JP2002535285A5 - - Google Patents
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- JP2002535285A5 JP2002535285A5 JP2000594485A JP2000594485A JP2002535285A5 JP 2002535285 A5 JP2002535285 A5 JP 2002535285A5 JP 2000594485 A JP2000594485 A JP 2000594485A JP 2000594485 A JP2000594485 A JP 2000594485A JP 2002535285 A5 JP2002535285 A5 JP 2002535285A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- preparation
- pharmaceutical composition
- inhibiting
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000016605 B-Cell Activating Factor Human genes 0.000 description 13
- 108010028006 B-Cell Activating Factor Proteins 0.000 description 13
- 210000003719 b-lymphocyte Anatomy 0.000 description 13
- 239000012634 fragment Substances 0.000 description 13
- 239000008194 pharmaceutical composition Substances 0.000 description 13
- 230000002401 inhibitory effect Effects 0.000 description 11
- 230000004663 cell proliferation Effects 0.000 description 7
- 208000030289 Lymphoproliferative disease Diseases 0.000 description 6
- 201000001268 lymphoproliferative syndrome Diseases 0.000 description 6
- 230000016784 immunoglobulin production Effects 0.000 description 5
- 208000023275 Autoimmune disease Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 208000026278 immune system disease Diseases 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000021766 negative regulation of B cell proliferation Effects 0.000 description 1
- 230000005401 negative regulation of immunoglobulin production Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11716999P | 1999-01-25 | 1999-01-25 | |
| US60/117,169 | 1999-01-25 | ||
| US14322899P | 1999-07-09 | 1999-07-09 | |
| US60/143,228 | 1999-07-09 | ||
| PCT/US2000/001788 WO2000043032A2 (en) | 1999-01-25 | 2000-01-25 | Baff, inhibitors thereof and their use in the modulation of b-cell response |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008303135A Division JP4955642B2 (ja) | 1999-01-25 | 2008-11-27 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012077812A Division JP2012126749A (ja) | 1999-01-25 | 2012-03-29 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002535285A JP2002535285A (ja) | 2002-10-22 |
| JP2002535285A5 true JP2002535285A5 (https=) | 2009-01-22 |
| JP5066314B2 JP5066314B2 (ja) | 2012-11-07 |
Family
ID=26815006
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000594485A Expired - Lifetime JP5066314B2 (ja) | 1999-01-25 | 2000-01-25 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2008303135A Expired - Fee Related JP4955642B2 (ja) | 1999-01-25 | 2008-11-27 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012012379A Withdrawn JP2012087145A (ja) | 1999-01-25 | 2012-01-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012077812A Pending JP2012126749A (ja) | 1999-01-25 | 2012-03-29 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2014090152A Pending JP2014141527A (ja) | 1999-01-25 | 2014-04-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008303135A Expired - Fee Related JP4955642B2 (ja) | 1999-01-25 | 2008-11-27 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012012379A Withdrawn JP2012087145A (ja) | 1999-01-25 | 2012-01-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2012077812A Pending JP2012126749A (ja) | 1999-01-25 | 2012-03-29 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
| JP2014090152A Pending JP2014141527A (ja) | 1999-01-25 | 2014-04-24 | 免疫応答におけるｂ細胞および免疫グロブリンの刺激および阻害における、ｂａｆｆ、関連するブロック剤およびそれらの使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6869605B2 (https=) |
| EP (5) | EP1146892B1 (https=) |
| JP (5) | JP5066314B2 (https=) |
| KR (1) | KR100834809B1 (https=) |
| CN (1) | CN100340292C (https=) |
| AT (2) | ATE515267T1 (https=) |
| AU (1) | AU762839B2 (https=) |
| BR (1) | BR0007719A (https=) |
| CA (1) | CA2360062A1 (https=) |
| CY (2) | CY1107453T1 (https=) |
| CZ (1) | CZ299819B6 (https=) |
| DE (1) | DE60004635T2 (https=) |
| DK (2) | DK1146892T3 (https=) |
| EA (1) | EA006108B1 (https=) |
| EE (1) | EE05699B1 (https=) |
| ES (1) | ES2204528T3 (https=) |
| HK (1) | HK1040628B (https=) |
| HU (1) | HUP0105283A3 (https=) |
| IL (3) | IL144202A0 (https=) |
| IS (1) | IS5993A (https=) |
| MX (1) | MXPA01007464A (https=) |
| NO (2) | NO20013641L (https=) |
| NZ (1) | NZ513284A (https=) |
| PL (1) | PL198934B1 (https=) |
| PT (2) | PT1415659E (https=) |
| SI (1) | SI1146892T1 (https=) |
| SK (1) | SK286665B6 (https=) |
| TR (2) | TR200102147T2 (https=) |
| WO (1) | WO2000043032A2 (https=) |
Families Citing this family (67)
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|---|---|---|---|---|
| US20030175208A1 (en) * | 1996-10-25 | 2003-09-18 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
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| EP0878552A1 (en) | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molecular detection of chromosome aberrations |
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| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
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| DK1385882T3 (da) | 2001-05-11 | 2008-02-11 | Amgen Inc | Peptider og relaterede molekyler, der binder til TALL-1 |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| BR0211614A (pt) * | 2001-08-03 | 2006-10-31 | Genentech Inc | polipeptìdeo tacis e br3 e empregos dos mesmos |
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| JP5570681B2 (ja) * | 2004-08-31 | 2014-08-13 | 興和株式会社 | 抗ヒトｂａｆｆ抗体 |
| EP2332563A3 (en) | 2004-10-13 | 2013-03-13 | The Washington University | Use of BAFF to treat sepsis |
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| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
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| ES2618543T3 (es) | 2005-11-23 | 2017-06-21 | Genentech, Inc. | Métodos y composiciones relacionados con ensayos de linfocitos B |
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| BRPI0711823A2 (pt) | 2006-05-15 | 2012-01-17 | Ares Trading Sa | métodos para tratamento de doenças auto-imunes com uma molécula de fusão taci-ig |
| WO2010093993A2 (en) * | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance |
| AU2011226689B2 (en) * | 2010-03-11 | 2016-09-01 | Kronos Bio, Inc. | Imidazopyridines Syk inhibitors |
| WO2013171296A1 (en) | 2012-05-16 | 2013-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic and treatment of sarcoidosis |
| CZ2012561A3 (cs) * | 2012-08-22 | 2013-10-23 | Masarykova Univerzita | B-bunecný aktivující faktor pro zvýsení sliznicní imunity kojencu a prípravek jej obsahující |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| EP2971077B1 (en) | 2013-03-15 | 2019-05-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment and prediction of myocardial infarction |
| KR101493592B1 (ko) | 2013-04-29 | 2015-02-17 | 부산대학교 산학협력단 | Ｓｏｃｓ3 단백질을 이용한 ｂａｆｆ 연관 면역질환 치료제 스크리닝 방법 |
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| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| WO2015100246A1 (en) | 2013-12-24 | 2015-07-02 | Ossianix, Inc. | Baff selective binding compounds and related methods |
| EA033604B1 (ru) | 2014-01-31 | 2019-11-08 | Boehringer Ingelheim Int | Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид |
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| EP3313429B1 (en) * | 2015-06-19 | 2021-10-06 | University Of Louisville Research Foundation, Inc. | Immunomodulation for the long term prevention and treatment of autoimmune diseases and foreign tissue rejection |
| CN107328620B (zh) * | 2017-06-23 | 2020-06-05 | 浙江普罗亭健康科技有限公司 | 用于流式细胞技术的封闭缓冲液及试剂盒 |
| WO2019126366A2 (en) * | 2017-12-19 | 2019-06-27 | The Johns Hopkins University | Baff therapy to promote anti- tumor immunity |
| US20210238295A1 (en) * | 2018-04-26 | 2021-08-05 | University Of Virginia Patent Foundation | Compositions and methods for treating abdominal aortic aneurysm |
| US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
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| CA2467521A1 (en) | 2001-11-16 | 2003-07-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to blys |
-
2000
- 2000-01-25 IL IL14420200A patent/IL144202A0/xx unknown
- 2000-01-25 EE EEP200100386A patent/EE05699B1/xx unknown
- 2000-01-25 DK DK00909970T patent/DK1146892T3/da active
- 2000-01-25 HU HU0105283A patent/HUP0105283A3/hu unknown
- 2000-01-25 AT AT03018879T patent/ATE515267T1/de active
- 2000-01-25 PL PL349772A patent/PL198934B1/pl unknown
- 2000-01-25 EP EP00909970A patent/EP1146892B1/en not_active Revoked
- 2000-01-25 EP EP03018879A patent/EP1415659B9/en not_active Revoked
- 2000-01-25 NZ NZ513284A patent/NZ513284A/en not_active IP Right Cessation
- 2000-01-25 CA CA002360062A patent/CA2360062A1/en not_active Abandoned
- 2000-01-25 HK HK02102203.7A patent/HK1040628B/en not_active IP Right Cessation
- 2000-01-25 DE DE60004635T patent/DE60004635T2/de not_active Expired - Fee Related
- 2000-01-25 KR KR1020017009356A patent/KR100834809B1/ko not_active Expired - Lifetime
- 2000-01-25 WO PCT/US2000/001788 patent/WO2000043032A2/en not_active Ceased
- 2000-01-25 CZ CZ20012696A patent/CZ299819B6/cs not_active IP Right Cessation
- 2000-01-25 SK SK1044-2001A patent/SK286665B6/sk not_active IP Right Cessation
- 2000-01-25 MX MXPA01007464A patent/MXPA01007464A/es active IP Right Grant
- 2000-01-25 JP JP2000594485A patent/JP5066314B2/ja not_active Expired - Lifetime
- 2000-01-25 EP EP10181337A patent/EP2319527A3/en not_active Ceased
- 2000-01-25 SI SI200030207T patent/SI1146892T1/xx unknown
- 2000-01-25 EA EA200100822A patent/EA006108B1/ru not_active IP Right Cessation
- 2000-01-25 TR TR2001/02147T patent/TR200102147T2/xx unknown
- 2000-01-25 PT PT03018879T patent/PT1415659E/pt unknown
- 2000-01-25 CN CNB008054878A patent/CN100340292C/zh not_active Expired - Lifetime
- 2000-01-25 AT AT00909970T patent/ATE247482T1/de active
- 2000-01-25 PT PT00909970T patent/PT1146892E/pt unknown
- 2000-01-25 DK DK03018879.1T patent/DK1415659T3/da active
- 2000-01-25 AU AU32142/00A patent/AU762839B2/en not_active Expired
- 2000-01-25 EP EP10180420.1A patent/EP2298332B1/en not_active Expired - Lifetime
- 2000-01-25 BR BR0007719-4A patent/BR0007719A/pt not_active Application Discontinuation
- 2000-01-25 EP EP15174329.1A patent/EP2974736A1/en not_active Withdrawn
- 2000-01-25 ES ES00909970T patent/ES2204528T3/es not_active Expired - Lifetime
-
2001
- 2001-01-25 TR TR2004/03498T patent/TR200403498T2/xx unknown
- 2001-07-06 IS IS5993A patent/IS5993A/is unknown
- 2001-07-09 IL IL144202A patent/IL144202A/en not_active IP Right Cessation
- 2001-07-24 NO NO20013641A patent/NO20013641L/no not_active Application Discontinuation
- 2001-07-24 US US09/911,777 patent/US6869605B2/en not_active Expired - Fee Related
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2003
- 2003-11-14 CY CY20031101083T patent/CY1107453T1/el unknown
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2008
- 2008-11-27 JP JP2008303135A patent/JP4955642B2/ja not_active Expired - Fee Related
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2009
- 2009-08-20 IL IL200498A patent/IL200498A0/en unknown
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2011
- 2011-10-05 CY CY20111100946T patent/CY1112458T1/el unknown
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2012
- 2012-01-24 JP JP2012012379A patent/JP2012087145A/ja not_active Withdrawn
- 2012-03-29 JP JP2012077812A patent/JP2012126749A/ja active Pending
- 2012-04-27 NO NO20120524A patent/NO20120524A1/no not_active Application Discontinuation
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2014
- 2014-04-24 JP JP2014090152A patent/JP2014141527A/ja active Pending
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