JP2002523366A5 - - Google Patents
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- Publication number
- JP2002523366A5 JP2002523366A5 JP2000565873A JP2000565873A JP2002523366A5 JP 2002523366 A5 JP2002523366 A5 JP 2002523366A5 JP 2000565873 A JP2000565873 A JP 2000565873A JP 2000565873 A JP2000565873 A JP 2000565873A JP 2002523366 A5 JP2002523366 A5 JP 2002523366A5
- Authority
- JP
- Japan
- Prior art keywords
- desmethylsibutramine
- didesmethylsibutramine
- sibutramine
- metabolite
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical class C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 description 50
- 229960004425 sibutramine Drugs 0.000 description 37
- 239000008194 pharmaceutical composition Substances 0.000 description 23
- 150000003839 salts Chemical class 0.000 description 21
- WQSACWZKKZPCHN-AWEZNQCLSA-N (1s)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Chemical compound C=1C=C(Cl)C=CC=1C1([C@@H](N)CC(C)C)CCC1 WQSACWZKKZPCHN-AWEZNQCLSA-N 0.000 description 20
- 239000003795 chemical substances by application Substances 0.000 description 20
- 150000001875 compounds Chemical class 0.000 description 20
- 239000012453 solvate Substances 0.000 description 20
- 238000004519 manufacturing process Methods 0.000 description 15
- 230000000069 prophylactic effect Effects 0.000 description 14
- 230000001225 therapeutic effect Effects 0.000 description 14
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 description 10
- 206010021639 Incontinence Diseases 0.000 description 7
- 208000017194 Affective disease Diseases 0.000 description 5
- 208000019022 Mood disease Diseases 0.000 description 5
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
- 208000000044 Amnesia Diseases 0.000 description 3
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 3
- 208000017667 Chronic Disease Diseases 0.000 description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 208000012902 Nervous system disease Diseases 0.000 description 3
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 201000009032 substance abuse Diseases 0.000 description 3
- 231100000736 substance abuse Toxicity 0.000 description 3
- 208000011117 substance-related disease Diseases 0.000 description 3
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 description 2
- FEROPKNOYKURCJ-UHFFFAOYSA-N 4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1C(CC2)CCN2C1 FEROPKNOYKURCJ-UHFFFAOYSA-N 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 2
- 208000026139 Memory disease Diseases 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 2
- 206010036618 Premenstrual syndrome Diseases 0.000 description 2
- 206010066218 Stress Urinary Incontinence Diseases 0.000 description 2
- 230000001668 ameliorated effect Effects 0.000 description 2
- 239000002269 analeptic agent Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 239000003420 antiserotonin agent Substances 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000002327 cardiovascular agent Substances 0.000 description 2
- 229940125692 cardiovascular agent Drugs 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 239000000221 dopamine uptake inhibitor Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000002895 emetic Substances 0.000 description 2
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical group C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 description 2
- 229960003727 granisetron Drugs 0.000 description 2
- 239000005554 hypnotics and sedatives Substances 0.000 description 2
- 229940005535 hypnotics and sedatives Drugs 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000006984 memory degeneration Effects 0.000 description 2
- 208000023060 memory loss Diseases 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 2
- 229960004503 metoclopramide Drugs 0.000 description 2
- 206010027599 migraine Diseases 0.000 description 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 2
- 201000003631 narcolepsy Diseases 0.000 description 2
- 229960005343 ondansetron Drugs 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- GZSKEXSLDPEFPT-IINYFYTJSA-N renzapride Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)N[C@H]1[C@H](C2)CCC[N@]2CC1 GZSKEXSLDPEFPT-IINYFYTJSA-N 0.000 description 2
- 229950003039 renzapride Drugs 0.000 description 2
- 239000000952 serotonin receptor agonist Substances 0.000 description 2
- 230000005586 smoking cessation Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 229960003688 tropisetron Drugs 0.000 description 2
- UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- 229950004681 zacopride Drugs 0.000 description 2
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 206010003805 Autism Diseases 0.000 description 1
- 208000020706 Autistic disease Diseases 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 208000022497 Cocaine-Related disease Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000022540 Consciousness disease Diseases 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 229940094659 Dopamine reuptake inhibitor Drugs 0.000 description 1
- 208000030814 Eating disease Diseases 0.000 description 1
- 208000034347 Faecal incontinence Diseases 0.000 description 1
- 208000019454 Feeding and Eating disease Diseases 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- 201000006792 Lennox-Gastaut syndrome Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010057852 Nicotine dependence Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000025569 Tobacco Use disease Diseases 0.000 description 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 description 1
- 208000021017 Weight Gain Diseases 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 230000003561 anti-manic effect Effects 0.000 description 1
- 239000000228 antimanic agent Substances 0.000 description 1
- 201000006145 cocaine dependence Diseases 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 235000014632 disordered eating Nutrition 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 208000024732 dysthymic disease Diseases 0.000 description 1
- 235000005686 eating Nutrition 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000011977 language disease Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 208000024449 overflow incontinence Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 208000012672 seasonal affective disease Diseases 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 206010046494 urge incontinence Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9766598P | 1998-08-24 | 1998-08-24 | |
| US60/097,665 | 1998-08-24 | ||
| US9930698P | 1998-09-02 | 1998-09-02 | |
| US60/099,306 | 1998-09-02 | ||
| US09/372,158 US6331571B1 (en) | 1998-08-24 | 1999-08-11 | Methods of treating and preventing attention deficit disorders |
| US09/372,158 | 1999-08-11 | ||
| PCT/US1999/019167 WO2000010551A2 (en) | 1998-08-24 | 1999-08-23 | Methods of using and compositions comprising dopamine reuptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002523366A JP2002523366A (ja) | 2002-07-30 |
| JP2002523366A5 true JP2002523366A5 (enExample) | 2006-10-12 |
Family
ID=27378425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000565873A Pending JP2002523366A (ja) | 1998-08-24 | 1999-08-23 | ドーパミン再取込みインヒビターを含有する組成物及びその使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6331571B1 (enExample) |
| EP (2) | EP1475086A3 (enExample) |
| JP (1) | JP2002523366A (enExample) |
| KR (3) | KR20080011354A (enExample) |
| CN (1) | CN100415222C (enExample) |
| AT (1) | ATE279184T1 (enExample) |
| AU (2) | AU772303B2 (enExample) |
| CA (1) | CA2341441C (enExample) |
| CZ (1) | CZ2001677A3 (enExample) |
| DE (1) | DE69921157T2 (enExample) |
| DK (1) | DK1107746T3 (enExample) |
| ES (1) | ES2226435T3 (enExample) |
| HU (1) | HUP0103408A3 (enExample) |
| ID (1) | ID28638A (enExample) |
| IL (2) | IL141531A0 (enExample) |
| NO (1) | NO20010943L (enExample) |
| NZ (1) | NZ510193A (enExample) |
| PL (1) | PL200264B1 (enExample) |
| PT (1) | PT1107746E (enExample) |
| WO (1) | WO2000010551A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6974838B2 (en) | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
| US6339106B1 (en) * | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
| US6476078B2 (en) * | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| US6323242B1 (en) | 1998-12-02 | 2001-11-27 | Peter Sterling Mueller | Treatment of disorders secondary to organic impairments |
| US6696495B2 (en) | 1998-12-02 | 2004-02-24 | Snowden Pharmaceuticals, Llc | Treatment of disorders secondary to organic impairments |
| IL145240A (en) * | 1999-03-19 | 2007-02-11 | Abbott Gmbh & Co Kg | Compound and its use in the treatment of eating disorders |
| EP2087892A3 (en) * | 1999-07-01 | 2009-09-30 | Pharmacia & Upjohn Company LLC | (S,S) reboxetine for treating age associated learning and mental disorders |
| US6399826B1 (en) * | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
| AU2002210816A1 (en) * | 2000-11-02 | 2002-05-15 | Torrent Pharmaceuticals Ltd | Process for preparation of beta-phenethylamine derivative |
| US20020115727A1 (en) * | 2000-12-04 | 2002-08-22 | Senanayake Chris H. | Synthesis, methods of using, and compositions of hydroxylated cyclobutylalkylamines |
| ATE409475T1 (de) * | 2001-02-20 | 2008-10-15 | Dinan Timothy Gerard | Behandlung von fibromyalgie mit pindolol |
| DE10142666A1 (de) * | 2001-08-31 | 2003-03-20 | Aventis Pharma Gmbh | Verwendung von C2-substituierten Indan-1-ol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| US7005138B2 (en) * | 2001-12-21 | 2006-02-28 | Duramed Pharmaceuticals, Inc. | Method of systematically delivering SSRIs |
| US20060263419A1 (en) * | 2002-03-12 | 2006-11-23 | Hans-Michael Wolff | Transdermal therapeutic system for Parkinson's Disease |
| JP2005531594A (ja) * | 2002-05-30 | 2005-10-20 | ニューロサーチ、アクティーゼルスカブ | 慢性苦痛の治療用トリプルモノアミン再取り込み阻害剤 |
| AU2003268361A1 (en) * | 2002-08-30 | 2004-03-19 | Watson Pharmaceuticals, Inc. | Drug delivery system for treating urinary incontinence |
| US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
| WO2005072715A1 (en) * | 2004-01-29 | 2005-08-11 | Sepracor Inc. | Use of (s)-didesmethylsibutraminefor treating, preventing and managing a sleep disorder |
| US20050171088A1 (en) * | 2004-01-30 | 2005-08-04 | Astrazeneca Ab | Treatment of psychoses with dibenzothiazepine antipsychotic |
| AU2005215376B2 (en) * | 2004-02-18 | 2011-01-20 | Sunovion Pharmaceuticals Inc. | Dopamine-agonist combination therapy with sedatives for improving sleep quality |
| US20050266085A1 (en) * | 2004-05-28 | 2005-12-01 | Warner Kevin S | Gelled emulsion and microemulsion formulations for dermal drug delivery |
| KR100618176B1 (ko) * | 2004-12-02 | 2006-09-01 | 휴먼팜 주식회사 | 시부트라민 주석산염, 이의 제조 방법 및 이를 포함하는약학적 조성물 |
| WO2006067060A2 (en) * | 2004-12-22 | 2006-06-29 | Ciba Specialty Chemicals Holding Inc. | Enantioselective synthesis of a sterically hindered amine |
| KR20060080817A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
| JP2008526836A (ja) * | 2005-01-06 | 2008-07-24 | シージェー チェイルジェダン コーポレーション | シブトラミンの無機酸塩 |
| KR20060080818A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 술폰산염 |
| KR20060093564A (ko) * | 2005-02-22 | 2006-08-25 | 종근당바이오 주식회사 | 무수 시부트라민 말산염 및 이의 제조 방법 |
| KR100632470B1 (ko) * | 2005-02-25 | 2006-10-12 | 민연식 | 결정성 시부트라민 캄실레이트염과 이의 제조방법 |
| BRPI0610780A2 (pt) * | 2005-04-22 | 2016-09-06 | Teva Pharma | formulação farmacéutica em tablete desintegrante, e, métodos para tratar um paciente em necessidade de tratamento com olanzapina, e para produzir a formulação farmacêutica em tablete |
| CA2612268A1 (en) * | 2005-06-17 | 2006-12-28 | Pfizer Products Inc. | Metabolites of 1-[6-(1-ethyl-1-hydroxy-propyl)-pyridin-3-yl]-3-[2-(4-methyl-piperazin-1-yl)-benzyl]-pyrrolidin-2-one as seratonin receptor antagonists |
| ATE554069T1 (de) * | 2006-03-10 | 2012-05-15 | Univ New York State Res Found | Verwendung von tetrahydropyridinen zur behandlung von erkrankungen des zentralnervensystems |
| US8748419B2 (en) | 2006-06-16 | 2014-06-10 | Theracos, Inc. | Treating obesity with muscarinic receptor M1 antagonists |
| US7893053B2 (en) | 2006-06-16 | 2011-02-22 | Theracos, Inc. | Treating psychological conditions using muscarinic receptor M1 antagonists |
| PL2114147T3 (pl) * | 2007-02-12 | 2012-10-31 | Vyrix Pharmaceuticals Inc | Zmniejszanie skutków ubocznych tramadolu |
| PL2120570T3 (pl) * | 2007-02-12 | 2012-10-31 | Vyrix Pharmaceuticals Inc | Leczenie współwystępującego przedwczesnego wytrysku i zaburzenia wzwodu prącia |
| WO2010022236A2 (en) * | 2008-08-20 | 2010-02-25 | The University Of Medicine And Dentistry Of New Jersey | Inhibiting obesity progression by inhibiting adipocyte differentiation with a pre-adipocyte autophagy inhibitor |
| WO2010093243A1 (en) | 2009-02-12 | 2010-08-19 | Coöperatieve Mirzorg U.A., Arnhem | Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders |
| WO2010126970A1 (en) * | 2009-04-28 | 2010-11-04 | Optmed, Inc. | Methods for treating and preventing erectile dysfunction |
| AU2011291506B2 (en) | 2010-08-19 | 2016-07-28 | Buck Institute For Age Research | Methods of treating mild cognitive impairment (mci) and related disorders |
| NL2022615B1 (en) | 2019-02-21 | 2020-08-31 | Patrick Alexander Unger | Pharmaceutical composition comprising tetrahydrocannabivarin for the prevention and treatment of overweight |
| CN113908295B (zh) * | 2021-11-12 | 2023-07-21 | 郑州大学第一附属医院 | 一种阿普唑仑包合物及其制备方法 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155670A (en) | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes |
| US3155669A (en) | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 2, 4, 8-triaza-spiro (4, 5) dec-2-enes |
| US3471515A (en) | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| GB1308191A (en) | 1970-04-06 | 1973-02-21 | Science Union & Cie | Thiochroman derivatives and a process for preparing them |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| DE3008993A1 (de) | 1980-03-08 | 1981-10-01 | Röhm Pharma GmbH, 6100 Darmstadt | Pharmazeutische zubereitungen |
| ZA821577B (en) | 1981-04-06 | 1983-03-30 | Boots Co Plc | Therapeutic agents |
| IE52768B1 (en) | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
| JPS5940638A (ja) | 1982-08-30 | 1984-03-06 | Fuji Photo Film Co Ltd | 直接ポジ用ハロゲン化銀写真乳剤 |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| GB8501192D0 (en) * | 1985-01-17 | 1985-02-20 | Boots Co Plc | Therapeutic agents |
| GB8531071D0 (en) | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| GB8704777D0 (en) * | 1987-02-28 | 1987-04-01 | Boots Co Plc | Medical treatment |
| JP2675573B2 (ja) | 1988-03-31 | 1997-11-12 | 科研製薬株式会社 | 脳機能改善剤 |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IE61928B1 (en) | 1988-11-29 | 1994-11-30 | Boots Co Plc | Treatment of obesity |
| GB8909209D0 (en) | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5250534A (en) | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
| US5104899A (en) | 1990-08-13 | 1992-04-14 | Sepracor, Inc. | Methods and compositions for treating depression using optically pure fluoxetine |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| EP0554172B1 (en) | 1992-01-28 | 1998-04-29 | Fujitsu Limited | Color surface discharge type plasma display device |
| US5780051A (en) | 1992-04-02 | 1998-07-14 | Dynagen, Inc. | Methods and articles of manufacture for nicotine cessation and monitoring nicotine use |
| JPH07508281A (ja) | 1992-06-23 | 1995-09-14 | セプラコア インコーポレーテッド | 光学的に純粋な（＋）シブトラミンを用いるうつ病およびその他の障害を治療する方法ならびに組成物 |
| EP0647134A4 (en) | 1992-06-23 | 1997-07-30 | Sepracor Inc | METHOD AND COMPOSITIONS FOR TREATING DEPRESSION AND OTHER DISEASES USING OPTICALLY PURE SIBUTRAMINE. |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| US5459164A (en) | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
| GB9402641D0 (en) | 1994-02-11 | 1994-04-06 | Boots Co Plc | Therapeutic agents |
| CA2134038C (en) | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
| ATE212860T1 (de) * | 1994-09-19 | 2002-02-15 | Fujisawa Pharmaceutical Co | Eine neuartige medizinische verwendung eines 5ht 3-antagonisten |
| GB9514464D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| GB9524681D0 (en) | 1995-12-02 | 1996-01-31 | Knoll Ag | Chemical process |
| DE19632423A1 (de) | 1996-08-12 | 1998-02-19 | Merck Patent Gmbh | Thienopyrimidine |
| GB9619757D0 (en) | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
| GB9619961D0 (en) | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| GB9619962D0 (en) | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| US5795880A (en) | 1996-12-30 | 1998-08-18 | Louisiana State University Medical Center Foundation | Method and composition for treating obesity and related disorders in animals comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent |
| US6127363A (en) | 1997-10-28 | 2000-10-03 | Vivus, Inc. | Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| GB9727131D0 (en) | 1997-12-24 | 1998-02-25 | Knoll Ag | Therapeutic agents |
| US6339106B1 (en) * | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
-
1999
- 1999-08-11 US US09/372,158 patent/US6331571B1/en not_active Expired - Lifetime
- 1999-08-23 KR KR1020087001197A patent/KR20080011354A/ko not_active Ceased
- 1999-08-23 CA CA2341441A patent/CA2341441C/en not_active Expired - Fee Related
- 1999-08-23 AT AT99945137T patent/ATE279184T1/de active
- 1999-08-23 PT PT99945137T patent/PT1107746E/pt unknown
- 1999-08-23 NZ NZ510193A patent/NZ510193A/en not_active IP Right Cessation
- 1999-08-23 ES ES99945137T patent/ES2226435T3/es not_active Expired - Lifetime
- 1999-08-23 PL PL346843A patent/PL200264B1/pl not_active IP Right Cessation
- 1999-08-23 IL IL14153199A patent/IL141531A0/xx unknown
- 1999-08-23 EP EP04018454A patent/EP1475086A3/en not_active Withdrawn
- 1999-08-23 WO PCT/US1999/019167 patent/WO2000010551A2/en not_active Ceased
- 1999-08-23 KR KR1020067012844A patent/KR100887008B1/ko not_active Expired - Fee Related
- 1999-08-23 CZ CZ2001677A patent/CZ2001677A3/cs unknown
- 1999-08-23 ID IDW20010700A patent/ID28638A/id unknown
- 1999-08-23 HU HU0103408A patent/HUP0103408A3/hu unknown
- 1999-08-23 EP EP99945137A patent/EP1107746B1/en not_active Expired - Lifetime
- 1999-08-23 KR KR1020017002288A patent/KR20010085553A/ko not_active Ceased
- 1999-08-23 DE DE69921157T patent/DE69921157T2/de not_active Expired - Lifetime
- 1999-08-23 AU AU57817/99A patent/AU772303B2/en not_active Ceased
- 1999-08-23 DK DK99945137T patent/DK1107746T3/da active
- 1999-08-23 CN CNB998124664A patent/CN100415222C/zh not_active Expired - Fee Related
- 1999-08-23 JP JP2000565873A patent/JP2002523366A/ja active Pending
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2001
- 2001-02-20 IL IL141531A patent/IL141531A/en not_active IP Right Cessation
- 2001-02-23 NO NO20010943A patent/NO20010943L/no not_active Application Discontinuation
- 2001-12-04 US US10/000,806 patent/US6538034B2/en not_active Expired - Lifetime
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2003
- 2003-03-25 US US10/395,298 patent/US7071234B2/en not_active Expired - Fee Related
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2004
- 2004-03-03 AU AU2004200875A patent/AU2004200875B2/en not_active Ceased
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