JP2002515013A - Cd28発現を調節するための方法および組成物 - Google Patents

Cd28発現を調節するための方法および組成物

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Publication number
JP2002515013A
JP2002515013A JP52435696A JP52435696A JP2002515013A JP 2002515013 A JP2002515013 A JP 2002515013A JP 52435696 A JP52435696 A JP 52435696A JP 52435696 A JP52435696 A JP 52435696A JP 2002515013 A JP2002515013 A JP 2002515013A
Authority
JP
Japan
Prior art keywords
oligomer
cells
seq
sequence
bases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP52435696A
Other languages
English (en)
Japanese (ja)
Inventor
タム,ロバート・シー
Original Assignee
アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/529,878 external-priority patent/US5932556A/en
Application filed by アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド filed Critical アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド
Priority claimed from PCT/US1996/001507 external-priority patent/WO1996024380A1/en
Publication of JP2002515013A publication Critical patent/JP2002515013A/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/111Antisense spanning the whole gene, or a large part of it
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/13Decoys
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/15Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/151Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/18Type of nucleic acid acting by a non-sequence specific mechanism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP52435696A 1995-02-09 1996-02-05 Cd28発現を調節するための方法および組成物 Pending JP2002515013A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US529,878 1990-05-25
US38704195A 1995-02-09 1995-02-09
US08/387,041 1995-02-09
US08/529,878 US5932556A (en) 1995-09-17 1995-09-17 Methods and compositions for regulation of CD28 expression
PCT/US1996/001507 WO1996024380A1 (en) 1995-02-09 1996-02-05 Methods and compositions for regulation of cd28 expression

Publications (1)

Publication Number Publication Date
JP2002515013A true JP2002515013A (ja) 2002-05-21

Family

ID=27011718

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52435696A Pending JP2002515013A (ja) 1995-02-09 1996-02-05 Cd28発現を調節するための方法および組成物

Country Status (7)

Country Link
JP (1) JP2002515013A (cs)
KR (1) KR100258826B1 (cs)
CN (1) CN1181021A (cs)
AU (1) AU703139B2 (cs)
CA (1) CA2211621A1 (cs)
CZ (1) CZ250097A3 (cs)
SK (1) SK108697A3 (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530057A (ja) * 2004-03-31 2007-11-01 ライオンズ アイ インスティチュート リミテッド Vegf転写物の安定性を調節するための治療的分子
JP2016127843A (ja) * 2009-09-25 2016-07-14 カッパーアールエヌエー,インコーポレイテッド フィラグリン(flg)の発現および活性の調整によるflg関連疾患の処置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923799A (en) * 1984-02-06 1990-05-08 The Ontario Cancer Institute T cell specific cDNA clone
US5254638A (en) * 1991-03-25 1993-10-19 The Reagents Of The University Of California Composite materials of interpenetrating inorganic and organic polymer networks
GB9310842D0 (en) * 1993-05-26 1993-07-14 Imperial College Gene identification

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530057A (ja) * 2004-03-31 2007-11-01 ライオンズ アイ インスティチュート リミテッド Vegf転写物の安定性を調節するための治療的分子
JP2016127843A (ja) * 2009-09-25 2016-07-14 カッパーアールエヌエー,インコーポレイテッド フィラグリン(flg)の発現および活性の調整によるflg関連疾患の処置

Also Published As

Publication number Publication date
SK108697A3 (en) 1998-04-08
CA2211621A1 (en) 1996-08-15
CN1181021A (zh) 1998-05-06
CZ250097A3 (cs) 1998-01-14
AU5295896A (en) 1996-08-27
MX9705963A (es) 1998-08-30
AU703139B2 (en) 1999-03-18
KR100258826B1 (ko) 2000-07-01
KR19980702101A (ko) 1998-07-15

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