CA2339996C - Method for treating hot flashes in humans - Google Patents
Method for treating hot flashes in humans Download PDFInfo
- Publication number
- CA2339996C CA2339996C CA002339996A CA2339996A CA2339996C CA 2339996 C CA2339996 C CA 2339996C CA 002339996 A CA002339996 A CA 002339996A CA 2339996 A CA2339996 A CA 2339996A CA 2339996 C CA2339996 C CA 2339996C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- hydroxy
- hot flashes
- phenyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000033830 Hot Flashes Diseases 0.000 title claims abstract description 68
- 206010060800 Hot flush Diseases 0.000 title claims abstract description 68
- 238000000034 method Methods 0.000 title abstract description 23
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical class [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 claims abstract description 39
- 125000000217 alkyl group Chemical group 0.000 claims description 74
- -1 glycopyrrolate analog compound Chemical class 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 41
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 32
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 26
- 125000005843 halogen group Chemical group 0.000 claims description 26
- 125000004423 acyloxy group Chemical group 0.000 claims description 24
- 125000003545 alkoxy group Chemical group 0.000 claims description 24
- 239000002253 acid Substances 0.000 claims description 18
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 18
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 17
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
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- 125000002252 acyl group Chemical group 0.000 claims description 9
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 28
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9862998P | 1998-08-31 | 1998-08-31 | |
| US60/098,629 | 1998-08-31 | ||
| US09/184,512 | 1998-11-02 | ||
| US09/184,512 US5962505A (en) | 1998-08-31 | 1998-11-02 | Method for treating hot flashes in humans |
| US09/360,074 US6395757B1 (en) | 1998-08-31 | 1999-07-23 | Method for treating hot flashes in humans |
| US09/360,074 | 1999-07-23 | ||
| PCT/US1999/019693 WO2000012087A1 (en) | 1998-08-31 | 1999-08-31 | Method for treating hot flashes in humans |
Publications (2)
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|---|---|
| CA2339996A1 CA2339996A1 (en) | 2000-03-09 |
| CA2339996C true CA2339996C (en) | 2009-06-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002339996A Expired - Lifetime CA2339996C (en) | 1998-08-31 | 1999-08-31 | Method for treating hot flashes in humans |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6395757B1 (enExample) |
| EP (1) | EP1123098A4 (enExample) |
| JP (1) | JP4601170B2 (enExample) |
| CN (1) | CN1315860A (enExample) |
| AU (1) | AU762126B2 (enExample) |
| CA (1) | CA2339996C (enExample) |
| WO (1) | WO2000012087A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10136404A1 (de) * | 2001-07-26 | 2003-02-20 | Johannes Wohlrab | Arzneiformulierung zur topischen Anwendung für die Therapie und Prophylaxe von Hyperhidrosis |
| US20050288343A1 (en) * | 2004-05-19 | 2005-12-29 | Andrew Rusowicz | Process of preparing substituted carbamates and intermediates thereof |
| EP1861361A1 (en) * | 2005-03-24 | 2007-12-05 | Sosei R&D Ltd. | Glycopyrronium salts and their therapeutic use |
| US20080260823A1 (en) * | 2007-04-20 | 2008-10-23 | Sciele Pharma, Inc. | Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea |
| US8053004B2 (en) * | 2007-10-08 | 2011-11-08 | Starmaker Products, Llc | Ointment for topical treatment of hot flashes and method of use |
| CN104507465A (zh) | 2012-06-08 | 2015-04-08 | 俄亥俄州立大学 | 使用生育三烯酚治疗灼伤和瘢痕损伤 |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| ES2981043T3 (es) | 2013-02-28 | 2024-10-07 | Journey Medical Corp | Procedimiento para fabricar tosilato de glicopirrolato treo |
| WO2015028976A2 (en) * | 2013-08-30 | 2015-03-05 | Mahesh Kandula | Compounds and methods for the treatment of inflammatory diseases |
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|---|---|---|---|---|
| US2956062A (en) | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
| US3943242A (en) | 1974-04-10 | 1976-03-09 | American Cyanamid Company | Deodorant composition containing a quaternary ammonium saccharinate salt |
| US4096254A (en) | 1976-05-10 | 1978-06-20 | Richardson-Merrell Inc. | Method of treating the symptoms of menopause and osteoporosis |
| US4824676A (en) * | 1984-10-11 | 1989-04-25 | Schering Corporation | Physiological means of enhancing transdermal delivery of drugs |
| AU592322B2 (en) * | 1984-10-11 | 1990-01-11 | Key Pharmaceuticals, Inc. | Physiological means of enhancing transdermal delivery of drugs |
| US5008111A (en) | 1984-10-11 | 1991-04-16 | Schering Corporation | Physiological means of enhancing transdermal delivery of drugs |
| US5155045A (en) | 1985-01-25 | 1992-10-13 | Trustees Of The University Of Penn. | Use of male essence to alter female endocrine response |
| US5223528A (en) | 1986-03-17 | 1993-06-29 | University Of Florida | Anticholinergic compounds, composititons and methods of treatment |
| US5258388A (en) | 1986-03-17 | 1993-11-02 | University Of Florida | Anticholinergic compounds, compositions and methods of treatment |
| US5462950A (en) | 1993-12-21 | 1995-10-31 | Eli Lilly And Company | Methods of treating menstrual symptoms and compositions therefore |
| US5512555A (en) | 1994-07-21 | 1996-04-30 | Merck & Co., Inc. | Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one |
| US5525347A (en) | 1995-01-31 | 1996-06-11 | Medical University Of South Carolina | Composition and methods for treating performance anxiety |
| US5744463A (en) | 1996-06-03 | 1998-04-28 | Bair; Glenn O. | Treatment of side effects of progestins and progesterone analogues used for birth control |
| US5962505A (en) * | 1998-08-31 | 1999-10-05 | Bobrove; Arthur M. | Method for treating hot flashes in humans |
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- 1999-07-23 US US09/360,074 patent/US6395757B1/en not_active Expired - Lifetime
- 1999-08-31 JP JP2000567204A patent/JP4601170B2/ja not_active Expired - Lifetime
- 1999-08-31 CA CA002339996A patent/CA2339996C/en not_active Expired - Lifetime
- 1999-08-31 AU AU59031/99A patent/AU762126B2/en not_active Ceased
- 1999-08-31 WO PCT/US1999/019693 patent/WO2000012087A1/en not_active Ceased
- 1999-08-31 EP EP99946669A patent/EP1123098A4/en not_active Withdrawn
- 1999-08-31 CN CN99810370A patent/CN1315860A/zh active Pending
Also Published As
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| EP1123098A1 (en) | 2001-08-16 |
| WO2000012087A1 (en) | 2000-03-09 |
| AU5903199A (en) | 2000-03-21 |
| CN1315860A (zh) | 2001-10-03 |
| EP1123098A4 (en) | 2002-01-02 |
| JP2002523458A (ja) | 2002-07-30 |
| AU762126B2 (en) | 2003-06-19 |
| CA2339996A1 (en) | 2000-03-09 |
| US6395757B1 (en) | 2002-05-28 |
| JP4601170B2 (ja) | 2010-12-22 |
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