JP2002514418A - 破骨細胞活性の阻害方法 - Google Patents
破骨細胞活性の阻害方法Info
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US8548798P | 1998-05-14 | 1998-05-14 | |
| US60/085,487 | 1998-05-14 | ||
| US11083698P | 1998-12-03 | 1998-12-03 | |
| US60/110,836 | 1998-12-03 | ||
| PCT/US1999/010588 WO1999058674A2 (en) | 1998-05-14 | 1999-05-13 | Method of inhibiting osteoclast activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002514418A true JP2002514418A (ja) | 2002-05-21 |
| JP2002514418A5 JP2002514418A5 (https=) | 2006-06-29 |
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| JP2000548465A Pending JP2002514418A (ja) | 1998-05-14 | 1999-05-13 | 破骨細胞活性の阻害方法 |
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| Country | Link |
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| US (2) | US20050089522A1 (https=) |
| EP (2) | EP1076699B1 (https=) |
| JP (1) | JP2002514418A (https=) |
| AT (2) | ATE412746T1 (https=) |
| AU (1) | AU762574B2 (https=) |
| CA (1) | CA2328140C (https=) |
| CY (1) | CY1111912T1 (https=) |
| DE (1) | DE69939822D1 (https=) |
| DK (1) | DK2009025T3 (https=) |
| ES (1) | ES2317694T3 (https=) |
| PT (1) | PT2009025E (https=) |
| WO (1) | WO1999058674A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| EP1803816A3 (en) * | 1996-12-13 | 2007-09-26 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| US6242213B1 (en) | 1996-12-23 | 2001-06-05 | Immunex Corporation | Isolated DNA molecules encoding RANK-L |
| WO1999058674A2 (en) | 1998-05-14 | 1999-11-18 | Immunex Corporation | Method of inhibiting osteoclast activity |
| KR100496063B1 (ko) | 1997-04-15 | 2005-06-21 | 산쿄 가부시키가이샤 | 신규단백질 및 그 제조방법 |
| US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| EP0975754B2 (en) * | 1997-04-16 | 2016-01-06 | Amgen Inc., | Osteoprotegerin binding proteins and their receptors |
| WO1998054201A1 (en) * | 1997-05-29 | 1998-12-03 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like protein 8 |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6492333B1 (en) | 1999-04-09 | 2002-12-10 | Osteoscreen, Inc. | Treatment of myeloma bone disease with proteasomal and NF-κB activity inhibitors |
| US6673771B1 (en) | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
| ATE448781T1 (de) * | 1999-07-28 | 2009-12-15 | Univ Pennsylvania | Methoden zur hemmung der aktivität der osteoklasten |
| US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
| AU2002231602A1 (en) * | 2001-02-09 | 2002-08-28 | Maxygen Holdings Ltd. | Rank ligand-binding polypeptides |
| WO2002080955A1 (en) * | 2001-03-22 | 2002-10-17 | Barnes-Jewish Hospital | Stimulation of osteogenesis using rank ligand fusion proteins |
| WO2002092623A1 (en) * | 2001-05-11 | 2002-11-21 | Research Development Foundation | INHIBITORS OF RECEPTOR ACTIVATOR OF NF-κB AND USES THEREOF |
| US20030017151A1 (en) * | 2001-05-17 | 2003-01-23 | Dougall William C. | Therapeutic use of rank antagonists |
| PH12012502440A1 (en) | 2001-06-26 | 2013-06-17 | Amgen Inc | Antibodies to opgl |
| CA2463478A1 (en) * | 2001-10-12 | 2003-08-14 | Barnes-Jewish Hospital | Methods for screening osteogenic compounds |
| WO2003086289A2 (en) | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
| WO2003103710A1 (ja) * | 2002-06-07 | 2003-12-18 | 三共株式会社 | 骨破壊の治療または予防剤組成物の併用効果 |
| TWI359026B (en) * | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
| JP5191487B2 (ja) * | 2007-06-05 | 2013-05-08 | オリエンタル酵母工業株式会社 | 新しい骨量増加薬 |
| JP6403999B2 (ja) * | 2014-06-05 | 2018-10-10 | 株式会社細川洋行 | レトルト包装用積層体及び容器 |
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| US6410516B1 (en) * | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
| AU661360B2 (en) | 1991-10-25 | 1995-07-20 | Immunex Corporation | Novel cytokine |
| US5716805A (en) | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| ATE240394T1 (de) * | 1992-10-23 | 2003-05-15 | Immunex Corp | Methoden zur herstellung löslicher, oligomerer proteine |
| US5741667A (en) | 1994-05-27 | 1998-04-21 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| WO1996034095A1 (en) | 1995-04-27 | 1996-10-31 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors |
| MX9709447A (es) * | 1995-06-07 | 1998-02-28 | Immunex Corp | Nueva muteina cd4ol. |
| US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
| US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
| JPH1057071A (ja) | 1996-08-19 | 1998-03-03 | Snow Brand Milk Prod Co Ltd | 新規ｄｎａ及びそれを用いた蛋白質の製造方法 |
| EP1803816A3 (en) | 1996-12-13 | 2007-09-26 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| AU5901598A (en) | 1996-12-20 | 1998-07-17 | Board Of Regents, The University Of Texas System | Compositions and methods of use for osteoclast inhibitory factors |
| WO1999058674A2 (en) | 1998-05-14 | 1999-11-18 | Immunex Corporation | Method of inhibiting osteoclast activity |
| US6271349B1 (en) * | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| US6242213B1 (en) | 1996-12-23 | 2001-06-05 | Immunex Corporation | Isolated DNA molecules encoding RANK-L |
| KR100496063B1 (ko) * | 1997-04-15 | 2005-06-21 | 산쿄 가부시키가이샤 | 신규단백질 및 그 제조방법 |
| US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
| EP0975754B2 (en) | 1997-04-16 | 2016-01-06 | Amgen Inc., | Osteoprotegerin binding proteins and their receptors |
| CA2229449A1 (en) | 1997-04-25 | 1998-10-25 | Takeda Chemical Industries, Ltd. | Novel receptor protein and its use |
| JP2002514079A (ja) | 1997-05-01 | 2002-05-14 | アムジエン・インコーポレーテツド | キメラｏｐｇポリペプチド |
| WO1998054201A1 (en) | 1997-05-29 | 1998-12-03 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like protein 8 |
| US6087555A (en) | 1997-10-15 | 2000-07-11 | Amgen Inc. | Mice lacking expression of osteoprotegerin |
| WO1999029865A2 (en) | 1997-12-12 | 1999-06-17 | The Rockefeller University | A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof |
| JPH11266872A (ja) | 1998-03-20 | 1999-10-05 | Suntory Ltd | ＮＦ−κＢの活性化を抑制する物質のスクリーニング方法 |
| US6790823B1 (en) | 1998-04-23 | 2004-09-14 | Amgen Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
| HUP0102492A2 (hu) | 1998-06-19 | 2001-11-28 | Smithkline Beecham Corp. | Amino-indanon származékok alkalmazása NF-kB transzkripciós faktor inhibitor hatású gyógyszerkészítmények előállítására |
| HUP0102782A3 (en) | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
| WO2001003719A2 (en) | 1999-07-09 | 2001-01-18 | Amgen Inc. | Combination therapy for conditions leading to bone loss |
| US20030144187A1 (en) | 1999-09-03 | 2003-07-31 | Colin R. Dunstan | Opg fusion protein compositions and methods |
| DE60034871T2 (de) | 1999-09-03 | 2008-01-17 | Amgen Inc., Thousand Oaks | Verfahren und zusammensetzungen zur prevention oder behandlung von krebs und von krebs assoziertem knochenverlust |
| AUPQ314799A0 (en) | 1999-09-29 | 1999-10-21 | University Of Western Australia, The | Bone cell factor |
| US20030103978A1 (en) | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
| DK2105449T3 (da) | 2000-02-23 | 2019-10-07 | Amgen Inc | Antagonistiske selektive bindemidler af osteoprotegerinbindende protein |
| AU2001288342A1 (en) | 2000-08-21 | 2002-03-04 | Smith Kline Beecham Corporation | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
| PH12012502440A1 (en) | 2001-06-26 | 2013-06-17 | Amgen Inc | Antibodies to opgl |
| WO2003086289A2 (en) | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
-
1999
- 1999-05-13 WO PCT/US1999/010588 patent/WO1999058674A2/en not_active Ceased
- 1999-05-13 ES ES99923021T patent/ES2317694T3/es not_active Expired - Lifetime
- 1999-05-13 CA CA2328140A patent/CA2328140C/en not_active Expired - Lifetime
- 1999-05-13 AT AT99923021T patent/ATE412746T1/de not_active IP Right Cessation
- 1999-05-13 PT PT08015570T patent/PT2009025E/pt unknown
- 1999-05-13 EP EP99923021A patent/EP1076699B1/en not_active Expired - Lifetime
- 1999-05-13 DE DE69939822T patent/DE69939822D1/de not_active Expired - Lifetime
- 1999-05-13 AU AU39888/99A patent/AU762574B2/en not_active Expired
- 1999-05-13 JP JP2000548465A patent/JP2002514418A/ja active Pending
- 1999-05-13 EP EP08015570A patent/EP2009025B1/en not_active Expired - Lifetime
- 1999-05-13 DK DK08015570.8T patent/DK2009025T3/da active
- 1999-05-13 AT AT08015570T patent/ATE517916T1/de active
-
2004
- 2004-11-30 US US10/999,523 patent/US20050089522A1/en not_active Abandoned
-
2008
- 2008-06-11 US US12/137,397 patent/US7790684B2/en not_active Expired - Fee Related
-
2011
- 2011-10-06 CY CY20111100954T patent/CY1111912T1/el unknown
Non-Patent Citations (5)
| Title |
|---|
| JPN6009045631, Ｇ． Ｄ． Ｒｏｏｄｍａｎ, "Ｏｓｔｅｏｃｌａｓｔ ｆｕｎｃｔｉｏｎ ｉｎ Ｐａｇｅｔ’ｓ ｄｉｓｅａｓｅ ａｎｄ ｍｕｌｔｉｐｌｅ ｍｙｅｌｏｍａ", Ｂｏｎｅ, 1995, Ｖｏｌｕｍｅ １７， Ｉｓｓｕｅ ２， Ｓｕｐｐｌｅｍｅｎｔ １, Ｓ５７−Ｓ６１ * |
| JPN7009004066, ＳＩＭＯＮＥＴ，Ｗ．Ｓ． ｅｔ ａｌ, "Ｏｓｔｅｏｐｒｏｔｅｇｅｒｉｎ： ａ ｎｏｖｅｌ ｓｅｃｒｅｔｅｄ ｐｒｏｔｅｉｎ ｉｎｖｏｌｖｅｄ ｉｎ ｔｈｅ ｒｅｇｕｌａｔｉｏｎ ｏｆ ｂｏｎｅ ｄｅｎｓｉｔｙ", Ｃｅｌｌ, 1997, Ｖｏｌ．８９， Ｎｏ．２, ｐ．３０９−１９ * |
| JPN7009004067, ＬＡＣＥＹ，Ｄ．Ｌ． ｅｔ ａｌ, "Ｏｓｔｅｏｐｒｏｔｅｇｅｒｉｎ ｌｉｇａｎｄ ｉｓ ａ ｃｙｔｏｋｉｎｅ ｔｈａｔ ｒｅｇｕｌａｔｅｓ ｏｓｔｅｏｃｌａｓｔ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ａｎｄ ａｃｔｉｖａｔｉｏｎ", Ｃｅｌｌ, 1998, Ｖｏｌ．９３， Ｎｏ．２, ｐ．１６５−７６ * |
| JPN7009004068, ＹＡＳＵＤＡ，Ｈ． ｅｔ ａｌ, "Ｏｓｔｅｏｃｌａｓｔ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｆａｃｔｏｒ ｉｓ ａ ｌｉｇａｎｄ ｆｏｒ ｏｓｔｅｏｐｒｏｔｅｇｅｒｉｎ／ｏｓｔｅｏｃｌａｓｔｏｇｅｎｅｓｉｓ−ｉｎｈｉｂｉｔｏｒｙ ｆａｃｔ", Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ, 1998, Ｖｏｌ．９５， Ｎｏ．７, ｐ．３５９７−６０２ * |
| JPN7009004069, ＡＮＤＥＲＳＯＮ，Ｄ．Ｍ． ｅｔ ａｌ, "Ａ ｈｏｍｏｌｏｇｕｅ ｏｆ ｔｈｅ ＴＮＦ ｒｅｃｅｐｔｏｒ ａｎｄ ｉｔｓ ｌｉｇａｎｄ ｅｎｈａｎｃｅ Ｔ−ｃｅｌｌ ｇｒｏｗｔｈ ａｎｄ ｄｅｎｄｒｉｔｉｃ−ｃｅｌｌ ｆｕｎｃｔｉｏｎ", Ｎａｔｕｒｅ, 1997, Ｖｏｌ．３９０， Ｎｏ．６６５６, ｐ．１７５−９ * |
Also Published As
| Publication number | Publication date |
|---|---|
| CY1111912T1 (el) | 2015-11-04 |
| WO1999058674A3 (en) | 2000-02-10 |
| DE69939822D1 (de) | 2008-12-11 |
| US20050089522A1 (en) | 2005-04-28 |
| CA2328140C (en) | 2012-03-13 |
| ES2317694T3 (es) | 2009-04-16 |
| EP2009025A1 (en) | 2008-12-31 |
| ATE412746T1 (de) | 2008-11-15 |
| WO1999058674A2 (en) | 1999-11-18 |
| DK2009025T3 (da) | 2011-11-14 |
| ATE517916T1 (de) | 2011-08-15 |
| EP2009025B1 (en) | 2011-07-27 |
| EP1076699A2 (en) | 2001-02-21 |
| AU3988899A (en) | 1999-11-29 |
| US20090004196A1 (en) | 2009-01-01 |
| EP1076699B1 (en) | 2008-10-29 |
| CA2328140A1 (en) | 1999-11-18 |
| US7790684B2 (en) | 2010-09-07 |
| PT2009025E (pt) | 2011-09-19 |
| AU762574B2 (en) | 2003-06-26 |
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