JP2003261434A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation having good compatibility with the skin and exhibiting high skin moisturizing effect, skin-beautifying effect and chapped skin-improving effect. <P>SOLUTION: This skin care preparation is obtained by combinedly using each of extracts from plants and fungi consisting of Ziziphus jujuba Mill., Coptis japonica (Thunb.) Makino, Paeonia lactiflora Pall., Angelica acutiloba (Sieb. et Zucc.) Kitagawa, Cnidium officinale Malino, Asiarum sieboldi (miq.) F. Maekawa, Scutellaria baicalensis Georgi, Uncaria gambir (Hunt) Rocb., Poria cocos (Fr.) Wolf, Cinnamomi cassia Presl., Phellodendron amurense Pupr., Curcuma domestica Valet., Syzygium aromaticum (L.) Merril et Perry, Artemisia princeps Pamp., Zingiber officinale Rosc., Ganoderma lucidum (Leyss. ex Fr.) Karst, Coix lachryma-jobi L., Prunus armeniaca L., Prunus persica (L.) Batsch, Citrus junos Tanaka, Pueraria lobata (Willd.) Ohwi, Citrus unshiu Marcovitch, Feniculum vulgare Miller, Cuminum cyminum L., or the like, with specific plant extracts. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin which contains a plurality of plant extracts in combination and is easily adapted to the skin, and can exert a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect.

[0002]

2. Description of the Related Art Conventionally, extracts of various kinds of plants such as medicinal plants have been used for external preparations for skin (Fragrance Journal, Extra edition No. 1, 1979,
The same magazine, Extra Edition 6, No. 6, 1986). In recent years, with the increasing tendency toward nature and plant protection due to animal welfare, there is an increasing tendency to seek active ingredients in plant extracts.

However, although plant extracts have various actions, their actions are generally not so strong in general, and when an external preparation for skin contains an amount of the plant extract which produces the expected action effect. However, undesired coloring or odor was sometimes observed, or the formulation stability was sometimes lowered. Attempts have been made to enhance the action effects by using multiple plant extracts in combination, but it is difficult to improve the skin condition sufficiently because various factors are involved in the physiological functions of the skin in a complicated manner. Is.

[0004]

Therefore, in the present invention, by sufficiently improving the physiological function of the skin, it is possible to exert a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect, and to be compatible with the skin. The aim was to obtain an external preparation for skin which is excellent in formulation stability and safety.

[0005]

[Means for Solving the Problems] As a result of various investigations for solving the above problems, as a result of containing one or more kinds selected from a specific plant and an extract of a specific plant and fungus in combination. It was found that good results were obtained, and the present invention was completed.

That is, in the present invention, 1. 1. One or two kinds of plant extracts selected from coltsfoot and merrilot, and jujube extract 2. 1. One or two kinds of plant extracts selected from coltsfoot and merilito, and Coptis chinensis extract 3. Japanese coltsfoot extract and peony extract 4. Japanese coltsfoot extract and Touki extract 5. 6. One or two kinds of plant extracts selected from coltsfoot and merlot, and senkyu extract 6. 6. One or more plant extracts selected from coltsfoot, celery, and merlot, and cinnamon extract 7. Melilot extract and Scutellaria asiatica extract 8. 8. One or more kinds of plant extracts selected from parsley, red peppermint, coltsfoot, elderberry, ononis, celery, merlot, loofah, and mallow, and Gambir extract 9. Melilot extract and Butterfinch extract 10. Calendula, parsley, coltsfoot, altea, tormentila, Ononis, safflower, savonosa,
11. one or more plant extracts selected from cucumber, meliloto, loofah, and cassia extract 11. Melilot extract and yellowfin extract 12. 13. One or two plant extracts selected from coltsfoot and merlot, and turmeric extract 13. 13. One or more plant extracts selected from parsley, coltsfoot, tormentilla, elderberry, ononis, and merlot, and clove extract 14. Coltsfoot, safflower, soapless, celery,
15. one or more plant extracts selected from melirote and mugwort extract 15. 16. One or two kinds of plant extracts selected from coltsfoot and merlot, and ginger extract 16. 17. One or more plant extracts selected from coltsfoot, celery, and merlot, and Ganoderma lucidum extract 17. One or two selected from coltsfoot, celery
Seed plant extract and adlay extract 18. 19. One or two kinds of plant extracts selected from coltsfoot and merlot, and apricot extract 19. 20. One or more kinds of plant extracts selected from coltsfoot, celery, and merlot, and peach extracts 20. 20. One or more kinds of plant extracts selected from coltsfoot, celery, and merlot, and yuzu extracts 21. Parsley, coltsfoot, tormentilla, elderflower, arnica, ononis, safflower, cucumber,
A plant extract of one or more kinds selected from Malva persicae, and a kudzu extract 22. 23. One or more kinds of plant extracts selected from parsley, kosui mint, coltsfoot, altea, tormentilla, ononis, saponum, and cucumber, and Unshu mandarin extract 23. Melilot extract and fennel extract 24. Calendula, Coltsfoot, Altea, Horse Chestnut, Tormentilla, Elderflower, Arnica, Ononis, St. John's wort, Genus ginger, sage, safflower, senburi, saponsou, cucumber, meliroth, loofah, Yukinoshita, button, 1 species of scabbard, spermaceae, spurge. Alternatively, two or more kinds of plant extracts and cumin extracts are combined and blended in a skin external preparation.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Plants and fungi used in the present invention will be described.

[0008] The Calendula officinalis ( Ca
Lendula officinalis L.) is a first-year or second-year herb belonging to the family Asteraceae ( Compositae ), and can be used for each part of leaves, stems, flowers, roots and the whole plant, but it is preferable to use flowers.

The parsley ( Petroselin used in the present invention
um crispum (Mill.) Nym. Ex AWHill.) is Umbelliferae (Um
belliferae ) is a perennial or perennial plant with leaves, stems,
Although it is possible to use each part of flowers, fruits, etc. and whole grass,
Preference is given to using leaves and stems.

The Melissa officinalis L. used in the present invention is Labiat ( Labiat ).
With regard to the perennial herb belonging to ae ), each part of leaves, stems, roots, flowers and the like and the whole plant can be used, but it is preferable to use the leaves.

The coltsfoot used in the present invention ( Tuss
ilago farfara L.) is a perennial plant belonging to the family Asteraceae ( Compositae ), and its leaves, stems, flowers, roots and other parts and whole plants can be used, but leaves or flowers are preferred.

[0012] The Altea ( Althaea officinalis L.) used in the present invention is a Malvaceae ( Malv
As a perennial plant belonging to aceae ), each part of leaves, stems, flowers, roots and the whole plant can be used, but it is preferable to use leaves or roots.

Horse chestnut ( Aesculus turbinata Blume; Aesculus hippocastanu) used in the present invention
m L.) is a tree belonging to the family Hippocastanaceae ( Hippocastanaceae ), and can be used for each part of leaves, branches, bark, flowers, fruits and the like, and it is preferable to use leaves, bark or fruits.

[0014] Torumenchira used in the present invention (Pote
ntilla tormentilla ) is a perennial plant belonging to the family Rosaceae and can be used for each part such as leaves, stems, flowers, roots and the whole plant, but it is preferable to use roots.

The Sambucus nigra L. used in the present invention is a honeysuckle family ( Caprifoliac).
As a perennial plant belonging to eae ), each part of leaves, stems, flowers, roots, fruits, berries and the like and whole plants can be used, but it is preferable to use flowers or berries.

Arnica m used in the present invention
ontana L.) is a perennial plant belonging to the family Asteraceae ( Compositae ) and can be used for all parts of leaves, stems, flowers, roots, etc. and one or two species selected from root and head flowers. It is preferable to use the above site.

[0017] Ononisu used in the present invention (Ononis s
pinosa L.) is a perennial plant belonging to the legume family ( Leguminosae ) and can be used for each part such as leaves, stems, flowers, roots and the whole plant, but it is preferable to use roots.

Hypericum perforatum ( Hype used in the present invention
ricum erectum Thunb .; Hypericum perforatum L.)
It is a perennial plant belonging to the family Hypericum ( Guttiferae ).
Although various parts such as stems, flowers and roots and whole plants can be used, it is preferable to use whole plants.

Genoshoko ( Ge
ranium nepalense Sweet. var. thunbergii (Sieb. et
Zucc.) Kudo) is a perennial plant belonging to the family Geraniumaceae , and can be used for each part of leaves, stems, flowers, fruits and the like, but it is preferable to use the whole plant.

The sage used in the present invention ( Salvia off
icinalis L.) is a perennial belonging to the Labiatae (Labiatae), leaves, stems, roots, it is possible to use the site and whole plant flowers, etc., it is preferable to use leaves.

[0021] Safflower used in the present invention ( Carhama
s tinctorius L.) is a two-year herb belonging to the family Asteraceae ( Compositae ), and can be used for each part of leaves, stems, flowers, roots and the whole plant.

The assembly used in the present invention ( Ophelia
japonica (Schult.) Griseb.) is a Gentaceae ( Gentiace )
Among the 1 to 2 year old plants belonging to ae ), each part of leaves, stems, roots, flowers and the like and the whole plant can be used, but it is preferable to use the whole plant. Further, dried whole grass of Assemblies is a herbal medicine called "Toyaku", and such herbal medicine can also be used.

Sapona used in the present invention
ria officinalis L.) is a Caryophyllacea ( Caryophyllacea)
For the perennial plant belonging to e ), each part of leaves, stems, roots, flowers, etc. and the whole plant can be used, but it is preferable to use the roots. Dried soap roots are soy sauce called "Saponaria roots", and such crude drugs can be used.

Cucumis ( Cucumis) used in the present invention
sativus L.) is a vine annual plant belonging to the family Cucurbitaceae and can be used in all parts of leaves, stems, flowers, fruits and the like, but it is preferable to use fruits.

Celery used in the present invention ( Apium grav
eloens L. var. dulce (Mill. ) Pers.) , the Umbelliferae (Um
For the 1-2 year-old plant belonging to Belliferae ), each part of leaves, stems, flowers, fruits and the like and the whole plant can be used, but it is preferable to use above-ground parts such as leaves and stems.

Melilot used in the present invention
tuis officinalis L.) is a perennial plant belonging to the legume family ( Leguminosae ), and can be used for each part of leaves, stems, flowers, fruits, and whole plants, but use above-ground parts such as leaves and stems. Is preferred.

Luffa cyli used in the present invention
ndrica (L.) Roem) is an annual herb belonging to the family Cucurbitaceae , and can be used for each part of leaves, stems, flowers, fruits, sap, and the whole plant.

Saxifr ( Saxifr) used in the present invention
aga stolonifera Meerb.) is a family of Saxifragaceae ( Saxifrag
As a perennial plant belonging to aceae ), each part of leaves, stems, flowers, fruits and the like and whole grass can be used, but it is preferable to use above-ground parts such as leaves and stems.

Buttons used in the present invention ( Paeonia su
ffruticosa Andr.) is a perennial plant belonging to the family Paeoniaceae , and can be used for all parts of leaves, stems, flowers, fruits, roots and the like, but it is preferable to use root bark. Dried button root bark is a crude drug called "button pie", and such crude drug can also be used.

The common mallow ( Ma) used in the present invention
Lva sylvestris L.) is a two-year herb belonging to the Umbelliferae family, and can be used for each part of leaves, stems, flowers, fruits, roots, and whole plants.

[0031] Hamamelis used in the present invention (Hamame
lis virginiana L.) is a hawthorn family ( Hamamelidacea
The annual plant belonging to e ) can be used for each part of leaves, stems, flowers, fruits, roots, and the whole plant, but it is preferable to use leaves.

Jujube ( Ziziphus j used in the present invention
ujuba Mill.) is a tree belonging to the family Rhamnaceae and can be used for each part of leaves, branches, stems, bark, roots, flowers, fruits, etc., but it is preferable to use fruits. Further, dried jujube fruit is a herbal medicine called "Thaisou", and such herbal medicine can also be used.

Coptis j used in the present invention
aponica (Thunb.) Makino) is a Ranuncu family ( Ranuncu)
laceae ) is a perennial plant which can be used for each part such as leaves, stems, flowers, fruits, roots and the whole plant, but it is preferable to use roots. In addition, the rhizome of ours is “ouren”.
It is also called a crude drug, and such a crude drug can also be used.

Peony ( Paeoni) used in the present invention
a lactiflora Pall.) is a perennial plant belonging to the family Paeoniaceae , and can be used for each part of leaves, stems, flowers, fruits, roots and the like, but it is preferable to use roots. Further, dried peonies roots have been used as a crude drug in the West.

Touki ( Angelica a used in the present invention
cutiloba (Sieb. et Zucc.) Kitagawa) is a family of Umbe
lliferae ), perennials belonging to the category of leaves, stems, flowers, fruits, roots, etc., and whole plants can be used, but roots are preferred. Further, dried Touki root is a kind of crude drug called "Touki", and such crude drug can also be used.

Cnidiu used in the present invention
m officinale Malino) is a perennial plant belonging to the family Apiaceae ( Umbelliferae ) and can be used for each part of leaves, stems, flowers, fruits, roots and the whole plant, but it is preferable to use rhizomes. Also, dried rhizome of senkyu is a kind of crude drug called "senkyu", and such crude drug can also be used.

Saishin ( Asiarum used in the present invention
sieboldi (miq.) F. Maekawa) is a perennial plant belonging to the family Aristrochiaceae , which includes leaves, stems, flowers,
Although it is possible to use each part of fruits, roots and the whole plant,
Preference is given to using rhizomes. In addition, dried rhizome of saishin is a kind of crude drug called "saishin", and such crude drug can also be used.

Scuttled willow ( Scut
ellaria baicalensis Georgi) is a Labiatae ( Labiatae )
Among the perennial plants belonging to the category, leaves, stems, flowers, fruits, roots and the like, and whole plants can be used, but rhizomes are preferred. Also, dried roots of Scutellaria baicalensis is a kind of crude drug called “Stadium avium”, and such crude drug can also be used.

Gambir tree ( Un
caria gambir (Hunt) Rocb.) is a Rubiacea ( Rubiacea)
Trees belonging to e ) can use leaves, branches, trunks, bark, roots, flowers, fruits and the like, but preferably leaves and shoots. Further, the dried aqueous extract of leaves and young branches of Gambir tree is a crude drug called “Acenyak”, and such a crude drug can also be used.

The butterbur mushroom used in the present invention ( Po
ria cocos (Fr.) Wolf) is a Polygonaceae ( Polypo
Basidiomycetes belonging to raceae ). Moreover, the dried sclerotium of Bukuritake mushrooms is a crude drug called "Bukryou", and such a crude drug can also be used.

Cassia ( Cinnamomi) used in the present invention
cassia Presl.) is a small tree belonging to the Lauraceae family, and can be used for each part of leaves, branches, stems, bark, roots, flowers, fruits, etc., but it is preferable to use bark. The dried bark of Cassia is a crude drug called "Keihi", and such crude drug can also be used.

[0042] Phellodend used in the present invention
ron amurense Pupr.) is a tree belonging to the citrus family ( Rutaceae ), and can use leaves, branches, stems, bark, roots, flowers, fruits and the like, but it is preferable to use bark.
Also, dried bark of yellowfin is “Oubaku”
This crude drug is called, and such crude drug can be used.

Turmeric used in the present invention ( Curcuma do
mestica Valet.) is a perennial herb belonging to the Zingiberaceae family, and can be used for each part of leaves, stems, flowers, fruits, roots and the like, but it is preferable to use rhizomes. Further, dried turmeric rhizome is a kind of crude drug called "turmeric", and such crude drug can also be used.

Clove ( Syzygium) used in the present invention
aromaticum (L.) Merril et Perry) is a tree that belongs to the family Myrtaceae , and includes leaves, branches, stems, bark,
Although various parts such as roots, flowers and fruits can be used, it is preferable to use buds or leaves. Further, dried buds of clove are crude drugs called "clove", and such crude drugs can also be used.

Artemisia used in the present invention
princeps Pamp.) is a perennial plant belonging to the family Asteraceae ( Compositae ) and can be used for each part of leaves, stems, flowers, fruits, roots and the like, but it is preferable to use leaves. Also, dried leaves of mugwort are a kind of crude drug called "mugwort", and such crude drugs can be used.

Ginger ( Zingiber) used in the present invention
officinale Rosc.) is a ginger family ( Zingiberaceae )
Among the perennial plants belonging to the category, leaves, stems, flowers, fruits, roots and the like, and whole plants can be used, but rhizomes are preferred. Further, dried ginger rhizome is a kind of crude drug called "ginger", and such crude drug can be used.

Ganoderma lucidum used in the present invention ( Gano
derma lucidum (Leyss. ex Fr.) Karst) is a Basidiomycetes belonging to ganodermataceae (Ganodermataceae).
The dried fruit body of Ganoderma lucidum is "Reishi"
It is a crude drug called, and this crude drug can also be used.

Coix lac used in the present invention
hryma-jobi L.) is an annual herb belonging to the family Gramineae , and can be used for each part of leaves, stems, flowers, seeds, roots, and the whole plant, but it is preferable to use seeds. In addition, seeds obtained by removing the seed coat of pearl barley are a kind of crude drug called "Yokuinin", and such crude drug can also be used.

Apricot ( Prunus arm) used in the present invention
eniaca L.) is a tree belonging to Rosaceae ,
Each part of leaves, branches, trunks, bark, roots, flowers, fruits, seeds and the like can be used, but seeds are preferably used. Apricot seeds are a kind of crude drug called "Kyonin", and such crude drug can also be used.

Peach ( Prunus persi) used in the present invention
ca (L.) Batsch) is a tree belonging to the family Rosaceae , which can use leaves, branches, stems, bark, roots, flowers, fruits, seeds, etc., but seeds are used. preferable. In addition, peach seeds are a kind of crude drug called "tonin", and such crude drug can also be used.

Citrus junos used in the present invention
Sieb. Et Tanaka) is a tree belonging to the citrus family ( Rutaceae ), and can be used in various parts such as leaves, branches, stems, bark, roots, flowers, fruits, seeds, and pericarps. Is preferably used.

Scraps ( Pueraria lob) used in the present invention
ata (Willd.) Ohwi) is a perennial plant belonging to the legume family ( Leguminosae ), and can be used for each part of leaves, stems, flowers, fruits and the like, but it is preferable to use roots. Kudzu root is a kind of crude drug called "Kakkon", and such crude drug can also be used.

Citrus unshiu Marcovitch used in the present invention is Rutacea ( Rutacea).
In the tree belonging to e ), each part of leaves, branches, trunks, bark, roots, flowers, fruits, seeds, pericarps and the like can be used, but it is preferable to use fruits, pericarps and leaves. Moreover, the dried skin of Unshu mandarin is a kind of crude drug called "Chinpi", and such crude drug can also be used.

Foenic used in the present invention
ulum vulgare Miller) is a perennial plant belonging to the family Umbelliferae ( Umbelliferae ), and it is possible to use each part of leaves, stems, roots, flowers, fruits and the like, and it is preferable to use fruits. Dried fennel fruit is a kind of crude drug called "fennel", and such crude drug can also be used.

Cuminum cy used in the present invention
minum L.) is a perennial plant belonging to the Umbelliferae family, and can be used for each part of leaves, stems, roots, flowers, fruits, seeds and the like, and it is preferable to use seeds.

Next, a method for extracting plant and fungal extracts used in the present invention will be described.

In the present invention, the above-mentioned plants and fungi may be used for extraction as they are, but in view of extraction efficiency, it is preferable to perform extraction after performing processes such as shredding, drying and crushing. The extraction is performed by immersing it in an extraction solvent. It may be stirred or homogenized in an extraction solvent in order to improve the extraction efficiency. As the extraction temperature, it is appropriate to set the temperature to about 5 ° C. to a temperature not higher than the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is suitable to be about 4 hours to 14 days.

As the extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate. It is possible to use polar organic solvents such as acetone, ketones such as ethyl methyl ketone, etc., and one kind or two or more kinds are selected from these and used. Alternatively, physiological saline, phosphate buffer, phosphate buffered saline, etc. may be used.

The extract of the above plant and fungus with the above solvent can be contained in the external preparation for skin according to the present invention as it is, but the concentrated and dried product can be redissolved in water or a polar solvent, or It may be used after purification treatment such as decolorization, deodorization, desalting or the like within a range that does not impair the action of improving the physiological function of skin, or after fractionation treatment by column chromatography. For storage, it can be used after being purified and then freeze-dried and dissolved in a solvent before use. It can also be used by encapsulating it in vesicles such as liposomes or in microcapsules.

The amount of the above-mentioned plant and fungal extract in the present invention to be added to the external preparation for skin is preferably 0.00.
It is in the range of 001 to 5% by weight, particularly 0.0001 to 1% by weight. Within this range, when formulated in combination with a specific plant and fungal extract, it does not affect the stability of the formulation and the plant and fungal extract in the formulation over time,
It is possible to exert a higher effect.

The external preparation for skin according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders and granules. In addition, skin cosmetics such as lotion, emulsion, cream, beauty essence, pack,
Makeup base lotion, base cosmetics such as makeup base cream, foundation of each dosage form such as milky liquid, oily, solid, etc., makeup cosmetics such as eye color, cheek color, cleansing cream, cleansing lotion, cleansing foam , It can also be provided as a skin cleansing agent such as face wash soap and body shampoo, and a hair cosmetic such as hair shampoo, hair rinse and hair treatment.

The external preparation for skin according to the present invention includes oily components, surfactants, humectants, pigments, UV absorbers, antioxidants, fragrances, antibacterial agents, in addition to the above plant and fungal extracts. It may also contain general raw materials for pharmaceuticals and cosmetics such as mildews, and physiologically active ingredients such as skin cell activating agents, anti-inflammatory agents, and whitening agents.

[0063]

EXAMPLES The features of the present invention will be described in detail with reference to Examples. First, a preparation example of each plant extract used in the present invention is shown below.

[Preparation Examples 1 to 49] 200 g of each of the plants and fungi shown in Table 1 was dried and pulverized, and extracted by stirring in 1 liter of 50% by volume ethanol aqueous solution at 20 ° C. for 3 days, and then filtered. The liquid was collected and the plant extracts according to Preparation Example 1 to Preparation Example 49 were obtained.

[0065]

[Table 1]

Next, examples of the external preparation for skin using the extracts of plants and fungi shown in Production Examples 1 to 48 will be shown.

[Examples 1 to 62, Comparative Examples 1 to 49] Beauty liquid (1) Beeswax 6.00 (wt%) (2) Cetanol 5.00 (3) Reduced lanolin 8.00 (4) Squalane 27. 50 (5) Glyceryl fatty acid ester 4.00 (6) Lipophilic glyceryl monostearate 2.00 (7) Polyoxyethylene (20 E.O.) sorbitan 5.00 Monolaurate (8) Propylene glycol 5. 00 (9) Methyl paraoxybenzoate 0.10 (10) Purified water 37.30 (11) Component 1 shown in Tables 2 to 4 (12) Component 2 0.05 shown in Tables 2 to 4 Production method : Mix the oil phase components (1) to (7), heat and dissolve to 75
℃. On the other hand, the water phase components (8) to (10) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the aqueous phase component to pre-emulsify it, then homogenize with a homomixer, and after cooling, (11) and (12) are added and mixed at 40 ° C.

[0068]

[Table 2]

[0069]

[Table 3]

[0070]

[Table 4]

For the above Examples 1 to 62 and Comparative Examples 1 to 49 of the present invention, the effect of improving rough skin was examined. A group of 10 healthy people aged 25 to 50 years was photographed with a microscope to observe the skin condition before inducing experimental rough skin, and the score was calculated according to the criteria shown in Table 5. Experimental rough skin was induced by treating the inner part of the upper arm with a mixed solution of ether and acetone (1: 1 by volume). Further, thereafter, the test serum was applied twice daily in the morning and at night for 7 days, and the skin condition score was obtained 1 and 7 days after the induction of rough skin, as described above. At the same time, the water content in the stratum corneum of the application site was measured 1 day and 7 days after the induction of rough skin. The stratum corneum water content was indicated by the measured value of skin surface conductance (μMuo). The results are shown in Tables 6-9.

[0072]

[Table 5]

[0073]

[Table 6]

[0074]

[Table 7]

[0075]

[Table 8]

[0076]

[Table 9]

As shown in Tables 6 to 9, by applying to the skin, the beauty essence prepared by combining the extracts of the specific plants and fungi according to Examples 1 to 62 of the present invention, It was shown that the skin roughening effect was improved and the water content of the stratum corneum increased. On the other hand, in Comparative Examples 1 to 49 in which the plant and fungal extracts are not used alone or in any combination, although the skin roughening improvement and the stratum corneum water content increase tendency are observed, the effect is more than in the examples. It was clearly low.

Further, the panelists of each group were evaluated for the easiness of the test beauty essence to adapt to the skin. In addition, during the use test period, an interview survey was conducted to find out if there was any feeling of skin irritation or abnormalities such as erythema or rash when the sample was used. Regarding the familiarity to the skin, the feeling of skin irritation, and the presence or absence of skin abnormality, the results were scored according to the evaluation criteria shown in Table 10 and the average value of 10 persons was calculated. The results are summarized in Tables 11 and 12.

[0079]

[Table 10]

[0080]

[Table 11]

[0081]

[Table 12]

In Tables 11 and 12, the use groups of Examples 1 to 62 of the present invention were evaluated to have good compatibility with the skin. Further, as shown in Table 11, no irritating sensation of skin or abnormal skin was observed in each of the samples used in the use test this time.

Example 63 Cleansing Massage Cream (1) Purified Water 22.20 (wt%) (2) 1,3-Butylene Glycol 7.00 (3) Sucrose Fatty Acid Ester 3.00 (4) N- Stearoyl-L-sodium glutamate 1.00 (5) Carboxyvinyl polymer (1% by weight aqueous solution) 15.00 (6) L-Arginine (10% by weight aqueous solution) 1.50 (7) Paraoxybenzoic acid ester 0.10 ( 8) Squalane 44.00 (9) Behenyl alcohol 1.50 (10) Lipophilic glyceryl monostearate 1.50 (11) Stearic acid 1.00 (12) Glyceryl triisostearate 1.00 (13) Hardened oil 0 .50 (14) Perfume 0.10 (15) Production Example 4 (Fukidanpopo) 0.10 (16) Production Example 20 (Merilot) 0.10 (17) Production Example 11 (Ononis) 0.10 (18) Production Example 27 (Oren) 0.10 (19) Production Example 35 (cassia) 0.10 (20) Production Example 37 (turmeric) 0.10 Production method: The oil phase components of (8) to (13) are mixed, heated and dissolved to 70
℃. On the other hand, the aqueous phase components (1) to (7) are mixed, dissolved and heated to 70 ° C. The oil phase is gradually added to this aqueous phase component to carry out preliminary emulsification, then uniformly emulsified with a homomixer, cooled, and (14) to (20) are added and mixed at 40 ° C.

Example 64 Lotion for Wiping (1) Purified Water 86.64 (wt%) (2) Ethanol 8.00 (3) Glycerin 4.00 (4) Polyglyceryl Monolaurate 0.70 (5 ) Sodium citrate 0.05 (6) Citric acid 0.01 (7) Sucrose fatty acid ester 0.04 (8) Paraoxybenzoic acid ester 0.01 (9) Perfume 0.05 (10) Production Example 2 (parsley) ) 0.10 (11) Production Example 17 (Soap) 0.10 (12) Production Example 27 (Oren) 0.10 (13) Production Example 29 (Touki) 0.10 (14) Production Example 4 (Fukidandelion) 0 10 Manufacturing method: Components (2) to (14) were sequentially added to (1) and mixed,
Dissolve and homogenize.

Example 65 Face Wash Foam (1) Myristic Acid 24.30 (wt%) (2) Palmitic Acid 3.65 (3) Self-Emulsifying Glycerin Monostearate 3.00 (4) Purified Water 38. 00 (5) Glycerin 17.00 (6) Potassium hydroxide 7.75 (7) Diglycerin 3.00 (8) 1,3-Butylene glycol 1.00 (9) N-stearoyl-L-glutamate disodium 1 0.000 (10) Polyglyceryl monolaurate 0.50 (11) Paraoxybenzoic acid ester 0.10 (12) Production Example 12 (Hypericum perforatum) 0.10 (13) Production Example 2 (parsley) 0.10 (14) Production Example 5 (Altea) 0.10 (15) Production Example 27 (Ourene) 0.10 (16) Production Example 29 (Touki) 0.10 (17) Production Example 4 (Fukidanpopo) 0.10 (18) Perfume 0.10 Manufacturing method: The oil phase components of (1) to (3) are mixed, heated and dissolved to 70
℃. On the other hand, the aqueous phase components (4) to (11) are mixed, dissolved and heated to 70 ° C. The above oil phase is gradually added to this aqueous phase component for saponification, followed by cooling and adding and mixing (12) to (18) at 40 ° C.

[Example 66] Cleansing cream (1) Purified water 10.80 (wt%) (2) Glycerin 15.80 (3) Sucrose fatty acid ester 5.00 (4) Polyoxyethylene glyceryl isostearate 3. 00 (5) 1,3-butylene glycol 1.00 (6) Methyl paraoxybenzoate 0.02 (7) Squalane 32.00 (8) Glyceryl tri-2-ethylhexanoate 18.55 (9) Neopentyl dicaprate Glycol 9.30 (10) Stearic acid 1.00 (11) Jojoba oil 1.00 (12) Beeswax 1.00 (13) Mixed fatty acid triglyceride 1.00 (14) Perfume 0.10 (15) Production Example 13 ( Genoshoko) 0.10 (16) Production Example 5 (Altea) 0.10 (17) Production Example 11 (Ononis) 0.10 (18) Production Example 27 (Ourene) 0.10 (19) Production Example 35 (Cassia) 0.10 (20) Production Example 37 (C Con) 0.10 (21) Production Example 4 (Fukitanpopo) 0.10 Production method: The oil phase components of (7) to (13) are mixed and heated to dissolve 70
℃. On the other hand, the aqueous phase components (1) to (6) are mixed, dissolved and heated to 70 ° C. The oil phase is gradually added to this aqueous phase component to preliminarily emulsify, then uniformly emulsified with a homomixer, cooled, and (14) to (21) are added and mixed at 40 ° C.

[Example 67] Face wash (1) Purified water 37.30 (% by weight) (2) Glycerin 17.00 (3) Potassium hydroxide 7.75 (4) Diglycerin 3.00 (5) 1 , 3-Butylene glycol 1.00 (6) Methyl paraoxybenzoate 0.10 (7) Myristic acid 24.30 (8) Palmitic acid 3.65 (9) Self-emulsifying glyceryl monostearate 3.00 (10) Maltitol hydroxyalkyl ether 1.00 (11) Coconut oil fatty acid amide propyl betaine solution (30% by weight aqueous solution) 1.00 (12) Perfume 0.30 (13) Production Example 12 (Hypericum perforatum) 0.10 (14) Production Example 2 (Parsley) 0.10 (15) Production Example 5 (Altea) 0.10 (16) Production Example 27 (Ourene) 0.10 (17) Production Example 29 (Touki) 0.10 (18) Production Example 4 (Fukey dandelion) 0.10 Manufacturing method: Mix the oil phase components (7) to (11) and melt by heating. To 70
℃. On the other hand, the aqueous phase components (1) to (6) are mixed, dissolved and heated to 70 ° C. The above oil phase is gradually added to this aqueous phase component for saponification, followed by cooling and adding and mixing (12) to (18) at 40 ° C.

Example 68 Lotion (1) Purified water 87.98 (% by weight) (2) Ethanol 10.00 (3) Glycerin 1.50 (4) Sodium citrate 0.09 (5) Citric acid 0.02 (6) Methyl paraoxybenzoate 0.05 (7) Sucrose fatty acid ester 0.04 (8) Fragrance 0.02 (9) Production Example 1 (Pinkweed) 0.05 (10) Production Example 9 ( Elderberry) 0.05 (11) Production Example 26 (jujube) 0.05 (12) Production Example 33 (Gambir tree) 0.05 (13) Production Example 36 (Kihada) 0.05 (14) Production Example 20 (Mellilot ) 0.05 Manufacturing method: The components (2) to (14) are sequentially added to (1) and mixed,
Dissolve and homogenize.

Example 69 Emulsion (1) Purified water 85.50 (% by weight) (2) Glycerin 3.60 (3) Carboxyvinyl polymer 0.10 (4) N-stearoyl-L-glutamate sodium 0.1. 24 (5) Methyl paraoxybenzoate 0.10 (6) 1,3-butylene glycol 0.01 (7) N-stearoyl-L-glutamate disodium 0.01 (8) Xanthan gum 0.01 (9) Polyacryl Sodium acid 0.01 (10) L-arginine 0.24 (11) squalane 3.24 (12) Stearic acid 0.72 (13) Cetanol 0.60 (14) Beeswax 0.48 (15) Lipophilic Mono Glycerin stearate 0.48 (16) Jojoba oil 0.10 (17) Mixed fatty acid triglyceride 0.10 (18) Behenyl alcohol 0.01 (19) Ethanol 4.00 (20) Perfume 0.05 (21) Production Example 5 (Altea) 0.05 (22) Production Example 11 (Ononis) 0.05 (23) Production Example 26 (Natsume) 0.05 (24) Production Example 28 (Peonies) 0.05 (25) Production Example 34 (Bukuritaketake) 0.05 (26) Production Example 36 (Kihada) 0.05 (27) Production Example 4 (Fukidanpopo) 0.05 (28) Production Example 20 (Meliloth) 0.05 Production method: The oil phase components of (11) to (18) are mixed and dissolved by heating. Then 70
℃. On the other hand, the aqueous phase components (1) to (10) are mixed, dissolved and heated to 70 ° C. The oil phase is gradually added to this water phase component to preliminarily emulsify, then uniformly emulsified with a homomixer, cooled, and (19) to (28) are added and mixed at 40 ° C.

[Example 70] Oil-in-water emulsion cream (1) Purified water 63.57 (% by weight) (2) 1,3-butylene glycol 10.00 (3) N-stearoyl-L-glutamate sodium salt 40 (4) Sucrose fatty acid ester 0.40 (5) L-arginine 0.13 (6) Methyl paraoxybenzoate 0.10 (7) Octyldodecyl myristate 7.00 (8) Glycerin 5.00 (9) Squalane 4.00 (10) Lipophilic glyceryl monostearate 3.50 (11) Beeswax 3.00 (12) Stearic acid 1.00 (13) Behenyl alcohol 1.00 (14) Palmitic acid 0.50 (15) Production Example 4 (Fukidandelion) 0.10 (16) Production Example 22 (Yukinoshita) 0.10 (17) Production Example 30 (Senkyu) 0.10 (18) Production Example 33 (Gambir tree) 0.10 Production method: (7) ~ Mix the oil phase components of (14), heat and dissolve to 7
℃. On the other hand, the aqueous phase components (1) to (6) are mixed, dissolved and heated to 70 ° C. The oil phase is gradually added to this aqueous phase component to preliminarily emulsify, then uniformly emulsify with a homomixer, cool and add (15) to (18) at 40 ° C. and mix.

Example 71 Pack (1) Purified water 67.97 (% by weight) (2) Polyvinyl alcohol 12.50 (3) Ethanol 10.00 (4) Glycerin 5.00 (5) Tri (capryl. Capric acid) Glycerin 0.10 (6) Polyethylene glycol (average molecular weight 1540) 3.00 (7) Sorbitan monolaurate 0.30 (8) Perfume 0.25 (9) Sucrose fatty acid ester 0.05 (10) Paraoxy Methyl benzoate 0.02 (11) Hydrogenated soybean phospholipid 0.01 (12) Production Example 1 (Panthera esculenta) 0.20 (13) Production Example 4 (Fukidandelion) 0.20 (14) Production Example 26 (jujube) ) 0.20 (15) Production Example 28 (peony) 0.20 Production method: The components (2) to (15) are sequentially added to (1) and mixed,
Dissolve and homogenize.

For each example of the present invention, 25 ° C.
When stored for 6 months, no change in state such as coloring, odor, aggregation, precipitation or deposition of contents components, and phase separation was observed.

[0093]

As described above in detail, according to the present invention, a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect are obtained.
Moreover, it was possible to obtain an external preparation for the skin, which had good compatibility with the skin and which was excellent in formulation stability and safety.

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Claims (24)

[Claims] 1. A skin external preparation comprising a jujube extract in combination with one or two kinds of plant extracts selected from coltsfoot and melilot. 2. An external preparation for skin, which comprises a combination of one or two plant extracts selected from coltsfoot and melilot, and an orenum extract. 3. A skin external preparation comprising a combination of coltsfoot extract and peony extract. 4. A skin external preparation comprising a combination of coltsfoot extract and Touki extract. 5. A skin external preparation comprising a combination of one or two kinds of plant extracts selected from coltsfoot and melilot, and a senkyu extract. 6. An external skin preparation comprising a combination of one or more plant extracts selected from coltsfoot, celery, and merlot with a sacin extract. 7. An external preparation for skin, which comprises a combination of a melilot extract and an extract of Scutellaria baicalensis. 8. One or two selected from parsley, red peppermint, coltsfoot, elderflower, ononis, celery, merilott, loofah, and swordfish.
A skin external preparation comprising a combination of at least one plant extract and a Gambir tree extract. 9. An external preparation for the skin, which comprises a combination of a melilot extract and an extract of Ganoderma lucidum. 10. A cassia extract is used in combination with one or more kinds of plant extracts selected from pearl millet, parsley, coltsfoot, altea, tormentilla, ononis, safflower, saponum, cucumber, merilito, loofah. External preparation for skin. 11. A skin external preparation comprising a combination of a melilot extract and a yellowfin extract. 12. A skin external preparation comprising a combination of one or two kinds of plant extracts selected from coltsfoot and merlot, and a turmeric extract. 13. A skin external preparation comprising a clove extract in combination with one or more plant extracts selected from parsley, coltsfoot, tormentilla, elderberry, ononis, and merlot. 14. An external preparation for skin, which comprises a combination of one or more kinds of plant extracts selected from coltsfoot, safflower, saponum, celery, and merilito with a mugwort extract. 15. An external preparation for skin, which comprises a combination of one or two kinds of plant extracts selected from coltsfoot and melilot, and a ginger extract. 16. A skin external preparation comprising a combination of one or more kinds of plant extracts selected from coltsfoot, celery, and merlot, and an extract of Ganoderma lucidum. 17. A skin external preparation comprising one or two kinds of plant extracts selected from coltsfoot and celery, and an adlay extract. 18. A skin external preparation comprising a combination of one or two kinds of plant extracts selected from coltsfoot and melilot, and an apricot extract. 19. A skin external preparation comprising a peach extract in combination with one or more plant extracts selected from coltsfoot, celery, and merlot. 20. An external preparation for skin, which comprises a combination of one or more kinds of plant extracts selected from coltsfoot, celery, and merlot with a yuzu extract. 21. An external preparation for skin, which comprises a kudzu extract in combination with one or more plant extracts selected from parsley, coltsfoot, tormentilla, elderflower, arnica, ononis, safflower, cucumber, and mallow. .. 22. Parsley, kosui mint, coltsfoot, altea, tormentila, ononis, savonosa,
A skin external preparation comprising one or more kinds of plant extracts selected from cucumber and an unshiu mandarin extract in combination. 23. A skin external preparation comprising a combination of a melilot extract and a fennel extract. 24. Calendula officinalis, coltsfoot, altea, horse chestnut, tormentila, elderberry, arnica, ononis, gentius, genopsis, sage, safflower, senburi, saponsou, cucumber, meriloto, luffa, yukinoshita, button, usus, button, usus. A skin external preparation comprising a cumin extract in combination with one or more selected plant extracts.