WO2003013585A8 - Mifaxin agonists and antagonists for use in the treatment of metabolic - Google Patents

Mifaxin agonists and antagonists for use in the treatment of metabolic

Info

Publication number
WO2003013585A8
WO2003013585A8 PCT/IB2002/003545 IB0203545W WO03013585A8 WO 2003013585 A8 WO2003013585 A8 WO 2003013585A8 IB 0203545 W IB0203545 W IB 0203545W WO 03013585 A8 WO03013585 A8 WO 03013585A8
Authority
WO
WIPO (PCT)
Prior art keywords
mifaxin
agonists
antagonists
activity
metabolic
Prior art date
Application number
PCT/IB2002/003545
Other languages
French (fr)
Other versions
WO2003013585A1 (en
Inventor
John Lucas
Deno Dialynas
Kristen Briggs
Aaron Scalia
Original Assignee
Genset Sa
John Lucas
Deno Dialynas
Kristen Briggs
Aaron Scalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset Sa, John Lucas, Deno Dialynas, Kristen Briggs, Aaron Scalia filed Critical Genset Sa
Publication of WO2003013585A1 publication Critical patent/WO2003013585A1/en
Publication of WO2003013585A8 publication Critical patent/WO2003013585A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to the field of metabolic research, in particular the discovery of compounds effective for reducing body mass and useful for treating obesity-related diseases and disorders. The obesity-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to, hyperlipidemia, atherosclerosis, insulin resistance, diabetes, and hypertension. In particular, the invention provides for methods of identifying and using AGONISTS and ANTAGONISTS of MIFAXIN activity, wherein said activity is selected from the group consisting of lipid partitioning, lipid metabolism, and insulin-like activity.
PCT/IB2002/003545 2001-08-08 2002-08-06 Mifaxin agonists and antagonists for use in the treatment of metabolic WO2003013585A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31151001P 2001-08-08 2001-08-08
US60/311,510 2001-08-08

Publications (2)

Publication Number Publication Date
WO2003013585A1 WO2003013585A1 (en) 2003-02-20
WO2003013585A8 true WO2003013585A8 (en) 2003-04-17

Family

ID=23207219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/003545 WO2003013585A1 (en) 2001-08-08 2002-08-06 Mifaxin agonists and antagonists for use in the treatment of metabolic

Country Status (1)

Country Link
WO (1) WO2003013585A1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837678T2 (en) * 1997-10-29 2007-12-27 Otsuka Pharmaceutical Co., Ltd. COMPOSITION FOR INHIBITING THE PROLIFERATION OF SMOOTH MUSCULATURE AND METHOD FOR THE DIAGNOSIS OF ARTERIOSCLEROSIS
WO1999059618A1 (en) * 1998-05-21 1999-11-25 Smithkline Beecham Corporation Acrp30r1l, a homolog of acrp30 (30 kd adipocyte complement-related protein)
CA2365255A1 (en) * 1999-03-24 2000-09-28 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9
CA2372815A1 (en) * 1999-05-11 2000-11-16 Incyte Genomics, Inc. Extracellular matrix and adhesion-associated proteins
AU5159500A (en) * 1999-05-27 2000-12-18 Zymogenetics Inc. Adipocyte complement related protein homolog zacrp7
ATE405655T1 (en) * 2000-01-14 2008-09-15 Serono Genetics Inst Sa OBG3 GLOBULAR HEAD AND ITS USES FOR REDUCING BODY WEIGHT

Also Published As

Publication number Publication date
WO2003013585A1 (en) 2003-02-20

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