JP2002226384A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new safe cosmetic composition. SOLUTION: An antiallergic agent, a histamine release inhibitor, a fibroblast growth promoter or a cosmetic composition is characterized by comprising a pig-derived and/or horse-derived placenta extract. Consequently, the extract has antiallergic (histamine release inhibition) action, fibroblast growth promoting action, ameliorates allergic/atopic dermatitis (e.g. flare, eczema, edema, tumor) and xeroderma and imparts the skin with gloss and firmness.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an antiallergic agent containing porcine and / or horse placenta extract, a histamine release inhibitor, a fibroblast growth promoter or an allergic / atopic agent containing these. It is effective for the prevention of skin inflammatory diseases (eg, redness, eczema, edema, swelling, etc.) and dry skin, and for the prevention and improvement of skin troubles that give the skin a luster and firmness. And the like to various cosmetic compositions.

[0002]

2. Description of the Related Art Today, environmental conditions are deteriorating, lifestyles are changing, and social life is becoming more complicated.
More and more people suffer from allergic diseases such as hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria due to drugs, rough skin, dry skin and the like. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, with its increase being sought in not only children but also in a wide range of ages up to adults.

Originally, in order to eliminate foreign substances (bacteria, pollen, mites, etc .: antigens), the living body must produce biological components (antibodies, lymphocytes, etc.) to counter it and protect the body. It has an immune function that works. However, sometimes the reaction becomes so sensitive that it becomes harmful to the body and causes various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into immediate type and delayed type.

[0004] Among allergic reactions, the frequency of onset is high, which is immediate type, and is mainly a reaction involving immunoglobulin E (IgE) antibody. This IgE is produced against allergens that have entered the body and has a strong effector effect on mast cells and basophils. Mast cells and basophils (a type of leukocyte) Cells having granules containing pharmacologically active amines such as serotonin, the former being present around blood vessels and connective tissues, and the latter being present in blood. On these cell membranes, there is a receptor that binds the IgE antibody and has the property of strongly binding to the IgE antibody, and for the IgE antibody bound to mast cells and basophils,
When the same type of allergen binds again, a number of active substances such as histamine and serotonin described above are released from these cells with degranulation, causing various allergic symptoms,
Symptoms such as redness and rash (urticaria) with itchiness on the skin, inflammation of the nose and eyes and itching and increased secretion of nasal discharge and tears, or difficulty in breathing due to congestion of the trachea Symptoms such as attacks (bronchial asthma) and the like are classified as allergic diseases of this type.

[0005] In immediate allergy, the process can be roughly classified into three stages. Each stage is classified according to its action point.
Attempts to alleviate or treat have been made. That is,
When a foreign antigen enters the body, the immunocompetent cell line produces IgE antibodies. Sensitization is established by sticking to the ball. This is the reaction referred to as the first step.

Next, when the sensitized cells are again contacted with an antigen, the cells undergo morphological changes such as vacuolation, swelling, and degranulation, and release chemical transmitters such as histamine, serotonin, and SRS-A. I do. This is called the second-stage reaction, and the released chemical mediators act on the contraction of smooth muscles such as bronchial muscles and gastrointestinal tract, increase in capillary permeability, neutrophil migration, platelet aggregation, etc. As a result, the process of developing allergic symptoms such as asthma, gastrointestinal allergy with back pain and diarrhea, nasal allergy, and urticaria is a reaction referred to as the third step.

Therefore, in a narrow sense, drugs acting in the first and second stages are prophylactics for allergic reactions and
Those acting in stages can be considered as symptomatic treatments. Currently, the most active research on antiallergic drugs is researching drugs that suppress this second stage.

It is said that individual aging or various diseases caused by the aging have a correlation with aging of all cells that can divide (reduction of division rate and cell function), and aging at the cell level. For the purpose of prevention, a large number of cell activators have been searched for. Among them, cell growth factor is one of cell activating agents, and various factors have already been confirmed.
24), water-soluble proteins derived from organs such as the chest line and spleen (JP-A-63-1
88697, 63-188698), and also extracts of bovine brain, bovine pituitary gland, and cockscomb (JP-A-01-175998), which are used in quasi-drugs and cosmetics.

[0009]

However, most of the conventionally used antiallergic agents are agents related to diseases caused by an immediate allergic reaction whose action point is relatively clear. For example, antispasmodics that relax smooth muscle and sympathomimetics that suppress the increase in permeability of capillaries, and further include antihistamines and the like,
These are all contrasting therapeutic agents that act in the third stage, and most of them are synthetic pharmaceuticals, and have problems in terms of side effects. Also, at present, few cell growth factors, which are one of the above-mentioned cell activators, exhibit a sufficient effect.

[0010]

[Means for Solving the Problems] In view of such circumstances,
The present inventors have started the development of a useful component having an excellent anti-allergic effect and having a fibroblast proliferation promoting effect. To have a histamine release inhibitory action and a fibroblast proliferation promoting action, and to be used as an antiallergic agent, a histamine release inhibitor, and a fibroblast proliferation promoter. In addition, allergic skin inflammatory diseases (eg, redness, edema, eczema, etc.) and atopic dermatitis containing pig and / or horse-derived placenta extract, improvement of dry skin, and gloss and tension on skin The present invention has been completed by providing a safe and effective cosmetic composition for prevention and improvement of skin troubles imparting the following.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION "Pig" as a source animal used in the present invention includes chordata phylum, mammalia, artiodactyla (bovine), subfamily boars (boars), wild boars, and pigs Sus s
It is a crofa (domestic) and is divided into true beasts. Pigs are breeds as domestic animals, and naturally, wild boar (Japanese wild boar) Sus scrofa leucomystax, wild boar (Ryukyu wild boar) Sus scrofa riukiuanus, and the like can be used. In addition, the breeding of pigs is progressing, including Berkshire, Yorkshire, Landrace, Hampshire, Polish China, Chinese pig, Inobuta, Guinea fog, Göttingen (mini pig), Chinese potberry pig, Duroc, Meishan Any type such as tons, or any of these hybrids can be used.

[0012] The "horse" as a source animal used in the present invention uses the placenta of the chordata phylum, the class Mammalia, the order Odes (Epidoptera), the equine family, and the equine Equus caballus (domestic).
Horses are useful as livestock and breeding is progressing, and American miniature horses, Arabs, Argentine miniature horses, willish ponies, willish mountain ponies, garage horses, kiso horses, quarter horses, thoroughbreds, sara, Shetland pony, Tsushima horse (Tsushima horse), Tokala horse, Hokkaido horse (Hokkaido Japanese), Noma horse, Hackney pony, Falabella pony, Breton type, Paint horse type, Percheron, Pony, Midget pony, Miniature horse, Morgan , Yonaguni horse or any of these hybrids can be used.

[0013] In the extraction from the pig or horse placenta of the present invention, the active ingredient can be extracted by using a suitable solvent or hydrolysis.
Processing such as freezing, thawing or heating for aseptic purposes, or
Oil-soluble components may be removed to remove hormones. As a solvent used for removing hormones, butanol, hexane, acetone and the like can be used.

[0014] The extraction solvent for the swine or horse placenta extract of the present invention includes water, physiological saline, alcohols (eg,
Lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin) or ketones such as acetone; esters such as ethyl ether, dioxane, acetonitrile and ethyl acetate; , Xylene, benzene, chloroform and the like can be used alone or in any combination of two or more kinds, and can also be used in a state where each solvent extract is combined. After the extraction, the extract may be filtered and sterilized as necessary, or the extract may be diluted, concentrated, and dried.

Furthermore, the placenta extraction from pigs or horses of the present invention can be carried out by hydrolysis and extraction, and in addition to hydrolysis by ordinary proteases, hydrolysis by acids and alkalis can be carried out. .

The term "protease" is a general term for enzymes that catalyze the hydrolysis of peptide bonds. It is called peptidase or protease. Peptidases are classified into peptidases and proteinases in a narrow sense. Peptidases (proteases) are classified into exopeptidases and endopeptidases according to their mode of action. In addition, they may be classified into acidic, neutral, and alkaline proteases. Representative exopeptidases include aminopeptidase, dipeptidase, dipeptidyl peptidase, tripeptidyl peptidase, carboxypeptidase and the like. Representative examples of endopeptidases include serine endopeptidase (serine protease, trypsin, chymotrypsin), cysteine endopeptidase (cysteine protease, thiol protease, papain), aspartate endopeptidase (acid protease, pepsin), metalloendopeptidase (metal Protease, carboxypeptidase) and the like.

In the narrow sense, the "acid" refers to a substance that generates hydrogen ions in an aqueous solution and neutralizes a base to form a salt. Hydrochloric acid, sulfuric acid, acetic acid and the like.

The term "alkali" is a generic term for compounds that neutralize acids. Generally, an aqueous solution having a hydroxyl group refers to a hydroxide of an alkali metal element or an alkaline earth metal element showing basicity, but in a broad sense can include a carbonate, and sodium hydroxide, potassium hydroxide, barium hydroxide, Examples include ammonium hydroxide, sodium carbonate, and ammonium carbonate.

The production method is usually carried out within the range of the boiling point of the solvent at normal temperature and normal pressure, and in the case of hydrolysis by enzymes, the hydrolysis is carried out at the optimum temperature and pH of each enzyme. After the extraction, filtration is performed, and if necessary, purification treatment such as deodorization, decolorization, and removal of allergen components is performed using a sterilization treatment, pH adjustment, an ion exchange resin, an activated carbon column, a dialysis membrane, or the like. In addition, ethanol, propylene glycol, 1,
An organic solvent such as 3-butylene glycol or an arbitrary mixture thereof can also be added. The obtained extract can be used as it is, but it can also be concentrated and dried to be used as a paste or powder.

The swine and / or horse placenta extract of the present invention can be used as it is as an antiallergic agent, a histamine release inhibitor,
In addition to being usable as a fibroblast growth promoter, it can be further contained in a cosmetic composition, but the content thereof is not particularly limited and may be an antiallergic agent, a histamine release inhibitor, a fibroblast growth promoter or a cosmetic. Composition, quality, expected degree of action will vary slightly,
In the total amount of the preparation, it can be used in a concentration range of 0.0001 to 20% by weight (preferably 0.001 to 10% by weight) as a dry matter. In the case of an extract, it can be used in this dry conversion amount.

Further, the dosage form of the antiallergic agent, histamine release inhibitor, fibroblast proliferation promoter or cosmetic composition of the present invention is arbitrary, and capsules, powders, granules, solids, liquids, gels, bubbles, It can be used in the form of an emulsion, cream, ointment, sheet or the like.

The field of application is, for example, generally applicable to various external preparations (including preparations used for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg, cosmetics) in suitable forms for use as liquids, gels, bubbles, emulsions, sheets, mist, sprays, etc. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, depilatory agents, shaving treatments, after-shave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, nail polish, nail enamel, nail enamel remover, cataplasm,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations applicable to the scalp / hair (eg, shampoos, rinses, hair treatments, pre-treatments) Agents, permanent liquids, hair dyes, hair styling agents, hair tonics, hair growth / hair restoration, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.), 5) For bathing in bath water 6) Others, including axillary deodorant and deodorant, deodorant, antiperspirant, sanitary goods, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, etc. Use for food and drink is also possible.

The method of adding the antiallergic agent, histamine release inhibitor, fibroblast growth promoter or cosmetic composition of the present invention may be added in advance or during the production. What is necessary is just to select suitably considering workability.

The antiallergic agent, histamine release inhibitor, fibroblast growth promoter or cosmetic composition of the present invention may be added to the above-mentioned essential components, if necessary, within a range that does not impair the effects of the present invention. The components and additives exemplified below can be arbitrarily selected and used in combination. The content in the preparation is not particularly limited, but is usually preferably 0.01 to 20%.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )etc.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid And synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol;
Synthetic alcohols such as hexyldecanol, isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, compression, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, etc. Select from alcohols, lower alcohols such as butanol, isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone and various organic solvents such as ethyl acetate. It is desirable to use one or a mixture of two or more of these. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
Antiseptic and buffering effects can also be expected.

Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsu-la-fuji (Kibo), Aotenma, Acacia, Akasho (Akasho), Akasuguri (fruit), Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akane Akane or Akane (Akane) Grass roots), red pheasant or geese (land yellow),
Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Wolverine palm), Akebi
(Kidori), Asa (Jin Asako), Malva Asagao or Asagao
(Toshiko), hydrangea (hydrangea), ashitaba (morning leaves), azuki (red azuki bean), asunaro, acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abiu, abiulana, rape and abemaki `` fruit '' ,Avocado,
Ama, Amacha (Amacha), Amachaworu, Amadokoro (Jade bamboo), Amana (Kojingi), Amaranthus (Hyuyu, Hagaito, Himogeito, Senninkok, Sugimorigeito,
Hosoagaitou, Aoagetoi, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Urizusensen), Arcana (Alcanna), Algarrobo (Cave), Altea, Arnica, Alpinia or Katsumadai
(Sorghum), aloe (lux), aloe vera, angelica, apricot or hon apricot (almond jelly), ansokko (benzoic acid), yellow sapote, scutellaria (biliary head), epimedium or primrose (inyokaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (primary), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), Itohimehagi (enshi), carob, and locust bean (Telexa) , Inubeil (Honagainubiru), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco
Iwahiba or iwamatsu (makikashiwa), oolong tea, fennel
(Fenka), Wheat (Chibusanoki), Ukiyagara (Sanryong), Uguisukagura `` fruit '', Himeukikyo, turmeric (Utsukin), Duckweed (buoying), Usubasaishin or Keirinsaishin or Oushusaishin (spicy), Usveniaoi , Foxglove, euphoria, moray eel
(Summer hay), Udo or Shishiudo (Kang-Kang, Independent, Tang-Kun), Unyadegato (Unkaria, Cat's Claw), Uba Tea, Ume (Oumei `` seed, pulp ''), Vladimir, Uwaurushi
(Kusaco peach), Unshu mandarin orange (Chen skin), Unboku,
Estragon, Ezokogi (Ezo Goka), Ezo lily of the valley,
Echinashi (Hoshibamurasakibarengiku), Enishida, Enokitake (Enotake), Ebisugusa or Cassia Tora (Keyoshiko), Elcampre, Elderberry `` fruit '', Elemi, Elingii or Pre Lotus Elinge, Ende
(Gossip, Sophora rice), ogre or Kibana-ohgi (Astragalus), Narco lily or Kagi Kurumabanaruko lily (Yoshisei), Ohhisasanoyuki or Sasanoyuki, Oren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Civil) , Ootsuji rafuji (self-defense), Psyllium (vegetative child, vegetative grass), psyllium thistle (Keju sashimi, bald man), eucalyptus (Haruko), pygmy cactus, pygmy pygmy or ophylla (white jitsu), pygmy pygmy (banaba), Beetle shabushi `` fruit '', giant beetle (grain sperm), beetle catechu, beetle hawthorn or hawthorn (mountain fry), barley
(Barley), oka, okazeri (snake bed), okra `` fruit '', oguruma (turnover), okururi higotai (yushu sashimi, indigo sashimi),
Panax ginseng or horseshoe ginseng (carrot), Hypericum perforatum or Hypericum perforatum or St. John's wort (brother's cut grass), Odorikosou (intermittent), Onamimi (blue ears),
Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Onoeran, Ononis, Halibut
(Hihayu), Ominaeshi (losing sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp," Yellow), cacao "fruit, peel, seeds", kaki (persimmon "leaf"), kagikazura
(Hooks of Choto), Persimmon or Kantriso (Rensenso), Kakiran, Gaku hydrangea, Cassia, Kasinaki (Kozou `` fruit ''), Kajutsu (Shazajutsu), Kashiwa (Yanagi, Yuzuha), Kascarilla, Kascara sagrada , Gypsophila, gypsophila, kanikusa (kinsato), kaniwa, carnation, valerian (valerian root), hippopotamus, birch or weeping birch (white birch),
Gerbera, Pumpkin, Capoknoki `` seed '', Kahoku Sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Kamiyatsude (weed), Kamkamu (duckling), Color, Karakakeman, Ragusuri or Shinakorasuri
(Our melon), crow squirrel (midsummer), oats, guarana `` seed '', karahoo (thick), karaya, garyu, karin
(Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Koryosai, Hakubaku), Kawazusha, Kawaratake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaranginjin (Blue Gourd), Kawamuragi (Inchinchinko) , Kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Canto, canna, canlan, raspberry (ezo strawberry,
Dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry, European strawberry), kiwi `` fruit,
Leaves, chrysanthemum cucumber (urorone), kikyo (bellflower, bellflower root), chrysanthemum (chrysanthemum, chrysanthemum, koseki nogiku),
Kikutaniki, Catalpa (Azumitsu), Rumex (Yotei), Pheasant (Kikomi), Kizuta, Kidachi Aloe, Kidachihakka, Kina, Kinoki (Shincona, Akakinoki), Quinua (Kinoa), Kihada (Huangbashi), Gymnema sylvesta, Kimmenkaku, Cabbage, cabbage "immature fruit", caraway,
Cucumber, Gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Kinkan grass), Kumquat `` fruit '', Ginsekai, Kimbusen, Kinma, Kinmizukiki (Sengaku grass), Kinran, Ginran, Kinryohen,
Guapeva Vermelha, Guava "fruit", guayule, Quercus infectria (gallicate), cucuin nut, cugenumaran, wolfberry (cucumber, cucumber, cucumber leaf,
(Skin bone), Cedar grass (Tenmen Fuyu), Kudzu (Kakkon), Camphor tree, Gooseberry `` fruit '', Xining ginseng
Kutiti River, Gardenia (Gardenia), Kunugi (Bokusou), Kupuas, Kubeba, Kumazasa, Kumatsuzura (Epispermia), Clara (Bite), Cranberry "Fruit", Chestnut "Seeds, Fruits, Astringent Skin", Curculigo Latifolia `` Fruits '', grapefruit `` fruits / leaves '', buckthorn, stag beetle (needs rescue), turtle crab or kurobana chick sprouts or cypress (extended life grass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi),
Kaigai (Thorndust, Ikutakeho), Celosia (Rooster, Chicken),
Gekkavidin, bay (laurel), Kenashisarutibara (Tsuchukuryo, Yamakiko), gentian, gennoshoko
(Old tongue grass), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Oveni mikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana bark)), Koushinbara (Monthly flower), Kosuihakka, Kozo `` Fruit '' , Kocha (tea), Kouhone (river bone), Kohon
(Straw book, Kara straw book), Koryang, Kouryokyo (Kora Kyo), Cilantro `` fruit '', Kourouen (Kohren), Koganebana (yellow gon), Cowberry (Koshibachi), Coco palm `` Fruit '',
Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
Burdock), kobotdur, sesame (sesame), sesame seeds (gensin), garnish (gomiko), sanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, conzlango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button or syna button or cinnamon (weird sen), cherry
(Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` Leaf, flower, fruit, bark (cherry bark) ''), cherry, pomegranate, sasa, sasabagin , Sage Modaka (Sawaka), Sweet Potato, Sugarcane, Sugar Beet, Sanebu Jujube (Satsuma Natsume), Saffron (Safflower, West Safflower), Sapodilla, Sapotea Marillo, Pomelo "Fruit", Sabonsou, Salmonberry "Fruit", Sarasin
(Masahima), Saranshito (Sand Ai Sashimi), Salvia (Sage),
Sawagikyo (Yamakona), Sawagurumi (Yamawomo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (Sanjin ginseng), Sanshuyu (sanshuyu), Sanshoyu (sansho), Sunzucon (Yamato) Root), shea
(Karite), Cyano (fruit), Shiitake (Shiitake), Sion
(Shiwon), Red-spotted squirrel, Shikunshi (Kimiko), Perilla or Aozo or Chirimenji or Kamenjiso (Shiyo-leaf, Shiso-so), Rosewood, Shinanoki, Shinanohonoki, Chinese forsythia (reamous forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshirohimeji) Bunashimeji, honjimeshi, shirotamogitake), shimokuren (hot spring), shimotsukesou, potato, peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat gate winter), shukukonemisou, shukushamitsu (sunin, Sand), Juzudama,
Palm `` fruit '', Shunran, ginger (ginger), Japanese hydrangea (Tsuneyama), shobu (iris, iris root), shizuku `` fruit '', shirakashi `` seed '', silane (byakyuu), shirogoshi `` seed '', white clover (clover) ), White adzuki bean (chicken bone), White bean iris (Small iris), White bean ivy “flower”, White bean (Nami Tenmi), Cinchona sassilbura, Jinjuge (Mizuka, Mizuka, Shencho flower), Cinnamon, Cinnammum cassia , Watermelon (watermelon), honeysuckle (gold and silver flowers, Shinobi winter),
Sorrel (acid model), swim berry (fruit), star apple, stevia, strawberry (fruit), suzu psycho (Xu Chang Lord), horsetail (Qingi), purslane (horse dent, horse dent), plum berry, sulgaran (Oran), Pinus densiflora `` cone '', larch, vegetation, walnuts, hawthorn, eucalypt, dandelion, horse chestnut (malonie),
Pear `` fruits '', snowy pear, elderflower, elderflower, juniper (juniper, juniper), yarrow (milfoil), rose, foliage, mistletoe, mint, or swordfish (Ishishone), Sekko (Sakura Sekko,
Red-crowned, Red-crowned, Red-crowned, Red-crowned, Red-crowned, Red-crowned, Red-crowned (Dendrobium, Stone), Cedron (Bowshuku-boku), Zeniaoi, Hirohase Nega, Senega, Seri, Sinensen, Sinensen, Sinensen Sengdan, Sennin cactus, Senna `` fruits and leaves '', Senninsou (large tate), Assemblage (drug),
Sengoku, souka (grass), elephant, sosinoubai, buckwheat `` seed '', soybean potato, rhubarb (daisuki), radish, soybean, daidai (orange, kikomi), takasagorurihigotai (southeast indigo), takasaburo (dry lotus) Grass), Takatodai
(Daigei), Takawarabi (Inu), Dark Sweet Cherry `` Fruit '', Tachiaoi, Tachijakosou (Thyme, Hyakuka), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', Onion, Tamashiba (Shinyi), Taranoki `` Fruit '' , Leaves, root bark '', tarayou (large leaf winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenjikubotan), tarwi, tanshiuchiwa, tanjin (dansan), dandelion (gakkoei) or white dandelion or moko dandelion, Dammar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', chix carrot (bamboo ginseng), chicory, chancapiedra (Kidachikomikansou), tulip, chocolate nose, Korean blossom (Ohio), Korean cinnamon (Bouyi) ), Artemisia (Aiba), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukushikaneran, Tsukuritake ( Mushrooms), Tsuchiakebi, Camellia, Camellia, Tsumekusa (lacquer lacustrine), Tsujukusa (Duckling grass), Tsuruazuki (red azuki bean), Tsurutsuchiakebi, Tsurudukudami (Hanshu crow), Tsuruna (Ban apricot), Tsuruninjin (four leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi,
Duberry `` fruit '', tengusa, tencha (tencha), tendai yak (crowd drug), touga (winter melon), toukaizuka,
Capsicum (Pepper), Touki (Toki), Calendula (Marigold), Tonabena (River cut), Maize or Maize hair (Nanban hair), Toad Mochi (Female Sadako), Toudodou or Korean gentian (Ryubile), Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), toshishi or mamedaoshi or pear, and eucommia (tochu `` bark, leaves,
Roots), ash (qin peel), tomato, tragacanth, triacanthus `` seed '', eustoma, tormentilla, dronoki, troloioi, tongue bean, Niseria berry `` fruit '', potato or yam (herbal medicine), squid
(Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsume bean or Hatehaki (sword bean), Natsumikan, Jujube (daijutsu), Naniwaibara (Kanakurako), Navena (intermittent), Nameko, Peanut (peanut), Nanten (Nanten) Fruit), Nanban karamushi (ramie), scented violet, nigaki (bitter tree), bitter mugwort (bitter), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon bark) or keishi (keishi),
Grey-eared plover, Chinese chive (Nirako), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (quintuple), leek, nemuki or nebu or nebi or nemlinoki or zigokubana (health), noami ( Daiji), Neubara (real fruit), Nori Kazura (Liao Xiaohua), Nogateto, Yarrow, Nodake (Maehu), Nobara, Nomomo, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbusouge, Roselle), Hyindou, Hauchiwa, Pau Dosse , Hakama Uraboshi (Bone Crushing), Hakuka Yumato, Hakusan Plover, Hakusen (Ringworm Skin), Huckleberry "Fruit", Hakobe (Horuko), Hashibami (Haruko), Hashiridokoro
(Roth root), basil, lotus (lotus, lotus, lotus), parsley
(Netherland jelly), naked mussel, batata, bee or medake (bamboo boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimbo), banana, hana mint, hanabishi (situri, shisuturi), vanilla bins , Papaya, mudweed (rat malt), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hamakakiran, hamagou or honey beetle
(Ritsuko Riko), Hamanas (maikai flower), Hamabofu (beach storm), Hamelis, palm, rose (rose), balata,
Balata rubber tree, agaric mushroom (aratake mushroom, white agaric mushroom, usukimori no kasa), haran, pariurus (bamboo jujube), parietalia, harkanran, balsamina (surreale, bitter gourd), harunire (yu bark, yu white bark, yuba), barbasco, harindou Handaikai
(Giant Sea), Breadfruit, Hiogi (Ranker), Lycopodium ginseng (Party), Pecan Nut, Higanbana (Shirubi, Jinjusha Hana), Higuru Madaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Hitotsuba (Stone) Reeds), Aedes fern,
Daisies (daisy), hinata nokozuchi (cow knees), hinio bulbul, hinoki, hiba, castor, sunflower, bell pepper,
Himeuzu (Tamaoi), Himegama (incense bud), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta `` fruit '', juniper, beakyu, hiyu `` fruit '',
Biloba oi, Hiroha okinagusa (Hakuto Okina), loquat "fruits, leaves, stems", betel nut (large clothes skin, betel nut), puerh tea (pu-cha), scallop (southern rattan), squirrel, serrata Winter leaves), fujibakama (orchid grass), faba bean (tonboshi), fujimokiki (choujizakura, shinbana), grape "fruit, peel, seeds, leaves", beech, beetle
(Cordyceps), Brazilian Licorice, Brazilian Carrot, Black Currant `` Fruit '', Blackberry, Bragnien, Plum `` Fruit '', Flucellaria, Blueberry
(Prunus avium), prunes, floral blanka, blonde psyllium, bundo (green beans), hazelnuts, loofah, hetsukaran, safflower (safflower), henneken, belladonna, berry `` fruits '', percea, perbianberg, pereschia grandifolia, benceisoa Or duckweed (Keiten), boysenberry "fruit", duckweed or elderweed or nendowe or hawakigi kokia
(Skin), Hosairan, Balsam (Hosen, acute child,
Translucent grass), Potteria sapota, Potteria lukuma,
Spinach, boufu (windbreak), spinach, physalis
(Torone), Honoki (Japanese thick and magnolia), Bokeh (Gourd), Hosoba Aburagiku (Biyoku), Hosobaoguruma, Hosovanaokera
(Soujutsu), Japanese beetle (Shinjuku Michiten), Japanese beetle, Bodaiju (bodice tree), button (peony `` flower, leaf,
Stalks, bark ''), buttonpi (peony bark), hops, jojoba, borage (ruriticsha), bordeaux, white berries `` fruits '', hon-oniku (meat jiyo, daitei), hon-sekkoku (iron bark stone, sparrow mountain stone) , Maizulten Nanshaw (Tennan Star), Maitake (Maitake), Ephedra (Masochism), Maca, Macadamia Nuts, Margaret (Mokshungiku), Macri (Seaweed), Magwa (Mulberry White Bark, Bark, Leaves), Magnolia・ Splengeri, Masaranpouba, Masaranzuba de Ceara, Masheira de Boi, Masahua (Tamanousenhallen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matta Oryo, Matsuhod (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanozadin (Bittersweet), Mulberry "Fruit", Quince, Malein (Below Mow) Watermelon), Mango, Mangosteen, Mansagna (Andesca Mitsure), Mansugurumi, Mandarin `` fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mizunyanagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobalan, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (extended skin), Munya, purple (purple root), purple or purple purple
(Purple beads), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, red seaweed (mother grass), red seaweed, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), ilex, mokko (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry , Moroheiya
(Burlap), yakawamurasakiimo, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow car) or himeyashabushi or giant yashabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal metal) , Mistletoe (willow parasitism), willow (river willow, twill willow, weeping willow, red willow, pussy willow, dog puppy willow, kinuyanagi, kolyanagi, unryuyanagi, yamayanagi, palm, yamayanagi, obanyanagi,
(European willow, fox, willow tree)
Japanese tobacco (Tsurusui, Tenmei), Japanese pokeweed (land), Japanese alder (Yamaharu), Japanese peach (Yumemei), Japanese sagebrush, Eucalyptus, Yukinoshita (Tiger ear grass), Yucca or flevifolia, Yuzu `` fruit '', lily, Artemisia, mugwort (Aiba),
Rigan (Raimaru), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaves, berries '', ratania (clameria), raccoon or shallot (scallop), lavender, longan (longan meat), agave (Aonouragetsu, fukurin) Agave), Ryokucha (green tea), Apple `` Fruits, seeds, leaves, roots '', Gentian, Rubus or Suabisimus (Tenryu), Ruritama thistle (Urajirohigotai, Xinjiang indigo sashimi), Reishi (Lichi, Lichi nucleus), Lettuce (Chisha), Red currant `` Fruit '', Red pitaya, Lemon `` Fruit '', Lemongrass, Forsythia or Chinese forsythia (forsythia), Astragalus, Lumbai (wax plum), Waxy palm, Lokon (Yoshi, Azuki), Loganberry `` Fruit '' , Rosemary (Mannenrou), Rosehip (Nobara), Wasabi, Cottonweed Remokou
(Chiyu) and the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaa nori, Susiaonori, Hiraaonori, Bowa nori, Hosoedao aonori), Anaausa algae [Aosa algae] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Junyashinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas spp .: Chlamydomonas spp., Akayukimo, Dunaliella spp .: Dunaliella spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Blue-green algae (Genus Lynchium: L., L., L., L .;
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Pleurotus spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russula genus: Bovine genus, Funorinoshike, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabo kintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Scutellariae, Osmanthus Nagaobabane: Nagaobabane,
Genus Funori: Hanafunori, Fukurofunori, Makunori, Kalexigusa: Kalexigusa, Sasamodoki: Hosobanotosakamaki, Hirohanokasakamuki, Yatsudegatatasakamoki, Kurosakamaki, Nezashinosakamukado, Yukasakanookado Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenija, honooo genus: honoo, genus genus: lyca genus, genus genus, genus nikonobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikunori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanisa, Saimi, Harigane, Lotus japonicus:
Lotus spiders, genus genus: Ikanoashi, Hosoibonori,
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishbukuro, Madaragusa: Togemadara, Echimadara, Taoyagousou: Genus Ottawa, Scrophularia , Hirata goat: Hirata goat, Dulce: Dars, Masagoshibari, Anadalus, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushinagi: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragons: Snapdragons, Snapdragons, Species: igis, keiigis, crickets, nigiri, amixa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usbeni: Usveni, Hasuginu: Hasuginu, Nagakonohanori: Nagakosugino, Genus: suginanu Yareusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia genus: Enashidazia, Simadadia genus: Isohagi, Shimadada, Dazimodoki genus: Daziomomodoki, Itogusa genus: Moletogusa, Futoigusa, Macri genus: Macri, Yanaginori genus: Hanayanagi, Yuna, Sanaginori, Mosanyugina, Sasa, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshig, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawwort: Genus Hakezakinokawa, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

The axle algae (Charus spider, Shiratamamo,
Hossiturimo: Hossiturimo, Lichnotumnus, Flasks: Himegrass, Chabograss, Tripera etc., Yellow algae (Hikarimo: Hikarimo etc.) and the like.

Materials derived from animal raw materials include cockscomb extract, swine or bovine stomach, duodenum, intestine, spleen extract or its decomposition product, bovine or swine brain tissue extract, and water-soluble collagen. , Collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk proteins and their degradation products or their derivatives, pigs or cattle Blood cell protein degradation products (globin peptide), bovine or swine hemoglobin degradation products (hemin,
Hematin, heme, protohem, heme iron, etc.), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, nucleic acid-related substances (Ribonucleic acid, deoxyribonucleic acid) and the like.

(14) Marine components Seawater such as deep water, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud Or mud (Fango) s, for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifelfango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc.

(15) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract or its decomposed product or These water-soluble derivatives, lactic acid fermented products of raw milk or skim milk powder, trehalose or derivatives thereof, and the like.

(16) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) UV absorbing / blocking agent benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonic acid salt, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid Derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate,
Methyl salicylate), anthranilic acid derivatives (methyl anthranilate), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin Guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin and the like.

(19) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and the like.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate ester magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, warmoko,
Clara, mugwort, honeysuckle, yellowfin, amberjack, matsuhodo, adlay barley, scotch, hops, hawthorn, eucalyptus, achillea millefolium, artea, calyx, mankeishi, hamamelis, yamaguwa, extended life grass, bellflower, toshishi, maizeko, sun dried, mao, Sengoku, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Gennoshoko, Kakkon, Licorice, Gotobiko, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku).

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(22) Turnover-promoting action / cell activator hydroquinone, lactic acid bacteria extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe,
Oregon, horsetail, gentian, burdock, sicon, carrot, hamamelis, hop, yokunin, odoranthus, assembly, touki, tokinsenka, amacha, hypericum, cucumber, tachikoso, rosemary, parsley) and the like.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) etc.

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidant Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emisoso, Birch, Salvia, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea) and the like.

(27) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract, propolis and the like.

(28) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, chloro Butanol, isopropylmethylphenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis and the like.

(29) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidone carboxylic acid or its Salt, Sodium Lactate, Mini Sasanishiki Extract, Bacillus Natto Metabolite, Natto Extract, Loofah Water, White Birch or Akamatsu Sap

(30) Inhibitors of elastase activity diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, salvia, elderberry, bollige, buttonpi), seaweed extract and the like.

(31) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(32) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(33) Peripheral blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, vanillamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activators Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, biotin, pentadecanoic acid glyceride and the like.

(36) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract and the like.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like;

(40) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(41) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(42) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Fengqiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batuuri essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(43) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

(44) Others Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers,
Vegetable proteins and their degradation products, animal and vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, There are foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorants / deodorants, etc., and when used in combination therewith, the effects of the present invention or other cosmetics It can be expected that additive or synergistic improvement of the objective effect will be achieved.

[0079]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Fresh healthy pig or horse placenta (10 kg) was crushed and blood was removed, and then n-butanol (4-
5 kg) and purified water (10-50 kg) are added and aseptically extracted. Next, the n-butanol layer was removed, and the collected purified water layer was concentrated under reduced pressure to completely remove the remaining n-butanol to obtain a placenta extract (solid content: 0.1 to 2.0%).

(Production Example 2) Placenta (10 kg) of fresh healthy pig or horse is aseptically frozen and thawed several times. After washing with water, it was crushed and blood was removed. Next, a 0.9% sodium chloride solution (10 to 50 kg) was added, and the mixture was stirred and extracted at low temperature. The supernatant was taken, ammonium sulfate was added at low temperature. The precipitate was dissolved again in purified water (5 kg), dialyzed, and purified water
(5 kg) and 1,3-butylene glycol or ethanol (30
%) And sterile-filtered to give a placenta extract (solids concentration 0.1 ~
2.0%).

(Production Example 3) Fresh healthy pig or horse placenta (10 kg) is washed with water, crushed and blood is removed. Purified water (10-50k
After the addition of g), the pH is adjusted to about 8.5, alkaline protease (0.1 to 0.8 kg) is added, and the enzyme is digested at about 55 ° C. for 2 hours. Then, after inactivating the enzyme at 80 ° C or higher,
Adjust the pH to 4.0-6.0 (preferably 5.5) and filter. After appropriately deodorizing and decoloring with activated carbon, placental hydrolyzed water-soluble components (solids concentration: 0.1 to 2.5%) were obtained by sterile filtration.

(Production Example 4) A fresh healthy Uta or equine placenta (10 kg) is washed with water, crushed and blood is removed. Purified water (10-50k
After adding g), pepsin (0.1-0.8 kg) is added at the same time, and the enzyme is digested at about 55 ° C. for 2 hours. Then, after inactivating the enzyme at 80 ° C. or higher, filtration is performed. After appropriately deodorizing and decoloring with activated carbon, placental hydrolyzed water-soluble components (solids concentration: 0.1 to 2.5%) were obtained by sterile filtration.

(Production Example 5) A fresh healthy pig or horse placenta (10 kg) is repeatedly aseptically frozen and thawed several times. After washing with water, it was crushed and blood was removed. Then hydrochloric acid solution (10-50k
g) is added, and the mixture is heated under reduced pressure at 110 ° C. for 24 hours to perform acid decomposition. After neutralization with sodium hydroxide solution, desalting is performed. This was filtered, purified water was added, and sterile filtration was performed to obtain a placental hydrolyzable water-soluble component (solid content: 0.1 to 2.0%).

(Production Example 6) A fresh healthy pig or horse placenta (10 kg) is repeatedly frozen and thawed several times under aseptic conditions. After washing with water, it was crushed and blood was removed. Next, a sodium hydroxide solution (10 to 50 kg) is added to carry out alkaline hydrolysis. After neutralization with a hydrochloric acid solution, desalting is performed. This is filtered, purified water is added and sterile filtration is performed.
0.1-2.0%).

(Test 1) Histamine Release Inhibition Test In a type I allergic reaction, histamine and other chemical mediators are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this study, compou, a histamine releasing reagent from rat mast cells, was used.
Test method to release histamine at nd48 / 80 (J. Soc. Cosme
t. Japan, Vol. 25, No. 4, P. 246 (1992)), the extract obtained in Production Example 1 was examined.

"Test Method and Evaluation Method" a. Sample The sample for the histamine release inhibition test is Production Example 1 of the present invention.
Pig or horse placenta extract (solid content: 0.5
%). As a control sample, cromolyn (manufactured by Sigma) was prepared under the same conditions and used for the test. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of a mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and the color was developed with o-phthaldialdehyde. The histamine release inhibition rate was determined by the following equation (Equation 1), and the results are shown in FIG.

<Equation 1> Histamine release inhibition rate (%) = ｛1- (AC) / (B
-C)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample in mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C : Fluorescent intensity of histamine spontaneously released from mast cells (A, B, C are measured values minus blind values)

(Test Results) As shown in FIG. 1, it was confirmed that the porcine or equine placenta extract of the present invention has a very strong histamine release inhibitory action as compared with cromolyn.
Therefore, it can be effectively used as an antiallergic agent. or,
Similar results were obtained for the swine or horse placenta extracts obtained in Production Examples 2 to 6 of the present invention.

(Test 2) Fibroblast proliferation promotion test The present inventors evaluated the fibroblast proliferation promotion effect using normal human skin fibroblasts.

"Test Method and Evaluation Method" a. Sample The sample of the fibroblast proliferation promotion test was prepared in Production Example 1 of the present invention.
The obtained pig or horse placenta extract (solid content: 0.1%
Was used for the test. In addition, as a control sample,
Purified water was prepared under the same conditions and used for the test. b. Test conditions The cells used were normal human skin fibroblasts purchased from RIKEN Cell Bank (NB1RGB, purchased from RIKEN Gene Bank and Cell Development Bank).
5 ml of inactivated Firtron fetal bovine serum (FBS) was added to the medium.
Eagle MEM medium (hereinafter referred to as 5% FBS-MEM) with the addition of 5% was used. The test medium was 0.5% fetal calf serum E
agle MEM (hereinafter, 0.5% FBS-MEM) was used. Culture conditions were performed at 37 ° C. and 5% CO ₂ . c. Measurement of the number of surviving normal human dermal fibroblasts Normal human dermal fibroblasts (hereinafter referred to as cells) are 5%
The cells were seeded on a 35 mm dish using FBS-MEM so as to have a density of 5 × 10 ⁴ cells / dish (2 mL), and cultured for 24 hours. The culture solution was replaced with 1.8 mL of 0.5% FBS-MEM, and 200 μL of each of the test sample and the comparative sample was added. The culture was continued for 9 days as it was, and the number of cells surviving was measured by counting the cells with a hemocytometer every three days. The results are shown in FIG.

(Test Results) As shown in FIG. 2, it was confirmed that the porcine or equine placenta extract of the present invention had an effect of proliferating normal human dermal fibroblasts. Available. Production Example 2 of the present invention
Similar results were obtained for the swine or equine placenta extracts obtained in ~ 6.

(Test 3) Safety test (1) Primary skin irritation test The porcine or equine placenta extract obtained in Production Examples 1 to 6 was purified water-purified so that the dry solid content concentration was about 1.0%. Prepared,
Japanese white rabbit with shaved back (female, 3 per group, weight 2.
3 kg). At 24, 48, and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. As a result, no erythema and edema were observed in all animals, and it was judged that there was no problem with regard to primary skin irritation.

(Test 4) Safety Test (2) Skin Cumulative Irritation Test Similarly, the swine or horse placenta extract obtained in Production Examples 1 to 6 was purified water so as to have a dry solid concentration of about 1.0%. Hartley-type guinea pig (female,
Once a day, 5 times a week on the skin of 3 animals per group, weight around 320g)
0.5 mL / animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. As a result, no erythema or edema was observed in any of the animals for 2 weeks, and it was judged that there was no problem with respect to the cumulative skin irritation.

(Test 5) Safety test (3) Single dose toxicity test The pig or horse placenta extract obtained in Production Examples 1 to 6 was used for 12.5 times.
% With purified water to give a concentration of 16 mL /
The kg amount was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks old) which had been fasted for 4 hours before the test, and the appearance and degree of toxicity symptoms were observed with time. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD50 was 2,000 mg / kg or more, and it was judged as a safe substance.

(Prescription example) Production of antiallergic agent, histamine release inhibitor, fibroblast growth promoter or cosmetic composition According to the above evaluation results, the formulation examples are shown below. May be produced by a conventional method in the production of, and only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Swine placenta extract of Preparation Example 1 (dry matter concentration: 1.0%) B: Horse placenta extraction of Preparation Example 1 Liquid (concentration of dry matter 1.0%) * Extract of any one of A and B 5.0 11. Preservative (p-hydroxybenzoate) appropriate amount 12. Purified water 100 residue

(Formulation Example 2) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12. Production placen horse extraction Liquid (0.5% dry matter concentration) 3.0 13. Hot water extract of Genoko ginger 1.0 14. Appropriate amount of preservative (paraoxybenzoate) 15. Purified water 100 residue

(Formulation Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Pig placenta extract of Production Example 4 (dry matter concentration 0.5%) 3.0 6. Grapefruit fruit or leaf hot water extract 3.0 7. Rice bran hot water extract 1.0 8. Olive oil 1.0 9. Shea fat 1.0 10. Butylhydroxyanisole 0.1 11. Vitamin E derivative 0.1 12. Preservative (benzalkonium chloride) Appropriate amount 13.Perfume (chamois water) Appropriate amount 14.Residual water with 100 purified water

(Formulation Example 4) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Horse of Production Example 5 Placenta extract (dry matter concentration 1.2%) 3.0 6. Grapefruit fruit or leaf hot water extract 1.0 7. Horse chestnut whole plant 50% ethanol extract 1.0 8. Kiwi fruit 50% ethanol extract 1.0 9. Antibacterial and preservative (Lactoferrin solution) Appropriate amount 10. Fragrance (Western thin water) Appropriate amount 11. Purified water 100 residue

(Formulation Example 5) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Pig placenta extract of Production Example 6 (dry matter concentration 0.8%) 3.0 5. Gentian whole plant 50% ethanol extract 1.0 6. Hamamelis leaf or bark 50% ethanol extract 1.0 7. Allantoin 0.2 8. Astringent (zinc sulfocarbonate) 0.2 9. Antibacterial and preservative (thiamine lauryl sulfate) Appropriate amount 10. Perfume (lavender water) Appropriate amount 11. Residual water with 100 purified water

(Formulation Example 6) Two-layer lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Pig placenta of Production Example 1 Extract (dry matter concentration 0.5%) 2.0 6. Pig placenta extract of Preparation Example 4 (dry matter concentration 0.5%) 2.0 7. Purple Root 50% Propylene Glycol Extract 2.0 8. Chestnut Fruit 30% Ethanol Extract Liquid 1.0 9. Ascorbic acid 0.2 10. Astringent (calamine) 0.1 11. Preservative (phenoxyethanol) qs 12. Flavor (lemon water) qs 13. Purified water 100

(Formulation Example 7) Carmine lotion (liquid to solid)% by weight 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. Pig placenta extract of Production Example 1 (dry matter concentration: 1.2%) 5.0 8. Perilla leaf extract 50% propylene glycol extract 2.0 9. Western linden tree flower or leaf 50% propylene glycol extract 1.0 10. Green tea leaf or stem 50 % 1,3-butylene glycol extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative (photosensitive element 201 & 401) qs 14. spice (ylang-ylang water) qs 15. Purified water 100

(Formulation Example 8) Pack weight% 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethyl cellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Pig placenta extract of Production Example 6 (dry matter concentration 0.5%) 2.0 6 Ginseng rhizome rhizome 30% ethanol extract 1.0 7. Rhododendron rhizome or root bark 50% propylene glycol extract 1.0 8. Preservative (paraoxybenzoate) qs 9. perfume (rose water) qs 10. Purified water 100

(Formulation Example 9) Peel-off pack% by weight 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Preparation example 6 Equine placenta extract (0.2% dry matter concentration) 2.0 8. Ethanol extract 50% of whole plant of Escherichia coli 9. 9. 50% propylene glycol extract of Spiraea flowers 1.0 10. Preservative (para-oxybenzoate) qs 11. Fragrance (Hiba) Water) Appropriate amount 12. Residual water with 100 purified water

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Production example 6 Swine placenta extract (0.4% dry matter concentration) 2.0 9. Parietaria leaf extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10. Dokudami leaf extract 2.0 (Ethanol: 1,3- (Butylene glycol = 1: 1 extraction solvent) 11. Birch bark extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 12. Liquid shea fat 1.0 13. Preservative (acrinol) 0.1 14. Fragrance ( Bodhi tree water) Appropriate amount 15. Purified water Residual to 100

(Formulation Example 11) Emollient cream weight% 1. stearic acid 2.0 2. stearyl alcohol 7.0 3. reduced lanolin 2.0 4. squalane 5.0 5. octyldodecanol 6.0 6. polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Porcine placenta extract of Preparation Example 5 (dry matter concentration 0.8%) 3.0 10. Shakuyane root 50% propylene glycol extract 1.0 11. Chamomile flower 50% Propylene glycol extract 1.0 12. Preservative (paraben) qs 13. perfume (cinch water) qs 14. Purified water 100 residue

(Formulation Example 12) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Production example Pig placenta extract of 3 (0.5% dry matter concentration) 3.0 8. Rosemary leaf or hot water extract 2.0 9. Loofah peel or fruit powder 2.0 10. Bifidobacterium extract 1.0 11. Dipotassium glycyrrhetinate 1.0 12. Preservative (Salicylic acid) 0.1 13. Perfume (bergamot water) Appropriate amount 14. Purified water 100 residue

(Formulation Example 13) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. A: Pig placenta extract of Preparation Example 1 (dry matter concentration 0.5%) B: Horse placenta extract of Preparation Example 1 (dry matter concentration 0.5%) C: Pig of Preparation Example 2 Placenta extract (dry matter concentration 0.5%) D: Horse placenta extract of Production Example 2 (dry matter concentration 0.5%) E: Pig placenta extract of Production Example 3 (dry matter concentration 0.5%) F: Production Example 3 Horse placenta extract (dry matter concentration 0.5%) G: Porcine placenta extract of Production Example 4 (dry matter concentration 0.5%) H: Horse placenta extract of Production Example 4 (dry matter concentration 0.5%) I: Production Example 5 J: Horse placenta extract of Preparation Example 5 (0.5% dry matter concentration) J: Porcine placenta extract of Preparation Example 6 Liquid (dry matter concentration: 0.5%) L: Horse placenta extract of Production Example 6 (dry matter concentration: 0.5%) * Any one of A to L extracts 5.0 10. Royal jelly extract 1.0 (ethanol: 1,3 -Butylene glycol = 1: 1 extract) 11.Glycyrrhetinic acid 1.0 12.Preservative (salicylic acid) 0.1 13.Perfume (Mugwort water) Appropriate amount 14.Purified water 100 residue

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. 70% Himematsutake 1,3-butylene glycol extract 1.0 5. Horse of Production Example 3 Placenta extract (dry matter concentration: 0.8%) 3.0 6. Wakame 70% 1,3-butylene glycol extract 0.5 7. Melilote flower or leaf 70% 1,3-butylene glycol extract 0.5 8. Amacha leaf leaf or stem 70% 1,3-butylene glycol extract 0.5 9. Usbenioi flower or leaf 50% propylene glycol extract 2.0 10. Polyethylene powder 0.5 11. Hydroxypropyl chitosan solution 0.5 12. Amino acid (glycine, glutamine, etc.) 0.5 13. Preservative (undecylene) Acid, phenol) Appropriate amount 14. pH adjuster Appropriate amount 15. Fragrance (lavender water) Appropriate amount 16. Purified water 100 residue

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 1.0 12. Titanium dioxide 5.0 13. Pig placenta extract of Production Example 4 ( Dry matter concentration 0.3%) 0.5 14. Cornflower 50% dipropylene glycol extract 0.5 15. Kakkon 50% dipropylene glycol extract 0.5 16. Preservative (paraben) qs 17. Fragrance (apple water) qs 18. Purified water 100 And the rest

(Formulation Example 16) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Pig placenta of Production Example 5 Extract (dry matter concentration 0.2%) 0.5 6. Burdock root 50% 1,3-butylene glycol extract 0.5 7. Barley whole plant 50% 1,3-butylene glycol extract 0.5 8. Feneceum fruit 30% 1,3 -Butylene glycol extract 2.0 9. Antioxidant (butylhydroxytoluene) qs 10. Fragrance (cornflower water) qs

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Color pigment (iron iron oxide) 1.0 15. Production Example 1 Pig placenta extract (0.3% dry matter concentration) 0.5 16. Balsam flower 50% 1,2-butylene glycol extract 0.5 17. Preservative (phenoxyethanol) qs 18. Fragrance (rose water) qs 19. Purified water 100 Residue to do

(Formulation Example 18) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Pig placenta extract of Preparation Example 1 (dry matter concentration 0.8%) 3.0 7. Horse placenta extract of Preparation Example 1 (dry matter concentration 0.8%) 3.0 8. Panax ginseng root 50% ethanol extract 1.0 9. Toki Root 30% 1,4-butylene glycol extract 1.0 10. Hydroxypropyl chitosan solution 2.0 11. Mucopolysaccharide solution 1.0 12. Antibacterial and preservative (photosensitive element 101) qs 13. pH adjuster qs 14. Fragrance (sandalwood) Water) Reasonable amount 15. Residual water with 100 purified water

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Pig placenta extract of Production Example 3 (dry matter) Concentration 1.0%) 2.0 6. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0 7. Coltsfoot flower or leaf 50% 1,3-butylene glycol extract 1.0 8. Hydroxyethylchitosan solution 1.0 9. Trehalo- Solution 1.0 10. Hydrolyzed silk solution 1.0 11. Antibacterial and preservative (benzalkonium chloride) qs 12. perfume (lavender water) qs 13. Purified water 100

(Formulation Example 20) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Horse placenta of Production Example 2 Extract (dry matter concentration 1.0%) 2.0 7. Loquat leaf 30% ethanol extract 1.0 8. Safflower whole plant 50% ethanol extract 1.0 9. Dutch jelly (parsley) leaf or stem 50% ethanol extract 1.0 10. Trehalo Solution 1.0 11. Hydrolyzed keratin solution 1.0 12. Suitable amount of antibacterial and preservative (benzalkonium chloride) 13. Suitable amount of fragrance (chamomile water) 14. Purified water 100

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Pig placenta extract of Production Example 3 ( (Dry matter concentration 1.4%) 2.0 6. Hops ears 50% ethanol extract 1.0 7. Carpronium chloride 0.3 8. Hinokitiol 0.5 9. Keratin decomposition solution 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) Appropriate amount 11. Perfume (Rosehip water) Appropriate amount 12. Residual water with 100 purified water

(Formulation Example 22) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Trimethylene glycol 5.0 6. Production Example 3 Equine placenta extract (dry matter concentration 1.0%) 2.0 7. Lemon fruit 50% 1,3-butylene glycol extract 0.5 8. Apple fruit 30% ethanol extract 1.0 9. Azulene 1.0 10. Antibacterial and preservative (paraben) , Benzalkonium chloride) Appropriate amount 11. Fragrance (jasmine water) Appropriate amount 12. Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Pig placenta extract of Production Example 1 (dry matter concentration) 0.7%) B: Horse placenta extract of Preparation Example 1 (dry matter concentration 0.7%) C: Pig placenta extract of Preparation Example 2 (dry matter concentration 0.7%) D: Horse placenta extract of Preparation Example 2 (dry matter concentration) E: Porcine placenta extract of Preparation Example 3 (dry matter concentration 0.7%) F: Horse placenta extract of Preparation Example 3 (dry matter concentration 0.7%) G: Pig placenta extract of Preparation Example 4 (dry) H: Horse placenta extract of Production Example 4 (dry matter concentration 0.7%) I: Porcine placenta extract of Production Example 5 (dry matter concentration 0.7%) J: Horse placenta extract of Production Example 5 K: Swine placenta extract of Preparation Example 6 (dry matter concentration 0.7%) L: Horse placenta extract of Preparation Example 6 (dry matter concentration 0.7%) * Any of A to L One kind of extract 5.0 5. Comfrey leaf or stem 50% ethanol extract 3.0 6. Lettuce leaf 50% ethanol extract 3.0 7. Preservative (phenoxyethanol) 0.1 8. Purified water 100 residue

(Formulation Example 24) Hair tonic weight% 1. 1-menthol 0.2 2. Ethanol 32.5 3. Polyoxyethylene hydrogenated castor oil 0.5 4. Propylene glycol 5.0 5. Diphenhydramine hydrochloride 0.3 6. Pig placenta extraction of Production Example 2 Liquid (concentration of dry matter 0.7%) 2.0 7. Hot extract of pepper fruit 1.0 8. Ethylene rhizome or rhizome 50% ethanol extract 1.0 9. Rhizome rhizome or rhizome 50% ethanol extract 1.0 10. Rhizoma rhizome or Root bark 50% ethanol extract 1.0 11. Carboxymethyl chitin solution 1.0 12. Vitamin E derivative 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Perfume (sage water) qs 15. Purified water 100

(Formulation Example 25) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Swine placenta extract of Production Example 4 (dry matter concentration: 0.7%) 2.0 3. Below-rooted rhizome or root bark 50% ethanol extract 1.04 .50% propylene glycol extract from T. japonicus whole plant 2.0 5. Vitamin E derivative 0.5 6. Pepper tincture 0.5 7. Resorcinol 0.5 8. Dipotassium glycyrrhizinate 0.5 9. Carboxymethyl chitin solution 0.5 10. Porcine hematin solution 0.5 11. Porcine mucin Solution 0.5 12. Amino acid (glycine, glutamine, etc.) 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Perfume (rosemary water) qs 15. Purified water 100

(Formulation Example 26) Hair restorer / hair restorer% by weight 1. Ethanol 60.0 2. Equine placenta extract of Production Example 5 (0.3% dry matter concentration) 2.0 3. Ethanol extract of whole plant 60% ethanol 4. Button rhizome Or root bark 60% ethanol extract 1.0 5. Canthari tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhizic acid 0.5 8. Resorcinol 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Antibacterial and preservative (paraben) 0.1 13.Perfume (lavender water) Appropriate amount 14.Purified water 100 residue

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. Pig placenta extract dry powder of Production Example 1 2.0 5. Senkyu hot water extract Dry powder 8.0 6. Jujube whole plant hot water extract dry powder 2.0 7. Satsuma mandarin 50% ethanol extract dry powder 1.0 8. Dye (Gunjo green) Appropriate amount

(Formulation Example 28) Granule bath agent weight% 1. Sodium hydrogen carbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Horse placenta extract dry powder of Production Example 1 2.0 5. Black tea hot water extract Dry powder 1.0 6. Iris leaf or root 70% ethanol extract dry powder 1.0 7. Apple juice powder 1.0 8. Dye (Gunjo, chromium hydroxide) Appropriate amount 9. Fragrance (Roman chamomile water) Appropriate amount

(Formulation Example 29) Coating protective agent Gauze or liniment cloth is impregnated with a prescription solution obtained by mixing an appropriate amount of the swine or horse placenta extract (dry matter concentration: 0.7%) of Example 1, an antibiotic, an anti-inflammatory agent and the like. And attach it to the wound.
In addition, the pig and horse placenta extract of Production Example 1 (dry matter concentration 0.5
%) May be directly applied locally and covered with gauze or the like.

(Formulation Example 30) Oral freshener weight% 1. Ethanol 20.0 2. Glycerin 15.0 3. Polyoxyethylene hydrogenated castor oil 1.0 4. Saccharin 0.2 5. Chlorohexidine 0.01 6. Pig or horse placenta extract of Production Example 1 Dry powder 0.1 7. Western thin leaf hot water extract dry powder 0.1 8. Dye (Gunjo green) qs 9. Purified water 100 residue

(Formulation Example 31) Dishwashing detergent weight% 1. Alkyl (C12) glucoside 20.0 2. Polyoxyethylene (3) Na dodecyl ether sulfate 10.0 3. Glycerin 2.0 4. Ethanol 5.0 6. Pigs of Production Example 1 or Horse placenta extract dry powder 0.1 7. Chamomile flower hot water extract dry powder 3.0 8. Purified water 100 residue

(Test 6) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. Use test is for 20-30 years old who suffers from skin diseases such as Kayumi / eczema and atopic dermatitis.
This was performed by applying an appropriate amount of the emulsion of Formulation Example 1 to the face over three months, twice a day, in the morning and at night, after washing the face. Incidentally, a control prepared by the same method except that the pig or horse placenta extract of the present invention was removed from the emulsion was used as a control. Also, the evaluation method is based on the following criteria,
The results are as shown in Table 1 and the numbers in the table represent the number of people. No one complained of skin abnormalities during the use period.

"Skin disease improving effect" Efficacy: Skin diseases such as skin swelling / eczema and atopic dermatitis were improved. Slightly effective: Skin diseases such as skin kayumi / eczema and atopic dermatitis were slightly improved. Ineffective: No change from before use.

[0130]

(Test Results) As shown in Table 1, the emulsion containing the swine or equine placenta extract of the present invention exhibited a good improvement effect on skin diseases such as skin rash / eczema and atopic dermatitis. confirmed.

(Test 7) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. The use test was conducted by a panel of 20 people aged 30 to 50 years old who suffered from dry skin or shiny / skin-free skin. This was done by applying over a period of months.
Incidentally, a control prepared by the same method except that the pig or horse placenta extract of the present invention was removed from the emulsion was used as a control. The evaluation was performed according to the following criteria. The results are as shown in Table 2 and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.

"Effect of improving skin feel" Efficacy: Dry skin and skin gloss / tension increased, and skin was improved. Slightly effective: Dry skin and skin gloss / tension increased slightly, and skin was improved. Ineffective: No change from before use.

[0134]

(Test Results) As shown in Table 2, the emulsion containing the swine or equine placenta extract of the present invention showed a significant gloss on the skin.
It was confirmed that tension was applied and dry skin was improved.

[0136]

The swine and / or equine placenta extract of the present invention has excellent antiallergic (histamine release inhibitory) action,
In addition, it has been confirmed that it has a fibroblast proliferation promoting action, and can be used as an antiallergic agent (histamine release inhibitor) or a fibroblast proliferation promoter. In addition, all forms of allergic / atopic skin inflammatory diseases (for example, redness, eczema, edema, swelling, etc.), improvement of dry skin, and gloss / tension to the skin to prevent and improve skin troubles Can be applied to cosmetic compositions (pharmaceuticals, quasi-drugs, cosmetics).

[Brief description of the drawings]

FIG. 1 is a graph showing the histamine release inhibitory effect of a swine or horse placenta extract of the present invention.

FIG. 2 is a diagram showing a fibroblast proliferation promoting effect of a pig or horse placenta extract of the present invention.

 ────────────────────────────────────────────────── ─── Continuing on the front page F term (reference) 4C083 AA032 AA071 AA072 AA082 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB442 AC022 AC032 AC072 AC102 AC122 AC132 AC182 AC242 AC312 AC422 AC432 AC442 AC472 AC522 AC542 AC552 AC582 AC64 AD212 AD322 AD442 AD452 AD512 AD532 AD642 AD662 CC04 CC05 CC06 CC07 CC12 CC19 CC23 CC25 CC33 CC37 CC38 CC39 CC41 DD05 DD27 DD31 DD33 EE12 4C087 AA01 AA02 BB58 NA14 ZA89 ZB13 ZB21

Claims (4)

[Claims] 1. An antiallergic agent comprising a placenta extract of pig and / or horse. 2. A histamine release inhibitor comprising a placenta extract of pig and / or horse. 3. An agent for promoting fibroblast proliferation, comprising a placenta extract of pig and / or horse. 4. A cosmetic composition comprising at least one of the antiallergic agents, histamine release inhibitors and fibroblast proliferation promoters according to claims 1 to 3. object.