JP2002501535A - 選択結合性超音波造影剤 - Google Patents
選択結合性超音波造影剤Info
- Publication number
- JP2002501535A JP2002501535A JP50084899A JP50084899A JP2002501535A JP 2002501535 A JP2002501535 A JP 2002501535A JP 50084899 A JP50084899 A JP 50084899A JP 50084899 A JP50084899 A JP 50084899A JP 2002501535 A JP2002501535 A JP 2002501535A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- biomolecule
- lipid
- microbubble shell
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/863,647 US6245318B1 (en) | 1997-05-27 | 1997-05-27 | Selectively binding ultrasound contrast agents |
| US08/863,647 | 1997-05-27 | ||
| PCT/US1998/010745 WO1998053857A1 (en) | 1997-05-27 | 1998-05-27 | Selectively binding ultrasound contrast agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002501535A true JP2002501535A (ja) | 2002-01-15 |
| JP2002501535A5 JP2002501535A5 (https=) | 2005-12-08 |
Family
ID=25341485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50084899A Pending JP2002501535A (ja) | 1997-05-27 | 1998-05-27 | 選択結合性超音波造影剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6245318B1 (https=) |
| EP (1) | EP0988062A4 (https=) |
| JP (1) | JP2002501535A (https=) |
| AU (1) | AU7600798A (https=) |
| CA (1) | CA2288013A1 (https=) |
| WO (1) | WO1998053857A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521338A (ja) * | 2004-01-07 | 2007-08-02 | アンビット バイオサイエンシス コーポレーション | 共役化された低分子 |
| JP2009529668A (ja) * | 2006-03-10 | 2009-08-20 | マギル ユニバーシティー | 超音波分子センサーおよびその使用 |
| JP2016503783A (ja) * | 2012-12-21 | 2016-02-08 | シェミン イェ,ジェームズ | 微粒子組成物 |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6261537B1 (en) * | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
| US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| US20070036722A1 (en) * | 1996-10-28 | 2007-02-15 | Pal Rongved | Separation processes |
| WO1999013918A2 (en) * | 1997-09-18 | 1999-03-25 | University Of Pittsburgh | Icam-1 selective echogenic microbubbles |
| CA2727746A1 (en) * | 1998-12-18 | 2000-06-22 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
| US6306132B1 (en) | 1999-06-17 | 2001-10-23 | Vivant Medical | Modular biopsy and microwave ablation needle delivery apparatus adapted to in situ assembly and method of use |
| AU2001263762A1 (en) * | 2000-05-02 | 2001-11-12 | Hahn-Meitner-Institut Berlin Gmbh | Molecular arrangement with a structural configuration and use thereof for quantum-mechanical information processing |
| US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| AU2001266696A1 (en) | 2000-06-02 | 2001-12-11 | Bracco Research Usa | Compounds for targeting endothelial cells |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| US6878147B2 (en) | 2001-11-02 | 2005-04-12 | Vivant Medical, Inc. | High-strength microwave antenna assemblies |
| US20080193490A1 (en) * | 2002-02-14 | 2008-08-14 | Andreas Hirsch | Use of Carbon Nanotube for Drug Delivery |
| US20040166152A1 (en) * | 2002-02-14 | 2004-08-26 | Andreas Hirsch | Use of buckysome or carbon nanotube for drug delivery |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| CA2666005C (en) | 2002-03-01 | 2016-01-19 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US20050100963A1 (en) * | 2002-03-01 | 2005-05-12 | Dyax Corporation | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US6752767B2 (en) | 2002-04-16 | 2004-06-22 | Vivant Medical, Inc. | Localization element with energized tip |
| US7197363B2 (en) | 2002-04-16 | 2007-03-27 | Vivant Medical, Inc. | Microwave antenna having a curved configuration |
| AU2003251858A1 (en) * | 2002-07-11 | 2004-02-02 | Targeson, Llc | Microbubble compositions, and methods for preparing and using same |
| EP2290100B1 (en) * | 2002-11-01 | 2014-02-19 | Iris International, Inc. | Kits for displacement Sandwich Immuno-PCR |
| CA2509248A1 (en) | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Polymeric reagents comprising a ketone or a related functional group |
| US7141612B2 (en) * | 2002-12-31 | 2006-11-28 | 3M Innovative Properties Company | Stabilized foams including surface-modified organic molecules |
| US7129277B2 (en) * | 2002-12-31 | 2006-10-31 | 3M Innovative Properties Company | Emulsions including surface-modified inorganic nanoparticles |
| US7001580B2 (en) * | 2002-12-31 | 2006-02-21 | 3M Innovative Properties Company | Emulsions including surface-modified organic molecules |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US7462703B2 (en) * | 2003-01-31 | 2008-12-09 | Max-Delbruck-Centrum Fur Molekulare Medizin | Agent for gene transfer |
| US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| JP4670083B2 (ja) * | 2003-02-04 | 2011-04-13 | ブラッコ・シュイス・ソシエテ・アノニム | 超音波造影剤およびその製造方法 |
| PT2949658T (pt) | 2003-03-03 | 2018-10-18 | Bracco Suisse Sa | Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos |
| US7311703B2 (en) | 2003-07-18 | 2007-12-25 | Vivant Medical, Inc. | Devices and methods for cooling microwave antennas |
| CN100563718C (zh) * | 2003-12-22 | 2009-12-02 | 伯拉考开发股份有限公司 | 用于反差成像的充气微囊组件 |
| US9248204B2 (en) * | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
| AU2005292083A1 (en) * | 2004-09-29 | 2006-04-13 | Alza Corporation | Microparticles and nanoparticles containing a lipopolymer |
| DE602005023529D1 (de) * | 2004-11-03 | 2010-10-21 | Iris Molecular Diagnostics Inc | Homogener nachweis von analyten |
| CN103091485A (zh) * | 2004-11-03 | 2013-05-08 | 艾瑞斯国际有限公司 | 用于亲和分离的微泡 |
| US20060140867A1 (en) * | 2004-12-28 | 2006-06-29 | Helfer Jeffrey L | Coated stent assembly and coating materials |
| US8257338B2 (en) * | 2006-10-27 | 2012-09-04 | Artenga, Inc. | Medical microbubble generation |
| JP5242408B2 (ja) | 2005-12-09 | 2013-07-24 | ブラッコ・スイス・ソシエテ・アノニム | ターゲットベクター・リン脂質コンジュゲート |
| US8068921B2 (en) | 2006-09-29 | 2011-11-29 | Vivant Medical, Inc. | Microwave antenna assembly and method of using the same |
| US8293214B2 (en) | 2006-12-19 | 2012-10-23 | Bracco Suisse S.A. | Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds |
| US8292880B2 (en) | 2007-11-27 | 2012-10-23 | Vivant Medical, Inc. | Targeted cooling of deployable microwave antenna |
| CN103884840A (zh) * | 2008-02-21 | 2014-06-25 | 艾瑞斯国际有限公司 | 早期确定前列腺癌治疗后复发的方法 |
| MX2010012473A (es) | 2008-05-23 | 2011-02-23 | Siwa Corp | Metodos, composiciones y aparato para facilitar la regeneracion. |
| EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| WO2010042815A2 (en) * | 2008-10-09 | 2010-04-15 | Duke University | Vhh antibody fragments for use in the detection and treatment of cancer |
| EP2470287A4 (en) | 2009-08-28 | 2015-01-21 | Univ Columbia | SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES |
| WO2011028690A1 (en) | 2009-09-01 | 2011-03-10 | The Trustees Of Columbia University In The City Of New York | Microbubble devices, methods and systems |
| US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
| EP2345732A1 (en) | 2010-01-19 | 2011-07-20 | Universite Paris Descartes | Methods for intracellular delivery of nucleic acids |
| BR112013002945A2 (pt) | 2010-08-09 | 2016-06-07 | Inst Nat Sante Rech Med | composição farmacâutica formulada com agente de eco-contraste de microbolhas e um ácido nucleico terapêutico de interesse para uso em um método para tratamento de uma doença ocular em um sujeito |
| US9649376B2 (en) | 2010-09-27 | 2017-05-16 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
| US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
| EP2748299B1 (en) | 2011-08-24 | 2018-03-14 | The Regents of The University of California | Targeting microbubbles |
| WO2014065513A1 (ko) * | 2012-10-25 | 2014-05-01 | 서강대학교 산학협력단 | 약물을 함유한 나노입자가 결합된 초음파 조영제 및 이의 제조방법 |
| US10471163B2 (en) | 2013-09-13 | 2019-11-12 | The General Hospital Corporation | Activatable fibrin-binding probes |
| WO2015198153A2 (en) | 2014-01-28 | 2015-12-30 | Targeson, Inc. | Isolation of cells and biological substances using buoyant microbubbles |
| WO2015134671A1 (en) | 2014-03-04 | 2015-09-11 | Targeson, Inc. | Molecular imaging contrast agents and uses thereof |
| JP6557681B2 (ja) | 2014-05-10 | 2019-08-07 | ダイアグノロジックス・エルエルシー | 浮力を用いて薬剤を単離または濃縮するためのシステムおよび装置 |
| AU2015292498B2 (en) | 2014-07-23 | 2020-11-05 | Ohio State Innovation Foundation | Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (TAG-72) |
| CN107001459B (zh) | 2014-09-19 | 2021-11-23 | Siwa有限公司 | 用于治疗炎症和自身免疫紊乱的抗age抗体 |
| US10052394B2 (en) | 2014-11-21 | 2018-08-21 | General Electric Company | Microbubble tether for diagnostic and therapeutic applications |
| US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
| US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
| WO2016118947A1 (en) | 2015-01-23 | 2016-07-28 | The University Of North Carolina At Chapel Hill | Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects |
| EP3310794B1 (en) | 2015-06-18 | 2025-08-06 | California Institute of Technology | Synthesis and application of microbubble-forming compounds |
| PT3337829T (pt) | 2016-02-19 | 2020-02-10 | Siwa Corp | Método e composição para o tratamento do cancro, matando células cancerosas metastáticas e prevenindo as metástases do cancro usando anticorpos para produtos finais de glicação avançada (pga) |
| CA3057829A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
| WO2017222535A1 (en) | 2016-06-23 | 2017-12-28 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
| US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
| US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
| US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
| US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
| CA3059803A1 (en) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| US12150813B2 (en) | 2019-05-10 | 2024-11-26 | The University Of North Carolina At Chapel Hill | Methods, systems, and computer readable media for generating super-resolution images of microvasculature using ultrasound |
| CN114364383A (zh) * | 2019-06-05 | 2022-04-15 | 微脉管治疗有限公司 | 检测和治疗血栓形成和血管斑块的组合物和方法 |
| US10953023B1 (en) | 2020-01-28 | 2021-03-23 | Applaud Medical, Inc. | Phospholipid compounds and formulations |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853228A (en) * | 1987-07-28 | 1989-08-01 | Micro-Pak, Inc. | Method of manufacturing unilamellar lipid vesicles |
| US5620689A (en) * | 1989-10-20 | 1997-04-15 | Sequus Pharmaceuuticals, Inc. | Liposomes for treatment of B-cell and T-cell disorders |
| US5656211A (en) * | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
| IN172208B (https=) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| BR9405798A (pt) * | 1993-02-22 | 1995-12-12 | Vivorx Pharmaceuticals Inc | Métodos para liberação in vivo de material biológico e composições úteis dos mesmos |
| EP0727225A3 (en) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
| CA2218541A1 (en) * | 1995-06-07 | 1996-12-19 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
| US6083484A (en) * | 1996-10-17 | 2000-07-04 | Molecular Biosystems, Inc. | Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents |
| GB9622368D0 (en) | 1996-10-28 | 1997-01-08 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| EP0973552B1 (en) * | 1996-10-28 | 2006-03-01 | Amersham Health AS | Improvements in or relating to diagnostic/therapeutic agents |
| GB9708265D0 (en) | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
-
1997
- 1997-05-27 US US08/863,647 patent/US6245318B1/en not_active Expired - Lifetime
-
1998
- 1998-05-27 AU AU76007/98A patent/AU7600798A/en not_active Abandoned
- 1998-05-27 CA CA002288013A patent/CA2288013A1/en not_active Abandoned
- 1998-05-27 WO PCT/US1998/010745 patent/WO1998053857A1/en not_active Ceased
- 1998-05-27 JP JP50084899A patent/JP2002501535A/ja active Pending
- 1998-05-27 EP EP98923799A patent/EP0988062A4/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521338A (ja) * | 2004-01-07 | 2007-08-02 | アンビット バイオサイエンシス コーポレーション | 共役化された低分子 |
| JP2009529668A (ja) * | 2006-03-10 | 2009-08-20 | マギル ユニバーシティー | 超音波分子センサーおよびその使用 |
| JP2016503783A (ja) * | 2012-12-21 | 2016-02-08 | シェミン イェ,ジェームズ | 微粒子組成物 |
| CN109999206A (zh) * | 2012-12-21 | 2019-07-12 | 叶学明 | 微粒组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0988062A4 (en) | 2003-04-23 |
| AU7600798A (en) | 1998-12-30 |
| WO1998053857A1 (en) | 1998-12-03 |
| CA2288013A1 (en) | 1998-12-03 |
| EP0988062A1 (en) | 2000-03-29 |
| US6245318B1 (en) | 2001-06-12 |
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