JP2002501379A5 - - Google Patents
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- Publication number
- JP2002501379A5 JP2002501379A5 JP1998544308A JP54430898A JP2002501379A5 JP 2002501379 A5 JP2002501379 A5 JP 2002501379A5 JP 1998544308 A JP1998544308 A JP 1998544308A JP 54430898 A JP54430898 A JP 54430898A JP 2002501379 A5 JP2002501379 A5 JP 2002501379A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Description
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4370097P | 1997-04-16 | 1997-04-16 | |
| US60/043,700 | 1997-04-16 | ||
| PCT/US1998/007723 WO1998046722A1 (en) | 1997-04-16 | 1998-04-15 | Direct expression of peptides into culture media |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011245398A Division JP5634971B2 (ja) | 1997-04-16 | 2011-11-09 | 培地へのペプチドの直接発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002501379A JP2002501379A (ja) | 2002-01-15 |
| JP2002501379A5 true JP2002501379A5 (ja) | 2005-11-10 |
| JP4907751B2 JP4907751B2 (ja) | 2012-04-04 |
Family
ID=21928441
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54430898A Expired - Lifetime JP4907751B2 (ja) | 1997-04-16 | 1998-04-15 | 培地へのペプチドの直接発現 |
| JP2011245398A Expired - Lifetime JP5634971B2 (ja) | 1997-04-16 | 2011-11-09 | 培地へのペプチドの直接発現 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011245398A Expired - Lifetime JP5634971B2 (ja) | 1997-04-16 | 2011-11-09 | 培地へのペプチドの直接発現 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US6103495A (ja) |
| EP (2) | EP2088188B1 (ja) |
| JP (2) | JP4907751B2 (ja) |
| AT (2) | ATE484572T1 (ja) |
| AU (1) | AU742270B2 (ja) |
| CA (1) | CA2285658C (ja) |
| DE (1) | DE69841939D1 (ja) |
| DK (2) | DK2088188T3 (ja) |
| ES (1) | ES2375330T3 (ja) |
| HU (1) | HUP0001272A3 (ja) |
| LT (1) | LT4701B (ja) |
| NO (1) | NO327325B1 (ja) |
| RU (1) | RU2218407C2 (ja) |
| WO (1) | WO1998046722A1 (ja) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE484572T1 (de) * | 1997-04-16 | 2010-10-15 | Unigene Lab Inc | Direkte expression von peptiden ins kulturmedium |
| KR100385298B1 (ko) * | 2000-09-05 | 2003-05-23 | 한국생명공학연구원 | 단백질 생산방법 |
| US7166575B2 (en) * | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| TW200411053A (en) | 2002-12-30 | 2004-07-01 | Ind Tech Res Inst | Nucleic acid encoding recombinant salmon calcitionin, expression vector thereof, and method for producing recombinant salmon calcitonin therewith |
| US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| EP1758927A4 (en) * | 2004-01-21 | 2008-09-17 | Unigene Lab Inc | PARATHYROID HORMONE AMIDE FRAGMENTS AND USES THEREOF |
| US8227241B2 (en) * | 2004-03-12 | 2012-07-24 | Unigene Laboratories, Inc. | Bacterial host cell for the direct expression of peptides |
| US7531518B2 (en) * | 2004-05-14 | 2009-05-12 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
| US7648965B2 (en) | 2004-05-14 | 2010-01-19 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
| US20060089723A1 (en) * | 2004-10-25 | 2006-04-27 | Murphy Kieran P | Method for bone augmentation |
| US7445911B2 (en) * | 2004-11-24 | 2008-11-04 | Unigene Laboratories Inc. | Enzymatic reactions in the presence of keto acids |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| US20060293667A1 (en) * | 2005-05-19 | 2006-12-28 | Agnes Vignery | Bone implant device and methods of using same |
| WO2006130806A2 (en) * | 2005-06-01 | 2006-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Assay for agonists and antagonists of ion channels and for regulators of genetic expression |
| WO2006132925A2 (en) | 2005-06-01 | 2006-12-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
| CA2613471C (en) | 2005-06-24 | 2016-09-06 | Unigene Laboratories, Inc. | Cell lines for expressing enzyme useful in the preparation of amidated products |
| CA2658654A1 (en) | 2006-07-24 | 2008-01-31 | Biorexis Pharmaceutical Corporation | Exendin fusion proteins |
| US8377863B2 (en) | 2007-05-29 | 2013-02-19 | Unigene Laboratories Inc. | Peptide pharmaceutical for oral delivery |
| RU2370280C2 (ru) * | 2007-10-08 | 2009-10-20 | Институт физико-химической биологии им. А.Н.Белозерского | СПОСОБ СУПЕРПРОДУКЦИИ В РАСТЕНИИ АНТИТЕЛ ПРОТИВ ОНКОГЕНА HER2/neu |
| US9422559B2 (en) | 2010-06-02 | 2016-08-23 | Shi-Lung Lin | Production and utilization of a novel anti-cancer drug in therapy |
| US9399773B2 (en) | 2012-08-10 | 2016-07-26 | Shi-Lung Lin | Production and extraction of MicroRNA precursor as drug for cancer therapy |
| CN102292346B (zh) | 2009-01-22 | 2015-12-02 | 关键生物科学有限公司 | 肥胖的治疗 |
| US9102753B2 (en) | 2011-06-15 | 2015-08-11 | Ugp Therapeutics, Inc. | Anti-inflammatory pharmaceutical products |
| JP6185468B2 (ja) * | 2011-08-12 | 2017-08-23 | メロ バイオテクノロジー インコーポレイテッドＭｅｌｌｏ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，Ｉｎｃ． | 原核細胞内においてヘアピン様ｒｎａを発現させる方法及び組成物 |
| EP3095484B1 (en) | 2011-11-02 | 2018-05-02 | KeyBioscience AG | Calcitonin mimetics for treating diseases and disorders |
| AU2012332265B2 (en) | 2011-11-02 | 2016-11-10 | Keybioscience Ag | Peptide analogs for treating diseases and disorders |
| US9102751B2 (en) * | 2012-05-18 | 2015-08-11 | Janssen Biotech, Inc. | Huwentoxin-IV variants and methods of use |
| US10414808B2 (en) | 2012-05-18 | 2019-09-17 | Janssen Biotech, Inc. | Huwentoxin-IV variants and methods of use |
| US10196662B2 (en) | 2012-08-10 | 2019-02-05 | Mello Biotechnology, Inc. | Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors |
| JP6375314B2 (ja) | 2013-03-05 | 2018-08-15 | エンテリス・バイオファーマ・インコーポレイテッドＥｎｔｅｒｉｓ Ｂｉｏｐｈａｒｍａ，Ｉｎｃ． | 固体経口投与剤 |
| KR20160064192A (ko) | 2013-10-03 | 2016-06-07 | 얀센 바이오테크 인코포레이티드 | 프로톡신-ii 변이체 및 사용 방법 |
| EP3321278B1 (en) | 2013-11-14 | 2019-01-09 | KeyBioscience AG | Calcitonin mimetics for treating diseases and disorders |
| CN103709236B (zh) * | 2013-12-23 | 2015-04-15 | 江南大学 | 一种可提高分泌效率的信号肽及其应用 |
| US9833411B2 (en) | 2015-01-12 | 2017-12-05 | Enteris Biopharma, Inc. | Solid oral dosage forms |
| MA41642A (fr) | 2015-03-03 | 2018-01-09 | Janssen Biotech Inc | Variants de protoxine ii et méthodes d'utilisation |
| EP3277304B1 (en) | 2015-04-02 | 2021-08-04 | Janssen Biotech, Inc. | Protoxin-ii variants and methods of use |
| WO2017095489A1 (en) | 2015-12-02 | 2017-06-08 | Shi-Lung Lin | Use of microrna precursors as drugs for inducing cd34-positive adult stem cell expansion |
| WO2017095458A1 (en) | 2015-12-02 | 2017-06-08 | Chih-Li Lin | A COMPOSITION AND METHOD OF USING miR-302 PRECURSORS AS DRUGS FOR TREATING ALZHEIMER'S DISEASES |
| GB201704429D0 (en) | 2017-03-21 | 2017-05-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
| GB201707955D0 (en) | 2017-05-18 | 2017-07-05 | Keybioscience Ag | Dual amylin and calcitonin receptor agonists for treating diseases and disorders |
| GB201813678D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
| GB201813677D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
| GB202001024D0 (en) | 2020-01-24 | 2020-03-11 | Key Bioscience Ag | Oxyntomodulin mimetics |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5332664A (en) * | 1981-07-15 | 1994-07-26 | Celltech Limited | Human calcitonin precursor polyprotein structural gene |
| US4595658A (en) | 1982-09-13 | 1986-06-17 | The Rockefeller University | Method for facilitating externalization of proteins synthesized in bacteria |
| US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4962055A (en) * | 1983-03-08 | 1990-10-09 | Rikagaku Kenkyusho | Plasmid, method for construction of the same, microorganisms carrying the plasmid and method for cultivation of the microorganism |
| US4757013A (en) * | 1983-07-25 | 1988-07-12 | The Research Foundation Of State University Of New York | Cloning vehicles for polypeptide expression in microbial hosts |
| US4708934A (en) * | 1984-09-27 | 1987-11-24 | Unigene Laboratories, Inc. | α-amidation enzyme |
| US6319685B1 (en) * | 1984-09-27 | 2001-11-20 | Unigene Laboratories, Inc. | Alpha-amidating enzyme compositions and processes for their production and use |
| US5747281A (en) * | 1984-09-28 | 1998-05-05 | Cornell Research Foundation, Inc. | System useful for the production of proteins from recombinant DNA in single celled organisms |
| DE3586386T2 (de) * | 1984-10-05 | 1993-01-14 | Genentech Inc | Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung. |
| DE3632037A1 (de) | 1986-09-20 | 1988-04-07 | Hoechst Ag | Gentechnisches verfahren zur herstellung von salm-calcitonin sowie mittel zur durchfuehrung dieses verfahrens |
| US5089406A (en) * | 1987-01-07 | 1992-02-18 | Allied-Signal Inc. | Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences |
| US4946790A (en) * | 1987-02-06 | 1990-08-07 | Mitsui Toatsu Chemicals, Inc. | Recombinant plasmid for the expression of L-phenylalanine ammonia-lyase and transformed strain carrying same |
| US5789234A (en) * | 1987-08-14 | 1998-08-04 | Unigene Laboratories, Inc. | Expression systems for amidating enzyme |
| US5223407A (en) | 1988-08-31 | 1993-06-29 | Allelix Inc. | Excretion of heterologous proteins from e. coli |
| JP2551399B2 (ja) * | 1989-08-15 | 1996-11-06 | 株式会社資生堂 | Ｃ末端アミド化に関与する酵素並びにその製造方法及びその使用 |
| US5240831A (en) * | 1991-01-10 | 1993-08-31 | Board Of Regents, The University Of Texas | Methods and compositions for the expression of biologically active eukaryotic cytochrome p45os in bacteria |
| US5547862A (en) * | 1993-07-29 | 1996-08-20 | Ambion Inc. | Vectors containing multiple promoters in the same orientation |
| US5589364A (en) * | 1994-07-29 | 1996-12-31 | Magainin Pharmaceuticals Inc. | Recombinant production of biologically active peptides and proteins |
| ATE484572T1 (de) * | 1997-04-16 | 2010-10-15 | Unigene Lab Inc | Direkte expression von peptiden ins kulturmedium |
-
1998
- 1998-04-15 AT AT98918334T patent/ATE484572T1/de not_active IP Right Cessation
- 1998-04-15 AT AT09006784T patent/ATE522598T1/de not_active IP Right Cessation
- 1998-04-15 EP EP09006784A patent/EP2088188B1/en not_active Expired - Lifetime
- 1998-04-15 CA CA2285658A patent/CA2285658C/en not_active Expired - Fee Related
- 1998-04-15 HU HU0001272A patent/HUP0001272A3/hu unknown
- 1998-04-15 RU RU99124196/13A patent/RU2218407C2/ru active
- 1998-04-15 US US09/060,765 patent/US6103495A/en not_active Expired - Lifetime
- 1998-04-15 DK DK09006784.4T patent/DK2088188T3/da active
- 1998-04-15 DK DK98918334.8T patent/DK1005526T3/da active
- 1998-04-15 EP EP98918334A patent/EP1005526B1/en not_active Expired - Lifetime
- 1998-04-15 DE DE69841939T patent/DE69841939D1/de not_active Expired - Lifetime
- 1998-04-15 AU AU71279/98A patent/AU742270B2/en not_active Ceased
- 1998-04-15 ES ES09006784T patent/ES2375330T3/es not_active Expired - Lifetime
- 1998-04-15 WO PCT/US1998/007723 patent/WO1998046722A1/en active IP Right Grant
- 1998-04-15 JP JP54430898A patent/JP4907751B2/ja not_active Expired - Lifetime
-
1999
- 1999-10-14 NO NO19995014A patent/NO327325B1/no not_active IP Right Cessation
- 1999-11-10 LT LT99-133A patent/LT4701B/lt not_active IP Right Cessation
-
2000
- 2000-02-08 US US09/500,009 patent/US6210925B1/en not_active Expired - Lifetime
-
2001
- 2001-02-09 US US09/780,878 patent/US6627438B2/en not_active Expired - Lifetime
- 2001-02-09 US US09/780,643 patent/US6737250B2/en not_active Expired - Lifetime
-
2004
- 2004-04-05 US US10/818,966 patent/US7968311B2/en not_active Expired - Fee Related
-
2011
- 2011-11-09 JP JP2011245398A patent/JP5634971B2/ja not_active Expired - Lifetime