JP2002523458A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002523458A5 JP2002523458A5 JP2000567204A JP2000567204A JP2002523458A5 JP 2002523458 A5 JP2002523458 A5 JP 2002523458A5 JP 2000567204 A JP2000567204 A JP 2000567204A JP 2000567204 A JP2000567204 A JP 2000567204A JP 2002523458 A5 JP2002523458 A5 JP 2002523458A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alkyl
- hydroxy
- quaternary ammonium
- ammonium salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 38
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical class [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 description 16
- 125000000217 alkyl group Chemical group 0.000 description 12
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 12
- -1 alkyl quaternary ammonium salts Chemical class 0.000 description 10
- 229940015042 glycopyrrolate Drugs 0.000 description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 8
- 125000004423 acyloxy group Chemical group 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 6
- 125000000753 cycloalkyl group Chemical group 0.000 description 6
- 125000005843 halogen group Chemical group 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 208000033830 Hot Flashes Diseases 0.000 description 4
- 206010060800 Hot flush Diseases 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 4
- 0 CC1(C)C(*C(*)(*)*)CN(*)CC1 Chemical compound CC1(C)C(*C(*)(*)*)CN(*)CC1 0.000 description 2
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000000392 cycloalkenyl group Chemical group 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 125000003884 phenylalkyl group Chemical group 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9862998P | 1998-08-31 | 1998-08-31 | |
| US60/098,629 | 1998-08-31 | ||
| US09/184,512 US5962505A (en) | 1998-08-31 | 1998-11-02 | Method for treating hot flashes in humans |
| US09/184,512 | 1998-11-02 | ||
| US09/360,074 | 1999-07-23 | ||
| US09/360,074 US6395757B1 (en) | 1998-08-31 | 1999-07-23 | Method for treating hot flashes in humans |
| PCT/US1999/019693 WO2000012087A1 (en) | 1998-08-31 | 1999-08-31 | Method for treating hot flashes in humans |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002523458A JP2002523458A (ja) | 2002-07-30 |
| JP2002523458A5 true JP2002523458A5 (enExample) | 2006-09-21 |
| JP4601170B2 JP4601170B2 (ja) | 2010-12-22 |
Family
ID=27378636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000567204A Expired - Lifetime JP4601170B2 (ja) | 1998-08-31 | 1999-08-31 | ヒトにおけるのぼせの処置のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6395757B1 (enExample) |
| EP (1) | EP1123098A4 (enExample) |
| JP (1) | JP4601170B2 (enExample) |
| CN (1) | CN1315860A (enExample) |
| AU (1) | AU762126B2 (enExample) |
| CA (1) | CA2339996C (enExample) |
| WO (1) | WO2000012087A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10136404A1 (de) * | 2001-07-26 | 2003-02-20 | Johannes Wohlrab | Arzneiformulierung zur topischen Anwendung für die Therapie und Prophylaxe von Hyperhidrosis |
| US20050288343A1 (en) * | 2004-05-19 | 2005-12-29 | Andrew Rusowicz | Process of preparing substituted carbamates and intermediates thereof |
| EP1861361A1 (en) * | 2005-03-24 | 2007-12-05 | Sosei R&D Ltd. | Glycopyrronium salts and their therapeutic use |
| US20080260823A1 (en) * | 2007-04-20 | 2008-10-23 | Sciele Pharma, Inc. | Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea |
| US8053004B2 (en) * | 2007-10-08 | 2011-11-08 | Starmaker Products, Llc | Ointment for topical treatment of hot flashes and method of use |
| EP2858639B1 (en) | 2012-06-08 | 2018-09-12 | The Ohio State University | Treating scar injury using tocotrienol |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| CA2902795C (en) | 2013-02-28 | 2021-06-15 | Dermira, Inc. | Glycopyrrolate salts |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| WO2015028976A2 (en) * | 2013-08-30 | 2015-03-05 | Mahesh Kandula | Compounds and methods for the treatment of inflammatory diseases |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2956062A (en) | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
| US3943242A (en) | 1974-04-10 | 1976-03-09 | American Cyanamid Company | Deodorant composition containing a quaternary ammonium saccharinate salt |
| US4096254A (en) | 1976-05-10 | 1978-06-20 | Richardson-Merrell Inc. | Method of treating the symptoms of menopause and osteoporosis |
| US5008111A (en) | 1984-10-11 | 1991-04-16 | Schering Corporation | Physiological means of enhancing transdermal delivery of drugs |
| IL76635A0 (en) * | 1984-10-11 | 1986-02-28 | Key Pharma | Physiological means of enhancing transdermal delivery of drugs |
| US4824676A (en) * | 1984-10-11 | 1989-04-25 | Schering Corporation | Physiological means of enhancing transdermal delivery of drugs |
| US5155045A (en) | 1985-01-25 | 1992-10-13 | Trustees Of The University Of Penn. | Use of male essence to alter female endocrine response |
| US5258388A (en) | 1986-03-17 | 1993-11-02 | University Of Florida | Anticholinergic compounds, compositions and methods of treatment |
| US5223528A (en) | 1986-03-17 | 1993-06-29 | University Of Florida | Anticholinergic compounds, composititons and methods of treatment |
| US5462950A (en) | 1993-12-21 | 1995-10-31 | Eli Lilly And Company | Methods of treating menstrual symptoms and compositions therefore |
| US5512555A (en) | 1994-07-21 | 1996-04-30 | Merck & Co., Inc. | Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one |
| US5525347A (en) | 1995-01-31 | 1996-06-11 | Medical University Of South Carolina | Composition and methods for treating performance anxiety |
| US5744463A (en) | 1996-06-03 | 1998-04-28 | Bair; Glenn O. | Treatment of side effects of progestins and progesterone analogues used for birth control |
| US5962505A (en) * | 1998-08-31 | 1999-10-05 | Bobrove; Arthur M. | Method for treating hot flashes in humans |
-
1999
- 1999-07-23 US US09/360,074 patent/US6395757B1/en not_active Expired - Lifetime
- 1999-08-31 CA CA002339996A patent/CA2339996C/en not_active Expired - Lifetime
- 1999-08-31 CN CN99810370A patent/CN1315860A/zh active Pending
- 1999-08-31 JP JP2000567204A patent/JP4601170B2/ja not_active Expired - Lifetime
- 1999-08-31 EP EP99946669A patent/EP1123098A4/en not_active Withdrawn
- 1999-08-31 AU AU59031/99A patent/AU762126B2/en not_active Ceased
- 1999-08-31 WO PCT/US1999/019693 patent/WO2000012087A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008509187A5 (enExample) | ||
| RU2005107314A (ru) | Пиримидопроизводные, характеризующиеся антипролиферативной активностью | |
| JP2012505836A5 (enExample) | ||
| JP2018524298A5 (enExample) | ||
| JP2004509061A5 (enExample) | ||
| RU2264401C3 (ru) | Производные хинуклидина, способ их получения, фармацевтическая композиция, способ лечения и промежуточные вещества | |
| JP2002520416A5 (enExample) | ||
| RU2000132188A (ru) | Производные эпотилонов, их синтез и применение | |
| JP2001526218A5 (enExample) | ||
| JP2004526745A5 (enExample) | ||
| JP2002523458A5 (enExample) | ||
| JP2005511547A5 (enExample) | ||
| JP2007507494A5 (enExample) | ||
| ES2141957T3 (es) | Uso de raloxifeno y sus analogos para la produccion de un medicamento para el tratamiento de enfermedades virales. | |
| JP2003519228A5 (enExample) | ||
| JP2003503449A5 (enExample) | ||
| CA2302568A1 (en) | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents | |
| BR9916860A (pt) | Método de reduzir colesterol do sangue e/outriglicerìdios do sangue em um indivìduo mamìfero,preparação em forma de unidade de dosagem, e,conjunto para administrar oralmente a mesma | |
| RU2002100058A (ru) | Кристаллические производные 1-метилкарбапенема | |
| HU211666A9 (en) | Antiviral compounds | |
| CA2126118A1 (en) | 5-Amino-8-Methyl-7-Pyrrolidinylquinoline-3-Carboxylic Acid Derivative | |
| JP2005513014A5 (enExample) | ||
| RU2005122615A (ru) | Соединения n-(индолэтил)циклоамина | |
| JP2002504505A5 (enExample) | ||
| JP2002509154A5 (enExample) |