JP2002528722A5 - - Google Patents
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- Publication number
- JP2002528722A5 JP2002528722A5 JP2000578660A JP2000578660A JP2002528722A5 JP 2002528722 A5 JP2002528722 A5 JP 2002528722A5 JP 2000578660 A JP2000578660 A JP 2000578660A JP 2000578660 A JP2000578660 A JP 2000578660A JP 2002528722 A5 JP2002528722 A5 JP 2002528722A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- autoantibody
- kit
- immobilized antibody
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 description 89
- 102000036639 antigens Human genes 0.000 description 89
- 108091007433 antigens Proteins 0.000 description 89
- 238000000034 method Methods 0.000 description 62
- 210000001124 body fluid Anatomy 0.000 description 38
- 239000000203 mixture Substances 0.000 description 36
- 239000000758 substrate Substances 0.000 description 34
- 239000010839 body fluid Substances 0.000 description 29
- 238000012216 screening Methods 0.000 description 17
- 238000002372 labelling Methods 0.000 description 12
- 102000009843 Thyroglobulin Human genes 0.000 description 11
- 238000012544 monitoring process Methods 0.000 description 11
- 229960002175 thyroglobulin Drugs 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 210000001685 thyroid gland Anatomy 0.000 description 10
- 230000001419 dependent effect Effects 0.000 description 9
- 108010036012 Iodide peroxidase Proteins 0.000 description 8
- 102000014267 Thyroid peroxidases Human genes 0.000 description 8
- 108010034949 Thyroglobulin Proteins 0.000 description 7
- 239000013641 positive control Substances 0.000 description 6
- 208000023275 Autoimmune disease Diseases 0.000 description 4
- 102000003911 Thyrotropin Receptors Human genes 0.000 description 4
- 108090000253 Thyrotropin Receptors Proteins 0.000 description 4
- 108010008775 thyroglobulin receptor Proteins 0.000 description 4
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 3
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 3
- 102000011923 Thyrotropin Human genes 0.000 description 3
- 108010061174 Thyrotropin Proteins 0.000 description 3
- 229940034208 thyroxine Drugs 0.000 description 3
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 3
- 229940035722 triiodothyronine Drugs 0.000 description 3
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 239000011149 active material Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 208000010928 autoimmune thyroid disease Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9823397.6 | 1998-10-27 | ||
| GBGB9823397.6A GB9823397D0 (en) | 1998-10-27 | 1998-10-27 | Assays for thyroid autoantibodies |
| PCT/GB1999/003548 WO2000025137A1 (en) | 1998-10-27 | 1999-10-27 | Assays for autoantibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002528722A JP2002528722A (ja) | 2002-09-03 |
| JP2002528722A5 true JP2002528722A5 (https=) | 2006-09-14 |
| JP4426110B2 JP4426110B2 (ja) | 2010-03-03 |
Family
ID=10841298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000578660A Expired - Lifetime JP4426110B2 (ja) | 1998-10-27 | 1999-10-27 | 自己抗体のためのアッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7001775B1 (https=) |
| EP (1) | EP1071956B1 (https=) |
| JP (1) | JP4426110B2 (https=) |
| AT (1) | ATE323286T1 (https=) |
| DE (1) | DE69930843T2 (https=) |
| GB (1) | GB9823397D0 (https=) |
| WO (1) | WO2000025137A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1456234B1 (en) | 2001-08-23 | 2014-04-09 | Rsr Limited | Epitope regions of a thyrotrophin (tsh) receptor, uses thereof and antibodies thereto |
| JP5662684B2 (ja) * | 2007-02-16 | 2015-02-04 | ジェンザイム コーポレーション | 甲状腺障害リスクの同定方法 |
| US20090286329A1 (en) * | 2008-05-19 | 2009-11-19 | Abbott Laboratoires | Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides |
| US20090286256A1 (en) * | 2008-05-19 | 2009-11-19 | Abbott Laboratories | Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides |
| WO2011085057A2 (en) * | 2010-01-06 | 2011-07-14 | The Regents Of The University Of Colorado, A Body Corporate | Methods for detecting insulin autoantibody |
| US12436148B2 (en) * | 2018-07-02 | 2025-10-07 | Siemens Healthcare Diagnostics Inc. | Direct immunoassay measurement of autoantibodies |
| US12163956B2 (en) * | 2019-02-21 | 2024-12-10 | Takeda Pharmaceutical Company Limited | Lateral flow immunoassay for measuring functional C1-esterase inhibitor (C1-INH) in plasma samples |
| WO2020210446A1 (en) * | 2019-04-12 | 2020-10-15 | Dyax Corp. | Lateral flow immunoassay for measuring functional c1-esterase inhibitor (c1-inh) in plasma samples |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622871A (en) * | 1987-04-27 | 1997-04-22 | Unilever Patent Holdings B.V. | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents |
| US3654090A (en) | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| NL7501215A (nl) * | 1975-02-01 | 1976-08-03 | Akzo Nv | Methode voor het aantonen en bepalen van een antigeen of antilichaam. |
| US4094647A (en) | 1976-07-02 | 1978-06-13 | Thyroid Diagnostics, Inc. | Test device |
| US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US4486530A (en) * | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| DE3484505D1 (de) * | 1983-12-19 | 1991-05-29 | Daiichi Pure Chemicals Co Ltd | Immuntest. |
| US4999285A (en) | 1984-11-15 | 1991-03-12 | Syntex (U.S.A.) Inc. | Chromatographic cassette |
| DE3445816C1 (de) | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| GB8526741D0 (en) | 1985-10-30 | 1985-12-04 | Boots Celltech Diagnostics | Binding assay device |
| US5120643A (en) * | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US5206177A (en) * | 1988-01-21 | 1993-04-27 | Boehringer Mannheim Corporation | Apparatus for determining an analyte and method therefor |
| US5077198A (en) * | 1988-04-14 | 1991-12-31 | Eastman Kodak Company | Diagnostic kit and method for rapid detection of antibodies |
| WO1991003483A1 (en) * | 1989-09-08 | 1991-03-21 | New England Medical Center Hospitals, Inc. | Tsh receptor |
| CA2110920A1 (en) * | 1991-06-13 | 1992-12-23 | Sinfu Tzeng | Assay for the detection of specific ligands |
| DE4120412C1 (https=) * | 1991-06-20 | 1993-01-07 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De | |
| US5229073A (en) * | 1992-02-27 | 1993-07-20 | Abbott Laboratories | One-step competitive immunoassay for the semiquantitative determination of plasma lipoprotein(a) |
| WO1993023073A1 (en) * | 1992-05-19 | 1993-11-25 | The Regents Of The University Of Michigan | Thyroid peroxidase epitopic regions |
| WO1994012878A1 (en) * | 1992-11-27 | 1994-06-09 | Gec-Marconi Limited | Separation method |
| DE4328070C1 (de) | 1993-08-20 | 1994-11-24 | Henning Berlin Gmbh | Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum |
| EP0719858A3 (en) | 1994-12-27 | 1997-12-29 | Tosoh Corporation | Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor |
| WO1996027129A1 (en) | 1995-02-28 | 1996-09-06 | Ehrenkranz Joel R L | Rapid, self-performing tsh immunoassay |
-
1998
- 1998-10-27 GB GBGB9823397.6A patent/GB9823397D0/en not_active Ceased
-
1999
- 1999-10-27 US US09/582,524 patent/US7001775B1/en not_active Expired - Lifetime
- 1999-10-27 WO PCT/GB1999/003548 patent/WO2000025137A1/en not_active Ceased
- 1999-10-27 JP JP2000578660A patent/JP4426110B2/ja not_active Expired - Lifetime
- 1999-10-27 DE DE69930843T patent/DE69930843T2/de not_active Expired - Lifetime
- 1999-10-27 EP EP99951000A patent/EP1071956B1/en not_active Expired - Lifetime
- 1999-10-27 AT AT99951000T patent/ATE323286T1/de active
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