JP2002520413A5 - - Google Patents
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- JP2002520413A5 JP2002520413A5 JP2000560126A JP2000560126A JP2002520413A5 JP 2002520413 A5 JP2002520413 A5 JP 2002520413A5 JP 2000560126 A JP2000560126 A JP 2000560126A JP 2000560126 A JP2000560126 A JP 2000560126A JP 2002520413 A5 JP2002520413 A5 JP 2002520413A5
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- JP
- Japan
- Prior art keywords
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- alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001424 substituent group Chemical group 0.000 description 57
- 125000000217 alkyl group Chemical group 0.000 description 46
- 150000001875 compounds Chemical class 0.000 description 45
- -1 benzyloxy, phenoxy, amino Chemical group 0.000 description 40
- 0 C*O*[C@]1c2cc(OC(F)(F)F)ccc2CN2[C@]1C(C1)N1C(CCCCC(C(c1cc(SCC3*CC3)c(**)c(O*)c1)=O)=O)C2O Chemical compound C*O*[C@]1c2cc(OC(F)(F)F)ccc2CN2[C@]1C(C1)N1C(CCCCC(C(c1cc(SCC3*CC3)c(**)c(O*)c1)=O)=O)C2O 0.000 description 35
- 125000003118 aryl group Chemical group 0.000 description 32
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 27
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 25
- 125000003302 alkenyloxy group Chemical group 0.000 description 20
- 125000003342 alkenyl group Chemical group 0.000 description 18
- 125000000753 cycloalkyl group Chemical group 0.000 description 17
- 229910052739 hydrogen Inorganic materials 0.000 description 15
- 239000001257 hydrogen Substances 0.000 description 15
- 125000003545 alkoxy group Chemical group 0.000 description 14
- 125000000392 cycloalkenyl group Chemical group 0.000 description 12
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 12
- 229910052736 halogen Inorganic materials 0.000 description 11
- 150000002367 halogens Chemical class 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 10
- 239000001301 oxygen Substances 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 8
- 125000000623 heterocyclic group Chemical group 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 229920006395 saturated elastomer Polymers 0.000 description 8
- 229910052799 carbon Inorganic materials 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 7
- 125000004104 aryloxy group Chemical group 0.000 description 6
- 125000004429 atom Chemical group 0.000 description 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 5
- 125000004093 cyano group Chemical group *C#N 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 229910052717 sulfur Inorganic materials 0.000 description 5
- 239000011593 sulfur Substances 0.000 description 5
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 5
- 108010025020 Nerve Growth Factor Proteins 0.000 description 4
- 208000012902 Nervous system disease Diseases 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 4
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 4
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 4
- 102000007072 Nerve Growth Factors Human genes 0.000 description 3
- 150000002431 hydrogen Chemical group 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 239000003900 neurotrophic factor Substances 0.000 description 3
- 239000000651 prodrug Substances 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 108090000099 Neurotrophin-4 Proteins 0.000 description 2
- 102100033857 Neurotrophin-4 Human genes 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 150000001721 carbon Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 125000000547 substituted alkyl group Chemical group 0.000 description 2
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 1
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 1
- OJCCSMKCUDKIMU-KAWXPABVSA-N CC(CCC(C1)C(C2CCC3)O)(CN(C4CCCC4)C1O)C1N2[C@@]31C(C(C1(CCCC1)OO)=O)=O Chemical compound CC(CCC(C1)C(C2CCC3)O)(CN(C4CCCC4)C1O)C1N2[C@@]31C(C(C1(CCCC1)OO)=O)=O OJCCSMKCUDKIMU-KAWXPABVSA-N 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N CC1CCCC1 Chemical compound CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- JSSKKCFDEASHBK-UHFFFAOYSA-N CCCC(C(C)=O)N Chemical compound CCCC(C(C)=O)N JSSKKCFDEASHBK-UHFFFAOYSA-N 0.000 description 1
- ASOCMLYAYGDUOO-UHFFFAOYSA-N Cc1ccc(CC2CCCC2)cc1 Chemical compound Cc1ccc(CC2CCCC2)cc1 ASOCMLYAYGDUOO-UHFFFAOYSA-N 0.000 description 1
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 description 1
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 description 1
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 description 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 102000015336 Nerve Growth Factor Human genes 0.000 description 1
- 108090000742 Neurotrophin 3 Proteins 0.000 description 1
- 102000004230 Neurotrophin 3 Human genes 0.000 description 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N OCc1ccccc1 Chemical compound OCc1ccccc1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229940053128 nerve growth factor Drugs 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 229940032018 neurotrophin 3 Drugs 0.000 description 1
- 229940097998 neurotrophin 4 Drugs 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 229940121392 rotamase inhibitor Drugs 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9329998P | 1998-07-17 | 1998-07-17 | |
| US60/093,299 | 1998-07-17 | ||
| US13288499P | 1999-05-06 | 1999-05-06 | |
| US60/132,884 | 1999-05-06 | ||
| PCT/US1999/015965 WO2000004020A1 (en) | 1998-07-17 | 1999-07-15 | Compounds, compositions, and methods for stimulating neuronal growth and elongation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520413A JP2002520413A (ja) | 2002-07-09 |
| JP2002520413A5 true JP2002520413A5 (https=) | 2006-09-07 |
Family
ID=26787372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000560126A Withdrawn JP2002520413A (ja) | 1998-07-17 | 1999-07-15 | ニューロンの成長および伸長を刺激するための化合物、組成物、および方法 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6630472B1 (https=) |
| EP (1) | EP1098897B1 (https=) |
| JP (1) | JP2002520413A (https=) |
| KR (1) | KR20010071920A (https=) |
| CN (1) | CN1318067A (https=) |
| AP (1) | AP2001002052A0 (https=) |
| AT (1) | ATE268772T1 (https=) |
| AU (1) | AU756912B2 (https=) |
| BG (1) | BG105268A (https=) |
| BR (1) | BR9912423A (https=) |
| CA (1) | CA2337377A1 (https=) |
| DE (1) | DE69917907T2 (https=) |
| DK (1) | DK1098897T3 (https=) |
| EA (1) | EA200100149A1 (https=) |
| EE (1) | EE200100032A (https=) |
| ES (1) | ES2226409T3 (https=) |
| GE (1) | GEP20043368B (https=) |
| HR (1) | HRP20010118A2 (https=) |
| HU (1) | HUP0200637A3 (https=) |
| ID (1) | ID27428A (https=) |
| IL (1) | IL140676A0 (https=) |
| IS (1) | IS5805A (https=) |
| LT (1) | LT4850B (https=) |
| LV (1) | LV12665B (https=) |
| NO (1) | NO20010191L (https=) |
| NZ (1) | NZ509211A (https=) |
| OA (1) | OA11581A (https=) |
| PL (1) | PL345598A1 (https=) |
| PT (1) | PT1098897E (https=) |
| SI (1) | SI20638A (https=) |
| SK (1) | SK462001A3 (https=) |
| TR (1) | TR200100122T2 (https=) |
| WO (1) | WO2000004020A1 (https=) |
| YU (1) | YU2901A (https=) |
| ZA (1) | ZA200100320B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818643B1 (en) * | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| CA2446795A1 (en) * | 2001-05-10 | 2002-11-14 | Agouron Pharmaceuticals, Inc. | Sulfamide, sulfamate, sulfonamide, urea, amide, alpha, alpha-difluoro amide oxalyl diamide, and heterobicycles fkbp-binding ligands |
| EP2899192A1 (en) * | 2014-01-24 | 2015-07-29 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
| EP3097103B1 (en) * | 2014-01-24 | 2017-11-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5109112A (en) | 1989-01-19 | 1992-04-28 | Merck & Co., Inc. | FK-506 cytosolic binding protein |
| US5196352A (en) | 1989-01-19 | 1993-03-23 | Merck & Co., Inc. | New FK-506 cytosolic binding protein |
| US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| US5256656A (en) * | 1990-07-31 | 1993-10-26 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives |
| US5187166A (en) * | 1990-07-31 | 1993-02-16 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives and their use as antiemetics |
| CA2068062A1 (en) | 1991-05-07 | 1992-11-08 | Stephen A. Parent | Yeast mutants |
| US5362629A (en) | 1991-08-05 | 1994-11-08 | President And Fellows Of Harvard College | Detection of immunosuppressants |
| US5344831A (en) * | 1992-01-31 | 1994-09-06 | Nisshin Flour Milling Co., Ltd. | Diazabicyclo derivatives |
| DE4219973A1 (de) | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| US5318895A (en) | 1992-10-05 | 1994-06-07 | Merck & Co., Inc. | Aspergillus niger mutants |
| US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
| JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
| US5612350A (en) | 1993-11-30 | 1997-03-18 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
| DE4341402A1 (de) | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| US5457182A (en) | 1994-02-15 | 1995-10-10 | Merck & Co., Inc. | FK-506 cytosolic binding protein, FKBP12.6 |
| US5622866A (en) | 1994-06-23 | 1997-04-22 | Merck & Co., Inc. | Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces |
| US5614547A (en) | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
| US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US5696135A (en) | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| US6037370A (en) | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| US5786378A (en) | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
| US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
| US5840736A (en) | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5780484A (en) | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
| US5811434A (en) | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
| AR010744A1 (es) | 1996-12-09 | 2000-07-12 | Guildford Pharmaceuticals Inc | Inhibidores polipropilos de ciclofilina |
| US5935989A (en) | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
| US5874449A (en) | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
| US5721256A (en) | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
| ZA98825B (en) | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
| US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
-
1999
- 1999-07-15 ES ES99934043T patent/ES2226409T3/es not_active Expired - Lifetime
- 1999-07-15 AT AT99934043T patent/ATE268772T1/de not_active IP Right Cessation
- 1999-07-15 TR TR2001/00122T patent/TR200100122T2/xx unknown
- 1999-07-15 BR BR9912423-8A patent/BR9912423A/pt not_active Application Discontinuation
- 1999-07-15 PL PL99345598A patent/PL345598A1/xx not_active Application Discontinuation
- 1999-07-15 GE GE4273A patent/GEP20043368B/en unknown
- 1999-07-15 EP EP99934043A patent/EP1098897B1/en not_active Expired - Lifetime
- 1999-07-15 AU AU49963/99A patent/AU756912B2/en not_active Ceased
- 1999-07-15 HR HR20010118A patent/HRP20010118A2/hr not_active Application Discontinuation
- 1999-07-15 JP JP2000560126A patent/JP2002520413A/ja not_active Withdrawn
- 1999-07-15 NZ NZ509211A patent/NZ509211A/xx unknown
- 1999-07-15 OA OA1200100015A patent/OA11581A/en unknown
- 1999-07-15 EA EA200100149A patent/EA200100149A1/ru unknown
- 1999-07-15 AP APAP/P/2001/002052A patent/AP2001002052A0/en unknown
- 1999-07-15 WO PCT/US1999/015965 patent/WO2000004020A1/en not_active Ceased
- 1999-07-15 ID IDW20010130A patent/ID27428A/id unknown
- 1999-07-15 KR KR1020017000654A patent/KR20010071920A/ko not_active Ceased
- 1999-07-15 EE EEP200100032A patent/EE200100032A/xx unknown
- 1999-07-15 PT PT99934043T patent/PT1098897E/pt unknown
- 1999-07-15 CA CA002337377A patent/CA2337377A1/en not_active Abandoned
- 1999-07-15 SI SI9920067A patent/SI20638A/sl not_active IP Right Cessation
- 1999-07-15 CN CN99810848A patent/CN1318067A/zh active Pending
- 1999-07-15 IL IL14067699A patent/IL140676A0/xx unknown
- 1999-07-15 DE DE69917907T patent/DE69917907T2/de not_active Expired - Fee Related
- 1999-07-15 YU YU2901A patent/YU2901A/sh unknown
- 1999-07-15 DK DK99934043T patent/DK1098897T3/da active
- 1999-07-15 HU HU0200637A patent/HUP0200637A3/hu unknown
- 1999-07-15 SK SK46-2001A patent/SK462001A3/sk unknown
- 1999-07-16 US US09/356,240 patent/US6630472B1/en not_active Expired - Fee Related
-
2001
- 2001-01-11 ZA ZA200100320A patent/ZA200100320B/en unknown
- 2001-01-12 IS IS5805A patent/IS5805A/is unknown
- 2001-01-12 NO NO20010191A patent/NO20010191L/no not_active Application Discontinuation
- 2001-02-15 LT LT2001012A patent/LT4850B/lt not_active IP Right Cessation
- 2001-02-16 BG BG105268A patent/BG105268A/xx unknown
- 2001-03-13 LV LV010023A patent/LV12665B/lv unknown
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