JP2002534219A5 - - Google Patents
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- JP2002534219A5 JP2002534219A5 JP2000593337A JP2000593337A JP2002534219A5 JP 2002534219 A5 JP2002534219 A5 JP 2002534219A5 JP 2000593337 A JP2000593337 A JP 2000593337A JP 2000593337 A JP2000593337 A JP 2000593337A JP 2002534219 A5 JP2002534219 A5 JP 2002534219A5
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- Prior art date
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- 239000000203 mixture Substances 0.000 description 37
- 210000004027 cell Anatomy 0.000 description 16
- 239000003504 photosensitizing agent Substances 0.000 description 15
- 210000001519 tissue Anatomy 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 13
- 206010028980 Neoplasm Diseases 0.000 description 8
- 230000001678 irradiating effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 239000003446 ligand Substances 0.000 description 6
- 239000012190 activator Substances 0.000 description 5
- 239000012634 fragment Substances 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 3
- 230000031700 light absorption Effects 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- 229940002612 prodrug Drugs 0.000 description 3
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- 241000124008 Mammalia Species 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 230000003394 haemopoietic effect Effects 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 210000003563 lymphoid tissue Anatomy 0.000 description 2
- 230000002165 photosensitisation Effects 0.000 description 2
- BBNQQADTFFCFGB-UHFFFAOYSA-N purpurin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1 BBNQQADTFFCFGB-UHFFFAOYSA-N 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 231100000216 vascular lesion Toxicity 0.000 description 2
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 1
- 208000022211 Arteriovenous Malformations Diseases 0.000 description 1
- 206010003226 Arteriovenous fistula Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 229960002749 aminolevulinic acid Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000005744 arteriovenous malformation Effects 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 208000025440 neoplasm of neck Diseases 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11623499P | 1999-01-15 | 1999-01-15 | |
| US09/271,575 | 1999-03-18 | ||
| US60/116,234 | 1999-03-18 | ||
| US09/271,575 US6602274B1 (en) | 1999-01-15 | 1999-03-18 | Targeted transcutaneous cancer therapy |
| PCT/US2000/000944 WO2000041727A1 (en) | 1999-01-15 | 2000-01-14 | Transcutaneous photodynamic treatment of targeted cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002534219A JP2002534219A (ja) | 2002-10-15 |
| JP2002534219A5 true JP2002534219A5 (enExample) | 2007-02-22 |
Family
ID=40418902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593337A Pending JP2002534219A (ja) | 1999-01-15 | 2000-01-14 | 標的細胞の経皮的な光力学的処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US6602274B1 (enExample) |
| EP (1) | EP1140176A1 (enExample) |
| JP (1) | JP2002534219A (enExample) |
| AU (1) | AU2413700A (enExample) |
| CA (1) | CA2356776A1 (enExample) |
| WO (1) | WO2000041727A1 (enExample) |
Families Citing this family (185)
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- 2000-01-14 AU AU24137/00A patent/AU2413700A/en not_active Abandoned
- 2000-01-14 WO PCT/US2000/000944 patent/WO2000041727A1/en not_active Ceased
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- 2000-01-14 JP JP2000593337A patent/JP2002534219A/ja active Pending
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2001
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2002
- 2002-12-10 US US10/317,269 patent/US20030109813A1/en not_active Abandoned
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2003
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2004
- 2004-03-16 US US10/802,284 patent/US7018395B2/en not_active Expired - Lifetime
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2005
- 2005-04-26 US US11/115,740 patent/US20050196401A1/en not_active Abandoned
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2007
- 2007-09-27 US US11/906,110 patent/US20080114285A1/en not_active Abandoned
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