JP2002534516A - 血中脂質低下活性および抗酸化活性を有するモルホリン誘導体 - Google Patents
血中脂質低下活性および抗酸化活性を有するモルホリン誘導体Info
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- JP2002534516A JP2002534516A JP2000593598A JP2000593598A JP2002534516A JP 2002534516 A JP2002534516 A JP 2002534516A JP 2000593598 A JP2000593598 A JP 2000593598A JP 2000593598 A JP2000593598 A JP 2000593598A JP 2002534516 A JP2002534516 A JP 2002534516A
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- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 description 1
- 229940125797 compound 12 Drugs 0.000 description 1
- 229940126543 compound 14 Drugs 0.000 description 1
- 229940125758 compound 15 Drugs 0.000 description 1
- 229940126142 compound 16 Drugs 0.000 description 1
- 229940125810 compound 20 Drugs 0.000 description 1
- 229940126086 compound 21 Drugs 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- LBAQSKZHMLAFHH-UHFFFAOYSA-N ethoxyethane;hydron;chloride Chemical compound Cl.CCOCC LBAQSKZHMLAFHH-UHFFFAOYSA-N 0.000 description 1
- JAXFJECJQZDFJS-XHEPKHHKSA-N gtpl8555 Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](B1O[C@@]2(C)[C@H]3C[C@H](C3(C)C)C[C@H]2O1)CCC1=CC=C(F)C=C1 JAXFJECJQZDFJS-XHEPKHHKSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002840 nitric oxide donor Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR990100015 | 1999-01-14 | ||
| GR99100015 | 1999-01-14 | ||
| GR990100227 | 1999-07-05 | ||
| GR99100227 | 1999-07-05 | ||
| PCT/GR2000/000003 WO2000042030A1 (en) | 1999-01-14 | 2000-01-14 | Hypolipidemic and antioxidant morpholine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002534516A true JP2002534516A (ja) | 2002-10-15 |
| JP2002534516A5 JP2002534516A5 (https=) | 2007-03-15 |
Family
ID=26316685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593598A Pending JP2002534516A (ja) | 1999-01-14 | 2000-01-14 | 血中脂質低下活性および抗酸化活性を有するモルホリン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6693192B1 (https=) |
| EP (1) | EP1140877A1 (https=) |
| JP (1) | JP2002534516A (https=) |
| CN (1) | CN1336922A (https=) |
| AU (1) | AU770267B2 (https=) |
| BR (1) | BR0007490A (https=) |
| CA (1) | CA2359476C (https=) |
| WO (1) | WO2000042030A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013530144A (ja) * | 2010-05-21 | 2013-07-25 | リサーチ・トライアングル・インスティチュート | 薬物依存を処置するためのヒドロキシブプロピオン類似体（政府支援研究または開発） |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005016402D1 (de) | 2004-05-24 | 2009-10-15 | Genvault Corp | Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form |
| WO2010031007A2 (en) | 2008-09-12 | 2010-03-18 | Genvault Corporation | Matrices and media for storage and stabilization of biomolecules |
| EP2419400A1 (en) | 2009-04-15 | 2012-02-22 | Research Triangle Institute | Monoamine reuptake inhibitors |
| JP2013526583A (ja) | 2010-05-21 | 2013-06-24 | リサーチ・トライアングル・インスティチュート | フェニルモルホリンおよびその類似体 |
| GR20100100333A (el) * | 2010-06-10 | 2012-01-31 | Αγγελικη Παναγιωτη Κουρουνακη | Μορφολινικα παραγωγα υποκατεστημενων διαφαινυλικων ενωσεων |
| CN102127031B (zh) * | 2011-01-17 | 2012-10-17 | 江苏江神药物化学有限公司 | 一种麻黄碱类化合物季胺盐及其合成方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3717560A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Neue 2-hydroxy-morpholine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
2000
- 2000-01-14 JP JP2000593598A patent/JP2002534516A/ja active Pending
- 2000-01-14 EP EP00900299A patent/EP1140877A1/en not_active Withdrawn
- 2000-01-14 US US09/869,881 patent/US6693192B1/en not_active Expired - Fee Related
- 2000-01-14 CA CA002359476A patent/CA2359476C/en not_active Expired - Fee Related
- 2000-01-14 BR BR0007490-0A patent/BR0007490A/pt not_active Application Discontinuation
- 2000-01-14 CN CN00802766A patent/CN1336922A/zh active Pending
- 2000-01-14 WO PCT/GR2000/000003 patent/WO2000042030A1/en not_active Ceased
- 2000-01-14 AU AU19960/00A patent/AU770267B2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3717560A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Neue 2-hydroxy-morpholine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
Non-Patent Citations (3)
| Title |
|---|
| JPN5002002856, Ｔａｎｉ， Ｅ． ｅｔ ａｌ．, ""Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｅｆｆｅｃｔ ｏｎ ｆｒｅｅ ｒａｄｉｃａｌ ｐｒｏｃｅｓｓｅｓ ｏｆ ｓｏｍｅ ｓｕｂｓｔｉｔｕｔｅｄ ｍｏｒｐｈｏｌｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ ｗｉｔｈ ｐｏｔｅ", Ａｒｚｎｅｉｍｉｔｔｅｌ−Ｆｏｒｓｃｈｕｎｇ／Ｄｒｕｇ Ｒｅｓｅａｒｃｈ, 1994, Ｖｏｌ．４４， Ｎｏ．９, ｐ．９９２−９９４, DE * |
| JPN5002002857, Ｂｅｃｋｅｔｔ， Ａ． Ｈ． ｅｔ ａｌ．, ""Ｔｈｅ ｒｅｌａｔｉｏｎｓｈｉｐ ｂｅｔｗｅｅｎ ｃｈｅｍｉｃａｌ ｓｔｒｕｃｔｕｒｅ ａｎｄ ｂａｓｉｃｉｔｙ ｉｎ ｓｏｍｅ ｍｏｒｐｈｏｌｉｎｅ ｃｏｍｐｏｕｎｄｓ"", Ａｒｚｎｅｉｍｉｔｔｅｌ−Ｆｏｒｓｃｈｕｎｇ／Ｄｒｕｇ Ｒｅｓｅａｒｃｈ, 1976, Ｖｏｌ．２６， Ｎｏ．１０, ｐ．１８１０−１８１１, DE * |
| JPN6010021551, Ｒｅｋｋａ， Ｅ． ｅｔ ａｌ．, ""Ｌｉｐｏｐｈｉｌｉｃｉｔｙ ｏｆ ｓｏｍｅ ｓｕｂｓｔｉｔｕｔｅｄ ｍｏｒｐｈｏｌｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ ｓｙｎｔｈｅｓｉｚｅｄ ａｓ ｐｏｔｅｎｔｉａｌ ａｎｔｉｎｏｃｉｃｅｐｔｉｖｅ ａ", Ａｒｃｈｉｖ ｄｅｒ Ｐｈａｒｍａｚｉｅ, 1990, Ｖｏｌ．３２３， Ｎｏ．１, ｐ．５３−５６, DE * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013530144A (ja) * | 2010-05-21 | 2013-07-25 | リサーチ・トライアングル・インスティチュート | 薬物依存を処置するためのヒドロキシブプロピオン類似体（政府支援研究または開発） |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0007490A (pt) | 2001-10-16 |
| AU1996000A (en) | 2000-08-01 |
| EP1140877A1 (en) | 2001-10-10 |
| CN1336922A (zh) | 2002-02-20 |
| US6693192B1 (en) | 2004-02-17 |
| CA2359476A1 (en) | 2000-07-20 |
| CA2359476C (en) | 2006-01-03 |
| WO2000042030A1 (en) | 2000-07-20 |
| AU770267B2 (en) | 2004-02-19 |
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