JP2002520281A5 - - Google Patents
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- Publication number
- JP2002520281A5 JP2002520281A5 JP2000558814A JP2000558814A JP2002520281A5 JP 2002520281 A5 JP2002520281 A5 JP 2002520281A5 JP 2000558814 A JP2000558814 A JP 2000558814A JP 2000558814 A JP2000558814 A JP 2000558814A JP 2002520281 A5 JP2002520281 A5 JP 2002520281A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- vitamin
- esters
- compound
- compound selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 16
- 229940046009 Vitamin E Drugs 0.000 description 11
- 229930003427 Vitamin E Natural products 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 150000002148 esters Chemical class 0.000 description 11
- 235000019165 vitamin E Nutrition 0.000 description 11
- 239000011709 vitamin E Substances 0.000 description 11
- 150000003712 vitamin E derivatives Chemical class 0.000 description 11
- 239000003814 drug Substances 0.000 description 10
- 230000000699 topical Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 210000004400 Mucous Membrane Anatomy 0.000 description 6
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 4
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 4
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 4
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 4
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 4
- 229940088597 Hormone Drugs 0.000 description 4
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 230000000843 anti-fungal Effects 0.000 description 4
- 229940121375 antifungals Drugs 0.000 description 4
- 230000003115 biocidal Effects 0.000 description 4
- 229940079593 drugs Drugs 0.000 description 4
- 239000005556 hormone Substances 0.000 description 4
- 229940079866 intestinal antibiotics Drugs 0.000 description 4
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 3
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 3
- 208000001688 Herpes Genitalis Diseases 0.000 description 2
- 206010023332 Keratitis Diseases 0.000 description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- 210000003491 Skin Anatomy 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- -1 antifungals Substances 0.000 description 2
- 150000001735 carboxylic acids Chemical class 0.000 description 2
- 201000004946 genital herpes Diseases 0.000 description 2
- 206010068172 Anal pruritus Diseases 0.000 description 1
- 208000004746 Atrophic Vaginitis Diseases 0.000 description 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-α-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 208000001780 Epistaxis Diseases 0.000 description 1
- 206010016092 Faecal incontinence Diseases 0.000 description 1
- 208000005232 Glossitis Diseases 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 206010036783 Proctitis ulcerative Diseases 0.000 description 1
- 208000003265 Stomatitis Diseases 0.000 description 1
- 206010064996 Ulcerative keratitis Diseases 0.000 description 1
- 206010068760 Ulcers Diseases 0.000 description 1
- 241001227561 Valgus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 229960001452 alpha-Tocopherol Acetate Drugs 0.000 description 1
- 125000004432 carbon atoms Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 201000007717 corneal ulcer Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 201000010666 keratoconjunctivitis Diseases 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drugs Drugs 0.000 description 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- 201000010727 rectal prolapse Diseases 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98A001586 | 1998-07-10 | ||
| IT98MI001586A ITMI981586A1 (it) | 1998-07-10 | 1998-07-10 | Vitamina e e suoi esteri per l'uso nel trattamento topico di patologie delle mucose |
| PCT/IB1999/001238 WO2000002554A1 (en) | 1998-07-10 | 1999-07-05 | Vitamin e and esters thereof for use in the topical treatment of mucosal pathologies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520281A JP2002520281A (ja) | 2002-07-09 |
| JP2002520281A5 true JP2002520281A5 (es) | 2006-08-24 |
Family
ID=11380415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000558814A Pending JP2002520281A (ja) | 1998-07-10 | 1999-07-05 | 粘膜疾患の局所治療における使用のためのビタミンｅおよびそのエステル |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1094807B1 (es) |
| JP (1) | JP2002520281A (es) |
| CN (1) | CN1135975C (es) |
| AT (1) | ATE238051T1 (es) |
| AU (1) | AU762860B2 (es) |
| BR (1) | BR9911945A (es) |
| CA (1) | CA2336990A1 (es) |
| CZ (1) | CZ301019B6 (es) |
| DE (1) | DE69907193T2 (es) |
| DK (1) | DK1094807T3 (es) |
| ES (1) | ES2196813T3 (es) |
| HU (1) | HU228921B1 (es) |
| IL (1) | IL140759A0 (es) |
| IT (1) | ITMI981586A1 (es) |
| NO (1) | NO20006719L (es) |
| NZ (1) | NZ509129A (es) |
| PL (1) | PL345500A1 (es) |
| PT (1) | PT1094807E (es) |
| RU (2) | RU2221561C2 (es) |
| SK (1) | SK284464B6 (es) |
| TR (2) | TR200100014T2 (es) |
| WO (1) | WO2000002554A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077604A1 (en) | 2001-12-19 | 2004-04-22 | Lenard Lichtenberger | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity |
| FR2819186A1 (fr) * | 2001-01-10 | 2002-07-12 | L M D | Cystine-voie orale-syndrome de l'oeil sec |
| FR2825088A1 (fr) * | 2001-05-25 | 2002-11-29 | Derma Dev | Nouveaux esters de tocopherol, leurs procedes d'obtention et leurs utilisations |
| US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| US9993558B2 (en) | 2004-10-01 | 2018-06-12 | Ramscor, Inc. | Sustained release eye drop formulations |
| US8541413B2 (en) * | 2004-10-01 | 2013-09-24 | Ramscor, Inc. | Sustained release eye drop formulations |
| US20080038316A1 (en) | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| CA2739658C (en) * | 2008-10-09 | 2016-11-08 | Ramscor, Inc. | Composition and method for treating dry eye syndrome |
| IT1394063B1 (it) * | 2009-05-11 | 2012-05-25 | Giuliani Spa | Composizione per uso oftalmico adatta al trattamento degli stati infiammatori dell'occhio e della sindrome dell'occhio secco |
| JP2013500302A (ja) * | 2009-07-27 | 2013-01-07 | サンセベリノ，レナト | Ｕｖ−ａ線に対する眼球内部構造保護用又は経上皮架橋術式による円錐角膜の治療用点眼液 |
| WO2013049749A2 (en) | 2011-09-29 | 2013-04-04 | Plx Pharma Inc. | pH DEPENDENT CARRIERS FOR TARGETED RELEASE OF PHARMACEUTICALS ALONG THE GASTROINTESTINAL TRACT, COMPOSITIONS THEREFROM, AND MAKING AND USING SAME |
| ES2700983T3 (es) * | 2012-06-08 | 2019-02-20 | Univ Ohio State | Tratamiento de lesión cicatricial usando tocotrienol |
| DE202014106007U1 (de) * | 2014-07-22 | 2015-07-23 | Bio.Lo.Ga. S.R.L. | Zusammensetzung zur Verwendung in der Vorbeugung und Behandlung allergischer Rhinitis |
| ES2757349T3 (es) * | 2014-10-22 | 2020-04-29 | Bio Lo Ga Srl | Composición farmacéutica para su uso en el aumento del trofismo de la mucosa nasal |
| JP2018507895A (ja) * | 2015-03-18 | 2018-03-22 | バイオヌークス スイス エスエー | ヘルペスを処置するための方法において使用するためのジヒドロケルセチンを含む組成物 |
| JP2017119669A (ja) * | 2015-10-15 | 2017-07-06 | ロート製薬株式会社 | 異物感改善用眼科組成物 |
| WO2020053783A1 (en) * | 2018-09-12 | 2020-03-19 | Neilos S.r.l. | A composition for use in the prevention and/or treatment of epistaxis |
| IT202000003620A1 (it) * | 2020-02-21 | 2021-08-21 | Hulka S R L | Uso di una formulazione per applicazione topica per il mantenimento dell’omeostasi vaginale |
| JP2023518822A (ja) | 2020-03-26 | 2023-05-08 | ピーエルエックス オプコ インコーポレイテッド | ｐＨ依存的再構築が可能な医薬キャリア、その製造方法及び使用方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59216812A (ja) * | 1983-05-26 | 1984-12-06 | Dowa Yakushiyou Kk | 頭髪育毛料 |
| JP2776837B2 (ja) * | 1988-08-11 | 1998-07-16 | 日本レダリー株式会社 | 消化性潰瘍治療剤 |
| US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
| IT1249711B (it) * | 1991-09-30 | 1995-03-09 | Boniscontro E Gazzone S R L | Composizioni farmaceutiche, per uso topico, contenenti "scavengers" di radicali liberi dell'ossigeno e antibatterici,indicate nella terapia dei tessuti superficiali. |
| CN1039087C (zh) * | 1993-12-29 | 1998-07-15 | 昆明宏达实业有限总公司 | 妇科病治疗保健外用药物 |
| IT1282778B1 (it) * | 1996-05-31 | 1998-03-31 | Giorgio Panin | Vitamina "e" acetato quale prodotto per applicazione topica |
| JPH10231243A (ja) * | 1997-02-20 | 1998-09-02 | Sekisui Chem Co Ltd | 粘膜炎症外用薬 |
-
1998
- 1998-07-10 IT IT98MI001586A patent/ITMI981586A1/it unknown
-
1999
- 1999-07-05 CN CNB998084328A patent/CN1135975C/zh not_active Expired - Lifetime
- 1999-07-05 JP JP2000558814A patent/JP2002520281A/ja active Pending
- 1999-07-05 WO PCT/IB1999/001238 patent/WO2000002554A1/en active IP Right Grant
- 1999-07-05 AU AU43858/99A patent/AU762860B2/en not_active Expired
- 1999-07-05 AT AT99926687T patent/ATE238051T1/de active
- 1999-07-05 NZ NZ509129A patent/NZ509129A/en not_active IP Right Cessation
- 1999-07-05 CA CA002336990A patent/CA2336990A1/en not_active Abandoned
- 1999-07-05 PT PT99926687T patent/PT1094807E/pt unknown
- 1999-07-05 DK DK99926687T patent/DK1094807T3/da active
- 1999-07-05 TR TR2001/00014T patent/TR200100014T2/xx unknown
- 1999-07-05 PL PL99345500A patent/PL345500A1/xx not_active Application Discontinuation
- 1999-07-05 CZ CZ20010036A patent/CZ301019B6/cs unknown
- 1999-07-05 BR BR9911945-5A patent/BR9911945A/pt not_active Application Discontinuation
- 1999-07-05 DE DE69907193T patent/DE69907193T2/de not_active Expired - Lifetime
- 1999-07-05 SK SK35-2001A patent/SK284464B6/sk unknown
- 1999-07-05 ES ES99926687T patent/ES2196813T3/es not_active Expired - Lifetime
- 1999-07-05 RU RU2001101122/15A patent/RU2221561C2/ru active
- 1999-07-05 EP EP99926687A patent/EP1094807B1/en not_active Expired - Lifetime
- 1999-07-05 IL IL14075999A patent/IL140759A0/xx unknown
- 1999-07-05 HU HU0102781A patent/HU228921B1/hu unknown
- 1999-07-05 TR TR2001/03710T patent/TR200103710T2/xx unknown
-
2000
- 2000-12-29 NO NO20006719A patent/NO20006719L/no not_active Application Discontinuation
-
2003
- 2003-09-11 RU RU2003128023/15A patent/RU2003128023A/ru not_active Application Discontinuation
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