JP2002529417A - スルホニル尿素、グリタゾンおよびビグアニドを含有する糖尿病用組み合わせ薬剤 - Google Patents
スルホニル尿素、グリタゾンおよびビグアニドを含有する糖尿病用組み合わせ薬剤Info
- Publication number
- JP2002529417A JP2002529417A JP2000580630A JP2000580630A JP2002529417A JP 2002529417 A JP2002529417 A JP 2002529417A JP 2000580630 A JP2000580630 A JP 2000580630A JP 2000580630 A JP2000580630 A JP 2000580630A JP 2002529417 A JP2002529417 A JP 2002529417A
- Authority
- JP
- Japan
- Prior art keywords
- troglitazone
- patients
- metformin
- sulfonylurea
- glitazone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 235000020880 diabetic diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
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- 238000003379 elimination reaction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
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- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229960004346 glimepiride Drugs 0.000 description 1
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 230000010030 glucose lowering effect Effects 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000004322 lipid homeostasis Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 125000006574 non-aromatic ring group Chemical group 0.000 description 1
- BNYHRGTXRPWASY-UHFFFAOYSA-N nonylsulfonylurea Chemical compound CCCCCCCCCS(=O)(=O)NC(N)=O BNYHRGTXRPWASY-UHFFFAOYSA-N 0.000 description 1
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- 125000000962 organic group Chemical group 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- XMSXOLDPMGMWTH-UHFFFAOYSA-N rivoglitazone Chemical compound CN1C2=CC(OC)=CC=C2N=C1COC(C=C1)=CC=C1CC1SC(=O)NC1=O XMSXOLDPMGMWTH-UHFFFAOYSA-N 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
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- 230000008685 targeting Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/189,132 | 1998-11-09 | ||
| US09/189,132 US6011049A (en) | 1997-02-19 | 1998-11-09 | Combinations for diabetes |
| PCT/US1999/018140 WO2000027401A1 (en) | 1998-11-09 | 1999-08-11 | Combinations for diabetes which contain a sulfonylurea, a glitazone and a biguanide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002529417A true JP2002529417A (ja) | 2002-09-10 |
Family
ID=22696072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000580630A Pending JP2002529417A (ja) | 1998-11-09 | 1999-08-11 | スルホニル尿素、グリタゾンおよびビグアニドを含有する糖尿病用組み合わせ薬剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6011049A (https=) |
| EP (2) | EP1514550A3 (https=) |
| JP (1) | JP2002529417A (https=) |
| AR (1) | AR020973A1 (https=) |
| AT (1) | ATE293980T1 (https=) |
| AU (1) | AU5347399A (https=) |
| CA (1) | CA2345524C (https=) |
| CO (1) | CO5150152A1 (https=) |
| CR (1) | CR6128A (https=) |
| DE (1) | DE69925019T2 (https=) |
| DK (1) | DK1128834T3 (https=) |
| ES (1) | ES2241305T3 (https=) |
| GT (1) | GT199900158A (https=) |
| HN (1) | HN1999000184A (https=) |
| PA (1) | PA8484901A1 (https=) |
| PE (1) | PE20001235A1 (https=) |
| PT (1) | PT1128834E (https=) |
| SI (1) | SI1128834T1 (https=) |
| UY (1) | UY25791A1 (https=) |
| WO (1) | WO2000027401A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008026668A1 (en) * | 2006-08-31 | 2008-03-06 | Daiichi Sankyo Company, Limited | Medicinal composition containing insulin resistance improving agent |
| JP2008517921A (ja) * | 2004-10-25 | 2008-05-29 | ノバルティス アクチエンゲゼルシャフト | Ｄｐｐ−ｉｖ阻害剤、ｐｐａｒ抗糖尿病薬およびメトホルミンの組合わせ剤 |
| JP2009523142A (ja) * | 2006-01-13 | 2009-06-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリアジン誘導体およびインスリン増感剤の組合せ |
| JP2019506374A (ja) * | 2015-12-23 | 2019-03-07 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | メトホルミンのバイオマーカーとしての増殖分化因子１５ |
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| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US6291495B1 (en) * | 1997-02-24 | 2001-09-18 | Robert B. Rieveley | Method and composition for the treatment of diabetes |
| US6284748B1 (en) | 1997-03-07 | 2001-09-04 | Metabasis Therapeutics, Inc. | Purine inhibitors of fructose 1,6-bisphosphatase |
| US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| KR100818845B1 (ko) | 1998-09-09 | 2008-04-01 | 메타베이시스 테라퓨틱스, 인크. | 신규한 프럭토스 1,6-비스포스파타제의 헤테로방향족 억제제 |
| US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
| GB9824893D0 (en) * | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| US6878749B2 (en) | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| US6586438B2 (en) * | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| JP2003525944A (ja) | 2000-03-08 | 2003-09-02 | メタバシス・セラピューティクス・インコーポレイテッド | 新規アリールフルクトース−１，６−ビスホスファターゼ阻害剤 |
| WO2001082867A2 (en) * | 2000-05-01 | 2001-11-08 | Aeropharm Technology, Inc. | A core formulation |
| US6780432B1 (en) * | 2000-05-01 | 2004-08-24 | Aeropharm Technology, Inc. | Core formulation |
| US6296874B1 (en) * | 2000-05-01 | 2001-10-02 | Aeropharm Technology Incorporated | Core formulation comprising troglitazone and abiguanide |
| US6610272B1 (en) | 2000-05-01 | 2003-08-26 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| AU2000273085A1 (en) * | 2000-10-02 | 2002-04-15 | Usv Limited | Sustained release pharmaceutical compositions containing metformin and method ofits production |
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| KR200249057Y1 (ko) * | 2001-03-22 | 2001-10-19 | 김진환 | 뚜껑, 받침대에 합체된 하수역류. 악취방지 장치 |
| FR2823225B1 (fr) * | 2001-04-04 | 2004-09-17 | Pierre Desreumaux | Utilisation de composes modulant l'activite de l'heterodimere rxr-ppar a titre de medicament pour le traitement de l'hepatite c, et procede de criblage correspondant |
| CA2443632C (en) * | 2001-04-10 | 2011-05-03 | Sun Pharmaceutical Industries Limited | Timed pulse release composition |
| US20040156903A1 (en) * | 2002-05-22 | 2004-08-12 | Abrams Andrew L.. | Metering and packaging of controlled release medication |
| SE0101980D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
| SE0101982D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
| AU2001273289B2 (en) * | 2001-07-10 | 2004-10-07 | Kos Life Sciences, Inc. | Core formulation comprising pioglitazone hydrochloride and a biguanide |
| AU2001273310B2 (en) * | 2001-07-10 | 2004-10-07 | Kos Life Sciences, Inc. | A core formulation |
| MXPA04000181A (es) * | 2001-07-10 | 2004-11-22 | Kos Life Sciences Inc | Formulacion de nucleo que comprende troglitazona y una biguanida. |
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| JP4965060B2 (ja) * | 2001-07-27 | 2012-07-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | バウヒニア抽出物 |
| KR100924478B1 (ko) * | 2001-07-30 | 2009-11-03 | 미쓰비시 타나베 파마 코퍼레이션 | 식후 과혈당 개선제 |
| FR2832633B1 (fr) * | 2001-11-28 | 2004-09-24 | Lipha | Composition pharmaceutique comprenant une association metformine et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete |
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| ATE361065T1 (de) * | 2002-01-25 | 2007-05-15 | Silanes Sa De Cv Lab | Pharmazeutische zusammensetzung zur kontrolle des blutzuckers bei patienten mit typ 2 diabetes |
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| MXPA05003252A (es) * | 2002-09-26 | 2005-07-05 | Eisai Co Ltd | Farmaco de combinacion. |
| IN192749B (https=) * | 2002-11-15 | 2004-05-15 | Ranbaxy Lab Ltd | |
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| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
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| US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| IL118778A (en) * | 1995-07-03 | 1999-07-14 | Sankyo Co | Pharmaceutical compositions for the treatment of arteriosclerosis and xanthoma containing an hmg-coa reductase inhibitor |
| GB9715295D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
-
1998
- 1998-11-09 US US09/189,132 patent/US6011049A/en not_active Expired - Fee Related
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1999
- 1999-06-01 HN HN1999000184A patent/HN1999000184A/es unknown
- 1999-08-11 ES ES99939130T patent/ES2241305T3/es not_active Expired - Lifetime
- 1999-08-11 PT PT99939130T patent/PT1128834E/pt unknown
- 1999-08-11 JP JP2000580630A patent/JP2002529417A/ja active Pending
- 1999-08-11 AU AU53473/99A patent/AU5347399A/en not_active Abandoned
- 1999-08-11 WO PCT/US1999/018140 patent/WO2000027401A1/en not_active Ceased
- 1999-08-11 EP EP04029821A patent/EP1514550A3/en not_active Withdrawn
- 1999-08-11 CA CA002345524A patent/CA2345524C/en not_active Expired - Fee Related
- 1999-08-11 SI SI9930780T patent/SI1128834T1/xx unknown
- 1999-08-11 EP EP99939130A patent/EP1128834B1/en not_active Expired - Lifetime
- 1999-08-11 DE DE69925019T patent/DE69925019T2/de not_active Expired - Fee Related
- 1999-08-11 DK DK99939130T patent/DK1128834T3/da active
- 1999-08-11 AT AT99939130T patent/ATE293980T1/de not_active IP Right Cessation
- 1999-09-17 GT GT199900158A patent/GT199900158A/es unknown
- 1999-10-26 AR ARP990105394A patent/AR020973A1/es unknown
- 1999-10-29 PA PA19998484901A patent/PA8484901A1/es unknown
- 1999-11-05 CR CR6128A patent/CR6128A/es unknown
- 1999-11-05 PE PE1999001121A patent/PE20001235A1/es not_active Application Discontinuation
- 1999-11-05 UY UY25791A patent/UY25791A1/es unknown
- 1999-11-05 CO CO99070009A patent/CO5150152A1/es unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008517921A (ja) * | 2004-10-25 | 2008-05-29 | ノバルティス アクチエンゲゼルシャフト | Ｄｐｐ−ｉｖ阻害剤、ｐｐａｒ抗糖尿病薬およびメトホルミンの組合わせ剤 |
| JP2009523142A (ja) * | 2006-01-13 | 2009-06-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリアジン誘導体およびインスリン増感剤の組合せ |
| WO2008026668A1 (en) * | 2006-08-31 | 2008-03-06 | Daiichi Sankyo Company, Limited | Medicinal composition containing insulin resistance improving agent |
| JP2019506374A (ja) * | 2015-12-23 | 2019-03-07 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | メトホルミンのバイオマーカーとしての増殖分化因子１５ |
| US10975434B2 (en) | 2015-12-23 | 2021-04-13 | Sanofi-Aventis Deutschland Gmbh | Growth differentiation factor 15 as biomarker for metformin |
| US11807905B2 (en) | 2015-12-23 | 2023-11-07 | Sanofi-Aventis Deutschland Gmbh | Growth differentiation factor 15 as biomarker for metformin |
| JP7454908B2 (ja) | 2015-12-23 | 2024-03-25 | サノフィ－アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | メトホルミンのバイオマーカーとしての増殖分化因子１５ |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69925019D1 (de) | 2005-06-02 |
| US6011049A (en) | 2000-01-04 |
| EP1514550A3 (en) | 2009-04-29 |
| SI1128834T1 (https=) | 2005-08-31 |
| AU5347399A (en) | 2000-05-29 |
| PA8484901A1 (es) | 2000-09-29 |
| AR020973A1 (es) | 2002-06-05 |
| CA2345524A1 (en) | 2000-05-18 |
| CO5150152A1 (es) | 2002-04-29 |
| PT1128834E (pt) | 2005-07-29 |
| GT199900158A (es) | 2001-03-10 |
| CA2345524C (en) | 2005-09-20 |
| EP1128834A1 (en) | 2001-09-05 |
| HN1999000184A (es) | 2000-02-10 |
| EP1514550A2 (en) | 2005-03-16 |
| DK1128834T3 (da) | 2005-07-04 |
| PE20001235A1 (es) | 2000-11-08 |
| ES2241305T3 (es) | 2005-10-16 |
| ATE293980T1 (de) | 2005-05-15 |
| CR6128A (es) | 2000-11-30 |
| WO2000027401A1 (en) | 2000-05-18 |
| DE69925019T2 (de) | 2006-03-02 |
| EP1128834B1 (en) | 2005-04-27 |
| UY25791A1 (es) | 2001-03-16 |
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