AR023628A1 - Uso de un agente efectivo para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras para la preparacion de un medicamento utilpara estimular la hematopoyesis, util para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras que acorta el tiempo en que - Google Patents
Uso de un agente efectivo para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras para la preparacion de un medicamento utilpara estimular la hematopoyesis, util para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras que acorta el tiempo en queInfo
- Publication number
- AR023628A1 AR023628A1 ARP990102086A ARP990102086A AR023628A1 AR 023628 A1 AR023628 A1 AR 023628A1 AR P990102086 A ARP990102086 A AR P990102086A AR P990102086 A ARP990102086 A AR P990102086A AR 023628 A1 AR023628 A1 AR 023628A1
- Authority
- AR
- Argentina
- Prior art keywords
- cells
- agent
- stimulate
- increase
- growth factor
- Prior art date
Links
- 210000000601 blood cell Anatomy 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 title 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 8
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 6
- 210000002536 stromal cell Anatomy 0.000 abstract 6
- 239000003102 growth factor Substances 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- 150000008575 L-amino acids Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Magnetic Treatment Devices (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8412898P | 1998-05-04 | 1998-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023628A1 true AR023628A1 (es) | 2002-09-04 |
Family
ID=22183048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102086A AR023628A1 (es) | 1998-05-04 | 1999-05-04 | Uso de un agente efectivo para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras para la preparacion de un medicamento utilpara estimular la hematopoyesis, util para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras que acorta el tiempo en que |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US6300314B1 (https=) |
| EP (1) | EP1075266A1 (https=) |
| JP (1) | JP2002513762A (https=) |
| KR (1) | KR20010052302A (https=) |
| AR (1) | AR023628A1 (https=) |
| AU (2) | AU770319C (https=) |
| BR (1) | BR9910251A (https=) |
| CA (1) | CA2331122A1 (https=) |
| IL (1) | IL139247A0 (https=) |
| MY (1) | MY132924A (https=) |
| NO (1) | NO20005488L (https=) |
| NZ (1) | NZ507730A (https=) |
| PE (1) | PE20000481A1 (https=) |
| TW (1) | TWI252107B (https=) |
| WO (1) | WO1999056753A1 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2304206A1 (en) * | 1997-09-29 | 1999-04-08 | Point Therapeutics, Inc. | Stimulation of hematopoietic cells in vitro |
| CA2331122A1 (en) * | 1998-05-04 | 1999-11-11 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| EP2305795B1 (en) | 2000-12-06 | 2019-07-03 | Celularity, Inc. | Method of collecting placental stem cells |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| WO2002055088A1 (en) | 2001-01-16 | 2002-07-18 | Nippon Kayaku Kabushiki Kaisha | Remedies for bone marrow suppression and infectious diseases and white blood cell count elevating agents |
| EP2316918B1 (en) | 2001-02-14 | 2015-07-01 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| WO2003045228A2 (en) * | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Methods for treating autoimmune disorders, and reagents related thereto |
| EP1469873A4 (en) * | 2001-11-26 | 2007-10-03 | Tufts College | PEPTIDOMIMETIC INHIBITORS FROM BEHIND PROLIN SPLENDING ENZYMES |
| CN100443917C (zh) * | 2001-12-17 | 2008-12-17 | 皇家飞利浦电子股份有限公司 | 磁共振方法和设备 |
| AU2003228793B2 (en) * | 2002-04-30 | 2008-01-03 | Trustees Of Tufts College | Smart Pro-Drugs of Serine Protease Inhibitors |
| US20050084490A1 (en) * | 2002-07-09 | 2005-04-21 | Point Therapeutics, Inc. | Boroproline compound combination therapy |
| AU2003298775B2 (en) | 2002-11-26 | 2008-07-17 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| WO2004103993A1 (en) | 2003-05-14 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7767828B2 (en) * | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| NZ547752A (en) * | 2003-11-12 | 2009-12-24 | Phenomix Corp | Heterocyclic boronic acid compounds for inhibiting dipeptidyl peptidase-IV |
| US7576121B2 (en) * | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US20050203027A1 (en) * | 2004-02-23 | 2005-09-15 | Trustees Of Tufts College | Inhibitors of dipeptidylpeptidase IV |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| JP2008501714A (ja) | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
| US20080112933A1 (en) * | 2004-11-08 | 2008-05-15 | Scadden David T | Methods and Compositions for Increasing Stem Cell Homing Using Gas Activators |
| DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| US7825139B2 (en) * | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| NZ597304A (en) | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
| EP1976978A2 (en) | 2005-12-29 | 2008-10-08 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| PL2471907T3 (pl) | 2005-12-29 | 2019-07-31 | Celularity, Inc. | Populacje komórek macierzystych łożyska |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| US20100247491A1 (en) * | 2007-02-01 | 2010-09-30 | Christof Westenfelder | Potentiation of Stem Cell Homing and Treatment of Organ Dysfunction or Organ Failure |
| NZ612888A (en) | 2007-02-12 | 2015-02-27 | Anthrogenesis Corp | Treatment of inflammatory diseases using placental stem cells |
| US20080195007A1 (en) * | 2007-02-12 | 2008-08-14 | Yury Podrazhansky | Method and device for using vibroacoustic stimulaton to enhance the production of adult stem cells in living organisms |
| US7674691B2 (en) * | 2007-03-07 | 2010-03-09 | International Business Machines Corporation | Method of manufacturing an electrical antifuse |
| US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| RU2536242C2 (ru) | 2007-09-28 | 2014-12-20 | Антродженезис Корпорейшн | Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров |
| EP2108960A1 (en) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY |
| CA2734237C (en) | 2008-08-20 | 2019-07-02 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| KR20200011604A (ko) | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| CA2734446C (en) | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
| RU2015130665A (ru) | 2008-11-19 | 2018-12-24 | Антродженезис Корпорейшн | Амниотические адгезивные клетки |
| MX353489B (es) | 2009-07-02 | 2018-01-16 | Anthrogenesis Corp | Metodo para producir eritrocitos sin celulas alimentadoras. |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| CA2771352A1 (en) | 2009-09-02 | 2011-03-10 | Merck Sharp & Dohme Corp. | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| CN103664873B (zh) | 2009-12-30 | 2016-06-15 | 深圳信立泰药业股份有限公司 | 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物 |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| US8853212B2 (en) | 2010-02-22 | 2014-10-07 | Merck Sharp & Dohme Corp | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes |
| AU2011237775A1 (en) | 2010-04-06 | 2012-11-22 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
| DK2556145T3 (en) | 2010-04-07 | 2016-11-07 | Anthrogenesis Corp | Angiogenesis using placental stem cells |
| EP2555783A1 (en) | 2010-04-08 | 2013-02-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| WO2011146358A1 (en) | 2010-05-21 | 2011-11-24 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| PH12013500547A1 (en) | 2010-09-22 | 2013-06-10 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012092485A1 (en) | 2010-12-31 | 2012-07-05 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory rna molecules |
| US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| US20140066369A1 (en) | 2011-04-19 | 2014-03-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| ES2707579T3 (es) | 2011-06-01 | 2019-04-04 | Celularity Inc | Tratamiento del dolor usando citoblastos placentarios |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| CN108383893A (zh) | 2011-08-30 | 2018-08-10 | 塔夫茨大学信托人 | 用于治疗实体瘤的fap-活化的蛋白酶体抑制剂 |
| WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013078286A1 (en) | 2011-11-22 | 2013-05-30 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting tgf beta signaling |
| WO2013122920A1 (en) | 2012-02-17 | 2013-08-22 | Merck Sharp & Dohme Corp. | Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| EP2874622A4 (en) | 2012-07-23 | 2015-12-30 | Merck Sharp & Dohme | TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| AU2014215458A1 (en) | 2013-02-05 | 2015-08-13 | Anthrogenesis Corporation | Natural killer cells from placenta |
| EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
| AU2018249822A1 (en) | 2017-04-03 | 2019-10-31 | Coherus Biosciences Inc. | PPArgamma agonist for treatment of progressive supranuclear palsy |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE296075C (https=) | ||||
| DE158109C (https=) | ||||
| DE270382C (https=) | ||||
| US4318904A (en) | 1980-04-25 | 1982-03-09 | Research Corporation | Peptide affinity labels for thrombin and other trypsin-like proteases |
| US4443609A (en) | 1980-05-19 | 1984-04-17 | Petrolite Corporation | Tetrahydrothiazole phosphonic acids or esters thereof |
| DD158109A1 (de) | 1981-04-10 | 1982-12-29 | Gunter Fischer | Verfahren zur hemmung der katalytischen aktivitaet von peptidhydrolasen |
| US4582821A (en) | 1983-11-16 | 1986-04-15 | E. I. Du Pont De Nemours And Company | Inhibition of cyclic nucleotide independent protein kinases |
| US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
| US4636492A (en) | 1984-08-29 | 1987-01-13 | E. I. Du Pont De Nemours And Company | Inhibition of viral protease activity by peptide halomethyl ketones |
| US4652552A (en) | 1984-09-10 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Tetrapeptide methyl ketone inhibitors of viral proteases |
| US4644055A (en) | 1984-12-17 | 1987-02-17 | E. I. Du Pont De Nemours And Company | Method for preparing specific inhibitors of virus-specified proteases |
| US4664262A (en) * | 1985-11-26 | 1987-05-12 | White Pamela J | Pill dispensing system |
| DD270382A1 (de) | 1986-10-31 | 1989-07-26 | Univ Halle Wittenberg | Verfahren zur kolorimetrischen bestimmung von dipeptidylpeptidase iv mittels dipeptidhydraziden |
| US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US5242904A (en) | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US4935493A (en) | 1987-10-06 | 1990-06-19 | E. I. Du Pont De Nemours And Company | Protease inhibitors |
| AU2613988A (en) | 1988-01-04 | 1989-08-01 | E.I. Du Pont De Nemours And Company | Multiple stage affinity process for isolation of specific cells from a cell mixture |
| US4963655A (en) | 1988-05-27 | 1990-10-16 | Mayo Foundation For Medical Education And Research | Boron analogs of amino acid/peptide protease inhibitors |
| US5215926A (en) | 1988-06-03 | 1993-06-01 | Cellpro, Inc. | Procedure for designing efficient affinity cell separation processes |
| AU633007B2 (en) | 1988-06-14 | 1993-01-21 | Cell-Sci Corporation | Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same |
| IL91307A0 (en) | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
| DE3840452A1 (de) | 1988-12-01 | 1990-06-07 | Hoechst Ag | (beta)-amino-boronsaeure-derivate |
| DE3842197A1 (de) | 1988-12-15 | 1990-06-21 | Hoechst Ag | Rasch spaltbares substrat fuer die hiv-protease |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| DD296075A5 (de) | 1989-08-07 | 1991-11-21 | Martin-Luther-Universitaet Halle-Wittenberg,De | Verfahren zur herstellung neuer inhibitoren der dipeptidyl peptidase iv |
| DE4033062A1 (de) | 1990-10-18 | 1992-04-23 | Merck Patent Gmbh | Aminosaeurederivate |
| EP0528858B1 (en) | 1990-04-14 | 1997-01-22 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type iv |
| US5462928A (en) | 1990-04-14 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US5378624A (en) | 1990-04-23 | 1995-01-03 | Cellpro, Incorporated | Methods for removing ligands from a particle surface |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| WO1991017767A1 (en) | 1990-05-21 | 1991-11-28 | New England Medical Center Hospitals, Inc. | Method of treating inhibition of dipeptidyl aminopeptidase type iv |
| US5288707A (en) | 1990-08-13 | 1994-02-22 | Sandoz Ltd. | Borolysine peptidomimetics |
| GB9017694D0 (en) | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
| FR2668069B1 (fr) * | 1990-10-18 | 1993-02-05 | Dassault Avions | Dispositif, notamment autonome et portable, pour extraire de la chaleur d'une source chaude. |
| JPH06504547A (ja) | 1990-12-28 | 1994-05-26 | ジョージア・テック・リサーチ・コーポレーション | ペプチドケトアミド、ケト酸およびケトエステル |
| WO1992017490A1 (en) | 1991-04-04 | 1992-10-15 | The Upjohn Company | Phosphorus containing compounds as inhibitors of retroviruses |
| IE922316A1 (en) | 1991-07-17 | 1993-01-27 | Smithkline Beecham Corp | Retroviral protease inhibitors |
| US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| WO1993005011A1 (en) | 1991-08-29 | 1993-03-18 | Sandoz Ltd. | Novel immunosuppressants |
| US6825169B1 (en) * | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
| ES2153831T3 (es) | 1991-10-22 | 2001-03-16 | New England Medical Center Inc | Inhibidores de dipeptidil-aminopeptidasa de tipo iv. |
| MX9206628A (es) | 1991-11-22 | 1993-05-01 | Boehringer Ingelheim Pharma | Ester de prolinaboronato y metodo para su preparacion. |
| WO1993016102A1 (en) | 1992-02-06 | 1993-08-19 | Dana-Farber Cancer Institute, Inc. | Human cd26 and methods for use |
| US5296604A (en) | 1992-05-15 | 1994-03-22 | Miles Inc. | Proline derivatives and compositions for their use as inhibitors of HIV protease |
| AU4794393A (en) | 1992-07-31 | 1994-03-03 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Producing increased numbers of hematopoietic cells by administering inhibitors of dipeptidyl peptidase iv |
| US5329028A (en) | 1992-08-05 | 1994-07-12 | Genentech, Inc. | Carbohydrate-directed cross-linking reagents |
| WO1994009132A1 (en) | 1992-08-21 | 1994-04-28 | Dana-Farber Cancer Institute, Inc. | Human cd26 and methods for use |
| FR2701951B1 (fr) | 1993-02-24 | 1995-06-09 | Adir | Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| MY131622A (en) | 1993-03-03 | 2007-08-30 | Novartis Ag | Organic compounds |
| US5384410A (en) | 1993-03-24 | 1995-01-24 | The Du Pont Merck Pharmaceutical Company | Removal of boronic acid protecting groups by transesterification |
| AU6773994A (en) | 1993-04-23 | 1994-11-21 | Cellpro, Incorporated | Methods for enriching fetal progenitor cells from maternal blood |
| SE9301911D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptide derivatives |
| FR2707170A1 (fr) | 1993-06-04 | 1995-01-13 | Pasteur Institut | Expression des récepteurs CD4 et CD26 dans des cellules recombinantes, inhibiteurs du récepteur CD26. |
| WO1995011689A1 (en) | 1993-10-29 | 1995-05-04 | Trustees Of Tufts College | Use of inhibitors of dipeptidyl-aminopeptidase to block entry of hiv into cells |
| NL9400309A (nl) | 1993-11-04 | 1995-06-01 | Eurogenetics Nv | Ligande die in staat is te binden aan de adenosine deaminase bindingsplaats van CD26. |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| US5489025A (en) * | 1994-03-01 | 1996-02-06 | Romick; Jerome M. | Unit-dose medication dispenser and multiple-dispenser frame therefor |
| FR2719049B1 (fr) | 1994-04-22 | 1996-06-14 | Pasteur Institut | Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules. |
| US5543396A (en) | 1994-04-28 | 1996-08-06 | Georgia Tech Research Corp. | Proline phosphonate derivatives |
| DE4416963C1 (de) | 1994-05-13 | 1995-07-13 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von enantiomerenreinen Diarylprolinolen |
| EP0764151A2 (en) | 1994-06-10 | 1997-03-26 | Universitaire Instelling Antwerpen | Purification of serine protease and synthetic inhibitors thereof |
| FR2721611B1 (fr) | 1994-06-22 | 1996-09-27 | Adir | Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent . |
| JPH11501506A (ja) * | 1994-12-12 | 1999-02-09 | ベス イスラエル デアコネス メディカル センター | キメラ型サイトカインおよびその利用 |
| US5856571A (en) | 1995-06-07 | 1999-01-05 | Cellpro, Incorporated | Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto |
| ATE204322T1 (de) | 1995-06-07 | 2001-09-15 | Aastrom Biosciences Inc | Vorrichtung und verfahren zum aufbewahren und zur züchtung biologischer zellen |
| AU722569B2 (en) * | 1995-12-29 | 2000-08-03 | Alg Company | Expansion of bone marrow stromal cells |
| US5965532A (en) * | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
| GB9624562D0 (en) * | 1996-11-27 | 1997-01-15 | Zeneca Ltd | Peptide derivatives |
| US6100234A (en) * | 1997-05-07 | 2000-08-08 | Tufts University | Treatment of HIV |
| US6040145A (en) * | 1997-05-07 | 2000-03-21 | Tufts University | Potentiation of the immune response |
| CA2304206A1 (en) | 1997-09-29 | 1999-04-08 | Point Therapeutics, Inc. | Stimulation of hematopoietic cells in vitro |
| CA2331122A1 (en) * | 1998-05-04 | 1999-11-11 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| EP1104293A1 (en) | 1998-08-21 | 2001-06-06 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| US20050084490A1 (en) | 2002-07-09 | 2005-04-21 | Point Therapeutics, Inc. | Boroproline compound combination therapy |
-
1999
- 1999-05-03 CA CA002331122A patent/CA2331122A1/en not_active Abandoned
- 1999-05-03 TW TW088107193A patent/TWI252107B/zh not_active IP Right Cessation
- 1999-05-03 IL IL13924799A patent/IL139247A0/xx unknown
- 1999-05-03 EP EP99921617A patent/EP1075266A1/en not_active Withdrawn
- 1999-05-03 WO PCT/US1999/009652 patent/WO1999056753A1/en not_active Ceased
- 1999-05-03 BR BR9910251-0A patent/BR9910251A/pt not_active Application Discontinuation
- 1999-05-03 US US09/304,199 patent/US6300314B1/en not_active Expired - Fee Related
- 1999-05-03 KR KR1020007012223A patent/KR20010052302A/ko not_active Ceased
- 1999-05-03 NZ NZ507730A patent/NZ507730A/xx unknown
- 1999-05-03 MY MYPI99001736A patent/MY132924A/en unknown
- 1999-05-03 JP JP2000546778A patent/JP2002513762A/ja active Pending
- 1999-05-03 AU AU38781/99A patent/AU770319C/en not_active Ceased
- 1999-05-04 PE PE1999000365A patent/PE20000481A1/es not_active Application Discontinuation
- 1999-05-04 AR ARP990102086A patent/AR023628A1/es unknown
-
2000
- 2000-10-31 NO NO20005488A patent/NO20005488L/no not_active Application Discontinuation
-
2001
- 2001-06-11 US US09/878,792 patent/US6770628B2/en not_active Expired - Fee Related
-
2004
- 2004-05-19 AU AU2004202138A patent/AU2004202138A1/en not_active Abandoned
- 2004-06-28 US US10/879,479 patent/US7067489B2/en not_active Expired - Fee Related
-
2006
- 2006-06-26 US US11/474,929 patent/US20070135354A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020013279A1 (en) | 2002-01-31 |
| TWI252107B (en) | 2006-04-01 |
| BR9910251A (pt) | 2001-01-02 |
| AU770319C (en) | 2004-11-25 |
| AU2004202138A1 (en) | 2004-06-10 |
| EP1075266A1 (en) | 2001-02-14 |
| WO1999056753A1 (en) | 1999-11-11 |
| US20050037976A1 (en) | 2005-02-17 |
| NO20005488L (no) | 2001-01-04 |
| NZ507730A (en) | 2004-02-27 |
| US7067489B2 (en) | 2006-06-27 |
| JP2002513762A (ja) | 2002-05-14 |
| NO20005488D0 (no) | 2000-10-31 |
| AU770319B2 (en) | 2004-02-19 |
| PE20000481A1 (es) | 2000-06-13 |
| AU3878199A (en) | 1999-11-23 |
| CA2331122A1 (en) | 1999-11-11 |
| US6770628B2 (en) | 2004-08-03 |
| KR20010052302A (ko) | 2001-06-25 |
| MY132924A (en) | 2007-10-31 |
| IL139247A0 (en) | 2001-11-25 |
| US20070135354A1 (en) | 2007-06-14 |
| US6300314B1 (en) | 2001-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR023628A1 (es) | Uso de un agente efectivo para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras para la preparacion de un medicamento utilpara estimular la hematopoyesis, util para incrementar el numero de celulas hematopoyeticas o celulas sanguineas maduras que acorta el tiempo en que | |
| KR100638684B1 (ko) | 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도 | |
| KR100355686B1 (ko) | 세트로렐릭스동결건조물의제조방법 | |
| TW359614B (en) | Composition containing benzimidazole compounds for rectal administration | |
| ES2002401A6 (es) | Procedimiento para preparar una composicion farmaceutica del tipo de transicion de fase loquido-gel por aumento de la fuerza ionica. | |
| PT85591A (en) | Process for the preparation of multiple unit dosage pharmaceutical compositions comprising as a pharmaceutilly active compound l-dopa | |
| ES8307491A1 (es) | Un metodo para preparar una composicion de gel acuoso semi- solido para alimentacion de heridos | |
| RU94046426A (ru) | Фармацевтические композиции, способы лечения лейкоза, способ повышения уровней стволовых клеток, антагонист с - kit - лиганда, антисмысловая нуклеиновая кислота, способ лечения меланомы, способ усиления трансфекции, способ переноса гена, способ увеличения уровней периферической крови, способ повышения уровней тромбоцитов, способы модификации биологической функции, способ лечения анемии, способ улучшения приживления костного мозга, способ ускорения восстановления костного мозга, способ лечения лейкопении | |
| CA2392050A1 (en) | Pharmaceutical formulations containing zolmitriptan | |
| DE04007657T1 (de) | Pharmazeutische Zusammensetzung aus fibrinolytischem Mittel | |
| WO1989010129A1 (en) | Pharmaceutical composition containing deoxyribonucleosides for wound healing | |
| EP0579830A1 (en) | Therapeutic agent for corneal lesion | |
| US6863891B2 (en) | Oligopeptide lyophilisate, their preparation and use | |
| US6270750B1 (en) | Proline-, glycine- and lysine-based pharmaceutical composition useful in dental treatment both in the injectable form and in the formulation for topical use | |
| JPH10265378A (ja) | 角膜上皮損傷治療剤 | |
| RU2002135669A (ru) | Олигопептиды | |
| US20150018287A1 (en) | Eye drops | |
| RU2005112720A (ru) | Фармацевтические композиции для улучшенного введения пептидов, происходящих от gp41 вич, и их использование в терапии | |
| AR005724A1 (es) | Derivados de ureido biologicamente activos utiles en el tratamiento de esclerosis multiple | |
| RU2008125169A (ru) | Терапевтическое средство для ускоренного заживления кожи, содержащее в качестве активного ингредиента грелин и его производные или вещество, воздействующее на рецептор ghs-r1а | |
| JPS60233017A (ja) | 更年期障害を治療するためのゴナドリベリンおよびゴナドリベリンアゴニストの使用 | |
| EP1530455B1 (en) | A pharmaceutical formulation and its use in the treatment of inner ear diseases | |
| KR101162389B1 (ko) | 손상된 결합조직 억제용 오르가노-실리콘의 용도 | |
| JPH01308235A (ja) | ヒト成長ホルモン経鼻剤 | |
| HU892527D0 (en) | Process for producing of low molecular weight prourochinase derivatives and manufacturing of pharmaceutical compositions comprising them as active ingredients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |