JP2002501535A - 選択結合性超音波造影剤 - Google Patents
選択結合性超音波造影剤Info
- Publication number
- JP2002501535A JP2002501535A JP50084899A JP50084899A JP2002501535A JP 2002501535 A JP2002501535 A JP 2002501535A JP 50084899 A JP50084899 A JP 50084899A JP 50084899 A JP50084899 A JP 50084899A JP 2002501535 A JP2002501535 A JP 2002501535A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- biomolecule
- lipid
- microbubble shell
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/863,647 | 1997-05-27 | ||
| US08/863,647 US6245318B1 (en) | 1997-05-27 | 1997-05-27 | Selectively binding ultrasound contrast agents |
| PCT/US1998/010745 WO1998053857A1 (en) | 1997-05-27 | 1998-05-27 | Selectively binding ultrasound contrast agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002501535A true JP2002501535A (ja) | 2002-01-15 |
| JP2002501535A5 JP2002501535A5 (https=) | 2005-12-08 |
Family
ID=25341485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50084899A Pending JP2002501535A (ja) | 1997-05-27 | 1998-05-27 | 選択結合性超音波造影剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6245318B1 (https=) |
| EP (1) | EP0988062A4 (https=) |
| JP (1) | JP2002501535A (https=) |
| AU (1) | AU7600798A (https=) |
| CA (1) | CA2288013A1 (https=) |
| WO (1) | WO1998053857A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521338A (ja) * | 2004-01-07 | 2007-08-02 | アンビット バイオサイエンシス コーポレーション | 共役化された低分子 |
| JP2009529668A (ja) * | 2006-03-10 | 2009-08-20 | マギル ユニバーシティー | 超音波分子センサーおよびその使用 |
| JP2016503783A (ja) * | 2012-12-21 | 2016-02-08 | シェミン イェ,ジェームズ | 微粒子組成物 |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6261537B1 (en) * | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
| US20070036722A1 (en) * | 1996-10-28 | 2007-02-15 | Pal Rongved | Separation processes |
| US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| AU9400798A (en) * | 1997-09-18 | 1999-04-05 | University Of Pittsburgh | Icam-1 selective echogenic microbubbles |
| EP1140204A2 (en) * | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
| US6306132B1 (en) * | 1999-06-17 | 2001-10-23 | Vivant Medical | Modular biopsy and microwave ablation needle delivery apparatus adapted to in situ assembly and method of use |
| JP2003532648A (ja) * | 2000-05-02 | 2003-11-05 | ハーン−マイトネル−インスチツート ベルリン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 構造形成した分子配列及び量子力学的情報処理のためのその使用 |
| US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| US7109167B2 (en) | 2000-06-02 | 2006-09-19 | Bracco International B.V. | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| US6878147B2 (en) | 2001-11-02 | 2005-04-12 | Vivant Medical, Inc. | High-strength microwave antenna assemblies |
| US20040166152A1 (en) * | 2002-02-14 | 2004-08-26 | Andreas Hirsch | Use of buckysome or carbon nanotube for drug delivery |
| US20080193490A1 (en) * | 2002-02-14 | 2008-08-14 | Andreas Hirsch | Use of Carbon Nanotube for Drug Delivery |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| AU2003278807A1 (en) | 2002-03-01 | 2004-08-13 | Bracco International B.V. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| ES2398393T3 (es) | 2002-03-01 | 2013-03-15 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7197363B2 (en) | 2002-04-16 | 2007-03-27 | Vivant Medical, Inc. | Microwave antenna having a curved configuration |
| US6752767B2 (en) | 2002-04-16 | 2004-06-22 | Vivant Medical, Inc. | Localization element with energized tip |
| AU2003251858A1 (en) * | 2002-07-11 | 2004-02-02 | Targeson, Llc | Microbubble compositions, and methods for preparing and using same |
| AU2003296925A1 (en) * | 2002-11-01 | 2004-06-07 | Leucadia Technologies, Inc. | Displacement sandwich immuno-pcr |
| EP1581260B1 (en) | 2002-12-31 | 2014-09-17 | Nektar Therapeutics | Polymeric reagents comprising a ketone or a related functional group |
| US7129277B2 (en) * | 2002-12-31 | 2006-10-31 | 3M Innovative Properties Company | Emulsions including surface-modified inorganic nanoparticles |
| US7001580B2 (en) * | 2002-12-31 | 2006-02-21 | 3M Innovative Properties Company | Emulsions including surface-modified organic molecules |
| US7141612B2 (en) * | 2002-12-31 | 2006-11-28 | 3M Innovative Properties Company | Stabilized foams including surface-modified organic molecules |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US7462703B2 (en) * | 2003-01-31 | 2008-12-09 | Max-Delbruck-Centrum Fur Molekulare Medizin | Agent for gene transfer |
| DE602004029010D1 (de) * | 2003-02-04 | 2010-10-21 | Bracco Suisse Sa | Ultraschall kontrastmittel und verfahren zur erstellung |
| US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| ES2396368T3 (es) | 2003-03-03 | 2013-02-21 | Dyax Corporation | Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos |
| US7311703B2 (en) | 2003-07-18 | 2007-12-25 | Vivant Medical, Inc. | Devices and methods for cooling microwave antennas |
| CA2547024C (en) * | 2003-12-22 | 2013-12-17 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
| JP4837663B2 (ja) * | 2004-08-18 | 2011-12-14 | ブラッコ・シュイス・ソシエテ・アノニム | 造影画像化のためのガス充填微小胞組成物 |
| WO2006039369A1 (en) * | 2004-09-29 | 2006-04-13 | Alza Corporation | Microparticles and nanoparticles containing a lipopolymer |
| EP2302078B1 (en) * | 2004-11-03 | 2015-07-15 | Iris Molecular Diagnostics, Inc. | Microbubbles for affinity concentration |
| DK1842226T3 (da) * | 2004-11-03 | 2010-10-18 | Iris Molecular Diagnostics Inc | Homogen analytpåvisning |
| US20060140867A1 (en) * | 2004-12-28 | 2006-06-29 | Helfer Jeffrey L | Coated stent assembly and coating materials |
| US8257338B2 (en) * | 2006-10-27 | 2012-09-04 | Artenga, Inc. | Medical microbubble generation |
| CA2631716C (en) | 2005-12-09 | 2013-11-26 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US8068921B2 (en) | 2006-09-29 | 2011-11-29 | Vivant Medical, Inc. | Microwave antenna assembly and method of using the same |
| EP2117603A2 (en) | 2006-12-19 | 2009-11-18 | Bracco International B.V. | Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds |
| US8292880B2 (en) | 2007-11-27 | 2012-10-23 | Vivant Medical, Inc. | Targeted cooling of deployable microwave antenna |
| CN103884840A (zh) * | 2008-02-21 | 2014-06-25 | 艾瑞斯国际有限公司 | 早期确定前列腺癌治疗后复发的方法 |
| RU2553225C2 (ru) | 2008-05-23 | 2015-06-10 | Сива Корпорейшн | Способ облегчения регенерации |
| EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| WO2010042815A2 (en) * | 2008-10-09 | 2010-04-15 | Duke University | Vhh antibody fragments for use in the detection and treatment of cancer |
| WO2011025893A1 (en) | 2009-08-28 | 2011-03-03 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for production of gas-filled microbubbles |
| WO2011028690A1 (en) * | 2009-09-01 | 2011-03-10 | The Trustees Of Columbia University In The City Of New York | Microbubble devices, methods and systems |
| US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
| EP2345732A1 (en) | 2010-01-19 | 2011-07-20 | Universite Paris Descartes | Methods for intracellular delivery of nucleic acids |
| PT2603238E (pt) | 2010-08-09 | 2014-10-22 | Inserm Inst Nat De La Santé Et De La Rech Médicale | Métodos e composições farmacêuticas para o tratamento de uma doença ocular num indíviduo |
| ES2725852T3 (es) | 2010-09-27 | 2019-09-27 | Siwa Corp | Eliminación selectiva de células modificadas por AGE para el tratamiento de la aterosclerosis |
| US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
| CN103917637B (zh) | 2011-08-24 | 2016-08-17 | 加州理工学院 | 靶向微泡 |
| US20150343079A1 (en) * | 2012-10-25 | 2015-12-03 | Sogang University Research Foundation | Ultrasound contrast agent with nanoparticles including drug and method for preparing the same |
| WO2015038968A1 (en) | 2013-09-13 | 2015-03-19 | The General Hospital Corporation | Activatable fibrin-binding probes |
| US20150219636A1 (en) | 2014-01-28 | 2015-08-06 | Targeson, Inc. | Isolation of cells and biological substances using buoyant microbubbles |
| US10265424B2 (en) | 2014-03-04 | 2019-04-23 | Trust-Biosonics, Inc. | Molecular imaging contrast agents and uses thereof |
| JP6557681B2 (ja) | 2014-05-10 | 2019-08-07 | ダイアグノロジックス・エルエルシー | 浮力を用いて薬剤を単離または濃縮するためのシステムおよび装置 |
| CA2956161A1 (en) | 2014-07-23 | 2016-01-28 | Ohio State Innovation Foundation | Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72) |
| EP3194439B1 (en) | 2014-09-19 | 2022-01-19 | Siwa Corporation | Anti-age antibodies for treating inflammation and auto-immune disorders |
| US10052394B2 (en) | 2014-11-21 | 2018-08-21 | General Electric Company | Microbubble tether for diagnostic and therapeutic applications |
| US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
| US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
| EP3247281B1 (en) | 2015-01-23 | 2020-12-02 | The University of North Carolina at Chapel Hill | Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects |
| US10646432B2 (en) | 2015-06-18 | 2020-05-12 | California Institute Of Technology | Synthesis and application of microbubble-forming compounds |
| HUE058854T2 (hu) | 2016-02-19 | 2022-09-28 | Siwa Corp | Módszer és készítmény a rák kezelésére, az áttétes rákos sejtek elpusztítására és a rák áttétképzõdésének megelõzésére a fejlett glikációs végtermékek (AGE) elleni antitest alkalmazásával |
| KR20180133452A (ko) | 2016-04-15 | 2018-12-14 | 시와 코퍼레이션 | 신경퇴행성 질환을 치료하기 위한 항-노화 항체 |
| JP2019518763A (ja) | 2016-06-23 | 2019-07-04 | シワ コーポレーション | 様々な疾患及び障害の治療において使用するためのワクチン |
| US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
| US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
| US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
| US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
| CA3059803A1 (en) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| WO2020231954A1 (en) | 2019-05-10 | 2020-11-19 | The University Of North Carolina At Chapel Hill Office Of Technology Commercialization | Methods, systems, and computer readable media for generating images of microvasculature using ultrasound |
| AU2020288807B2 (en) * | 2019-06-05 | 2025-05-08 | Microvascular Therapeutics, Llc | Compositions and methods of detecting and treating thrombosis and vascular plaques |
| US10953023B1 (en) | 2020-01-28 | 2021-03-23 | Applaud Medical, Inc. | Phospholipid compounds and formulations |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853228A (en) * | 1987-07-28 | 1989-08-01 | Micro-Pak, Inc. | Method of manufacturing unilamellar lipid vesicles |
| US5620689A (en) * | 1989-10-20 | 1997-04-15 | Sequus Pharmaceuuticals, Inc. | Liposomes for treatment of B-cell and T-cell disorders |
| US5656211A (en) * | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
| IN172208B (https=) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| NZ262679A (en) * | 1993-02-22 | 1997-08-22 | Vivorx Pharmaceuticals Inc | Compositions for in vivo delivery of pharmaceutical agents where the agents are contained in a polymeric shell |
| EP0727225A3 (en) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
| EP0831932B1 (en) * | 1995-06-07 | 2004-05-06 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
| US6083484A (en) * | 1996-10-17 | 2000-07-04 | Molecular Biosystems, Inc. | Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents |
| GB9708265D0 (en) | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| WO1998018501A2 (en) * | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| GB9622368D0 (en) | 1996-10-28 | 1997-01-08 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
-
1997
- 1997-05-27 US US08/863,647 patent/US6245318B1/en not_active Expired - Lifetime
-
1998
- 1998-05-27 EP EP98923799A patent/EP0988062A4/en not_active Withdrawn
- 1998-05-27 CA CA002288013A patent/CA2288013A1/en not_active Abandoned
- 1998-05-27 AU AU76007/98A patent/AU7600798A/en not_active Abandoned
- 1998-05-27 WO PCT/US1998/010745 patent/WO1998053857A1/en not_active Ceased
- 1998-05-27 JP JP50084899A patent/JP2002501535A/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521338A (ja) * | 2004-01-07 | 2007-08-02 | アンビット バイオサイエンシス コーポレーション | 共役化された低分子 |
| JP2009529668A (ja) * | 2006-03-10 | 2009-08-20 | マギル ユニバーシティー | 超音波分子センサーおよびその使用 |
| JP2016503783A (ja) * | 2012-12-21 | 2016-02-08 | シェミン イェ,ジェームズ | 微粒子組成物 |
| CN109999206A (zh) * | 2012-12-21 | 2019-07-12 | 叶学明 | 微粒组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US6245318B1 (en) | 2001-06-12 |
| EP0988062A1 (en) | 2000-03-29 |
| EP0988062A4 (en) | 2003-04-23 |
| CA2288013A1 (en) | 1998-12-03 |
| AU7600798A (en) | 1998-12-30 |
| WO1998053857A1 (en) | 1998-12-03 |
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