JP3457807B2 - Skin heterogeneity improving enhancer and composition containing the same - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin unevenness improving agent and a skin unevenness improving agent and a skin unevenness improving agent suitable for improving and preventing dullness caused by aging and the like. Concerning the contained cosmetics.

[0002]

2. Description of the Related Art Everyone has a desire to look more beautiful than others. For this reason, the mechanism for making the product look beautiful has been studied, and various cosmetics have been developed based on the results. For example, a cosmetic containing a moisturizing component such as sodium hyaluronate can improve the water retention of the skin and prevent the formation of wrinkles, and a cosmetic containing an ascorbic acid derivative suppresses the production of melanin. It can prevent the skin color from becoming black. Among such technological innovations, the phenomenon of so-called "dullness" has not been clarified yet, and the cosmetics for improving it have not yet been developed. "Dullness" here is a state in which the skin color appears darker with a reddish tint, and it feels sagging without a lively feeling, and it is already known that it increases as you get sick and age. Known and nobody wants to be in this state. Treatment with the cosmetics developed so far can improve "dullness", but moisturizing cosmetics improve or prevent wrinkles, or whitening cosmetics produce melanin. The effect is not so large that the whiteness is suppressed. It is said that "dullness" is different from these physiological phenomena in different types and causes.

Under these circumstances, the inventors of the present invention "dull"
As a result of repeated studies for the cause of the above, it was found that "dullness" was caused by non-uniformity of the fine structure of the skin. However, for materials that improve such non-uniformity of skin, that is, non-uniformity of low brightness distribution, non-uniformity of melanin distribution or non-uniformity of stratum corneum exfoliation, The reality is that nothing is known at all.

On the other hand, the plant essence shown in (a) below improves such skin non-uniformity, and the plant essence shown in (b) enhances such skin non-uniformity improving action. It was not known at all to do and as a result significantly improve "dullness". (A) Birch (Betula pendula Roth.), Jujuba millet (Zizyphus jujuba Mill.), Rose family (Rosa multiflora Thun.), Hypericum (Hypericum erectum Thun.), Hypericum perforum
L.), Lamiaceae sage (Salvia officinalis L.), Peony peony (Paeonia lactiflora Pall), Nettle nettle (Urtica thunbergiana Sie. Or Urtica)
dioica L.), Lotus lotus (NelumbonaceaeNelumbo) (b) Seriaceous lichen (Ligusticum wallichi F)
r.), ginger turmeric (Curcuma longa L.), cucurbitaceae loofah (Luffa cylindria Roem.), sesameaceae genus (Rhemania glutinosa Lib.), Asteraceae mosquito (Car
thamus tinctorius L.), Araliaceae carrot (Panax gi)
nseng CA Meyer), Apiaceae (Scutellaria b)
aicalensis Geo.) Tonin (Purnus persica Ba)
t.)

[0005]

The present invention has been made under such circumstances, and provides a material for improving skin non-uniformity, a material for enhancing the skin non-uniformity improving action, and a cosmetic for improving dullness. The challenge is to provide.

[0006]

In view of the above situation, the inventors of the present invention have conducted intensive studies to find the cause of "dullness", and as a result, found that the nonuniformity of the skin is a major factor. Based on this finding, we conducted further research in search of substances that have the effect of improving skin non-uniformity.
We found such an effect in the essence of the plant shown in. As a result of further studies, it was found that the plant essence shown in (b) below has an effect of enhancing the dullness improving effect resulting from such skin non-uniformity improving effect. As a result of repeated studies, it was confirmed that the cosmetics containing the essence of (a) and the essence of (b) have an excellent effect of improving "dullness" and completed the invention. Hereinafter, the present invention will be described in detail with a focus on embodiments of the invention. (A) Birch (Betula pendula Roth.), Jujuba millet (Zizyphus jujuba Mill.), Rose family (Rosa multiflora Thun.), Hypericum (Hypericum erectum Thun.), Hypericum perforum
L.), Lamiaceae sage (Salvia officinalis L.), Peony peony (Paeonia lactiflora Pall), Nettle nettle (Urtica thunbergiana Sie. Or Urtica)
dioica L.) (b) Ceriaceae senkyu (Ligusticum wallichi F)
r.), ginger turmeric (Curcuma longa L.), cucurbitaceae loofah (Luffa cylindria Roem.), sesameaceae genus (Rhemania glutinosa Lib.), Asteraceae mosquito (Car
thamus tinctorius L.), Araliaceae carrot (Panax gi)
nseng CA Meyer), Apiaceae (Scutellaria b)
aicalensis Geo.) Tonin (Purnus persica Ba)
t.)

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Skin non-uniformity improving agent of the present invention The skin non-uniformity improving agent used in the present invention comprises one or more of the following plant essences (a). . Here, the essence is a plant itself, a processed product obtained by drying, crushing, or shredding a part or all of the plant, a part or all of the plant, or a solvent extract of the processed product or removal of the solvent thereof. It is a general term for products and their fractions. The most preferable of these essences is a solvent extract of a part or all of the plant body, or a processed product thereof, or a solvent-removed product thereof. The solvent used for solvent extraction is preferably a polar solvent, and examples of the polar solvent include alcohols such as methanol and ethanol, esters such as ethyl acetate and methyl formate, nitriles such as acetonitrile, ethers such as diethyl ether and tetrahydrofuran. Preferred examples thereof include halogenated hydrocarbons such as chloroform and methylene chloride, ketones such as acetone and methyl ethyl ketone, polyhydric alcohols such as 1,3-butanediol and glycerin, and water. These may be used alone or in combination of two or more. Among these, more preferable is a method of extraction using one or more selected from alcohols, polyhydric alcohols and water. The extraction method may be carried out according to a usual method, for example, adding 1 to 10 times the solvent to the plant or the processed product of the plant, and soaking it for several days at room temperature and for several hours at a temperature near the boiling point. Just do it. It is also possible to add stirring appropriately. The extract thus obtained may be used as it is, or the solvent may be removed by distillation under reduced pressure or the like, or may be purified by silica gel column chromatography, liquid-liquid extraction or the like before use. The production examples are shown below. (A) Birch (Betula pendula Roth.), Jujuba millet (Zizyphus jujuba Mill.), Rose family (Rosa multiflora Thun.), Hypericum (Hypericum erectum Thun.), Hypericum perforum
L.), Lamiaceae sage (Salvia officinalis L.), Peony peony (Paeonia lactiflora Pall), Nettle nettle (Urtica thunbergiana Sie. Or Urtica)
dioica L.)

[Production Example 1] Birch leaves, bark, xylem 1
After adding 1 Kg of 1,3-butanediol to Kg and heating at 90 ° C. for 3 hours, the insoluble matter was filtered off to obtain 0.8 Kg of skin non-uniformity improver 1.

[Production Example 2] Birch leaves, bark, xylem 1
A 50% ethanol aqueous solution (10 l) was added to Kg, the mixture was refluxed for 2 hours, the insoluble matter was filtered off, and the solvent was distilled off to obtain 68 g of a skin heterogeneity improving agent 2.

[Production Example 3] 1K dried product of Taiso fruit
10 g of 50% ethanol aqueous solution was added to g, refluxed for 2 hours, insoluble matter was filtered off, and the solvent was distilled off to obtain 430 g of skin non-uniformity improving agent 3.

[Production Example 4] Dried product 1 of the fruits of Ages 1
A 50% ethanol aqueous solution (10 l) was added to Kg, the mixture was refluxed for 2 hours, the insoluble matter was filtered off, and the solvent was distilled off to obtain 180 g of skin heterogeneity improving agent 4.

[Production Example 5] 1 kg of whole plant of Hypericum perforatum
50% ethanol aqueous solution (10 L) was added to the mixture, the mixture was refluxed for 2 hours, the insoluble matter was filtered off, and the solvent was distilled off to obtain 144 g of skin heterogeneity improving agent 5.

[Production Example 6] To 1 kg of whole grass of St. John's wort, 10 l of 50% ethanol aqueous solution was added, and the mixture was refluxed for 2 hours. The insoluble matter was filtered off and the solvent was distilled off to obtain 138 g of a skin heterogeneity improving agent. Got 6.

[Production Example 7] To 1 kg of roots of peony, 10 l of 50% ethanol aqueous solution was added and refluxed for 2 hours.
The insoluble matter was filtered off and the solvent was distilled off to obtain 251 g of a skin non-uniformity improving agent 7.

[Production Example 8] 50 per 1 kg of nettle leaves
10% aqueous ethanol solution was added, the mixture was refluxed for 2 hours, the insoluble matter was filtered off, and the solvent was distilled off to obtain 165 g of a skin heterogeneity improving agent 8.

[Production Example 9] To 1 Kg of lotus root lotus, 10 l of 50% ethanol was added and refluxed for 2 hours. Insoluble matter was filtered off and the solvent was distilled off to obtain 123 g of skin heterogeneity improving agent 9. Obtained.

(2) Skin Heterogeneity Improvement Enhancer of the Present Invention The skin heterogeneity improvement enhancer of the present invention comprises one or more plant essences shown in (b) below. Here, the essence is a plant itself, a processed product obtained by drying, crushing, or shredding a part or all of the plant, a part or all of the plant, or a solvent extract of the processed product or removal of the solvent thereof. It is a general term for products and their fractions. The most preferable of these essences is a solvent extract of a part or all of the plant body, or a processed product thereof, or a solvent-removed product thereof. The solvent used for solvent extraction is preferably a polar solvent, and examples of the polar solvent include alcohols such as methanol and ethanol, esters such as ethyl acetate and methyl formate, nitriles such as acetonitrile, ethers such as diethyl ether and tetrahydrofuran. , Halogenated hydrocarbons such as chloroform and methylene chloride,
Ketones such as acetone and methyl ethyl ketone, 1,3-
Preference is given to polyhydric alcohols such as butanediol and glycerin, and water. These may be used alone or in combination of two or more. Among these, more preferable is a method of extraction using one or more selected from alcohols, polyhydric alcohols and water. The extraction method may be carried out according to a usual method, for example, adding 1 to 10 times the solvent to the plant or the processed product of the plant, and soaking it for several days at room temperature and for several hours at a temperature near the boiling point. Just do it. It is also possible to add stirring appropriately. The extract thus obtained may be used as it is, or the solvent may be removed by distillation under reduced pressure or the like, or may be purified by silica gel column chromatography, liquid-liquid extraction or the like before use. The production examples are shown below. (B) Limeticum wallichi F
r.), ginger turmeric (Curcuma longa L.), cucurbitaceous loofah (Luffa cylindria Roem.), sesameaceae genus (Rhemania glutinosa Lib.), asteraceae (Car)
thamus tinctorius L.), Araliaceae carrot (Panax gi)
nseng CA Meyer), Apiaceae (Scutellaria b)
aicalensis Geo.) Tonin (Purnus persica Ba)
t.)

[Production Example 10] Rhizome 1 of Asteraceae
Add 50 l of 50% ethanol to Kg, reflux for 2 hours,
The insoluble material was filtered off and the solvent was distilled off to obtain 135 g of skin unevenness improving agent 1.

[Production Example 11] Turmeric root 1 of Ginger family Turmeric
Add 50 l of 50% ethanol to Kg, reflux for 2 hours,
The insoluble matter was filtered off and the solvent was distilled off to obtain 181 g of skin heterogeneity improving agent 2.

[Production Example 12] Above-ground part 1K of loofah family Luffa
50% ethanol (10 l) was added to g, refluxed for 2 hours, insoluble matter was filtered off, and the solvent was distilled off to obtain 123 g of skin heterogeneity improving agent 3.

[Production Example 13] 10 kg of 50% ethanol was added to 1 kg of roots of scorpionaceae, and the mixture was refluxed for 2 hours. Insoluble matter was filtered off and the solvent was distilled off to give 322 g of skin heterogeneity-improving agent 4. Got

[Production Example 14] To 1 Kg of Asteraceae moss flowers, 10 l of 50% ethanol was added, and the mixture was refluxed for 2 hours. Insoluble matters were filtered off and the solvent was distilled off to obtain 85 g of a skin heterogeneity enhancer 5 Got

[Production Example 15] Root 1 of Carrot family carrot
Add 50 l of 50% ethanol to Kg, reflux for 2 hours,
The insoluble material was filtered off and the solvent was distilled off to obtain 185 g of skin unevenness improving agent 6.

[Manufacturing Example 16] 1K root part of Apiaceae
50 g of ethanol was added to 10 g of the mixture, the mixture was refluxed for 2 hours, the insoluble matter was filtered off, and the solvent was distilled off to obtain 165 g of a skin heterogeneity improving agent 7.

[Production Example 17] 1 kg of kernel of tonin of the family Rosaceae
50% ethanol (10 l) was added to the mixture, the mixture was refluxed for 2 hours, the insoluble matter was filtered off, and the solvent was distilled off to obtain 105 g of skin heterogeneity-improving and enhancing agent 8.

(3) Cosmetic of the present invention The cosmetic of the present invention is characterized by containing the above-mentioned skin non-uniformity improving agent and skin non-uniformity improving enhancer. The skin non-uniformity improving agent or the skin non-uniformity improving enhancer may contain only one kind, or may contain two or more kinds. The type of the cosmetic of the present invention is not particularly limited as long as it is a generally known cosmetic, and examples thereof include basic cosmetics such as cream and emulsion, foundations, makeup cosmetics such as lip colors. Hair oils, hair tonics, shampoos, hair cosmetics such as conditioners, nail polishes such as manicures and pedicures, cleaning agents such as body shampoos and soaps, bath agents such as bath bubbles and bath essences can be preferably exemplified. This is because the skin non-uniformity improving agent of the present invention can improve not only the non-uniformity of the skin but also the non-uniformity of the human tissue close to the skin, and thus can exert a preferable action on the hair and nails. . The content of the skin non-uniformity improving agent in the cosmetic of the present invention is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, and 0.0
More preferably, it is 5 to 1% by weight. The preferable content of the skin non-uniformity improving and enhancing agent in the cosmetic of the present invention is 0.
The amount is 001 to 10% by weight, more preferably 0.01 to 5% by weight, still more preferably 0.05 to 1% by weight. The preferable ratio of the skin non-uniformity improving agent to the skin non-uniformity improving agent is 1: 9 to 9: 1, more preferably 1: 4 to 4: 1, and further preferably 1: 3 to 3: 1. preferable. The cosmetics of the present invention may contain optional components usually used in cosmetics in addition to these skin non-uniformity improving agents and skin non-uniformity improving agents. Such optional components include hydrocarbons such as petrolatum and microcrystalline wax,
Esters such as jojoba oil and gallow, triglycerides such as beef tallow and olive oil, higher alcohols such as cetanol and oleyl alcohol, fatty acids such as stearic acid and oleic acid, and polyhydric alcohols such as glycerin and 1,3-butanediol. , Nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, thickeners such as ethanol and carbopol, preservatives, UV absorbers, antioxidants, pigments, powders, etc. It can be illustrated. The cosmetic material of the present invention can be produced by treating these raw materials by a usual method. The cosmetic of the present invention has an action of improving unevenness of the skin and improving and preventing dullness. Therefore, the cosmetic of the present invention can make the person who wears it look younger than the actual age and is also suitable as a cosmetic for preventing and improving aging.

[0027]

【Example】

[Example 1] A lotion was prepared according to the following formulation. That is, the prescription ingredients were heated and dissolved at 80 ° C., stirred and cooled to obtain a lotion. 1,3-Butanediol 5 parts by weight Glycerin 5 parts by weight Sodium hyaluronate 0.1 parts by weight Methylparaben 0.1 parts by weight Skin non-uniformity improving agent 1 0.1 parts by weight Skin non-uniformity improving enhancer 10 .3 parts by weight Benzalkonium chloride 0.1 parts by weight Sodium dihydrogen phosphate 0.1 parts by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Perfume 0.1 parts by weight water 82 parts by weight

Example 2 A lotion was prepared according to the following formulation. That is, the prescription ingredients were heated and dissolved at 80 ° C., stirred and cooled to obtain a lotion. 1,3-Butanediol 5 parts by weight Glycerin 5 parts by weight Sodium hyaluronate 0.1 parts by weight Methylparaben 0.1 parts by weight Skin non-uniformity improving agent 2 0.1 parts by weight Skin non-uniformity improving enhancer 20 1 part by weight Skin non-uniformity improver 3 0.5 parts by weight Benzalkonium chloride 0.1 parts by weight Sodium dihydrogen phosphate 0.1 parts by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Perfume 0.1 part by weight Water 81.7 parts by weight

Example 3 A lotion was prepared according to the following formulation. That is, the prescription ingredients were heated and dissolved at 80 ° C., stirred and cooled to obtain a lotion. 1,3-Butanediol 5 parts by weight Glycerin 5 parts by weight Sodium chondroitin sulfate 0.1 parts by weight Methylparaben 0.1 parts by weight Skin non-uniformity improver 4 0.5 parts by weight Skin non-uniformity improvement enhancer 30 1 part by weight Skin non-uniformity-enhancing enhancer 4 0.1 part by weight Benzalkonium chloride 0.1 part by weight Sodium dihydrogen phosphate 0.1 part by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 Weight part Fragrance 0.1 weight part Water 81.7 weight part

Example 4 A cream was prepared according to the following formulation. That is, the components a, b, and c were heated and dissolved at 80 ° C., k was well kneaded, and b was added to dilute, and c was gradually added to emulsify. This was stirred and cooled to obtain a cream. A 1,3-butanediol 5 parts by weight 70% maltitol aqueous solution 10 parts by weight methylparaben 0.3 parts by weight butylparaben 0.1 parts by weight triglycerin diisostearate 4 parts by weight liquid paraffin 7 parts by weight carnauba wax 3 Parts by weight Dimethicone (1 c.s.) 4 parts by weight C water 65.4 parts by weight Skin non-uniformity improver 5 0.5 parts by weight Skin non-uniformity improver 6 0.5 parts by weight Skin non-uniformity Improvement enhancer 5 0.1 part by weight Non-uniformity of skin Improvement enhancer 6 1 part by weight Sodium hyaluronate 0.1 part by weight

Example 5 A foundation was prepared according to the following formulation. That is, each component of a, b and c is at 80 ° C.
It was dissolved by heating with, kneaded well with A, diluted with B, dispersed with D, and gradually added with C to emulsify. This was stirred and cooled to obtain a foundation. A 1,3-butanediol 5 parts by weight 70% maltitol aqueous solution 10 parts by weight methylparaben 0.3 parts by weight butylparaben 0.1 parts by weight triglycerin diisostearate 4 parts by weight liquid paraffin 7 parts by weight carnauba wax 3 Parts by weight Dimethicone (1 c.s.) 4 parts by weight C water 48.9 parts by weight Skin non-uniformity improver 7 0.5 parts by weight Skin non-uniformity enhancer 7 0.1 Sodium hyaluronate 0.1 Parts by weight titanium dioxide 8 parts by weight talc 3 parts by weight sericite 2 parts by weight yellow iron oxide 3 parts by weight red iron oxide 2 parts by weight

Example 6 A hair tonic was prepared according to the following formulation. That is, the ingredients were weighed and solubilized with stirring at room temperature to obtain a hair tonic. Ethinyl estradiol 0.1 parts by weight Capsicum tincture 0.1 parts by weight Menthol 0.1 parts by weight Skin non-uniformity improver 8 0.1 parts by weight Skin non-uniformity enhancer 8 0.1 parts by weight Ethanol 40 parts by weight Parts 1,3-butanediol 5 parts by weight water 54.5 parts by weight

Example 7 A bath agent was prepared according to the following formulation. That is, the ingredients were weighed in a kneader and kneaded well to obtain a bath preparation. Sodium sulfate 60 parts by weight Lavender oil 10 parts by weight 1,3-butanediol 10 parts by weight Skin non-uniformity improver 9 1 parts by weight Skin non-uniformity enhancer 1 10 parts by weight Glycerin 9 parts by weight

Example 8 Regarding the skin non-uniformity improving agents 1 to 9 of the present invention, in the presence of the skin non-uniformity improving enhancer 1,
The effect of improving skin non-uniformity was measured. That is, the upper arm of 20 volunteers was irradiated with ultraviolet B of 0.8 MED twice to create a non-uniform skin model. A sample was administered to the model for 4 weeks, and the morphology was observed 5 weeks later. The morphological observation items were the determination of the distribution of the low-brightness portion, the determination of the melanin distribution, and the nonuniformity of the stratum corneum exfoliation. To determine the distribution of the low-brightness part, the uniformity of the distribution of the low-brightness part when the skin is irradiated with light at an angle of 45 degrees and captured as an image with a CCD camera is rated as 2: very uniform, 1: is uniform, and 0 is a score. .5: somewhat uniform, score 0: non-uniform and judged by the naked eye. The distribution of melanin was determined by stripping the horny layer with cellophane tape, performing Fontana-Masson staining and hematoxylin-eosin staining, visually observing the distribution of melanin in each cell under a microscope, and judging by the following criteria. Rating 2: Distribution is extremely uniform, Rating 1: Distribution is uniform, 0.5: Distribution is slightly uniform,
0: Distribution is non-uniform. At the same time, the method of peeling the stratum corneum was also judged according to the following criteria. Rating 2: Very uniform peeling method, Rating 1: Uniform peeling method, 0.5: Some uniform peeling method, 0: Non-uniform peeling method. The results are shown in Table 1 as an average score. Samples were prepared by dissolving each of the skin non-uniformity improving agents at a concentration of 1% and the skin non-uniformity improving agent 1 at a concentration of 1% in a 50% ethanol aqueous solution, and a control of 50%. An aqueous ethanol solution was used.
In the case of no treatment, no ultraviolet irradiation was performed and nothing was administered.
Control 1 is the one to which the skin heterogeneity improving agent is not added, and the skin non-uniformity improving agent 1 is added, and Control 2 is the skin non-uniformity improving agent is not added to the skin non-uniformity improving enhancer 1. Was used. From this, it is understood that the combination of the skin non-uniformity improving agent and the skin non-uniformity improving enhancer of the present invention is excellent in the skin non-uniformity improving action. Furthermore, it is also found that the skin non-uniformity improvement enhancer alone cannot improve the skin non-uniformity.

[0035]

[Table 1]

[Example 9] Regarding the skin non-uniformity improving agents 1 to 8 of the present invention, in the presence of the skin non-uniformity improving agent 1,
The effect of improving skin non-uniformity was measured. That is, the upper arm of 20 volunteers was irradiated with ultraviolet B of 0.8 MED twice to create a non-uniform skin model. A sample was administered to the model for 4 weeks, and the morphology was observed 5 weeks later. The morphological observation items were the determination of the distribution of the low-brightness portion, the determination of the melanin distribution, and the nonuniformity of the stratum corneum exfoliation. To determine the distribution of the low-brightness part, the uniformity of the distribution of the low-brightness part when the skin is irradiated with light at an angle of 45 degrees and captured as an image with a CCD camera is rated as 2: very uniform, 1: is uniform, and 0 is a score. .5: somewhat uniform, score 0: non-uniform and judged by the naked eye. The distribution of melanin was determined by stripping the horny layer with cellophane tape, performing Fontana-Masson staining and hematoxylin-eosin staining, visually observing the distribution of melanin in each cell under a microscope, and judging by the following criteria. Rating 2: Distribution is extremely uniform, Rating 1: Distribution is uniform, 0.5: Distribution is slightly uniform,
0: Distribution is non-uniform. At the same time, the method of peeling the stratum corneum was also judged according to the following criteria. Rating 2: Very uniform peeling method, Rating 1: Uniform peeling method, 0.5: Some uniform peeling method, 0: Non-uniform peeling method. The results are shown in Table 1 as an average score. In addition, the test sample contained 1% of each skin non-uniformity improving agent at a concentration of 1%, and the skin non-uniformity improving enhancer 1
-8 was dissolved in a 50% ethanol aqueous solution at a concentration of 1%, and a 50% ethanol aqueous solution was used as a control. In the case of no treatment, no ultraviolet irradiation was performed and nothing was administered. Control 1 is the one to which the skin non-uniformity improving agent is not added and the skin non-uniformity improving agent 1 is added, and Control 2 is the skin non-uniformity improving agent 1 is not added to the skin non-uniformity improving agent. The one to which only 1 was added was used. The results are shown in Table 2 as an average score. From this, it is understood that the combination of the skin non-uniformity improving agent and the skin non-uniformity improving enhancer of the present invention is excellent in the skin non-uniformity improving action.

[0037]

[Table 2] [Example 10] Using the lotion of Example 1, a use test was conducted using 20 women in one group suffering from dullness. That is, the sample lotion was applied twice a day in the morning and twice a day for 2 months, and the improvement of dullness was answered by a questionnaire. Control group 1 uses the skin heterogeneity improving agent 1 of Example 1 replaced with water, control group 2 uses the skin heterogeneity improving agent 1 replaced with water, and control group 3 The skin non-uniformity improving agent 1 and the skin non-uniformity improving agent 1 were replaced with water. The results are shown in Table 3. From this, it is understood that the cosmetic of the present invention is excellent in the effect of improving dullness.

[0038]

[Table 3]

[0039]

Industrial Applicability According to the present invention, it is possible to provide a material which improves non-uniformity of skin and improves dullness.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI A61K 35/78 A61K 35/78 HM QS T A61P 17/00 A61P 17/00 (72) Inventor Nobuhiro Ando Yokohama City, Kanagawa Prefecture 1 Takashimadai, Kanagawa-ku 1 Yokohama Research Laboratory, Pola Chemical Industry Co., Ltd. (56) Reference JP-A-9-268118 (JP, A) JP-A-6-24937 (JP, A) JP-A-5-51314 ( (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50 JISC file (JOIS)

Claims (3)

(57) [Claims] 1. Having one or more kinds selected from the following plant essences having the skin non-uniformity improving action shown in (a) and the skin non-uniformity enhancing action shown in (b). Improves the unevenness of skin microstructure caused by unevenness of low brightness distribution, unevenness of melanin distribution or unevenness of stratum corneum, which consists of one or more kinds selected from plant essence. (B) Birch (Betula pendula Roth.), Zizyphus jujuba Mill., Rosa multiflora Thun., Hypericum perforatum. Hypericum erectum Thun.), Hypericum perforatum (Hypericum perforatum)
L.), Lamiaceae sage (Salvia officinalis L.), Button family peony (Paeonia lactiflora Pall.), Nettle family nettle (Urtica thunbergiana Sie. Or Urtica)
dioica L.), Lotus lotus (Nelumbonaceae Nelumbo) (b) Ligusticum wallichi F
r.), ginger turmeric (Curcuma longa L.), cucurbitaceae loofah (Luffa cylindria Roem.), sesameaceae genus (Rhemania glutinosa Lib.), Asteraceae mosquito (Car
thamus tinctorius L.), Araliaceae carrot (Panax gi)
nseng CA Meyer), Apiaceae (Scutellaria b)
aicalensis Geo.) Tonin (Purnus persica Ba)
t.). 2. The agent for improving heterogeneity of skin microstructure according to claim 1, wherein the plant essences (a) and (b) are extracts of a plant with a polar solvent. 3. A cosmetic for improving dullness, which comprises the agent for improving nonuniformity of skin microstructure according to claim 1 or 2.