JP2002514663A - アロエペクチン - Google Patents
アロエペクチンInfo
- Publication number
- JP2002514663A JP2002514663A JP2000548377A JP2000548377A JP2002514663A JP 2002514663 A JP2002514663 A JP 2002514663A JP 2000548377 A JP2000548377 A JP 2000548377A JP 2000548377 A JP2000548377 A JP 2000548377A JP 2002514663 A JP2002514663 A JP 2002514663A
- Authority
- JP
- Japan
- Prior art keywords
- pectin
- aloe
- aloe pectin
- extraction
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001814 pectin Substances 0.000 title claims abstract description 464
- 229920001277 pectin Polymers 0.000 title claims abstract description 463
- 235000010987 pectin Nutrition 0.000 title claims abstract description 462
- 235000011399 aloe vera Nutrition 0.000 title claims abstract description 244
- 241001116389 Aloe Species 0.000 title claims abstract description 229
- 239000011575 calcium Substances 0.000 claims abstract description 25
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 22
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 19
- 238000001556 precipitation Methods 0.000 claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 claims abstract description 9
- 239000000758 substrate Substances 0.000 claims abstract description 8
- 125000002091 cationic group Chemical group 0.000 claims abstract description 4
- 238000000605 extraction Methods 0.000 claims description 139
- 238000000034 method Methods 0.000 claims description 88
- 239000000243 solution Substances 0.000 claims description 61
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 41
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 34
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 31
- 102000004190 Enzymes Human genes 0.000 claims description 30
- 108090000790 Enzymes Proteins 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 24
- 239000000126 substance Substances 0.000 claims description 23
- 150000001768 cations Chemical class 0.000 claims description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims description 20
- 239000002738 chelating agent Substances 0.000 claims description 19
- 230000011987 methylation Effects 0.000 claims description 18
- 238000007069 methylation reaction Methods 0.000 claims description 18
- 239000012266 salt solution Substances 0.000 claims description 15
- 239000003513 alkali Substances 0.000 claims description 13
- 239000011324 bead Substances 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 12
- 102000036639 antigens Human genes 0.000 claims description 12
- 108091007433 antigens Proteins 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 11
- 159000000000 sodium salts Chemical class 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 9
- 238000003860 storage Methods 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 8
- MPQBLCRFUYGBHE-AXMZGBSTSA-N (2r,3r,4s,5s)-2,4,5-trihydroxy-3-methoxyhexanal Chemical compound O=C[C@H](O)[C@H](OC)[C@@H](O)[C@H](C)O MPQBLCRFUYGBHE-AXMZGBSTSA-N 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 159000000007 calcium salts Chemical class 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000000265 homogenisation Methods 0.000 claims description 5
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000003456 ion exchange resin Substances 0.000 claims description 3
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 3
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 239000003957 anion exchange resin Substances 0.000 claims 1
- 239000010903 husk Substances 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 112
- 239000000835 fiber Substances 0.000 abstract description 82
- 235000002961 Aloe barbadensis Nutrition 0.000 abstract description 15
- 239000007788 liquid Substances 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 7
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract description 6
- 210000000170 cell membrane Anatomy 0.000 abstract description 2
- 244000186892 Aloe vera Species 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 85
- 239000011780 sodium chloride Substances 0.000 description 45
- 235000000346 sugar Nutrition 0.000 description 44
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 43
- 210000002421 cell wall Anatomy 0.000 description 33
- 239000000523 sample Substances 0.000 description 32
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical class OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 25
- 230000007935 neutral effect Effects 0.000 description 25
- 230000015572 biosynthetic process Effects 0.000 description 22
- 241000220225 Malus Species 0.000 description 19
- 235000011430 Malus pumila Nutrition 0.000 description 18
- 235000015103 Malus silvestris Nutrition 0.000 description 18
- 235000020971 citrus fruits Nutrition 0.000 description 17
- 241000207199 Citrus Species 0.000 description 16
- 244000144927 Aloe barbadensis Species 0.000 description 15
- 241000196324 Embryophyta Species 0.000 description 14
- 229920002230 Pectic acid Polymers 0.000 description 14
- 108010059820 Polygalacturonase Proteins 0.000 description 14
- 239000000725 suspension Substances 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 150000008163 sugars Chemical class 0.000 description 12
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 11
- 230000027455 binding Effects 0.000 description 11
- 238000009739 binding Methods 0.000 description 11
- 239000009194 citrus pectin Substances 0.000 description 11
- 229940040387 citrus pectin Drugs 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 229920001282 polysaccharide Polymers 0.000 description 11
- 239000005017 polysaccharide Substances 0.000 description 11
- 150000004804 polysaccharides Chemical class 0.000 description 11
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 10
- 241000208818 Helianthus Species 0.000 description 10
- 235000003222 Helianthus annuus Nutrition 0.000 description 10
- 235000021536 Sugar beet Nutrition 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 10
- 239000002953 phosphate buffered saline Substances 0.000 description 10
- 239000010318 polygalacturonic acid Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000006640 acetylation reaction Methods 0.000 description 9
- 239000000872 buffer Substances 0.000 description 9
- 238000001914 filtration Methods 0.000 description 9
- 229930182830 galactose Natural products 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 239000002244 precipitate Substances 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 8
- 230000021736 acetylation Effects 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 7
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 238000005119 centrifugation Methods 0.000 description 7
- -1 pectate salts Chemical class 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 229920000189 Arabinogalactan Polymers 0.000 description 6
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 6
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 6
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 6
- 235000019312 arabinogalactan Nutrition 0.000 description 6
- 238000007068 beta-elimination reaction Methods 0.000 description 6
- 235000014633 carbohydrates Nutrition 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 description 5
- 239000001904 Arabinogalactan Substances 0.000 description 5
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 5
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- 238000012360 testing method Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 4
- 101001096557 Dickeya dadantii (strain 3937) Rhamnogalacturonate lyase Proteins 0.000 description 4
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
- 239000007983 Tris buffer Substances 0.000 description 4
- 229920001284 acidic polysaccharide Polymers 0.000 description 4
- 150000004805 acidic polysaccharides Chemical class 0.000 description 4
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 4
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- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical group COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 4
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- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 4
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 3
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- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
- C08B37/0048—Processes of extraction from organic materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/06—Pectin; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/06—Pectin; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/078,204 US5929051A (en) | 1998-05-13 | 1998-05-13 | Aloe pectins |
| US09/078,204 | 1998-05-13 | ||
| PCT/US1999/010335 WO1999058575A1 (en) | 1998-05-13 | 1999-05-12 | Aloe pectins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002514663A true JP2002514663A (ja) | 2002-05-21 |
| JP2002514663A5 JP2002514663A5 (https=) | 2006-07-13 |
Family
ID=22142598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000548377A Pending JP2002514663A (ja) | 1998-05-13 | 1999-05-12 | アロエペクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5929051A (https=) |
| EP (2) | EP1607407A3 (https=) |
| JP (1) | JP2002514663A (https=) |
| KR (1) | KR100587423B1 (https=) |
| AU (1) | AU3898999A (https=) |
| CA (1) | CA2331744C (https=) |
| DE (1) | DE69927498T2 (https=) |
| WO (1) | WO1999058575A1 (https=) |
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| JP2010110268A (ja) * | 2008-11-07 | 2010-05-20 | T Hasegawa Co Ltd | 粘性物質の除去されたアロエ葉肉加工品の製造方法 |
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| JP2015522561A (ja) * | 2012-06-06 | 2015-08-06 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 高誘導型一酸化窒素合成酵素と関連する疾患を処置するためのガラクト−ラムノガラクツロネート組成物 |
| JP2017514961A (ja) * | 2014-05-08 | 2017-06-08 | ナノセラピューティクス・インコーポレイテッドＮａｎｏｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｏ−アセチル化高分子ポリガラクツロン酸およびＶｉ多糖類ワクチンとしてのその利用 |
| JP2021519354A (ja) * | 2018-03-26 | 2021-08-10 | シーピー ケルコ エイピーエス | メチルエステル化度が低く、固有粘度が高いことを特徴とするペクチン |
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- 1999-05-12 EP EP99921889A patent/EP1086141B1/en not_active Expired - Lifetime
- 1999-05-12 WO PCT/US1999/010335 patent/WO1999058575A1/en not_active Ceased
- 1999-05-12 DE DE69927498T patent/DE69927498T2/de not_active Expired - Lifetime
- 1999-05-12 KR KR1020007012701A patent/KR100587423B1/ko not_active Expired - Fee Related
- 1999-05-12 CA CA2331744A patent/CA2331744C/en not_active Expired - Lifetime
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007504129A (ja) * | 2003-08-29 | 2007-03-01 | デルサイト バイオテクノロジーズ， インコーポレイテッド | 陰イオン性多糖類を含むインサイチュゲルでの生理学的な薬剤の送達 |
| JP4765020B2 (ja) * | 2003-08-29 | 2011-09-07 | ナノセラピューティクス・インコーポレイテッド | 陰イオン性多糖類を含むインサイチュゲルでの生理学的な薬剤の送達 |
| JP2010110268A (ja) * | 2008-11-07 | 2010-05-20 | T Hasegawa Co Ltd | 粘性物質の除去されたアロエ葉肉加工品の製造方法 |
| JP2015503658A (ja) * | 2011-12-28 | 2015-02-02 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ヒト疾患処置用の新規糖薬剤の組成物 |
| JP2017149976A (ja) * | 2011-12-28 | 2017-08-31 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ヒト疾患処置用の新規糖薬剤の組成物 |
| JP2018076519A (ja) * | 2011-12-28 | 2018-05-17 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ヒト疾患処置用の新規糖薬剤の組成物 |
| JP2015522561A (ja) * | 2012-06-06 | 2015-08-06 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 高誘導型一酸化窒素合成酵素と関連する疾患を処置するためのガラクト−ラムノガラクツロネート組成物 |
| JP2017514961A (ja) * | 2014-05-08 | 2017-06-08 | ナノセラピューティクス・インコーポレイテッドＮａｎｏｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｏ−アセチル化高分子ポリガラクツロン酸およびＶｉ多糖類ワクチンとしてのその利用 |
| JP2021519354A (ja) * | 2018-03-26 | 2021-08-10 | シーピー ケルコ エイピーエス | メチルエステル化度が低く、固有粘度が高いことを特徴とするペクチン |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2331744A1 (en) | 1999-11-18 |
| CA2331744C (en) | 2010-10-05 |
| EP1086141A1 (en) | 2001-03-28 |
| DE69927498D1 (de) | 2006-02-09 |
| KR20010052346A (ko) | 2001-06-25 |
| DE69927498T2 (de) | 2006-07-13 |
| WO1999058575A1 (en) | 1999-11-18 |
| EP1607407A2 (en) | 2005-12-21 |
| AU3898999A (en) | 1999-11-29 |
| EP1607407A3 (en) | 2006-05-24 |
| EP1086141B1 (en) | 2005-09-28 |
| US5929051A (en) | 1999-07-27 |
| KR100587423B1 (ko) | 2006-06-08 |
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