JP2002068973A5 - - Google Patents
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- Publication number
- JP2002068973A5 JP2002068973A5 JP2000304746A JP2000304746A JP2002068973A5 JP 2002068973 A5 JP2002068973 A5 JP 2002068973A5 JP 2000304746 A JP2000304746 A JP 2000304746A JP 2000304746 A JP2000304746 A JP 2000304746A JP 2002068973 A5 JP2002068973 A5 JP 2002068973A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- cyclohexen
- methyl
- trimethyl
- production example
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 description 5
- FGMAOXGOTRUOKJ-UHFFFAOYSA-N 3-(15-hydroxypentadecyl)-2,4,4-trimethylcyclohex-2-en-1-one Chemical compound CC1=C(CCCCCCCCCCCCCCCO)C(C)(C)CCC1=O FGMAOXGOTRUOKJ-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 4
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000024245 cell differentiation Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- CWZACLGIXULVCV-UHFFFAOYSA-N 3-(15-hydroxypentadecyl)-4-methylcyclohex-2-en-1-one Chemical compound CC1CCC(=O)C=C1CCCCCCCCCCCCCCCO CWZACLGIXULVCV-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 0 *C(*)(CC1)C(*)=C(*)C1=O Chemical compound *C(*)(CC1)C(*)=C(*)C1=O 0.000 description 1
- QJUIMZKRLGOMDK-UHFFFAOYSA-N 14-[7-(benzenesulfonyl)-8-methyl-1,4-dioxaspiro[4.5]decan-7-yl]tetradecan-1-ol Chemical compound C1C(S(=O)(=O)C=2C=CC=CC=2)(CCCCCCCCCCCCCCO)C(C)CCC21OCCO2 QJUIMZKRLGOMDK-UHFFFAOYSA-N 0.000 description 1
- VKXZRJZWAYBBAE-UHFFFAOYSA-N 14-bromotetradecan-1-ol Chemical compound OCCCCCCCCCCCCCCBr VKXZRJZWAYBBAE-UHFFFAOYSA-N 0.000 description 1
- UNNNLVVXTUETAT-UHFFFAOYSA-N 3-(12-hydroxydodecyl)-2,4,4-trimethylcyclohex-2-en-1-one Chemical compound CC1=C(CCCCCCCCCCCCO)C(C)(C)CCC1=O UNNNLVVXTUETAT-UHFFFAOYSA-N 0.000 description 1
- PKWPHLCCQVCBLJ-UHFFFAOYSA-N 3-(14-hydroxytetradecyl)-4-methylcyclohex-2-en-1-one Chemical group CC1CCC(=O)C=C1CCCCCCCCCCCCCCO PKWPHLCCQVCBLJ-UHFFFAOYSA-N 0.000 description 1
- FLPBIOUJTQLUAU-UHFFFAOYSA-N 3-(18-hydroxyoctadecyl)-2,4,4-trimethylcyclohex-2-en-1-one Chemical compound CC1=C(CCCCCCCCCCCCCCCCCCO)C(C)(C)CCC1=O FLPBIOUJTQLUAU-UHFFFAOYSA-N 0.000 description 1
- VGVHNLRUAMRIEW-UHFFFAOYSA-N 4-methylcyclohexan-1-one Chemical compound CC1CCC(=O)CC1 VGVHNLRUAMRIEW-UHFFFAOYSA-N 0.000 description 1
- XOBVEZYLDYRXKM-UHFFFAOYSA-N 7-(benzenesulfonyl)-8-methyl-1,4-dioxaspiro[4.5]decane Chemical compound C1C(S(=O)(=O)C=2C=CC=CC=2)C(C)CCC21OCCO2 XOBVEZYLDYRXKM-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000004450 alkenylene group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 1
- 239000012230 colorless oil Substances 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical compound O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 description 1
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 1
- OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- RXHONFUPUZJGQP-UHFFFAOYSA-N trimethyl-(4-methylcyclohexen-1-yl)oxysilane Chemical compound CC1CCC(O[Si](C)(C)C)=CC1 RXHONFUPUZJGQP-UHFFFAOYSA-N 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000304746A JP2002068973A (ja) | 2000-06-16 | 2000-10-04 | 幹細胞分化誘導促進剤 |
| AT01972471T ATE450602T1 (de) | 2000-10-04 | 2001-09-19 | Stemzelldifferenzierung induzierende promoter |
| EP01972471A EP1322748B1 (en) | 2000-10-04 | 2001-09-19 | Stem cell differentiation-inducing promoter |
| PCT/JP2001/008136 WO2002029014A2 (en) | 2000-10-04 | 2001-09-19 | Stem cell differentiation-inducing promoter |
| DE60140685T DE60140685D1 (de) | 2000-10-04 | 2001-09-19 | Stemzelldifferenzierung induzierende promoter |
| US10/381,586 US20040115810A1 (en) | 2000-10-04 | 2001-09-19 | Stem cell differentiation-inducing promoter |
| CA2424207A CA2424207C (en) | 2000-10-04 | 2001-09-19 | Stem cell differentiation-inducing promoter |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000181133 | 2000-06-16 | ||
| JP2000-181133 | 2000-06-16 | ||
| JP2000304746A JP2002068973A (ja) | 2000-06-16 | 2000-10-04 | 幹細胞分化誘導促進剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002068973A JP2002068973A (ja) | 2002-03-08 |
| JP2002068973A5 true JP2002068973A5 (enExample) | 2006-06-22 |
Family
ID=26594076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000304746A Pending JP2002068973A (ja) | 2000-06-16 | 2000-10-04 | 幹細胞分化誘導促進剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002068973A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4035332B2 (ja) * | 2002-01-22 | 2008-01-23 | 明治乳業株式会社 | シクロヘキセノン長鎖アルコールの製造法 |
| CA2583699C (en) * | 2004-10-13 | 2012-11-20 | Meiji Dairies Corporation | Stat3 phosphorylation inhibitor and notch1 expression inhibitor |
| CN101180041B (zh) * | 2005-01-18 | 2011-04-13 | 明治乳业株式会社 | 感觉障碍治疗剂 |
| TWI511727B (zh) | 2014-07-02 | 2015-12-11 | Everfront Biotech Inc | 苯酞化合物之應用 |
| NZ728386A (en) * | 2014-07-04 | 2018-02-23 | Everfront Biotech Inc | Use of phthalide compound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2539665B2 (ja) * | 1988-06-20 | 1996-10-02 | 日本臓器製薬株式会社 | 神経疾患治療剤 |
| US5786391A (en) * | 1995-01-11 | 1998-07-28 | Cornell Research Foundation, Inc. | Regulating gene expression using retinoids with Ch2 OH or related groups at the side chain terminal position |
| JP2000515137A (ja) * | 1996-07-12 | 2000-11-14 | マサチューセッツ インスティチュート オブ テクノロジー | 軸索の成長を制御する方法 |
| DE69811905T2 (de) * | 1997-08-13 | 2003-11-06 | Meiji Milk Products Co. Ltd., Tokio/Tokyo | Cyclohexenon langketten alkohol und diese enthaltendes arzneimittel |
| PL195273B1 (pl) * | 1997-08-29 | 2007-08-31 | Vertex Pharma | Związki wykazujące aktywność neuronalną, kompozycja farmaceutyczna zawierająca taki związek oraz zastosowanie tych związków |
-
2000
- 2000-10-04 JP JP2000304746A patent/JP2002068973A/ja active Pending
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