09-22
EP0164843A2 (de) 1985-12-18
IL74902A (en) 1990-12-23
JPH0448799B2 (de) 1992-08-07
AU563671B2 (en) 1987-07-16
NL980021I2 (nl) 1999-02-01
JPH0655681B2 (ja) 1994-07-27
JPS62132892A (ja) 1987-06-16
EP0164843B1 (de) 1991-06-19
AU4122985A (en) 1985-12-12
EP0164843A3 (en) 1987-09-23
JPS6122029A (ja) 1986-01-30

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