EA200100149A1 - Соединения, композиции и способы стимуляции роста и удлинения нейронов - Google Patents
Соединения, композиции и способы стимуляции роста и удлинения нейроновInfo
- Publication number
- EA200100149A1 EA200100149A1 EA200100149A EA200100149A EA200100149A1 EA 200100149 A1 EA200100149 A1 EA 200100149A1 EA 200100149 A EA200100149 A EA 200100149A EA 200100149 A EA200100149 A EA 200100149A EA 200100149 A1 EA200100149 A1 EA 200100149A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- methods
- compositions
- protein
- fkbp
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 210000002569 neuron Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000004936 stimulating effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 abstract 3
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 abstract 3
- 101710103508 FK506-binding protein Proteins 0.000 abstract 1
- 101710104425 FK506-binding protein 2 Proteins 0.000 abstract 1
- 101710104423 FK506-binding protein 3 Proteins 0.000 abstract 1
- 101710104333 FK506-binding protein 4 Proteins 0.000 abstract 1
- 101710104342 FK506-binding protein 5 Proteins 0.000 abstract 1
- 101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 abstract 1
- 101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 101710114693 Outer membrane protein MIP Proteins 0.000 abstract 1
- 101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 abstract 1
- 101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 abstract 1
- 101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 abstract 1
- 101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 abstract 1
- 101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 abstract 1
- 101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 abstract 1
- 101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 abstract 1
- 101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 abstract 1
- 101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 abstract 1
- 102100020739 Peptidyl-prolyl cis-trans isomerase FKBP4 Human genes 0.000 abstract 1
- 101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 abstract 1
- 101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 abstract 1
- 101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 abstract 1
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 abstract 1
- 101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 abstract 1
- 101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 abstract 1
- 101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 abstract 1
- 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 abstract 1
- 101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 abstract 1
- 101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 abstract 1
- 102000009658 Peptidylprolyl Isomerase Human genes 0.000 abstract 1
- 108010020062 Peptidylprolyl Isomerase Proteins 0.000 abstract 1
- 101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000028600 axonogenesis Effects 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9329998P | 1998-07-17 | 1998-07-17 | |
| US13288499P | 1999-05-06 | 1999-05-06 | |
| PCT/US1999/015965 WO2000004020A1 (en) | 1998-07-17 | 1999-07-15 | Compounds, compositions, and methods for stimulating neuronal growth and elongation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200100149A1 true EA200100149A1 (ru) | 2001-08-27 |
Family
ID=26787372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100149A EA200100149A1 (ru) | 1998-07-17 | 1999-07-15 | Соединения, композиции и способы стимуляции роста и удлинения нейронов |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6630472B1 (https=) |
| EP (1) | EP1098897B1 (https=) |
| JP (1) | JP2002520413A (https=) |
| KR (1) | KR20010071920A (https=) |
| CN (1) | CN1318067A (https=) |
| AP (1) | AP2001002052A0 (https=) |
| AT (1) | ATE268772T1 (https=) |
| AU (1) | AU756912B2 (https=) |
| BG (1) | BG105268A (https=) |
| BR (1) | BR9912423A (https=) |
| CA (1) | CA2337377A1 (https=) |
| DE (1) | DE69917907T2 (https=) |
| DK (1) | DK1098897T3 (https=) |
| EA (1) | EA200100149A1 (https=) |
| EE (1) | EE200100032A (https=) |
| ES (1) | ES2226409T3 (https=) |
| GE (1) | GEP20043368B (https=) |
| HR (1) | HRP20010118A2 (https=) |
| HU (1) | HUP0200637A3 (https=) |
| ID (1) | ID27428A (https=) |
| IL (1) | IL140676A0 (https=) |
| IS (1) | IS5805A (https=) |
| LT (1) | LT4850B (https=) |
| LV (1) | LV12665B (https=) |
| NO (1) | NO20010191L (https=) |
| NZ (1) | NZ509211A (https=) |
| OA (1) | OA11581A (https=) |
| PL (1) | PL345598A1 (https=) |
| PT (1) | PT1098897E (https=) |
| SI (1) | SI20638A (https=) |
| SK (1) | SK462001A3 (https=) |
| TR (1) | TR200100122T2 (https=) |
| WO (1) | WO2000004020A1 (https=) |
| YU (1) | YU2901A (https=) |
| ZA (1) | ZA200100320B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818643B1 (en) * | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| CA2446795A1 (en) * | 2001-05-10 | 2002-11-14 | Agouron Pharmaceuticals, Inc. | Sulfamide, sulfamate, sulfonamide, urea, amide, alpha, alpha-difluoro amide oxalyl diamide, and heterobicycles fkbp-binding ligands |
| EP2899192A1 (en) * | 2014-01-24 | 2015-07-29 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
| EP3097103B1 (en) * | 2014-01-24 | 2017-11-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5109112A (en) | 1989-01-19 | 1992-04-28 | Merck & Co., Inc. | FK-506 cytosolic binding protein |
| US5196352A (en) | 1989-01-19 | 1993-03-23 | Merck & Co., Inc. | New FK-506 cytosolic binding protein |
| US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| US5256656A (en) * | 1990-07-31 | 1993-10-26 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives |
| US5187166A (en) * | 1990-07-31 | 1993-02-16 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives and their use as antiemetics |
| CA2068062A1 (en) | 1991-05-07 | 1992-11-08 | Stephen A. Parent | Yeast mutants |
| US5362629A (en) | 1991-08-05 | 1994-11-08 | President And Fellows Of Harvard College | Detection of immunosuppressants |
| US5344831A (en) * | 1992-01-31 | 1994-09-06 | Nisshin Flour Milling Co., Ltd. | Diazabicyclo derivatives |
| DE4219973A1 (de) | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| US5318895A (en) | 1992-10-05 | 1994-06-07 | Merck & Co., Inc. | Aspergillus niger mutants |
| US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
| JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
| US5612350A (en) | 1993-11-30 | 1997-03-18 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
| DE4341402A1 (de) | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| US5457182A (en) | 1994-02-15 | 1995-10-10 | Merck & Co., Inc. | FK-506 cytosolic binding protein, FKBP12.6 |
| US5622866A (en) | 1994-06-23 | 1997-04-22 | Merck & Co., Inc. | Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces |
| US5614547A (en) | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
| US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US5696135A (en) | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| US6037370A (en) | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| US5786378A (en) | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
| US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
| US5840736A (en) | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5780484A (en) | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
| US5811434A (en) | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
| AR010744A1 (es) | 1996-12-09 | 2000-07-12 | Guildford Pharmaceuticals Inc | Inhibidores polipropilos de ciclofilina |
| US5935989A (en) | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
| US5874449A (en) | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
| US5721256A (en) | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
| ZA98825B (en) | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
| US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
-
1999
- 1999-07-15 ES ES99934043T patent/ES2226409T3/es not_active Expired - Lifetime
- 1999-07-15 AT AT99934043T patent/ATE268772T1/de not_active IP Right Cessation
- 1999-07-15 TR TR2001/00122T patent/TR200100122T2/xx unknown
- 1999-07-15 BR BR9912423-8A patent/BR9912423A/pt not_active Application Discontinuation
- 1999-07-15 PL PL99345598A patent/PL345598A1/xx not_active Application Discontinuation
- 1999-07-15 GE GE4273A patent/GEP20043368B/en unknown
- 1999-07-15 EP EP99934043A patent/EP1098897B1/en not_active Expired - Lifetime
- 1999-07-15 AU AU49963/99A patent/AU756912B2/en not_active Ceased
- 1999-07-15 HR HR20010118A patent/HRP20010118A2/hr not_active Application Discontinuation
- 1999-07-15 JP JP2000560126A patent/JP2002520413A/ja not_active Withdrawn
- 1999-07-15 NZ NZ509211A patent/NZ509211A/xx unknown
- 1999-07-15 OA OA1200100015A patent/OA11581A/en unknown
- 1999-07-15 EA EA200100149A patent/EA200100149A1/ru unknown
- 1999-07-15 AP APAP/P/2001/002052A patent/AP2001002052A0/en unknown
- 1999-07-15 WO PCT/US1999/015965 patent/WO2000004020A1/en not_active Ceased
- 1999-07-15 ID IDW20010130A patent/ID27428A/id unknown
- 1999-07-15 KR KR1020017000654A patent/KR20010071920A/ko not_active Ceased
- 1999-07-15 EE EEP200100032A patent/EE200100032A/xx unknown
- 1999-07-15 PT PT99934043T patent/PT1098897E/pt unknown
- 1999-07-15 CA CA002337377A patent/CA2337377A1/en not_active Abandoned
- 1999-07-15 SI SI9920067A patent/SI20638A/sl not_active IP Right Cessation
- 1999-07-15 CN CN99810848A patent/CN1318067A/zh active Pending
- 1999-07-15 IL IL14067699A patent/IL140676A0/xx unknown
- 1999-07-15 DE DE69917907T patent/DE69917907T2/de not_active Expired - Fee Related
- 1999-07-15 YU YU2901A patent/YU2901A/sh unknown
- 1999-07-15 DK DK99934043T patent/DK1098897T3/da active
- 1999-07-15 HU HU0200637A patent/HUP0200637A3/hu unknown
- 1999-07-15 SK SK46-2001A patent/SK462001A3/sk unknown
- 1999-07-16 US US09/356,240 patent/US6630472B1/en not_active Expired - Fee Related
-
2001
- 2001-01-11 ZA ZA200100320A patent/ZA200100320B/en unknown
- 2001-01-12 IS IS5805A patent/IS5805A/is unknown
- 2001-01-12 NO NO20010191A patent/NO20010191L/no not_active Application Discontinuation
- 2001-02-15 LT LT2001012A patent/LT4850B/lt not_active IP Right Cessation
- 2001-02-16 BG BG105268A patent/BG105268A/xx unknown
- 2001-03-13 LV LV010023A patent/LV12665B/lv unknown
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