CY1108966T1 - Παρεντερικη φαρμακοτεχνικη μορφη πιπερασιλλινης - Google Patents
Παρεντερικη φαρμακοτεχνικη μορφη πιπερασιλλινηςInfo
- Publication number
- CY1108966T1 CY1108966T1 CY20091100433T CY091100433T CY1108966T1 CY 1108966 T1 CY1108966 T1 CY 1108966T1 CY 20091100433 T CY20091100433 T CY 20091100433T CY 091100433 T CY091100433 T CY 091100433T CY 1108966 T1 CY1108966 T1 CY 1108966T1
- Authority
- CY
- Cyprus
- Prior art keywords
- piperacillin
- component
- shelf life
- pharmaceutical form
- parenteral pharmaceutical
- Prior art date
Links
- IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 title abstract 4
- 229960002292 piperacillin Drugs 0.000 title abstract 4
- 241000894006 Bacteria Species 0.000 abstract 1
- 108020004256 Beta-lactamase Proteins 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 239000008121 dextrose Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 abstract 1
- 229960003865 tazobactam Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/255,513 US6207661B1 (en) | 1999-02-22 | 1999-02-22 | Premixed formulation of piperacillin sodium and tazobactam sodium injection |
| EP00906992A EP1154770B1 (en) | 1999-02-22 | 2000-01-21 | Parenteral formulation of piperacillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108966T1 true CY1108966T1 (el) | 2014-07-02 |
Family
ID=22968672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100433T CY1108966T1 (el) | 1999-02-22 | 2009-04-13 | Παρεντερικη φαρμακοτεχνικη μορφη πιπερασιλλινης |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6207661B1 (enExample) |
| EP (1) | EP1154770B1 (enExample) |
| JP (2) | JP2002537335A (enExample) |
| AT (1) | ATE426404T1 (enExample) |
| AU (1) | AU2856200A (enExample) |
| CA (1) | CA2361392C (enExample) |
| CY (1) | CY1108966T1 (enExample) |
| DE (1) | DE60041868D1 (enExample) |
| DK (1) | DK1154770T3 (enExample) |
| ES (1) | ES2322790T3 (enExample) |
| PT (1) | PT1154770E (enExample) |
| WO (1) | WO2000050035A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20011718A1 (it) * | 2001-08-03 | 2003-02-03 | Istituto Biochimico Italiano | Processo per la preparazione del sale sodico dell'acido-6(d-(-)-alpha-(4-etil-2,3-diosso-1-piperazinocarbonilammino)fenilacetammido)penicill |
| ES2298672T3 (es) * | 2003-04-14 | 2008-05-16 | Wyeth Holdings Corporation | Composiciones que contienen piperacilina y tazobactam utiles para inyeccion. |
| WO2004098643A1 (en) * | 2003-04-14 | 2004-11-18 | Wyeth Holdings Corporation | Compositions containing piperacillin and tazobactam useful for injection |
| US6900184B2 (en) * | 2003-04-14 | 2005-05-31 | Wyeth Holdings Corporation | Compositions containing pipercillin and tazobactam useful for injection |
| RU2007111484A (ru) * | 2004-10-14 | 2008-11-20 | Вайет (Us) | Составы, содержащие пиперациллин, тазобактам и аминокарбоновую кислоту в растворителе лактата натрия |
| ES2284318B1 (es) * | 2005-04-13 | 2008-11-01 | Labiana Development, S.L. | Procedimiento de obtencion de una mezcla en polvo de una sal sodica de piperaciclina y tazobactama, util para su administracion por via inyectable. |
| EP1787641A1 (de) * | 2005-11-22 | 2007-05-23 | Helm AG | Tazobactam-Piperacillin-Lyophilisat |
| US20070286817A1 (en) * | 2006-06-07 | 2007-12-13 | Wyeth | Treating cystic fibrosis with antibiotics via a swirler delivery |
| US20070286818A1 (en) * | 2006-06-07 | 2007-12-13 | Wyeth | Treating cystic fibrosis with antibiotics via an aerosol drug |
| CN1927201B (zh) * | 2006-08-25 | 2011-06-01 | 天津和美生物技术有限公司 | 含哌拉西林的抗生素复方 |
| US20100035845A1 (en) * | 2008-08-06 | 2010-02-11 | Wyeth | Tigecycline formulations |
| EP3616695B1 (en) | 2011-09-09 | 2024-10-23 | Merck Sharp & Dohme LLC | Ceftolozane/tazobactam for treating intrapulmonary infections |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| US9320740B2 (en) | 2013-03-15 | 2016-04-26 | Merck Sharp & Dohme Corp. | Ceftolozane-tazobactam pharmaceutical compositions |
| EP2893929B1 (en) | 2013-03-15 | 2025-04-16 | Merck Sharp & Dohme LLC | Ceftolozane antibiotic compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US10376496B2 (en) | 2013-09-09 | 2019-08-13 | Merck, Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| CN103550216B (zh) * | 2013-10-30 | 2015-03-11 | 济南康和医药科技有限公司 | 一种哌拉西林钠他唑巴坦钠药物组合物及其制备方法 |
| EP3261615A1 (en) * | 2015-02-23 | 2018-01-03 | Sandoz AG | Penicillin retard composition for intramuscular injection |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2179348A5 (enExample) | 1972-04-06 | 1973-11-16 | Berthoud Sa | |
| US4452778A (en) | 1980-03-31 | 1984-06-05 | Eli Lilly And Company | Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms |
| CA1209477A (en) | 1981-03-26 | 1986-08-12 | Bruce E. Haeger | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| US4477452A (en) | 1981-03-26 | 1984-10-16 | American Cyanamid Company | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| US4534977A (en) | 1981-03-26 | 1985-08-13 | American Cyanamid Company | Composition of matter comprising a low bulk density lyophilized preparation of Sodium Piperacillin |
| US4552763A (en) | 1981-12-21 | 1985-11-12 | Eli Lilly And Company | Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms |
| US4594247A (en) | 1981-12-21 | 1986-06-10 | Eli Lilly And Company | Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms |
| US4562073A (en) | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| US4535078A (en) | 1984-04-06 | 1985-08-13 | The Trustees Of Columbia University In The City Of New York | Antibacterial composition comprising silver sulfadiazine and sodium piperacillin |
| BG46664A1 (en) * | 1985-08-16 | 1990-02-15 | Druzhestven N Izsledovatelski | Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid |
| IT1213352B (it) | 1986-10-06 | 1989-12-20 | Valleambrosia Di Rozzano Milan | Procedimento per la preparazione dell'acido 6-[d(-)-alfa-(4-etil-2,3-diossipiperazin-1-ilcarbonilamino)-alfa-fenilace tamido]penicillanico e intermedi utili in detto procedimento. |
| FR2690340B1 (fr) * | 1992-04-24 | 1995-02-24 | Scr Newmed | Nouveau procédé de stabilisation des préparations pharmaceutiques liquides et les compositions pharmaceutiques ainsi stabilisées en résultant. |
| US5358853A (en) | 1992-08-03 | 1994-10-25 | Akzo Av | Liquid thromboplastin reagent |
| JP3233407B2 (ja) | 1993-11-06 | 2001-11-26 | 大鵬薬品工業株式会社 | 結晶性ペニシリン誘導体並びにその製造及び使用 |
| JPH0859471A (ja) * | 1994-08-25 | 1996-03-05 | Taiho Yakuhin Kogyo Kk | 抗マラリア剤 |
| JPH0867638A (ja) * | 1994-08-31 | 1996-03-12 | Nikken Chem Co Ltd | エリスリトール含有注射剤 |
| US5650421A (en) | 1995-03-31 | 1997-07-22 | Baxter International Inc. | Premixed famotidine formulation |
| JPH1050800A (ja) * | 1996-08-05 | 1998-02-20 | Canon Sales Co Inc | 処理装置 |
| JPH10168091A (ja) * | 1996-12-12 | 1998-06-23 | Ss Pharmaceut Co Ltd | ジアミン白金錯体及びこれを含有する医薬 |
-
1999
- 1999-02-22 US US09/255,513 patent/US6207661B1/en not_active Expired - Lifetime
-
2000
- 2000-01-21 PT PT00906992T patent/PT1154770E/pt unknown
- 2000-01-21 CA CA002361392A patent/CA2361392C/en not_active Expired - Lifetime
- 2000-01-21 ES ES00906992T patent/ES2322790T3/es not_active Expired - Lifetime
- 2000-01-21 DE DE60041868T patent/DE60041868D1/de not_active Expired - Lifetime
- 2000-01-21 JP JP2000600646A patent/JP2002537335A/ja not_active Withdrawn
- 2000-01-21 EP EP00906992A patent/EP1154770B1/en not_active Expired - Lifetime
- 2000-01-21 DK DK00906992T patent/DK1154770T3/da active
- 2000-01-21 AT AT00906992T patent/ATE426404T1/de active
- 2000-01-21 AU AU28562/00A patent/AU2856200A/en not_active Abandoned
- 2000-01-21 WO PCT/US2000/001588 patent/WO2000050035A2/en not_active Ceased
-
2006
- 2006-09-04 JP JP2006239375A patent/JP4820244B2/ja not_active Expired - Lifetime
-
2009
- 2009-04-13 CY CY20091100433T patent/CY1108966T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000050035A2 (en) | 2000-08-31 |
| PT1154770E (pt) | 2009-04-27 |
| CA2361392C (en) | 2007-08-07 |
| DE60041868D1 (de) | 2009-05-07 |
| ATE426404T1 (de) | 2009-04-15 |
| WO2000050035A3 (en) | 2000-12-07 |
| DK1154770T3 (da) | 2009-06-29 |
| JP2006316075A (ja) | 2006-11-24 |
| AU2856200A (en) | 2000-09-14 |
| ES2322790T3 (es) | 2009-06-29 |
| CA2361392A1 (en) | 2000-08-31 |
| US6207661B1 (en) | 2001-03-27 |
| JP4820244B2 (ja) | 2011-11-24 |
| JP2002537335A (ja) | 2002-11-05 |
| EP1154770B1 (en) | 2009-03-25 |
| EP1154770A2 (en) | 2001-11-21 |
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