CO4970737A1 - Derivados de bencimidazol - Google Patents
Derivados de bencimidazolInfo
- Publication number
- CO4970737A1 CO4970737A1 CO98032828A CO98032828A CO4970737A1 CO 4970737 A1 CO4970737 A1 CO 4970737A1 CO 98032828 A CO98032828 A CO 98032828A CO 98032828 A CO98032828 A CO 98032828A CO 4970737 A1 CO4970737 A1 CO 4970737A1
- Authority
- CO
- Colombia
- Prior art keywords
- 8alkyl
- hydrogen
- aryl
- alkyl
- haloc1
- Prior art date
Links
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 7
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000001627 3 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000001963 4 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- -1 C1-8alkoxy Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9711982.0A GB9711982D0 (en) | 1997-06-10 | 1997-06-10 | Benzimidazole derivatives |
| GBGB9714552.8A GB9714552D0 (en) | 1997-07-11 | 1997-07-11 | Benzimidazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4970737A1 true CO4970737A1 (es) | 2000-11-07 |
Family
ID=26311687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98032828A CO4970737A1 (es) | 1997-06-10 | 1998-06-09 | Derivados de bencimidazol |
Country Status (34)
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR19990081940A (ko) | 1996-01-23 | 1999-11-15 | 그레이엄 브레레톤, 레슬리 에드워즈 | 항바이러스제로서 변형된 벤즈이미다졸 누클레오시드 |
| CA2297076A1 (en) | 1997-07-30 | 1999-02-11 | The Regents Of The University Of Michigan | Lyxofuranosyl benzimidazoles as antiviral agents |
| DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
| GB0008939D0 (en) | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
| PT1368028E (pt) | 2001-03-12 | 2007-11-26 | Avanir Pharmaceuticals | Compostos de benzimidazole para modulação de ige e inibição da proliferação celular |
| AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| AU2004261663A1 (en) * | 2003-08-01 | 2005-02-10 | Janssen Pharmaceutica N.V. | Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides |
| US20110070192A1 (en) * | 2003-11-14 | 2011-03-24 | Bruno Tse | Method of preparation of novel nucleoside analogs and uses |
| WO2006091646A2 (en) * | 2005-02-22 | 2006-08-31 | The Regents Of The University Of Michigan | Small molecule inhibitors of mdm2 and uses thereof |
| DE102005019549A1 (de) * | 2005-04-25 | 2006-12-14 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Diaminobenzimidazol |
| WO2007070947A1 (en) * | 2005-12-22 | 2007-06-28 | Alchemia Ltd | Antibacterial agents |
| US8927528B2 (en) | 2006-01-19 | 2015-01-06 | The Regents Of The University Of Michigan | Composition for treating hearing loss |
| US8338397B2 (en) | 2006-01-19 | 2012-12-25 | The Regents Of The University Of Michigan | Composition and method of treating side effects from antibiotic treatment |
| US7951845B2 (en) | 2006-01-19 | 2011-05-31 | The Regents Of The University Of Michigan | Composition and method of treating hearing loss |
| US9889156B2 (en) | 2006-01-19 | 2018-02-13 | The Regents Of The University Of Michigan | Method for treating noise-induced hearing loss (NIHL) |
| US9919008B2 (en) | 2006-01-19 | 2018-03-20 | The Regents Of The University Of Michigan | Method for treating age-related hearing loss (ARHL) |
| US9770433B2 (en) | 2006-01-19 | 2017-09-26 | The Regents Of The University Of Michigan | Composition and method for treating tinnitus |
| US10238599B2 (en) | 2006-01-19 | 2019-03-26 | The Regents Of The University Of Michigan | Composition and method for treating congenital cytomegalovirus induced hearing loss |
| USRE46372E1 (en) | 2006-01-19 | 2017-04-25 | The Regents Of The Univerity Of Michigan | Method for treating hearing loss |
| CN101821277B (zh) | 2007-08-15 | 2014-05-07 | Isis制药公司 | 四氢吡喃核酸类似物 |
| WO2009100045A1 (en) * | 2008-02-04 | 2009-08-13 | Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
| EP2265627A2 (en) | 2008-02-07 | 2010-12-29 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexitol nucleic acid analogs |
| AU2009296820B2 (en) | 2008-09-26 | 2014-03-20 | Merck Sharp & Dohme Llc | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US8563746B2 (en) | 2008-10-29 | 2013-10-22 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| WO2010091308A2 (en) | 2009-02-06 | 2010-08-12 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
| US8536320B2 (en) | 2009-02-06 | 2013-09-17 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| JP6005628B2 (ja) | 2010-04-28 | 2016-10-12 | アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物 |
| US8546344B2 (en) | 2010-10-28 | 2013-10-01 | Viropharma Incorporated | Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole |
| WO2014134493A1 (en) * | 2013-03-01 | 2014-09-04 | Los Alamos National Security, Llc | Broad spectrum antibiotic compounds and use thereof |
| US9926556B2 (en) | 2014-04-28 | 2018-03-27 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds |
| WO2016089845A1 (en) * | 2014-12-01 | 2016-06-09 | Virginia Commonwealth University | A convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction |
| RU2629670C2 (ru) * | 2016-08-04 | 2017-08-31 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа |
| KR102583547B1 (ko) | 2020-03-30 | 2023-10-06 | (주)바이오메트릭스 테크놀로지 | 신규한 벤지미다졸 유도체, 이의 제조방법 및 이의 항암제 용도 |
| EP3907230B1 (en) * | 2020-03-30 | 2024-08-28 | Biometrix Technology Inc. | Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same |
| CN114096549A (zh) * | 2020-06-23 | 2022-02-25 | 博美利克斯技术公司 | 新型苯并咪唑衍生物、其制备方法及其作为抗癌剂或者抗病毒剂的用途 |
| KR102449266B1 (ko) | 2020-06-23 | 2022-09-30 | (주)바이오메트릭스 테크놀로지 | 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법 |
| KR102342313B1 (ko) | 2021-08-27 | 2021-12-24 | (주)바이오메트릭스 테크놀로지 | 벤지미다졸-탄수화물 결합체 화합물을 포함하는 미셀, 이의 제조방법, 이의 항암제 또는 항바이러스제로서의 용도 |
| CN119119151A (zh) * | 2024-09-04 | 2024-12-13 | 斯坦德药典标准物质研发(湖北)有限公司 | 一种马立巴韦的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1491244A (fr) | 1966-03-09 | 1967-08-11 | Nouveaux benzimidazoles solubles | |
| FR1476350A (fr) | 1966-04-18 | 1967-04-07 | Yale & Towne G M B H | Ferme-porte automatique à frein |
| US3655901A (en) | 1970-07-30 | 1972-04-11 | Merck & Co Inc | Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles |
| DE2130030A1 (de) | 1971-06-18 | 1972-12-21 | Bayer Ag | Fungizide und bakterizide Mittel |
| ES8101067A1 (es) | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| EP0304624A3 (de) | 1987-07-29 | 1989-03-22 | F. Hoffmann-La Roche Ag | Benzimidazol-2-yl-pyridiniumverbindungen |
| IT1226100B (it) | 1988-07-07 | 1990-12-10 | Dompe Farmaceutici Spa | Derivati benzimidazolici farmacologicamente attivi. |
| US5248672A (en) | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
| ZA923641B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| EP0521463A3 (en) | 1991-07-04 | 1993-04-14 | Hoechst Aktiengesellschaft | Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents |
| GB9205071D0 (en) | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| AU5447094A (en) | 1992-10-21 | 1994-05-09 | Regents Of The University Of Michigan, The | Polysubstituted benzimidazoles as antiviral agents |
| US5399580A (en) | 1993-03-08 | 1995-03-21 | Burroughs Wellcome Co. | Therapeutic nucleosides-uses |
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
-
1998
- 1998-06-08 DK DK98936306T patent/DK0994890T3/da active
- 1998-06-08 HU HU0002224A patent/HUP0002224A3/hu unknown
- 1998-06-08 CN CN98807910A patent/CN1265665A/zh active Pending
- 1998-06-08 NZ NZ501415A patent/NZ501415A/en unknown
- 1998-06-08 AP APAP/P/1999/001707A patent/AP1262A/en active
- 1998-06-08 TR TR1999/03053T patent/TR199903053T2/xx unknown
- 1998-06-08 PT PT98936306T patent/PT994890E/pt unknown
- 1998-06-08 CA CA002293470A patent/CA2293470C/en not_active Expired - Lifetime
- 1998-06-08 KR KR1019997011599A patent/KR20010020465A/ko not_active Ceased
- 1998-06-08 AU AU85360/98A patent/AU740792C/en not_active Ceased
- 1998-06-08 ID IDW20000038A patent/ID24054A/id unknown
- 1998-06-08 MA MA25102A patent/MA26504A1/fr unknown
- 1998-06-08 EP EP98936306A patent/EP0994890B1/en not_active Expired - Lifetime
- 1998-06-08 PL PL98337773A patent/PL337773A1/xx unknown
- 1998-06-08 IL IL13328598A patent/IL133285A0/xx unknown
- 1998-06-08 SK SK1714-99A patent/SK171499A3/sk unknown
- 1998-06-08 EE EEP199900564A patent/EE9900564A/xx unknown
- 1998-06-08 JP JP50153899A patent/JP4548866B2/ja not_active Expired - Lifetime
- 1998-06-08 EA EA199901031A patent/EA002305B1/ru not_active IP Right Cessation
- 1998-06-08 US US09/424,934 patent/US6455507B1/en not_active Expired - Lifetime
- 1998-06-08 ES ES98936306T patent/ES2205527T3/es not_active Expired - Lifetime
- 1998-06-08 BR BR9810745-3A patent/BR9810745A/pt not_active IP Right Cessation
- 1998-06-08 WO PCT/EP1998/003380 patent/WO1998056761A2/en not_active Ceased
- 1998-06-08 DE DE69816992T patent/DE69816992T2/de not_active Expired - Lifetime
- 1998-06-08 AT AT98936306T patent/ATE246700T1/de not_active IP Right Cessation
- 1998-06-09 MY MYPI98002560A patent/MY132872A/en unknown
- 1998-06-09 TW TW087109162A patent/TW565566B/zh not_active IP Right Cessation
- 1998-06-09 HR HR980303A patent/HRP980303B1/xx not_active IP Right Cessation
- 1998-06-09 PE PE1998000488A patent/PE84099A1/es not_active Application Discontinuation
- 1998-06-09 CO CO98032828A patent/CO4970737A1/es unknown
- 1998-06-10 AR ARP980102756A patent/AR012964A1/es not_active Application Discontinuation
-
1999
- 1999-12-06 IS IS5285A patent/IS5285A/is unknown
- 1999-12-09 NO NO19996086A patent/NO314847B1/no not_active IP Right Cessation
- 1999-12-09 OA OA9900275A patent/OA11230A/en unknown
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