JP2002527414A5 - - Google Patents
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- Publication number
- JP2002527414A5 JP2002527414A5 JP2000575820A JP2000575820A JP2002527414A5 JP 2002527414 A5 JP2002527414 A5 JP 2002527414A5 JP 2000575820 A JP2000575820 A JP 2000575820A JP 2000575820 A JP2000575820 A JP 2000575820A JP 2002527414 A5 JP2002527414 A5 JP 2002527414A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- hydrogen
- substituted
- iodo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 125000003545 alkoxy group Chemical group 0.000 description 5
- -1 chloro, fluoro, iodo Chemical group 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 5
- 125000001188 haloalkyl group Chemical group 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- 201000002674 obstructive nephropathy Diseases 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000001309 chloro group Chemical group Cl* 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 125000002346 iodo group Chemical group I* 0.000 description 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 3
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 125000005362 aryl sulfone group Chemical group 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 230000036740 Metabolism Effects 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000035786 metabolism Effects 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10413298P | 1998-10-14 | 1998-10-14 | |
| US60/104,132 | 1998-10-14 | ||
| PCT/US1999/023779 WO2000021910A2 (en) | 1998-10-14 | 1999-10-13 | 1,2-disubstituted cyclopropanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002527414A JP2002527414A (ja) | 2002-08-27 |
| JP2002527414A5 true JP2002527414A5 (US20080131398A1-20080605-C00009.png) | 2006-12-21 |
Family
ID=22298823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000575820A Pending JP2002527414A (ja) | 1998-10-14 | 1999-10-13 | １，２−ジ置換シクロプロパン |
Country Status (5)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2809396B1 (fr) | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| US6908935B2 (en) * | 2002-05-23 | 2005-06-21 | Amgen Inc. | Calcium receptor modulating agents |
| US7176322B2 (en) * | 2002-05-23 | 2007-02-13 | Amgen Inc. | Calcium receptor modulating agents |
| SI2821067T1 (en) | 2003-09-12 | 2018-03-30 | Amgen Inc. | Quick spray formulation of cinacalcet |
| WO2005065050A2 (ja) | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | ２環化合物 |
| EP1757582B1 (en) | 2004-05-28 | 2015-12-30 | Mitsubishi Tanabe Pharma Corporation | Arylalkylamines and process for production thereof |
| AP2007004157A0 (en) | 2005-03-17 | 2007-10-31 | Pfizer | N- (N-sulfonylaminomethyl) cyclo-propanecarboxamide derivatives useful for the treatment of pain |
| JP2008533170A (ja) * | 2005-03-17 | 2008-08-21 | アムジエン・インコーポレーテツド | 石灰化減少方法 |
| JP5309014B2 (ja) * | 2006-03-23 | 2013-10-09 | アムジエン・インコーポレーテツド | シナカルセットの多形体の製造および使用のための方法および組成物 |
| BRPI0710814A2 (pt) * | 2006-04-20 | 2011-08-16 | Amgen Inc | formulações de emulsão estável |
| US7743661B2 (en) * | 2006-04-26 | 2010-06-29 | Halliburton Energy Services, Inc. | Fiber optic MEMS seismic sensor with mass supported by hinged beams |
| EP2139462B1 (en) | 2007-03-30 | 2014-01-22 | Amgen Inc. | Calcimimetic compounds for use in the treatment of bowel disorders |
| WO2010104882A1 (en) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Methods of modulating sperm motility |
| JP2012528084A (ja) | 2009-05-27 | 2012-11-12 | レオ ファーマ アクティーゼルスカブ | 新規のカルシウム感知受容体調節化合物およびその医薬用途 |
| US8765676B2 (en) | 2009-05-27 | 2014-07-01 | Leo Pharma A/S | Calcium sensing receptor modulating compounds and pharmaceutical use thereof |
| US8497271B2 (en) * | 2009-10-07 | 2013-07-30 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| CN102958907A (zh) | 2010-06-30 | 2013-03-06 | 利奥制药有限公司 | 钙敏感受体激动化合物的新多晶型 |
| EP2588444A1 (en) | 2010-06-30 | 2013-05-08 | Leo Pharma A/S | New polymorphic form of a calcimimetic compound |
| US20130267516A1 (en) | 2010-11-26 | 2013-10-10 | Leo Pharma A/S | Substituted cyclopentyl-azines as casr-active compounds |
| RU2013128968A (ru) | 2010-11-26 | 2015-01-10 | Лео Фарма А/С | Соединения, активные в отношении кальций-чувствительного рецептора |
| JP2014507375A (ja) | 2010-11-26 | 2014-03-27 | レオ ファーマ アクティーゼルスカブ | カルシウム感知受容体活性化合物 |
| EP2643291A2 (en) | 2010-11-26 | 2013-10-02 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
| JP2016504306A (ja) * | 2012-12-10 | 2016-02-12 | ハー・ルンドベック・アクチエゼルスカベット | ニコチン性アセチルコリン受容体の新規な陽性アロステリックモジュレータ |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3802981A1 (de) | 1988-02-02 | 1989-08-10 | Basf Ag | Verfahren zur reduktion reduzierbarer verbindungen |
| FR2636625B1 (fr) | 1988-09-01 | 1990-11-09 | Jouveinal Sa | Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese |
| US5169780A (en) | 1989-06-22 | 1992-12-08 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
| DE69233572T2 (de) | 1991-08-23 | 2006-08-31 | NPS Pharmaceuticals, Inc., Salt Lake City | Screening-Verfahren für Kalzium-Rezeptor aktive Verbindungen |
| US6071970A (en) | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| ATE267009T1 (de) | 1993-02-23 | 2004-06-15 | Brigham & Womens Hospital | Calciumrezeptoraktive moleküle |
| CA2182680A1 (en) | 1994-02-08 | 1995-08-17 | Alan L. Mueller | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US5504253A (en) | 1994-07-15 | 1996-04-02 | Nps Pharmaceuticals, Inc. | Amine preparation |
| AU3414295A (en) | 1994-08-19 | 1996-03-14 | Nps Pharmaceuticals, Inc. | Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases |
| ES2234768T3 (es) | 1994-10-21 | 2005-07-01 | Nps Pharmaceuticals, Inc. | Compuestos capaces de modular la actividad del receptor de calcio. |
| CA2176854A1 (en) * | 1995-06-07 | 1996-12-08 | Daniel J. Keavy | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics |
| US5753709A (en) * | 1995-06-07 | 1998-05-19 | Bristol-Myers Squibb Company | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics |
-
1999
- 1999-10-13 JP JP2000575820A patent/JP2002527414A/ja active Pending
- 1999-10-13 US US09/417,319 patent/US6172091B1/en not_active Expired - Lifetime
- 1999-10-13 WO PCT/US1999/023779 patent/WO2000021910A2/en active IP Right Grant
- 1999-10-13 CA CA002347092A patent/CA2347092A1/en not_active Abandoned
- 1999-10-13 AU AU64279/99A patent/AU760889B2/en not_active Ceased
