WO2007067516A3 - Multiple myeloma - Google Patents

Multiple myeloma Download PDF

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Publication number
WO2007067516A3
WO2007067516A3 PCT/US2006/046355 US2006046355W WO2007067516A3 WO 2007067516 A3 WO2007067516 A3 WO 2007067516A3 US 2006046355 W US2006046355 W US 2006046355W WO 2007067516 A3 WO2007067516 A3 WO 2007067516A3
Authority
WO
WIPO (PCT)
Prior art keywords
multiple myeloma
methods
treating multiple
compounds
relates
Prior art date
Application number
PCT/US2006/046355
Other languages
French (fr)
Other versions
WO2007067516A2 (en
Inventor
Donald P Mcdonnell
Suzanne E Wardell
Original Assignee
Univ Duke
Donald P Mcdonnell
Suzanne E Wardell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Donald P Mcdonnell, Suzanne E Wardell filed Critical Univ Duke
Publication of WO2007067516A2 publication Critical patent/WO2007067516A2/en
Publication of WO2007067516A3 publication Critical patent/WO2007067516A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/36—Arsenic; Compounds thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates, in general, to multiple myeloma and, in particular, to a method of treating multiple myeloma and compounds and compositions suitable for use in such a method. The invention further relates to methods of identifying compounds suitable for use in treating multiple myeloma and to methods of predicting a patient's responsiveness to the instant treatment methods.
PCT/US2006/046355 2005-12-06 2006-12-06 Multiple myeloma WO2007067516A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74252105P 2005-12-06 2005-12-06
US60/742,521 2005-12-06

Publications (2)

Publication Number Publication Date
WO2007067516A2 WO2007067516A2 (en) 2007-06-14
WO2007067516A3 true WO2007067516A3 (en) 2008-02-07

Family

ID=38123417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046355 WO2007067516A2 (en) 2005-12-06 2006-12-06 Multiple myeloma

Country Status (1)

Country Link
WO (1) WO2007067516A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037638B1 (en) 2013-08-22 2021-04-23 Ванда Фармасьютикалз Инк. Multiple myeloma treatment
US20160199323A1 (en) * 2013-08-22 2016-07-14 Vanda Pharmaceuticals, Inc. Cancer treatment
CA2998682A1 (en) * 2015-09-21 2017-03-30 Ifom Fondazione Istituto Firc Di Oncologia Molecolare New therapeutic strategies against blood cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030149096A1 (en) * 2001-02-05 2003-08-07 Pezzuto John M. Cancer chemopreventative compounds and compositions and methods of treating cancers
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose
US20040204339A1 (en) * 2001-04-24 2004-10-14 Dimartino Jorge F. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US20050112630A1 (en) * 2001-11-07 2005-05-26 Shaughnessy John D. Diagnosis, prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030149096A1 (en) * 2001-02-05 2003-08-07 Pezzuto John M. Cancer chemopreventative compounds and compositions and methods of treating cancers
US20040204339A1 (en) * 2001-04-24 2004-10-14 Dimartino Jorge F. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US20050112630A1 (en) * 2001-11-07 2005-05-26 Shaughnessy John D. Diagnosis, prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOBBS ET AL.: "Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activity in murine skin and tumors", CANCER RES., vol. 62, 2002, pages 67 - 74 *
JANSEN ET AL.: "Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition", PNAS, vol. 101, 2004, pages 7199 - 7204 *
PARK ET AL.: "Arsenic Trioxide.mediated growth inhibition in MC/CAR myeloma cells via cell cyde arrest in association with induction of cyclin-dependent kinase inhibitor", CANCER RES., vol. 60, 2000, pages 3065 - 3071 *
RUEFIL ET AL.: "The histone deacetylase inhibitor and chemotherapeutic agent suberoylanlilde hdroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species", PNAS, vol. 98, 2001, pages 10833 - 10838 *

Also Published As

Publication number Publication date
WO2007067516A2 (en) 2007-06-14

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