JP2002524021A - 分子相互作用の検出および薬剤発見のための電気化学的プローブ - Google Patents

分子相互作用の検出および薬剤発見のための電気化学的プローブ

Info

Publication number
JP2002524021A
JP2002524021A JP53496498A JP53496498A JP2002524021A JP 2002524021 A JP2002524021 A JP 2002524021A JP 53496498 A JP53496498 A JP 53496498A JP 53496498 A JP53496498 A JP 53496498A JP 2002524021 A JP2002524021 A JP 2002524021A
Authority
JP
Japan
Prior art keywords
binding pair
electrode
reaction chamber
biological binding
electrochemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP53496498A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002524021A5 (enExample
Inventor
フォークス,ダナ・エム
ソープ,エイチ・ホールデン
Original Assignee
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル
ノヴァロン・ファーマシューティカル・コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル, ノヴァロン・ファーマシューティカル・コーポレイション filed Critical ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル
Publication of JP2002524021A publication Critical patent/JP2002524021A/ja
Publication of JP2002524021A5 publication Critical patent/JP2002524021A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/004Enzyme electrodes mediator-assisted
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01DNA viruses
    • G01N2333/02Hepadnaviridae, e.g. hepatitis B virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16HIV-1, HIV-2
    • G01N2333/162HIV-1, HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, DC4-Binding site
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/36Assays involving biological materials from specific organisms or of a specific nature from bacteria from Actinomyces; from Streptomyces (G)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/415Assays involving biological materials from specific organisms or of a specific nature from plants
    • G01N2333/42Lectins, e.g. concanavalin, phytohaemagglutinin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4727Calcium binding proteins, e.g. calmodulin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
    • G01N2333/50Fibroblast growth factors [FGF]
    • G01N2333/503Fibroblast growth factors [FGF] basic FGF [bFGF]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/7056Selectin superfamily, e.g. LAM-1, GlyCAM, ELAM-1, PADGEM
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745Assays involving non-enzymic blood coagulation factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972Plasminogen activators
    • G01N2333/9726Tissue plasminogen activator

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Composite Materials (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP53496498A 1997-02-06 1998-02-06 分子相互作用の検出および薬剤発見のための電気化学的プローブ Ceased JP2002524021A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3691997P 1997-02-06 1997-02-06
US60/036,919 1997-02-06
US60/059,049 1997-06-19
US5904997P 1997-09-16 1997-09-16
PCT/US1998/002440 WO1998035232A2 (en) 1997-02-06 1998-02-06 Electrochemical detection of specific binding

Publications (2)

Publication Number Publication Date
JP2002524021A true JP2002524021A (ja) 2002-07-30
JP2002524021A5 JP2002524021A5 (enExample) 2005-05-12

Family

ID=26713622

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53496498A Ceased JP2002524021A (ja) 1997-02-06 1998-02-06 分子相互作用の検出および薬剤発見のための電気化学的プローブ

Country Status (10)

Country Link
US (1) US20020012943A1 (enExample)
EP (1) EP0970375A2 (enExample)
JP (1) JP2002524021A (enExample)
KR (1) KR20000070821A (enExample)
CN (1) CN1249815A (enExample)
AU (1) AU729118B2 (enExample)
CA (1) CA2279571A1 (enExample)
NO (1) NO993764L (enExample)
NZ (1) NZ336910A (enExample)
WO (1) WO1998035232A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006520469A (ja) * 2003-03-14 2006-09-07 アピビオ エスアーエス 生体分子検出のための方法と装置
JP2014052224A (ja) * 2012-09-05 2014-03-20 National Institute Of Advanced Industrial & Technology エンドトキシンの濃度測定方法およびエンドトキシンの濃度測定装置

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US6413410B1 (en) 1996-06-19 2002-07-02 Lifescan, Inc. Electrochemical cell
US6346387B1 (en) 1995-06-27 2002-02-12 Xanthon, Inc. Detection of binding reactions using labels detected by mediated catalytic electrochemistry
US6863801B2 (en) * 1995-11-16 2005-03-08 Lifescan, Inc. Electrochemical cell
AUPN661995A0 (en) 1995-11-16 1995-12-07 Memtec America Corporation Electrochemical cell 2
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
AUPO581397A0 (en) 1997-03-21 1997-04-17 Memtec America Corporation Sensor connection means
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US6287874B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
RU2161653C2 (ru) * 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
JP4530541B2 (ja) * 1998-09-17 2010-08-25 クリニカル・マイクロ・センサーズ・インコーポレイテッド 被検体検出のためのシグナル検出法
AU1241000A (en) 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
EP2320231A3 (en) * 1999-01-23 2012-07-18 Minerva Biotechnologies Corporation Assays involving sam-modified colloids and non-colloidal structures
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
ES2319380T3 (es) 1999-07-26 2009-05-07 Clinical Micro Sensors, Inc. Determinacion de secuencias de acido nucleico usando la deteccion electronica.
WO2001017670A1 (en) * 1999-09-09 2001-03-15 Ben-Gurion University Of The Negev Matrices of probes and their preparation
US7625951B2 (en) * 2000-07-13 2009-12-01 University Of Kentucky Research Foundation Stimuli-responsive hydrogel microdomes integrated with genetically engineered proteins for high-throughput screening of pharmaceuticals
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
DE10112505C1 (de) * 2001-03-15 2003-01-30 Iongate Biosciences Gmbh Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung
DK2330407T3 (da) 2001-09-14 2013-06-24 Arkray Inc Fremgangsmåde, værktøj og indretning til at måle en koncentration
US7202028B2 (en) 2001-09-24 2007-04-10 The University Of North Carolina At Chapel Hill Methods for the electrochemical detection of multiple target compounds
EP1442289A2 (en) 2001-10-10 2004-08-04 Lifescan, Inc. Electrochemical cell
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US20030180814A1 (en) * 2002-03-21 2003-09-25 Alastair Hodges Direct immunosensor assay
US7052694B2 (en) * 2002-07-16 2006-05-30 Mayo Foundation For Medical Education And Research Dendritic cell potentiation
CN102592040B (zh) * 2002-07-24 2016-12-21 基德姆生物科学有限公司 药物发现的方法
CN1668918A (zh) 2002-07-24 2005-09-14 基德姆生物科学有限公司 药物发现的方法
CN1217192C (zh) * 2002-11-21 2005-08-31 北京博奥生物芯片有限责任公司 光电化学标记物和用其进行光电化学分析的方法、仪器与试剂盒
CN100392385C (zh) * 2002-12-03 2008-06-04 博奥生物有限公司 亲和反应的化学放大电化学检测方法及其试剂盒
US20050244811A1 (en) * 2003-12-15 2005-11-03 Nano-Proprietary, Inc. Matrix array nanobiosensor
JP4685089B2 (ja) * 2004-03-09 2011-05-18 エレメント シックス ベスローテン フェンノートシャップ ダイヤモンド粒子を含有する電気化学的センサー
BRPI0518455A2 (pt) * 2004-11-22 2008-11-18 Home Diagnostics Inc biossensores para mediÇço de produto de anÁlise em fluido e respectivos mÉtodos de mediÇço da concentraÇço do produto de anÁlise
US20070292855A1 (en) * 2005-08-19 2007-12-20 Intel Corporation Method and CMOS-based device to analyze molecules and nanomaterials based on the electrical readout of specific binding events on functionalized electrodes
WO2007035527A2 (en) 2005-09-15 2007-03-29 Duke University Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
US7816025B2 (en) * 2006-08-23 2010-10-19 Canon Kabushiki Kaisha Enzyme electrode, enzyme electrode producing method, sensor and fuel cell each using enzyme electrode
WO2008026214A1 (en) 2006-08-31 2008-03-06 Technion Research & Development Foundation Ltd. Controllable binding and dissociation of chemical entities and electrode devices therefore
US7892816B2 (en) * 2006-09-28 2011-02-22 Colorado State University Research Foundation Electrochemical detection of substrates
KR100869589B1 (ko) * 2006-12-19 2008-11-21 단국대학교 산학협력단 바이오센서를 이용한 생체 물질의 정량적 측정 방법
US20100221846A1 (en) * 2007-10-12 2010-09-02 Nxp B.V. Sensor, a sensor array, and a method of operating a sensor
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
CN103108587B (zh) 2010-05-17 2016-09-21 申提留斯控股有限公司 检测装置和相关使用方法
KR101226655B1 (ko) * 2011-01-28 2013-01-25 서강대학교산학협력단 전기화학적 방법을 기반으로 한 세포 주기 측정 방법
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
CN104730130B (zh) * 2015-04-16 2017-08-04 天津商业大学 测定gpr70受体和其配基相互作用强度的电化学生物传感器的制备方法
GB201507509D0 (en) * 2015-04-30 2015-06-17 Inside Biometrics Ltd Electrochemical Test Device
GB201507506D0 (en) 2015-04-30 2015-06-17 Inside Biometrics Ltd Electrochemical test device
EP3325966B1 (en) 2015-07-20 2021-01-20 Sentilus Holdco, LLC Chips, detectors, and methods of making and using the same
CN106248767B (zh) * 2016-07-15 2018-12-07 济南大学 一种用于检测癌细胞中h2s的三维纸分析器件的制备方法
WO2018165566A1 (en) 2017-03-09 2018-09-13 Auburn University Differential circuit for background correction in electrochemical measurements
US11505799B2 (en) 2017-07-07 2022-11-22 Innamed, Inc. Aptamers for measuring lipoprotein levels
US11560565B2 (en) 2018-06-13 2023-01-24 Auburn University Electrochemical detection nanostructure, systems, and uses thereof
EP4229211A4 (en) * 2020-10-15 2025-04-02 SRI International BINDING ASSAYS WITH A VARIETY OF SYNTHETIC COMPOUNDS, TARGETS AND COUNTERTARGETS
US20240241115A1 (en) * 2021-04-09 2024-07-18 Chen Yu Chen System, devices, and methods for measuring antibody titer and glycosylation
CN114923968A (zh) * 2022-04-21 2022-08-19 山东理工大学 一种检测新冠病毒核壳蛋白的光电化学生物传感器的制备方法及应用
WO2025035209A1 (en) * 2023-08-11 2025-02-20 Mcmaster University Label-free multimeric aptamer biosensor system for real-time monitoring of target analytes in a one-pot configuration
CN118471377B (zh) * 2024-04-29 2025-04-15 淮南市必就科技有限公司 应用电流鉴定的电化学储能站内对象识别系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2285713T3 (es) * 1995-06-07 2007-11-16 Bioveris Corporation Enzimoinmunoanalisis electroquimioluminiscente.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006520469A (ja) * 2003-03-14 2006-09-07 アピビオ エスアーエス 生体分子検出のための方法と装置
JP2014052224A (ja) * 2012-09-05 2014-03-20 National Institute Of Advanced Industrial & Technology エンドトキシンの濃度測定方法およびエンドトキシンの濃度測定装置

Also Published As

Publication number Publication date
AU6651798A (en) 1998-08-26
CN1249815A (zh) 2000-04-05
US20020012943A1 (en) 2002-01-31
EP0970375A2 (en) 2000-01-12
AU729118B2 (en) 2001-01-25
CA2279571A1 (en) 1998-08-13
NZ336910A (en) 2001-09-28
WO1998035232A2 (en) 1998-08-13
KR20000070821A (ko) 2000-11-25
NO993764D0 (no) 1999-08-03
NO993764L (no) 1999-09-28
WO1998035232A3 (en) 1999-03-04

Similar Documents

Publication Publication Date Title
JP2002524021A (ja) 分子相互作用の検出および薬剤発見のための電気化学的プローブ
Paleček et al. Electroactivity of nonconjugated proteins and peptides. Towards electroanalysis of all proteins
Paleček Past, present and future of nucleic acids electrochemistry
US12135323B1 (en) Serially deposited biomolecules
Scheller et al. Research and development in biosensors
Puiu et al. A modular electrochemical peptide-based sensor for antibody detection
JP2002523747A (ja) 電気化学的アフィニティーアッセイ
JP5305254B2 (ja) 標的物質の検出方法
Wang et al. Capture of p53 by electrodes modified with consensus DNA duplexes and amplified voltammetric detection using ferrocene-capped gold nanoparticle/streptavidin conjugates
Tan et al. Hybrid peptide-molecularly imprinted polymer interface for electrochemical detection of vancomycin in complex matrices
WO2018031497A1 (en) Single-step, reagentless detection by protein-based electrochemical biosensors using steric interference
Chakma et al. Development of electrochemical impedance spectroscopy based malaria aptasensor using HRP‐II as target biomarker
Meini et al. A sensitive and selective thrombin impedimetric aptasensor based on tailored aptamers obtained by solid-phase synthesis
Dorčák et al. Lysine, Arginine, and Histidine Residues in Peptide‐Catalyzed Hydrogen Evolution at Mercury Electrodes
Chin et al. Strategy to immobilize peptide probe selected through in vitro ribosome display for electrochemical aptasensor application
JP3993049B2 (ja) 生理活性物質の電気化学的分析用素子およびそれを用いる分析方法
Evtugyn et al. Label-free aptasensor for thrombin determination based on the nanostructured phenazine mediator
Fojta et al. Osmium tetroxide, 2, 2′-bipyridine: electroactive marker for probing accessibility of tryptophan residues in proteins
Ostatná et al. Changes of electrocatalytic response of bovine serum albumin after its methylation and acetylation
Hu et al. Biomolecular interfaces based on self-assembly and self-recognition form biosensors capable of recording molecular binding and release
CN108841828A (zh) 一种特异性识别妥布霉素的单链dna适配体及其应用
Černocká et al. Voltammetric and chronopotentiometric protein structure-sensitive analysis
Strmečki et al. Immunoassays of chemically modified polysaccharides, glycans in glycoproteins and ribose in nucleic acids
CN210376224U (zh) 一种检测l-精氨酸的传感器
Meirinho et al. Electrochemical aptasensor array for multiple detection of human osteopontin

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040827

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040827

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070116

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070330

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070521

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20070829

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20071009