JP2002513762A5 - - Google Patents
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- JP2002513762A5 JP2002513762A5 JP2000546778A JP2000546778A JP2002513762A5 JP 2002513762 A5 JP2002513762 A5 JP 2002513762A5 JP 2000546778 A JP2000546778 A JP 2000546778A JP 2000546778 A JP2000546778 A JP 2000546778A JP 2002513762 A5 JP2002513762 A5 JP 2002513762A5
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- Prior art keywords
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 description 58
- 239000003795 chemical substances by application Substances 0.000 description 41
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 28
- 239000003814 drug Substances 0.000 description 20
- 229940079593 drug Drugs 0.000 description 19
- 239000003112 inhibitor Substances 0.000 description 14
- 108010050095 PT-100 dipeptide Proteins 0.000 description 12
- FKCMADOPPWWGNZ-YUMQZZPRSA-N [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid Chemical group CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O FKCMADOPPWWGNZ-YUMQZZPRSA-N 0.000 description 12
- 230000001681 protective effect Effects 0.000 description 11
- 210000002536 stromal cell Anatomy 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 239000003102 growth factor Substances 0.000 description 7
- 210000000601 blood cell Anatomy 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 210000000440 neutrophil Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 3
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000012258 culturing Methods 0.000 description 2
- 208000004235 neutropenia Diseases 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 0 *B(*)*(C1=*)N(*C(C2N(*)C**2)=O)CC1=C Chemical compound *B(*)*(C1=*)N(*C(C2N(*)C**2)=O)CC1=C 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8412898P | 1998-05-04 | 1998-05-04 | |
| US60/084,128 | 1998-05-04 | ||
| PCT/US1999/009652 WO1999056753A1 (en) | 1998-05-04 | 1999-05-03 | Hematopoietic stimulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002513762A JP2002513762A (ja) | 2002-05-14 |
| JP2002513762A5 true JP2002513762A5 (https=) | 2007-03-01 |
Family
ID=22183048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000546778A Pending JP2002513762A (ja) | 1998-05-04 | 1999-05-03 | 造血刺激 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US6300314B1 (https=) |
| EP (1) | EP1075266A1 (https=) |
| JP (1) | JP2002513762A (https=) |
| KR (1) | KR20010052302A (https=) |
| AR (1) | AR023628A1 (https=) |
| AU (2) | AU770319C (https=) |
| BR (1) | BR9910251A (https=) |
| CA (1) | CA2331122A1 (https=) |
| IL (1) | IL139247A0 (https=) |
| MY (1) | MY132924A (https=) |
| NO (1) | NO20005488L (https=) |
| NZ (1) | NZ507730A (https=) |
| PE (1) | PE20000481A1 (https=) |
| TW (1) | TWI252107B (https=) |
| WO (1) | WO1999056753A1 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE357509T1 (de) * | 1997-09-29 | 2007-04-15 | Point Therapeutics Inc | Stimulierung von hämatopoietischen zellen im vitro |
| IL139247A0 (en) * | 1998-05-04 | 2001-11-25 | Point Therapeutics Inc | Hematopoietic stimulation |
| US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| DK1349918T3 (da) | 2000-12-06 | 2014-11-10 | Anthrogenesis Corp | Fremgangsmåde til indsamling af stamceller fra moderkagen |
| JP4170758B2 (ja) | 2001-01-16 | 2008-10-22 | 日本化薬株式会社 | 骨髄抑制治療剤、感染症治療剤及び白血球数増加剤 |
| EP2316919B1 (en) | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| WO2003045228A2 (en) * | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Methods for treating autoimmune disorders, and reagents related thereto |
| EP2316470A3 (en) | 2001-11-26 | 2011-08-24 | Trustees Of Tufts College | Peptidomimetic inhibitors of post-proline cleaving enzymes |
| EP1554595B1 (en) * | 2001-12-17 | 2008-05-14 | Koninklijke Philips Electronics N.V. | Magnetic resonance method |
| US7691967B2 (en) * | 2002-04-30 | 2010-04-06 | Trustees Of Tufts College | Smart pro-drugs of serine protease inhibitors |
| WO2004004661A2 (en) * | 2002-07-09 | 2004-01-15 | Point Therapeutics, Inc. | Boroproline compound combination therapy |
| AU2003298775B2 (en) | 2002-11-26 | 2008-07-17 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| JP2007511467A (ja) | 2003-05-14 | 2007-05-10 | タケダ サン ディエゴ インコーポレイテッド | ジペプチジルペプチダーゼインヒビター |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7576121B2 (en) * | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| SG134333A1 (en) * | 2003-11-12 | 2007-08-29 | Phenomix Corp | Heterocyclic boronic acid compounds |
| US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7767828B2 (en) * | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| AU2005216970B2 (en) * | 2004-02-23 | 2011-07-07 | Trustees Of Tufts College | Inhibitors of dipeptidylpeptidase IV for regulating glucose metabolism |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7687638B2 (en) | 2004-06-04 | 2010-03-30 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
| US20080112933A1 (en) * | 2004-11-08 | 2008-05-15 | Scadden David T | Methods and Compositions for Increasing Stem Cell Homing Using Gas Activators |
| DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| US7825139B2 (en) * | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| DK1957633T3 (en) | 2005-10-13 | 2014-03-17 | Anthrogenesis Corp | Immunomodulation USING PLACE SPEECH STEM CELLS |
| CN101389754A (zh) | 2005-12-29 | 2009-03-18 | 人类起源公司 | 胎盘干细胞和第二来源干细胞的联合培养 |
| PT2471904T (pt) | 2005-12-29 | 2019-02-25 | Celularity Inc | População de células estaminais placentárias |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
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| US7674691B2 (en) * | 2007-03-07 | 2010-03-09 | International Business Machines Corporation | Method of manufacturing an electrical antifuse |
| US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| NZ599825A (en) | 2007-09-28 | 2014-10-31 | Anthrogenesis Corp | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
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| WO2010021715A1 (en) | 2008-08-20 | 2010-02-25 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| KR20240052847A (ko) | 2008-08-20 | 2024-04-23 | 셀룰래리티 인코포레이티드 | 개선된 세포 조성물 및 그의 제조 방법 |
| CA2734446C (en) | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
| AU2009316541B2 (en) | 2008-11-19 | 2015-08-06 | Celularity Inc. | Amnion derived adherent cells |
| US8586360B2 (en) | 2009-07-02 | 2013-11-19 | Anthrogenesis Corporation | Method of producing erythrocytes without feeder cells |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| BR112012004335A8 (pt) | 2009-09-02 | 2016-06-21 | Merck Sharp & Dohme | Composto, composição farmacêutica, e, uso do composto. |
| CN102791701B (zh) | 2009-12-30 | 2014-02-12 | 深圳信立泰药业股份有限公司 | 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物 |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| US8853212B2 (en) | 2010-02-22 | 2014-10-07 | Merck Sharp & Dohme Corp | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes |
| CA2795513A1 (en) | 2010-04-06 | 2011-10-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| LT2556145T (lt) | 2010-04-07 | 2016-11-10 | Anthrogenesis Corporation | Angiogenezė naudojant placentos kamienines ląsteles |
| MX2012011543A (es) | 2010-04-08 | 2013-05-06 | Anthrogenesis Corp | Tratamiento de sarcoidosis empleando celulas madre placentarias. |
| US8980929B2 (en) | 2010-05-21 | 2015-03-17 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| ES2666746T3 (es) | 2010-07-13 | 2018-05-07 | Anthrogenesis Corporation | Métodos para generar linfocitos citolíticos naturales |
| EP3323818A1 (en) | 2010-09-22 | 2018-05-23 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
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| PL2753334T3 (pl) | 2011-08-30 | 2022-12-12 | Trustees Of Tufts College | Aktywowane przez fap inhibitory proteasomu do leczenia guzów litych |
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| WO2013122920A1 (en) | 2012-02-17 | 2013-08-22 | Merck Sharp & Dohme Corp. | Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| EP2874622A4 (en) | 2012-07-23 | 2015-12-30 | Merck Sharp & Dohme | TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS |
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| CN115137753A (zh) | 2013-02-05 | 2022-10-04 | 细胞结构公司 | 来自胎盘的自然杀伤细胞 |
| EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
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| DE296075C (https=) | ||||
| DE158109C (https=) | ||||
| DE270382C (https=) | ||||
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| NL9400309A (nl) | 1993-11-04 | 1995-06-01 | Eurogenetics Nv | Ligande die in staat is te binden aan de adenosine deaminase bindingsplaats van CD26. |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| US5489025A (en) * | 1994-03-01 | 1996-02-06 | Romick; Jerome M. | Unit-dose medication dispenser and multiple-dispenser frame therefor |
| FR2719049B1 (fr) | 1994-04-22 | 1996-06-14 | Pasteur Institut | Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules. |
| US5543396A (en) | 1994-04-28 | 1996-08-06 | Georgia Tech Research Corp. | Proline phosphonate derivatives |
| DE4416963C1 (de) | 1994-05-13 | 1995-07-13 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von enantiomerenreinen Diarylprolinolen |
| AU2790895A (en) | 1994-06-10 | 1996-01-05 | Universitaire Instelling Antwerpen | Purification of serine protease and synthetic inhibitors thereof |
| FR2721611B1 (fr) | 1994-06-22 | 1996-09-27 | Adir | Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent . |
| DE69534265T2 (de) * | 1994-12-12 | 2006-05-04 | Beth Israel Deaconess Medical Center, Inc., Boston | Chimäre zytokine und ihre verwendung |
| ATE204322T1 (de) | 1995-06-07 | 2001-09-15 | Aastrom Biosciences Inc | Vorrichtung und verfahren zum aufbewahren und zur züchtung biologischer zellen |
| US5856571A (en) | 1995-06-07 | 1999-01-05 | Cellpro, Incorporated | Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto |
| ATE208812T1 (de) * | 1995-12-29 | 2001-11-15 | Alg Company | Vermehrung von knochenmarksstützzellen |
| US5965532A (en) | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
| GB9624562D0 (en) | 1996-11-27 | 1997-01-15 | Zeneca Ltd | Peptide derivatives |
| US6040145A (en) | 1997-05-07 | 2000-03-21 | Tufts University | Potentiation of the immune response |
| US6100234A (en) | 1997-05-07 | 2000-08-08 | Tufts University | Treatment of HIV |
| ATE357509T1 (de) | 1997-09-29 | 2007-04-15 | Point Therapeutics Inc | Stimulierung von hämatopoietischen zellen im vitro |
| IL139247A0 (en) * | 1998-05-04 | 2001-11-25 | Point Therapeutics Inc | Hematopoietic stimulation |
| WO2000010549A1 (en) | 1998-08-21 | 2000-03-02 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| WO2004004661A2 (en) | 2002-07-09 | 2004-01-15 | Point Therapeutics, Inc. | Boroproline compound combination therapy |
-
1999
- 1999-05-03 IL IL13924799A patent/IL139247A0/xx unknown
- 1999-05-03 NZ NZ507730A patent/NZ507730A/xx unknown
- 1999-05-03 TW TW088107193A patent/TWI252107B/zh not_active IP Right Cessation
- 1999-05-03 JP JP2000546778A patent/JP2002513762A/ja active Pending
- 1999-05-03 MY MYPI99001736A patent/MY132924A/en unknown
- 1999-05-03 WO PCT/US1999/009652 patent/WO1999056753A1/en not_active Ceased
- 1999-05-03 CA CA002331122A patent/CA2331122A1/en not_active Abandoned
- 1999-05-03 BR BR9910251-0A patent/BR9910251A/pt not_active Application Discontinuation
- 1999-05-03 AU AU38781/99A patent/AU770319C/en not_active Ceased
- 1999-05-03 EP EP99921617A patent/EP1075266A1/en not_active Withdrawn
- 1999-05-03 KR KR1020007012223A patent/KR20010052302A/ko not_active Ceased
- 1999-05-03 US US09/304,199 patent/US6300314B1/en not_active Expired - Fee Related
- 1999-05-04 AR ARP990102086A patent/AR023628A1/es unknown
- 1999-05-04 PE PE1999000365A patent/PE20000481A1/es not_active Application Discontinuation
-
2000
- 2000-10-31 NO NO20005488A patent/NO20005488L/no not_active Application Discontinuation
-
2001
- 2001-06-11 US US09/878,792 patent/US6770628B2/en not_active Expired - Fee Related
-
2004
- 2004-05-19 AU AU2004202138A patent/AU2004202138A1/en not_active Abandoned
- 2004-06-28 US US10/879,479 patent/US7067489B2/en not_active Expired - Fee Related
-
2006
- 2006-06-26 US US11/474,929 patent/US20070135354A1/en not_active Abandoned
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