JP2002504105A5 - - Google Patents

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Publication number
JP2002504105A5
JP2002504105A5 JP1999501538A JP50153899A JP2002504105A5 JP 2002504105 A5 JP2002504105 A5 JP 2002504105A5 JP 1999501538 A JP1999501538 A JP 1999501538A JP 50153899 A JP50153899 A JP 50153899A JP 2002504105 A5 JP2002504105 A5 JP 2002504105A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1999501538A
Other languages
English (en)
Japanese (ja)
Other versions
JP4548866B2 (ja
JP2002504105A (ja
Filing date
Publication date
Priority claimed from GBGB9711982.0A external-priority patent/GB9711982D0/en
Priority claimed from GBGB9714552.8A external-priority patent/GB9714552D0/en
Application filed filed Critical
Priority claimed from PCT/EP1998/003380 external-priority patent/WO1998056761A2/en
Publication of JP2002504105A publication Critical patent/JP2002504105A/ja
Publication of JP2002504105A5 publication Critical patent/JP2002504105A5/ja
Application granted granted Critical
Publication of JP4548866B2 publication Critical patent/JP4548866B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP50153899A 1997-06-10 1998-06-08 ベンゾイミダゾール誘導体 Expired - Lifetime JP4548866B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9711982.0A GB9711982D0 (en) 1997-06-10 1997-06-10 Benzimidazole derivatives
GB9711982.0 1997-06-10
GBGB9714552.8A GB9714552D0 (en) 1997-07-11 1997-07-11 Benzimidazole derivatives
GB9714552.8 1997-07-11
PCT/EP1998/003380 WO1998056761A2 (en) 1997-06-10 1998-06-08 Benzimidazole derivatives

Publications (3)

Publication Number Publication Date
JP2002504105A JP2002504105A (ja) 2002-02-05
JP2002504105A5 true JP2002504105A5 (enExample) 2006-01-05
JP4548866B2 JP4548866B2 (ja) 2010-09-22

Family

ID=26311687

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50153899A Expired - Lifetime JP4548866B2 (ja) 1997-06-10 1998-06-08 ベンゾイミダゾール誘導体

Country Status (34)

Country Link
US (1) US6455507B1 (enExample)
EP (1) EP0994890B1 (enExample)
JP (1) JP4548866B2 (enExample)
KR (1) KR20010020465A (enExample)
CN (1) CN1265665A (enExample)
AP (1) AP1262A (enExample)
AR (1) AR012964A1 (enExample)
AT (1) ATE246700T1 (enExample)
AU (1) AU740792C (enExample)
BR (1) BR9810745A (enExample)
CA (1) CA2293470C (enExample)
CO (1) CO4970737A1 (enExample)
DE (1) DE69816992T2 (enExample)
DK (1) DK0994890T3 (enExample)
EA (1) EA002305B1 (enExample)
EE (1) EE9900564A (enExample)
ES (1) ES2205527T3 (enExample)
HR (1) HRP980303B1 (enExample)
HU (1) HUP0002224A3 (enExample)
ID (1) ID24054A (enExample)
IL (1) IL133285A0 (enExample)
IS (1) IS5285A (enExample)
MA (1) MA26504A1 (enExample)
MY (1) MY132872A (enExample)
NO (1) NO314847B1 (enExample)
NZ (1) NZ501415A (enExample)
OA (1) OA11230A (enExample)
PE (1) PE84099A1 (enExample)
PL (1) PL337773A1 (enExample)
PT (1) PT994890E (enExample)
SK (1) SK171499A3 (enExample)
TR (1) TR199903053T2 (enExample)
TW (1) TW565566B (enExample)
WO (1) WO1998056761A2 (enExample)

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DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
CA2441177A1 (en) 2001-03-12 2002-09-19 Avanir Pharmaceuticals Benzimidazole compounds for modulating ige and inhibiting cellular proliferation
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
WO2004024655A2 (en) 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
WO2005012242A2 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica Nv Substituted benzimidazole-, benztriazole-, and benzimidazolone-o-glucosides
WO2005049582A1 (en) * 2003-11-14 2005-06-02 Auspex Pharmaceuticals, Inc. Method of preparation of novel nucleoside analogs and uses
KR100944301B1 (ko) * 2005-02-22 2010-02-24 더 리젠츠 오브 더 유니버시티 오브 미시간 Mdm2의 소분자 억제제 및 이의 용도
DE102005019549A1 (de) * 2005-04-25 2006-12-14 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Diaminobenzimidazol
WO2007070947A1 (en) * 2005-12-22 2007-06-28 Alchemia Ltd Antibacterial agents
US10238599B2 (en) 2006-01-19 2019-03-26 The Regents Of The University Of Michigan Composition and method for treating congenital cytomegalovirus induced hearing loss
US9889156B2 (en) 2006-01-19 2018-02-13 The Regents Of The University Of Michigan Method for treating noise-induced hearing loss (NIHL)
US8927528B2 (en) 2006-01-19 2015-01-06 The Regents Of The University Of Michigan Composition for treating hearing loss
USRE46372E1 (en) 2006-01-19 2017-04-25 The Regents Of The Univerity Of Michigan Method for treating hearing loss
US7951845B2 (en) 2006-01-19 2011-05-31 The Regents Of The University Of Michigan Composition and method of treating hearing loss
US9919008B2 (en) 2006-01-19 2018-03-20 The Regents Of The University Of Michigan Method for treating age-related hearing loss (ARHL)
US9770433B2 (en) 2006-01-19 2017-09-26 The Regents Of The University Of Michigan Composition and method for treating tinnitus
US8338397B2 (en) 2006-01-19 2012-12-25 The Regents Of The University Of Michigan Composition and method of treating side effects from antibiotic treatment
KR101654007B1 (ko) 2007-08-15 2016-09-05 아이오니스 파마수티컬즈, 인코포레이티드 테트라하이드로피란 핵산 유사체
WO2009100045A1 (en) * 2008-02-04 2009-08-13 Translational Genomics Research Institute Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
US8530640B2 (en) 2008-02-07 2013-09-10 Isis Pharmaceuticals, Inc. Bicyclic cyclohexitol nucleic acid analogs
JP5764064B2 (ja) 2008-09-26 2015-08-12 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 抗糖尿病薬として有用な新規な環状ベンゾイミダゾール誘導体
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
MX2011004505A (es) 2008-10-29 2011-05-31 Merck Sharp & Dohme Derivados novedosos de bencimidazol ciclico, utiles como agentes antidiabeticos.
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010090969A1 (en) 2009-02-06 2010-08-12 Isis Pharmaceuticals, Inc. Tetrahydropyran nucleic acid analogs
WO2010091308A2 (en) 2009-02-06 2010-08-12 Isis Pharmaceuticals, Inc. Oligomeric compounds and methods
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP6005628B2 (ja) 2010-04-28 2016-10-12 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US9382294B2 (en) 2013-03-01 2016-07-05 Los Alamos National Security, Llc Broad spectrum antibiotic compounds and use thereof
DK3137476T3 (da) 2014-04-28 2019-11-18 Ionis Pharmaceuticals Inc Linker-modificerede oligomerforbindelser
WO2016089845A1 (en) * 2014-12-01 2016-06-09 Virginia Commonwealth University A convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
EP3907230B1 (en) 2020-03-30 2024-08-28 Biometrix Technology Inc. Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same
KR102583547B1 (ko) 2020-03-30 2023-10-06 (주)바이오메트릭스 테크놀로지 신규한 벤지미다졸 유도체, 이의 제조방법 및 이의 항암제 용도
JP7376108B2 (ja) * 2020-06-23 2023-11-08 バイオメトリックス テクノロジーズ インコーポレイテッド 新規なベンズイミダゾール誘導体、その製造方法及びその抗癌剤または抗ウイルス剤としての用途
KR102449266B1 (ko) 2020-06-23 2022-09-30 (주)바이오메트릭스 테크놀로지 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법
KR102342313B1 (ko) 2021-08-27 2021-12-24 (주)바이오메트릭스 테크놀로지 벤지미다졸-탄수화물 결합체 화합물을 포함하는 미셀, 이의 제조방법, 이의 항암제 또는 항바이러스제로서의 용도
CN119119151A (zh) * 2024-09-04 2024-12-13 斯坦德药典标准物质研发(湖北)有限公司 一种马立巴韦的制备方法

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FR1491244A (fr) 1966-03-09 1967-08-11 Nouveaux benzimidazoles solubles
FR1476350A (fr) 1966-04-18 1967-04-07 Yale & Towne G M B H Ferme-porte automatique à frein
US3655901A (en) 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
DE2130030A1 (de) 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
ES8101067A1 (es) 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
EP0304624A3 (de) 1987-07-29 1989-03-22 F. Hoffmann-La Roche Ag Benzimidazol-2-yl-pyridiniumverbindungen
IT1226100B (it) 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
EP0521463A3 (en) * 1991-07-04 1993-04-14 Hoechst Aktiengesellschaft Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents
GB9205071D0 (en) 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
AU5447094A (en) 1992-10-21 1994-05-09 Regents Of The University Of Michigan, The Polysubstituted benzimidazoles as antiviral agents
US5399580A (en) 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides

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