JP2002537335A5 - - Google Patents
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- Publication number
- JP2002537335A5 JP2002537335A5 JP2000600646A JP2000600646A JP2002537335A5 JP 2002537335 A5 JP2002537335 A5 JP 2002537335A5 JP 2000600646 A JP2000600646 A JP 2000600646A JP 2000600646 A JP2000600646 A JP 2000600646A JP 2002537335 A5 JP2002537335 A5 JP 2002537335A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- range
- solution
- composition according
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000008194 pharmaceutical composition Substances 0.000 description 31
- 239000000243 solution Substances 0.000 description 25
- 238000000034 method Methods 0.000 description 19
- 239000000872 buffer Substances 0.000 description 12
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 12
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 11
- 239000001509 sodium citrate Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 10
- 229960002292 piperacillin Drugs 0.000 description 10
- 229960003865 tazobactam Drugs 0.000 description 9
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008121 dextrose Substances 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 3
- NDIURPSCHWTXDC-UHFFFAOYSA-N 2-(4,5-dimethoxy-2-nitrophenyl)acetohydrazide Chemical compound COC1=CC(CC(=O)NN)=C([N+]([O-])=O)C=C1OC NDIURPSCHWTXDC-UHFFFAOYSA-N 0.000 description 2
- 229960005264 piperacillin sodium Drugs 0.000 description 2
- 229960000373 tazobactam sodium Drugs 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/255,513 | 1999-02-22 | ||
| US09/255,513 US6207661B1 (en) | 1999-02-22 | 1999-02-22 | Premixed formulation of piperacillin sodium and tazobactam sodium injection |
| PCT/US2000/001588 WO2000050035A2 (en) | 1999-02-22 | 2000-01-21 | Premixed formulation of piperacillin sodium and tazobactam sodium injection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006239375A Division JP4820244B2 (ja) | 1999-02-22 | 2006-09-04 | ピペラジンナトリウムおよびタゾバクタムナトリウムの注射の予備混合処方物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002537335A JP2002537335A (ja) | 2002-11-05 |
| JP2002537335A5 true JP2002537335A5 (enExample) | 2006-01-05 |
Family
ID=22968672
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600646A Withdrawn JP2002537335A (ja) | 1999-02-22 | 2000-01-21 | ピペラシリンナトリウムおよびタゾバクタムナトリウムの注射の予備混合処方物 |
| JP2006239375A Expired - Lifetime JP4820244B2 (ja) | 1999-02-22 | 2006-09-04 | ピペラジンナトリウムおよびタゾバクタムナトリウムの注射の予備混合処方物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006239375A Expired - Lifetime JP4820244B2 (ja) | 1999-02-22 | 2006-09-04 | ピペラジンナトリウムおよびタゾバクタムナトリウムの注射の予備混合処方物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6207661B1 (enExample) |
| EP (1) | EP1154770B1 (enExample) |
| JP (2) | JP2002537335A (enExample) |
| AT (1) | ATE426404T1 (enExample) |
| AU (1) | AU2856200A (enExample) |
| CA (1) | CA2361392C (enExample) |
| CY (1) | CY1108966T1 (enExample) |
| DE (1) | DE60041868D1 (enExample) |
| DK (1) | DK1154770T3 (enExample) |
| ES (1) | ES2322790T3 (enExample) |
| PT (1) | PT1154770E (enExample) |
| WO (1) | WO2000050035A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20011718A1 (it) * | 2001-08-03 | 2003-02-03 | Istituto Biochimico Italiano | Processo per la preparazione del sale sodico dell'acido-6(d-(-)-alpha-(4-etil-2,3-diosso-1-piperazinocarbonilammino)fenilacetammido)penicill |
| ES2298672T3 (es) * | 2003-04-14 | 2008-05-16 | Wyeth Holdings Corporation | Composiciones que contienen piperacilina y tazobactam utiles para inyeccion. |
| WO2004098643A1 (en) * | 2003-04-14 | 2004-11-18 | Wyeth Holdings Corporation | Compositions containing piperacillin and tazobactam useful for injection |
| US6900184B2 (en) * | 2003-04-14 | 2005-05-31 | Wyeth Holdings Corporation | Compositions containing pipercillin and tazobactam useful for injection |
| RU2007111484A (ru) * | 2004-10-14 | 2008-11-20 | Вайет (Us) | Составы, содержащие пиперациллин, тазобактам и аминокарбоновую кислоту в растворителе лактата натрия |
| ES2284318B1 (es) * | 2005-04-13 | 2008-11-01 | Labiana Development, S.L. | Procedimiento de obtencion de una mezcla en polvo de una sal sodica de piperaciclina y tazobactama, util para su administracion por via inyectable. |
| EP1787641A1 (de) * | 2005-11-22 | 2007-05-23 | Helm AG | Tazobactam-Piperacillin-Lyophilisat |
| US20070286817A1 (en) * | 2006-06-07 | 2007-12-13 | Wyeth | Treating cystic fibrosis with antibiotics via a swirler delivery |
| US20070286818A1 (en) * | 2006-06-07 | 2007-12-13 | Wyeth | Treating cystic fibrosis with antibiotics via an aerosol drug |
| CN1927201B (zh) * | 2006-08-25 | 2011-06-01 | 天津和美生物技术有限公司 | 含哌拉西林的抗生素复方 |
| US20100035845A1 (en) * | 2008-08-06 | 2010-02-11 | Wyeth | Tigecycline formulations |
| EP3616695B1 (en) | 2011-09-09 | 2024-10-23 | Merck Sharp & Dohme LLC | Ceftolozane/tazobactam for treating intrapulmonary infections |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| US9320740B2 (en) | 2013-03-15 | 2016-04-26 | Merck Sharp & Dohme Corp. | Ceftolozane-tazobactam pharmaceutical compositions |
| EP2893929B1 (en) | 2013-03-15 | 2025-04-16 | Merck Sharp & Dohme LLC | Ceftolozane antibiotic compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US10376496B2 (en) | 2013-09-09 | 2019-08-13 | Merck, Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| CN103550216B (zh) * | 2013-10-30 | 2015-03-11 | 济南康和医药科技有限公司 | 一种哌拉西林钠他唑巴坦钠药物组合物及其制备方法 |
| EP3261615A1 (en) * | 2015-02-23 | 2018-01-03 | Sandoz AG | Penicillin retard composition for intramuscular injection |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2179348A5 (enExample) | 1972-04-06 | 1973-11-16 | Berthoud Sa | |
| US4452778A (en) | 1980-03-31 | 1984-06-05 | Eli Lilly And Company | Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms |
| CA1209477A (en) | 1981-03-26 | 1986-08-12 | Bruce E. Haeger | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| US4477452A (en) | 1981-03-26 | 1984-10-16 | American Cyanamid Company | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| US4534977A (en) | 1981-03-26 | 1985-08-13 | American Cyanamid Company | Composition of matter comprising a low bulk density lyophilized preparation of Sodium Piperacillin |
| US4552763A (en) | 1981-12-21 | 1985-11-12 | Eli Lilly And Company | Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms |
| US4594247A (en) | 1981-12-21 | 1986-06-10 | Eli Lilly And Company | Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms |
| US4562073A (en) | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| US4535078A (en) | 1984-04-06 | 1985-08-13 | The Trustees Of Columbia University In The City Of New York | Antibacterial composition comprising silver sulfadiazine and sodium piperacillin |
| BG46664A1 (en) * | 1985-08-16 | 1990-02-15 | Druzhestven N Izsledovatelski | Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid |
| IT1213352B (it) | 1986-10-06 | 1989-12-20 | Valleambrosia Di Rozzano Milan | Procedimento per la preparazione dell'acido 6-[d(-)-alfa-(4-etil-2,3-diossipiperazin-1-ilcarbonilamino)-alfa-fenilace tamido]penicillanico e intermedi utili in detto procedimento. |
| FR2690340B1 (fr) * | 1992-04-24 | 1995-02-24 | Scr Newmed | Nouveau procédé de stabilisation des préparations pharmaceutiques liquides et les compositions pharmaceutiques ainsi stabilisées en résultant. |
| US5358853A (en) | 1992-08-03 | 1994-10-25 | Akzo Av | Liquid thromboplastin reagent |
| JP3233407B2 (ja) | 1993-11-06 | 2001-11-26 | 大鵬薬品工業株式会社 | 結晶性ペニシリン誘導体並びにその製造及び使用 |
| JPH0859471A (ja) * | 1994-08-25 | 1996-03-05 | Taiho Yakuhin Kogyo Kk | 抗マラリア剤 |
| JPH0867638A (ja) * | 1994-08-31 | 1996-03-12 | Nikken Chem Co Ltd | エリスリトール含有注射剤 |
| US5650421A (en) | 1995-03-31 | 1997-07-22 | Baxter International Inc. | Premixed famotidine formulation |
| JPH1050800A (ja) * | 1996-08-05 | 1998-02-20 | Canon Sales Co Inc | 処理装置 |
| JPH10168091A (ja) * | 1996-12-12 | 1998-06-23 | Ss Pharmaceut Co Ltd | ジアミン白金錯体及びこれを含有する医薬 |
-
1999
- 1999-02-22 US US09/255,513 patent/US6207661B1/en not_active Expired - Lifetime
-
2000
- 2000-01-21 PT PT00906992T patent/PT1154770E/pt unknown
- 2000-01-21 CA CA002361392A patent/CA2361392C/en not_active Expired - Lifetime
- 2000-01-21 ES ES00906992T patent/ES2322790T3/es not_active Expired - Lifetime
- 2000-01-21 DE DE60041868T patent/DE60041868D1/de not_active Expired - Lifetime
- 2000-01-21 JP JP2000600646A patent/JP2002537335A/ja not_active Withdrawn
- 2000-01-21 EP EP00906992A patent/EP1154770B1/en not_active Expired - Lifetime
- 2000-01-21 DK DK00906992T patent/DK1154770T3/da active
- 2000-01-21 AT AT00906992T patent/ATE426404T1/de active
- 2000-01-21 AU AU28562/00A patent/AU2856200A/en not_active Abandoned
- 2000-01-21 WO PCT/US2000/001588 patent/WO2000050035A2/en not_active Ceased
-
2006
- 2006-09-04 JP JP2006239375A patent/JP4820244B2/ja not_active Expired - Lifetime
-
2009
- 2009-04-13 CY CY20091100433T patent/CY1108966T1/el unknown
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