JP2002505100A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002505100A5 JP2002505100A5 JP2000534632A JP2000534632A JP2002505100A5 JP 2002505100 A5 JP2002505100 A5 JP 2002505100A5 JP 2000534632 A JP2000534632 A JP 2000534632A JP 2000534632 A JP2000534632 A JP 2000534632A JP 2002505100 A5 JP2002505100 A5 JP 2002505100A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- human
- embryonic
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cells Anatomy 0.000 description 82
- 210000000287 oocyte Anatomy 0.000 description 10
- 210000002950 fibroblast Anatomy 0.000 description 7
- 230000004069 differentiation Effects 0.000 description 6
- 102000016736 Cyclins Human genes 0.000 description 5
- 108050006400 Cyclins Proteins 0.000 description 5
- 210000004962 mammalian cells Anatomy 0.000 description 5
- 206010059512 Apoptosis Diseases 0.000 description 4
- -1 Bcl-w Proteins 0.000 description 4
- 102000006601 Thymidine Kinase Human genes 0.000 description 4
- 108020004440 Thymidine Kinase Proteins 0.000 description 4
- 230000006907 apoptotic process Effects 0.000 description 4
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 4
- 230000001809 detectable Effects 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- 230000001225 therapeutic Effects 0.000 description 4
- 101710041887 vBCL2 Proteins 0.000 description 4
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 101710032374 BCL2L1 Proteins 0.000 description 2
- 102100015655 BCL2L1 Human genes 0.000 description 2
- 102100007320 BNIP3 Human genes 0.000 description 2
- 101700007682 BNIP3 Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 210000003855 Cell Nucleus Anatomy 0.000 description 2
- 101710029818 DA18 Proteins 0.000 description 2
- 101700045225 DHX9 Proteins 0.000 description 2
- 102100017780 DHX9 Human genes 0.000 description 2
- 101700057458 Drice Proteins 0.000 description 2
- 101710012545 E1B Proteins 0.000 description 2
- 210000003981 Ectoderm Anatomy 0.000 description 2
- 210000001900 Endoderm Anatomy 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 241000283086 Equidae Species 0.000 description 2
- 101700002184 GATA4 Proteins 0.000 description 2
- 101700059151 HNF4A Proteins 0.000 description 2
- 210000002510 Keratinocytes Anatomy 0.000 description 2
- 101710025233 LLGL1 Proteins 0.000 description 2
- 101700031439 MCL1 Proteins 0.000 description 2
- 102100002383 MCL1 Human genes 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 210000003716 Mesoderm Anatomy 0.000 description 2
- 101710040019 ORF16 Proteins 0.000 description 2
- 241000283898 Ovis Species 0.000 description 2
- 206010061536 Parkinson's disease Diseases 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 101710028925 RP016 Proteins 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 101700074015 VPP Proteins 0.000 description 2
- 102100006622 VPS26A Human genes 0.000 description 2
- 101710012303 VPS26A Proteins 0.000 description 2
- 101700030690 YO02 Proteins 0.000 description 2
- 230000003213 activating Effects 0.000 description 2
- 230000001058 adult Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 101700069648 ced-9 Proteins 0.000 description 2
- 230000007159 enucleation Effects 0.000 description 2
- 210000002919 epithelial cells Anatomy 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 102000006495 integrins Human genes 0.000 description 2
- 108010044426 integrins Proteins 0.000 description 2
- 101700053671 manC Proteins 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 210000002569 neurons Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 101710027505 ywlE Proteins 0.000 description 2
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 description 1
- 206010001897 Alzheimer's disease Diseases 0.000 description 1
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010007709 Cartilage disease Diseases 0.000 description 1
- 206010007710 Cartilage injury Diseases 0.000 description 1
- 210000001612 Chondrocytes Anatomy 0.000 description 1
- 206010012601 Diabetes mellitus Diseases 0.000 description 1
- 210000001161 Embryo, Mammalian Anatomy 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N Ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
- 229960002963 Ganciclovir Drugs 0.000 description 1
- 210000003494 Hepatocytes Anatomy 0.000 description 1
- 201000001971 Huntington's disease Diseases 0.000 description 1
- 208000005230 Leg Ulcer Diseases 0.000 description 1
- 210000002751 Lymph Anatomy 0.000 description 1
- 210000004698 Lymphocytes Anatomy 0.000 description 1
- 208000003627 Muscular Dystrophy Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 210000004927 Skin cells Anatomy 0.000 description 1
- 206010040943 Skin ulcer Diseases 0.000 description 1
- 208000008513 Spinal Cord Injury Diseases 0.000 description 1
- 206010061367 Spinal cord disease Diseases 0.000 description 1
- 206010046566 Urinary tract disease Diseases 0.000 description 1
- 208000000207 Urologic Disease Diseases 0.000 description 1
- 201000003883 cystic fibrosis Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 210000002308 embryonic cell Anatomy 0.000 description 1
- 230000002496 gastric Effects 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 201000010238 heart disease Diseases 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 230000000968 intestinal Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 201000009673 liver disease Diseases 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 210000000663 muscle cells Anatomy 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 230000002485 urinary Effects 0.000 description 1
- 201000001923 urinary system disease Diseases 0.000 description 1
- 201000011528 vascular disease Diseases 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3294598A | 1998-03-02 | 1998-03-02 | |
US09/032,945 | 1998-03-02 | ||
PCT/US1999/004608 WO1999045100A1 (en) | 1998-03-02 | 1999-03-02 | Embryonic or stem-like cell lines produced by cross-species nuclear transplantation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002505100A JP2002505100A (ja) | 2002-02-19 |
JP2002505100A5 true JP2002505100A5 (zh) | 2006-06-15 |
Family
ID=21867727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000534632A Pending JP2002505100A (ja) | 1998-03-02 | 1999-03-02 | 種間核移植によって作製された胚性または幹細胞様細胞株 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1060243A4 (zh) |
JP (1) | JP2002505100A (zh) |
CN (1) | CN1299408A (zh) |
AU (1) | AU759322B2 (zh) |
BR (1) | BR9908499A (zh) |
CA (1) | CA2323094A1 (zh) |
IL (1) | IL138201A0 (zh) |
NZ (1) | NZ506808A (zh) |
WO (1) | WO1999045100A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003525031A (ja) * | 1999-09-14 | 2003-08-26 | ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス | 交雑種核移植によって産生された胚細胞または幹様細胞系及びドナー細胞の遺伝子改変または組織培養条件によって胚発達を増強する方法 |
BR0014864A (pt) * | 1999-10-15 | 2002-11-19 | Advanced Cell Tech Inc | Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem |
JP2004500066A (ja) * | 1999-12-20 | 2004-01-08 | ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ ア | 異種間核移植により生成する胚あるいは幹様細胞 |
US6921665B2 (en) | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
US6576464B2 (en) | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
AU2002250020A1 (en) * | 2001-02-02 | 2002-08-19 | Erik Forsberg | Method of cloning transgenic mammalian animals using pseudonuclei |
US20050066379A1 (en) * | 2001-11-06 | 2005-03-24 | Huizhen Sheng | Preparing somatic embryo by utilizing rabbit oocyte |
EP1443106A4 (en) | 2001-11-06 | 2005-04-27 | Univ Shanghai 2Nd Medical | EMBRYONIC STEM CELLS DERIVED FROM SOMATIC CELLS, AND DIFFERENTIATED CELLS THEREOF |
EP1490487A4 (en) * | 2002-04-01 | 2007-08-29 | Gtc Biotherapeutics Inc | METHOD FOR SELECTING CELLULAR LINES SUITABLE FOR CORE TRANSFER IN MAMMAL SPECIES |
WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
WO2013177228A1 (en) * | 2012-05-22 | 2013-11-28 | Loma Linda University | Generation of integration/transgene-free stem cells |
AU2015267148B2 (en) * | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5905042A (en) * | 1996-04-01 | 1999-05-18 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Cultured inner cell mass cell lines derived from bovine or porcine embryos |
WO1998007841A1 (en) * | 1996-08-19 | 1998-02-26 | University Of Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
EP0973871A1 (en) * | 1997-03-06 | 2000-01-26 | Infigen, Inc. | Method of cloning animals |
AU8587598A (en) * | 1997-07-26 | 1999-02-16 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
-
1999
- 1999-03-02 JP JP2000534632A patent/JP2002505100A/ja active Pending
- 1999-03-02 AU AU29795/99A patent/AU759322B2/en not_active Ceased
- 1999-03-02 CA CA002323094A patent/CA2323094A1/en not_active Abandoned
- 1999-03-02 CN CN99805691A patent/CN1299408A/zh active Pending
- 1999-03-02 EP EP99911062A patent/EP1060243A4/en not_active Withdrawn
- 1999-03-02 IL IL13820199A patent/IL138201A0/xx not_active IP Right Cessation
- 1999-03-02 BR BR9908499-6A patent/BR9908499A/pt not_active Application Discontinuation
- 1999-03-02 WO PCT/US1999/004608 patent/WO1999045100A1/en active IP Right Grant
- 1999-03-02 NZ NZ506808A patent/NZ506808A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Tian et al. | Cloning animals by somatic cell nuclear transfer–biological factors | |
Inoue et al. | Development of new inbred transgenic strains of rats with LacZ or GFP | |
US20060240556A1 (en) | Use of RNA interference for the creation of lineage specific ES and other undifferentiated cells and production of differentiated cells in vitro by co-culture | |
AU740709B2 (en) | Embryonic or stem-like cell lines produced by cross species nuclear transplanta tion | |
US20060247195A1 (en) | Method of altering cell properties by administering rna | |
JP2003503071A (ja) | 脱分化レシピエント細胞への細胞質移入 | |
JP2001509362A5 (zh) | ||
Chojnacka-Puchta et al. | CRISPR/Cas9 gene editing in a chicken model: current approaches and applications | |
JP2002537803A (ja) | 異種間核移植により産生される胚性細胞株あるいは幹様細胞株 | |
JP2001509361A (ja) | 分化した無血清飢餓細胞からの供与核を用いるクローニング | |
JP2002505100A5 (zh) | ||
JP2003508079A (ja) | 老年期体細胞からクローン化された動物中の細胞寿命のテロメア回復と延長 | |
Kawarasaki et al. | Profile of new green fluorescent protein transgenic Jinhua pigs as an imaging source | |
US20040072343A1 (en) | Cell reprogramming | |
CN1299408A (zh) | 通过异种间的核移植产生的胚细胞或干细胞样细胞系 | |
Skrzyszowska et al. | Generation of transgenic rabbits by the novel technique of chimeric somatic cell cloning | |
US20040040050A1 (en) | Production of agricultural animals from embryonic stem (es) cells | |
JP2004500038A (ja) | 選択したドナー細胞を用いる核移植 | |
Woessner | The Evolution of Patents on Life-Transgenic Animals, Clones and Stem Cells | |
KR20200132740A (ko) | 요산분해효소를 과발현하는 줄기세포를 유효성분으로 포함하는 통풍의 예방 또는 치료용 조성물 | |
JP2005523685A (ja) | 体細胞由来胚幹細胞及びそれらの分化子孫 | |
JP2006522609A (ja) | 動物の体細胞核移植と関係する紡錘体欠損を修正するための方法 | |
JP4321936B2 (ja) | 不死化血管周皮細胞株 | |
WO2023143637A1 (zh) | 一种实用型类脑微器官的构建与应用 | |
JP2003530848A (ja) | 同種異系の核及びミトコンドリアを含む多能細胞 |