JP2002540197A5 - - Google Patents
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- Publication number
- JP2002540197A5 JP2002540197A5 JP2000607997A JP2000607997A JP2002540197A5 JP 2002540197 A5 JP2002540197 A5 JP 2002540197A5 JP 2000607997 A JP2000607997 A JP 2000607997A JP 2000607997 A JP2000607997 A JP 2000607997A JP 2002540197 A5 JP2002540197 A5 JP 2002540197A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- alkynyl
- alkenyl
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 hydroxy, mercapto Chemical class 0.000 description 25
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 6
- 125000000623 heterocyclic group Chemical group 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 125000000753 cycloalkyl group Chemical group 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 125000000069 2-butynyl group Chemical group [H]C([H])([H])C#CC([H])([H])* 0.000 description 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 description 1
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000004419 alkynylene group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9907055.9 | 1999-03-29 | ||
| GBGB9907055.9A GB9907055D0 (en) | 1999-03-29 | 1999-03-29 | Antibacterial agents |
| PCT/GB2000/001175 WO2000058294A1 (en) | 1999-03-29 | 2000-03-28 | Antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002540197A JP2002540197A (ja) | 2002-11-26 |
| JP2002540197A5 true JP2002540197A5 (https=) | 2007-05-24 |
Family
ID=10850463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000607997A Withdrawn JP2002540197A (ja) | 1999-03-29 | 2000-03-28 | 抗菌剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6503897B1 (https=) |
| EP (1) | EP1165532B1 (https=) |
| JP (1) | JP2002540197A (https=) |
| AT (1) | ATE286887T1 (https=) |
| AU (1) | AU3565700A (https=) |
| DE (1) | DE60017374T2 (https=) |
| ES (1) | ES2235844T3 (https=) |
| GB (1) | GB9907055D0 (https=) |
| WO (1) | WO2000058294A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004018453A1 (ja) * | 2002-08-23 | 2004-03-04 | Dainippon Pharmaceutical Co., Ltd. | プロリン誘導体 |
| US7442793B2 (en) | 2002-12-11 | 2008-10-28 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| WO2005000835A1 (en) * | 2003-06-26 | 2005-01-06 | Novartis Ag | Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines |
| KR100753796B1 (ko) * | 2006-07-28 | 2007-08-31 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
| SG181983A1 (en) * | 2009-12-28 | 2012-08-30 | Ajinomoto Kk | Lanthionine derivative |
| CN102452998B (zh) * | 2010-10-20 | 2014-12-10 | 天津药物研究院 | N-甲酰羟胺类化合物及其制备方法和用途 |
| KR101462851B1 (ko) | 2012-10-24 | 2014-11-18 | 일동제약주식회사 | 신규 펩티드 데포르밀라제 저해제 화합물 및 그 제조방법 |
| US9889204B2 (en) * | 2014-08-11 | 2018-02-13 | The Regents Of The University Of California | Polymeric antibiotics |
| CA3248935A1 (en) | 2022-04-14 | 2023-10-19 | W. L. Gore & Associates, Inc. | CHEMICAL ENTITIES |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2132851C1 (ru) * | 1993-08-05 | 1999-07-10 | Синтекс (Ю.Эс.Эй) Инк. | Производные амидов, являющиеся ингибиторами матричных металлопротеаз, фармацевтическая композиция |
| US6013792A (en) | 1993-08-05 | 2000-01-11 | Syntex (U.S.A.), Inc. | Matrix metalloprotease inhibitors |
| JP2000511882A (ja) | 1996-04-12 | 2000-09-12 | ブリストル―マイヤーズ・スクイブ・カンパニー | Ａｃｅ阻害剤及び／またはｎｅｐ阻害剤として有用なｎ―ホルミルヒドロキシルアミン化合物 |
| DK1052984T3 (da) * | 1998-02-07 | 2004-09-20 | Vernalis Oxford Ltd | Antibakterielle midler |
| US6288063B1 (en) | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
-
1999
- 1999-03-29 GB GBGB9907055.9A patent/GB9907055D0/en not_active Ceased
-
2000
- 2000-03-28 WO PCT/GB2000/001175 patent/WO2000058294A1/en not_active Ceased
- 2000-03-28 ES ES00914262T patent/ES2235844T3/es not_active Expired - Lifetime
- 2000-03-28 AU AU35657/00A patent/AU3565700A/en not_active Abandoned
- 2000-03-28 JP JP2000607997A patent/JP2002540197A/ja not_active Withdrawn
- 2000-03-28 DE DE60017374T patent/DE60017374T2/de not_active Expired - Fee Related
- 2000-03-28 AT AT00914262T patent/ATE286887T1/de not_active IP Right Cessation
- 2000-03-28 EP EP00914262A patent/EP1165532B1/en not_active Expired - Lifetime
- 2000-03-28 US US09/914,049 patent/US6503897B1/en not_active Expired - Fee Related
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