JP2002003321A - Antibacterial and antiseptic agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antibacterial and antiseptic agent utilizing a natural material, especially an antibacterial and antiseptic agent for cosmetic material. SOLUTION: This antibacterial and antiseptic agent contains an extract of aragonite as an active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an antibacterial agent and a preservative, particularly to an antibacterial agent for cosmetics and a preservative for cosmetics.

[0002]

2. Description of the Related Art Cosmetics generally refer to products used to cleanse, beautify, increase attractiveness, and change the shape of a person's body, and from the viewpoint of the manufacturing industry, are classified into basic cosmetics and finish cosmetics. There are two main categories. Basic cosmetics include lotions, emulsions, creams, pomades, tics, facial cleansers, shampoos, hair restorers, hair restorers, hair liquids, etc. Finish cosmetics include oscilloscopes, lipsticks, lipsticks, foundations, nail enamels , Eye shadow, mascara and the like.

[0003] Since these various cosmetics are usually rich in moisture and nutrients, microorganisms such as bacteria and fungi easily grow and propagate, and are susceptible to spoilage by microorganisms. On the other hand, in the process of manufacturing and distributing cosmetics and in the process of using cosmetics by consumers, there is a possibility that microorganisms may accidentally enter the cosmetics. When microorganisms are mixed into cosmetics and grow and propagate in cosmetics, deterioration in quality, skin damage due to deterioration of components, infectious diseases caused by pathogenic bacteria, opportunistic infections caused by non-pathogenic bacteria, harmful effects caused by bacterial cell components and metabolites are caused. Can occur.

[0004] Therefore, cosmetics are manufactured, and the manufactured cosmetics pass through the distribution process to the hands of consumers. Until the consumers finish using the cosmetics, the growth of microorganisms accidentally mixed into the cosmetics is suppressed. It is necessary to kill and prevent the growth and propagation of microorganisms in cosmetics.

At present, phenols such as parahydroxybenzoic acid, amphoteric surfactants such as alkylaminoethylglycine hydrochloride, and trichlorocarbanilate are used as antibacterial agents and preservatives to prevent the growth and propagation of microorganisms in cosmetics. Acid amides such as lids and halogenated bisphenols such as hexachlorophene are used.

[0006] Increasing the amount of these antibacterial agents and preservatives in cosmetics or using a compound having strong antibacterial and preservative effects can improve the antibacterial properties and preservability of cosmetics. On the other hand, it is toxic not only to microorganisms but also to the human body (eg, skin irritation, skin sensitization,
Cytotoxicity) and may cause skin disorders (eg, allergic contact dermatitis).

For example, parabens, which are widely used as preservatives for medicines and foods, such as cosmetics, are known to be substances that easily cause allergy, and there have been reports of cases that actually caused contact dermatitis. Have been. In addition, the toxicity of parabens is
It is known to cause vomiting, acidosis, rash, fever, methemoglobinosis, hepatitis and the like.

Accordingly, from the viewpoint of safety, the types and amounts of antibacterial agents and preservatives that can be incorporated into cosmetics are regulated. In some cases, it cannot be incorporated into cosmetics. In addition, microorganisms that grow and propagate in cosmetics are often Escherichia coli and Pseudomonas aeruginosa, which can cause drug (drug) resistance. Antibacterial and preservative effects may not be exhibited.

[0009]

SUMMARY OF THE INVENTION An object of the present invention is to provide an antibacterial agent and preservative utilizing natural products, particularly an antibacterial agent for cosmetics and a preservative for cosmetics.

[0010]

In order to achieve the above object, the antibacterial agent and the preservative of the present invention are characterized by containing an aragonite extract as an active ingredient. In the antibacterial agent and preservative of the present invention, the extract is preferably an extract obtained using a polar solvent as an extraction solvent. In the antibacterial agent and preservative of the present invention, the antibacterial agent and preservative are preferably a cosmetic antibacterial agent and a cosmetic preservative.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.

The antibacterial agent and preservative of the present invention are characterized in that an extract of aragonite is used as an active ingredient.

Here, "aragonite"
Is a calcium carbonate mineral, also called "aragonite". The term “mineral” generally refers to an inorganic substance existing in nature and having a certain chemical composition and crystal structure.

The aragonite is produced, for example, when it fills the pores of a volcanic rock, when it precipitates from a high-temperature hot spring, and when it occurs in the oxidized zone of the ore deposit, it contains, for example, hakenite, ryoaenite, peacock ore, and dolomite. And a case where they are produced as veins in the gaps of jadeite or in the altered places of basic igneous rocks. Since aragonite is a natural product, it contains silicon dioxide (Si) as an ingredient other than calcium carbonate (CaCO ₃ ).
O ₂ ), aluminum oxide (Al ₂ O ₃ ), iron oxide (Fe ₂ O ₃ ),
_May contain magnesium oxide (MgO), phosphorus pentoxide (P ₂ O ₅ ), and the like. In addition, part of Ca in aragonite is Sr,
It may be substituted with Ba, Pb, or the like.

Typical aragonite production areas include, for example, Matsushiro mine in Shimane prefecture and Kamioka mine in Gifu prefecture.
The composition analysis value of aragonite from Matsushiro is CaO 55.96%, C
O ₂ 43.95%, MgO 0.03%, insoluble content 0.13% (total 100.07
%) (Chemical Dictionary 1, compact edition, 328 pages, edited by the Chemical Dictionary Editor's Committee, published by Kyoritsu Shuppan Co., Ltd.).

The crystallographic properties, physical properties, chemical properties and the like of aragonite are as follows. Aragonite is orthorhombic, has a aragonite-type structure, and is polymorphic to borealite. Aragonite is colorless, white to light green,
They are yellow, purple, blue and the like, and have glass luster. Aragonite has a columnar shape, but may be hexagonal due to twinning. Aragonite shows a flame reaction of calcium and is soluble in acids such as hydrochloric acid. When an aragonite powder sample is boiled with a dilute solution of cobalt nitrate, a precipitate of basic cobalt carbonate is formed to exhibit a reddish purple color.

In the antibacterial agent and preservative of the present invention, the term "extract" includes an extract obtained by the extraction treatment, a diluent or a concentrate of the extract, a dried product obtained by drying the extract, Alternatively, any of these crude products or purified products are included.

In the extraction treatment, it is preferable to use aragonite itself as an extraction raw material, but it is not always necessary to use aragonite itself, and any substance including aragonite may be used as an extraction raw material. For example, rock or soil containing aragonite can be used as an extraction raw material.

Therefore, in the antibacterial agent and the preservative of the present invention, the term “extract of aragonite” includes not only an extract from aragonite itself but also any extract containing aragonite, such as an extract from rock or soil containing aragonite. Also included are extracts from objects.

The source of the aragonite used as the extraction raw material in the extraction treatment is not particularly limited, but it is preferable to use aragonite contained in the volcaniclastic flow deposits in the Akan caldera area in Hokkaido. This aragonite is
It is thought that it was formed by the precipitation of groundwater components that grew out from near the lake bottom and organic matter such as animals and plants existing in Lake Akan.It is characterized by containing humic acid as a trace amount of organic matter. , Silicate compounds, aluminum oxide, iron oxide and the like. In the extraction process,
Aragonite isolated from the volcaniclastic flow deposits in the Akan caldera area in Hokkaido may be used as the extraction raw material, or the volcaniclastic flow deposits in the Akan caldera area in Hokkaido may be used directly as the extraction raw material.

The aragonite, rocks and soil containing aragonite used as an extraction raw material in the extraction treatment may be in any shape, but from the viewpoint of the efficiency of the extraction treatment, they are formed into granules or powder by treatment such as pulverization. It is preferred to use one. However, if the pulverization is excessive, a sufficient filtration treatment may be required in a subsequent step, so that coarse pulverization is preferred.

As the extraction solvent used in the extraction treatment, it is preferable to use a polar solvent. Examples of the polar solvent include water, methanol, ethanol, propanol, 1,3-butylene glycol, glycerin, propylene glycol and the like, and these can be used alone or in combination of two or more.

Among these extraction solvents, it is particularly preferable to use water. Here, the “water” includes pure water, tap water, well water, mineral water, mineral water, hot spring water, spring water, fresh water, and the like, as well as those subjected to various treatments. Examples of the treatment include sterilization, sterilization, filtration, ion exchange, adjustment of osmotic pressure, buffering, and the like. Therefore, "water" also includes ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered saline, and the like.

Before the extraction with the polar solvent, a pretreatment using a non-polar solvent such as hexane or benzene may be performed. By performing such a pretreatment, the extraction with the polar solvent can be performed efficiently. it can.

The extraction treatment is not particularly limited as long as the soluble components contained in the aragonite can be eluted into the extraction solvent, and can be carried out according to a conventional method.

The extraction treatment can be carried out, for example, by immersing aragonite, an extraction material such as rock or soil containing aragonite in an extraction solvent. At this time, the amount of the extraction solvent is not particularly limited and can be appropriately adjusted depending on the amount of the extraction raw material and the like, but it is usually 500 to 10,000 ml, preferably 500 to 5000 ml, more preferably 1000 ml, based on 100 g of the extraction raw material.
~ 2000 ml. The number of immersion days is not particularly limited, and can be appropriately adjusted depending on the amount of the extraction raw material, the amount of the extraction solvent, and the like, but is usually 1 to 60 days, preferably 3 to 30 days, and more preferably 7 to 14 days. is there. The extraction temperature is usually 10 ~ 80 ℃
And preferably 20 to 60 ° C. The extraction may generally be performed at room temperature. During the extraction treatment, the aragonite may be immersed in the extraction solvent and then left as it is, or may be appropriately shaken or stirred.

The extract of aragonite can be obtained by eluting the soluble component contained in aragonite into the extraction solvent by the extraction treatment. When the extraction residue of aragonite contains an extraction residue, it is preferable to remove the extraction residue by performing a treatment such as filtration, but even if the aragonite extract contains the aragonite used as the extraction raw material, Good. The aragonite extract may be diluted or concentrated according to a conventional method to obtain a diluent or concentrate of the extract, a dried product obtained by drying the extract, or a crude product or a purified product thereof. , Drying, purification and the like.

The aragonite extract obtained as described above has an antibacterial action and an antiseptic action.

As used herein, the term "antibacterial action" refers to the action of suppressing the generation, growth or growth of microorganisms, or the action of killing microorganisms. The term "preservative action" refers to the action of adding to a target substance. Means the action of inhibiting the growth of microorganisms in the substance and preventing the substance from spoiling. In addition,
"Microorganisms" include bacteria, molds and the like.

Although the mechanism of the antibacterial and preservative actions of the aragonite extract has not been elucidated so far, it has been shown in the examples described later that the aragonite extract has the antibacterial and preservative actions. As can be seen, the antimicrobial and preservatives of the present invention utilize the antimicrobial and preservative effects of such aragonite extracts.

The aragonite extract can be used as it is as an antibacterial agent or preservative, but may be formulated according to a conventional method. In the case of formulation, pharmaceutically acceptable carriers such as dextrin and cyclodextrin and other auxiliaries can be added to the aragonite extract to facilitate storage and handling. The aragonite extract can be made into any dosage form such as a powder or a tablet by formulation.

The microorganisms to which the antibacterial agent and preservative of the present invention can exert antibacterial and preservative effects include Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa.

The antibacterial agent and preservative of the present invention can be used for imparting antibacterial and antiseptic properties to cosmetics, pharmaceuticals, foods, and the like. It is preferably used as an antibacterial agent for cosmetics and a preservative for cosmetics.

The antibacterial agent for cosmetics can be used not only as a preservative for cosmetics, but also for killing microorganisms present on the skin and the like of the user of the cosmetic and for cleaning the skin and the like of the user.

The cosmetics to which the antibacterial agent for cosmetics and the preservative for cosmetics can be blended are not particularly limited, and specific examples thereof include:
Skin cosmetics such as ointments, creams, emulsions, lotions, packs, etc., hair cosmetics such as hair restoration, hair restoration, hair growth, hair tonic, pomade, hair liquid, set lotion, other hair styling, hair perfume, cologne, etc. Cosmetic products for fragrances, bath agents such as liquid bath agents, etc., and the like, and the compounding ratio of the aragonite extract to these cosmetics is usually 0.
0001-10% by weight, preferably 0.01-1% by weight.

These various cosmetics should be blended with a main ingredient, auxiliaries and the like generally used in the production of various cosmetics, as long as the antibacterial and preservatives of the present invention are not impaired. Can be.

For example, glycerin, collagen, hyaluronic acid and its salts, chondroitic acid and its salts, chitin, and glycerin, collagen, hyaluronic acid and its salts can be used as constituents in skin cosmetics together with the aragonite extract.
Moisturizing agents such as chitosan; UV absorbers such as amyl paradimethylaminobenzoate; complex lipids such as glycerophospholipids and sphingophospholipids; β-carotene, oil-soluble licorice extract, lycochalcone A, baicalin, baicalein and other active oxygen scavenging effects Azulene, glycyrrhizic acid and its salts, glycyrrhetic acid and its derivatives, anti-inflammatory substances such as zinc oxide; riboflavin;
Vitamins and derivatives thereof such as tocopherol, ascorbic acid and folic acid; oily components such as jojoba oil, lanolin, liquid paraffin, squalane and isostearyl alcohol; surfactants such as sodium stearyl sulfate, cetyl sulfate diethanolamine and glycerin stearate; Antioxidants such as sodium citrate; Preservatives such as ethyl paraben; Cholesterols such as oak extract, chamomile extract, liquorice root extract, rosemary extract, and horse chestnut extract; plant sterols; lipoproteins; Microorganism-derived components such as bacterial cultures, lactic acid bacterial cultures, yeast extracts, and liquorice extracts; algal extracts such as brown algae extracts and red algae extracts; blood circulation promoters such as γ-oryzanol; Agent; fragrance; alcohol; carboxy polymer, etc. Nebazai; titanium yellow, safflower other colorants, and the like.

When aragonite extraction water obtained by using water as an extraction solvent is used as an antibacterial agent for cosmetics and a preservative for cosmetics, aragonite is used instead of water used in the production of cosmetics. Extract can be used. In this case, the cosmetics to which the antibacterial agent for cosmetics and the preservative for cosmetics can be blended may be any cosmetics as long as water is used as a raw material. When blending aragonite extract water into cosmetics as an antibacterial agent for cosmetics and a preservative for cosmetics, the aragonite extract water may be diluted as necessary.

[0039]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the scope of the present invention is not limited to these Examples and the like.

[Production Example 1] A dried product of a volcaniclastic flow deposit in the Akan caldera area of Hokkaido was used as an extraction raw material.
This dried product was subjected to a pulverizing treatment with a hammer to set the particle size to about 1 to 5 cm. 100 g of the extraction raw material was placed in a beaker, 2,000 ml of ion-exchanged water was added, the mixture was left to stand for 2 weeks with a lid, and then filtered with a cloth to obtain an aragonite extract.
The cloth used for filtration is a commercially available gauze, and the size of the mesh is such that fine stones do not fall.

[Production Example 2] Extraction raw material 10 similar to Production Example 1
Put 0 g in a beaker, add 1000 ml of tap water, close the lid,
After standing for a week, the mixture was filtered with a filter paper (manufactured by Advantech) to obtain an aragonite extract.

Test Example 1 The aragonite extract prepared in Production Examples 1 and 2, a 0.1% paraben solution as a control,
An antibacterial test was performed on Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli using ion-exchanged water as a blank.

The test method is as follows. Production Example 1
Each of the aragonite extract, the 0.1% paraben solution, and the ion-exchanged water prepared in steps 2 and 3 was sterilized by filtration with a 0.2 μm membrane filter, and then dispensed into 10 ml portions. Then, one loopful of Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli were placed in 5 ml of sterilized water and suspended, and the suspension was diluted 100-fold and 1000-fold. A 1000-fold diluted bacterial solution was prepared. After adding and mixing 0.5 ml of each bacterial solution to an extract of aragonite subjected to filtration sterilization, a paraben solution and ion-exchanged water, respectively,
0.1 ml of each mixture was uniformly applied to a SCDLP agar medium (manufactured by Wako Pure Chemical Industries, Ltd.) and a BGLB agar medium (manufactured by Eiken Chemical Co., Ltd.) with a conical rod. S for Bacillus subtilis and Pseudomonas aeruginosa
Using CDLP agar, BGLB for E. coli
After culturing each at 37 ° C. using an agar medium,
On days 2, 2 and 8, the number of colonies of each microorganism formed was determined.

(1) Results of cultivation of Bacillus subtilis The number of B. subtilis colonies formed on the 0th, 2nd and 8th days of the culture was the same as that of the aragonite extract prepared in Production Example 1.
When mixed with 100-fold diluted bacterial solution, 2
When the aragonite extract prepared in Production Example 1 was mixed and cultured with the 1000-fold diluted bacterial solution, 85, 41, and 300 cells were prepared in Production Example 2, 88, 220, and 2000, respectively. When the aragonite extract and the 100-fold diluted bacterial solution were mixed and cultured, 335, 286, and 960, respectively, the aragonite extract prepared in Production Example 2 and the 1000-fold diluted bacterial solution were mixed and cultured. 39, 53 and 95 respectively
Was individual. In contrast, 0.1% paraben solution and 100%
295 each when mixed and cultured with a 1: 2 dilution
, 162 and 540, and 25, 62 and 78, respectively, when the 0.1% paraben solution and the 1000-fold diluted bacterial solution were mixed and cultured. Further, each of the 353 when cultured by mixing the ion-exchanged water and 100-fold diluted bacterial solution, 238 pieces and> 10 ^5, when cultured by mixing the ion-exchanged water and 1000-fold diluted bacterial solution Had 40, 80 and> 10 ⁵ respectively. The results of the culture of Bacillus subtilis are summarized in Table 1 below.

[Table 1] On day 0, day 2 and day 8 100-fold diluted solution of the extract of Preparation Example 1 288 220 2,000 2000-fold diluted solution 85 41 300 300-fold extract of Preparation Example 2 Diluent 335 286 960 1000-fold diluted 39 39 53 95 0.1% paraben solution 100-fold diluted 295 162 540 1000-fold diluted 25 25 62 78 100-fold ion-exchanged water 353 238 pcs> 10 ⁵ 1000-fold diluted solution 40 pcs 80 pcs> 10 ⁵ pcs

(2) Results of Pseudomonas aeruginosa culture The number of Pseudomonas aeruginosa colonies formed on the 0th, 2nd and 8th days of the culture was the same as that of the aragonite extract prepared in Production Example 1.
When culturing by mixing with 100-fold diluted bacterial solution, 1
When the aragonite extract prepared in Production Example 1 and the 1000-fold diluted bacterial solution were mixed and cultured, 60, 187, and 240 cells were prepared in Production Example 2, 32, 56, and 84, respectively. When the aragonite extract and the 100-fold diluted bacterial solution were mixed and cultured, 118, 277, and 950, respectively, Production Example 2
When the aragonite extract prepared in the above was mixed and cultured with the 1000-fold diluted bacterial solution, the numbers were 45, 52 and 95, respectively. On the other hand, when a 0.1% paraben solution and a 100-fold diluted bacterial solution were mixed and cultured, 68 cells and 15 cells were used, respectively.
When 5 and 530 cells were mixed and cultured with a 0.1% paraben solution and a 1,000-fold diluted bacterial solution, 22, 67 and 78 cells were used, respectively.
Was individual. When ion-exchanged water and a 100-fold diluted bacterial solution were mixed and cultured, 95, 350 and> 1
0 ^3, respectively 28 when cultured by mixing the ion-exchanged water and 1000-fold diluted bacterial solution was 138 and> 10 ^3. The results of the culture of P. aeruginosa are summarized in Table 2 below.

[Table 2] On day 0, day 2 and day 8 100 times dilution of extract of Preparation Example 1 160 187 240 times 1000 times dilution 32 56 84 100 times extract of Preparation 2 Diluent 118 277 950 1000 times diluted 45 52 95 95 % 0.1% paraben solution 100 times diluted 68 155 530 1000 times diluted 22 22 67 78 100 times diluted ion exchange water 95 350 350> 10 ³ 1000-fold dilution 28 28 138> 10 ³

(3) Results of Escherichia coli Culture The number of Escherichia coli colonies formed on the 0th, 2nd, and 8th days of the cultivation was the same as that of the aragonite extract prepared in Production Example 1.
When mixed with 100-fold diluted bacterial solution, 2
03, 229 and 1260, and when aragonite extract prepared in Production Example 1 and a 1000-fold diluted bacterial solution were mixed and cultured, 82, 113 and 240 cells were prepared in Production Example 2, respectively. When aragonite extract and 100-fold diluted bacterial solution are mixed and cultured, 538, 640 and 1150 cells are mixed, respectively, and the aragonite extract prepared in Production Example 2 and 1000-fold diluted bacterial solution are mixed and cultured. 135, 181 and
There were 475. On the other hand, 0.1% paraben solution and 1
When the cells were mixed and cultured with a 1: 100 dilution, 18
0, 225 and 340, 68 and 94 respectively when 0.1% paraben solution and 1000-fold diluted bacterial solution were mixed and cultured.
And 140. When ion-exchanged water and a 100-fold diluted bacterial solution were mixed and cultured, 228 of each were cultured,> 1
0 ⁵ and> 10 ^5, respectively 75 pieces when cultured by mixing the ion-exchanged water and 1000-fold diluted bacterial solution,> 10 ⁵ and was> 10 ^five. The results of the culture of E. coli are summarized in Table 3 below.

[Table 3] Day 0 Day 2 Day 8 Extract 100 times dilution of Preparation Example 1 203 229 1260 1000 times dilution 82 113 240 100 times extraction of Preparation Example 2 Diluent 538 640 1150 1000-fold diluent 135 181 475 0.1% Paraben solution 100-fold diluent 180 225 340 1000-fold diluent 68 94 94 140-fold ion-exchanged water 100-fold diluent 228 Pcs> 10 ⁵ pcs> 10 ⁵ 1000x dilution 75 pcs> 10 ⁵ pcs> 10 ⁵ pcs

(4) Antibacterial activity of aragonite extract As shown in the above results, when cultivation was performed using the aragonite extract prepared in Production Examples 1 and 2, culture was performed using ion-exchanged water. The number of colonies of each microorganism formed was smaller than in the case where the method was performed. This indicates that the aragonite extract has an antibacterial effect on microorganisms such as Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli. That is, the purpose of suppressing the generation, growth or growth of microorganisms,
Alternatively, it has been shown that aragonite extracts can be used as antimicrobial agents to achieve the purpose of killing microorganisms.
Furthermore, it has been shown that aragonite extract can be used as a preservative in order to prevent the growth of microorganisms in the substance by adding it to the substance and to achieve the purpose of preventing spoilage of the substance. In addition, the aragonite extract,
It has been shown that by adjusting the amount of paraben used, antibacterial action comparable to that of paraben, which is widely used as a preservative for cosmetics, medicines and foods, can be exerted.

[Formulation Example 1] Using the aragonite extract prepared in Production Example 1, a lotion having the following composition was produced according to a conventional method. Squalane 8.0 g Sorbitol 1.0 g Glycerin 1.0 g Sucrose fatty acid ester 0.2 g Ethanol 10.0 g Flavor 0.1 g Aragonite extract (Production Example 1) Remainder (total amount is 100 g)

[Formulation Example 2] Using the aragonite extract prepared in Production Example 2, a cream having the following composition was produced according to a conventional method. Stearic acid 2.0 g Stearyl alcohol 7.0 g Reduced lanolin 2.0 g Squalane 5.0 g Octidedecanol 6.0 g Castor oil 2.0 g Cetylpyridium chloride 3.0 g Flavor 0.3 g Propylene glycol 5.0 g Aragonite extract (Preparation example 2) And

[Formulation Example 3] Using the aragonite extract prepared in Production Example 1, a hair solid having the following composition was produced according to a conventional method. Liquid paraffin 20.0 g Lanolin alcohol 2.7 g Lauric acid diethanolamide 6.0 g Cetyl ether 5.0 g Polyoxyethylene fatty acid amide 6.0 g Fragrance 0.3 g Aragonite extract (Preparation example 1) Remainder (total amount is 100 g)

[Formulation Example 4] Using the aragonite extract prepared in Production Example 2, a liquid bath preparation having the following composition was produced according to a conventional method. Dipotassium glycyrrhizinate 0.3g Sodium polyoxyretylene lauryl ether sulfate 60.0g Sodium chloride 2.0g Coconut oil fatty acid polyoxyethylene glyceryl 4.0g Coconut oil fatty acid diethanolamide 1.0g Fragrance 0.2g Aragonite extract (Preparation example 2) 100g)

[0055]

According to the present invention, an antibacterial agent and a preservative containing an aragonite extract as an active ingredient are provided. The antibacterial agent and preservative of the present invention are particularly useful as an antibacterial agent for cosmetics and a preservative for cosmetics. When the active ingredient of the antibacterial agent and the preservative of the present invention is aragonite extracted water (extract obtained from aragonite using water as an extraction solvent), if it is used instead of water used in producing cosmetics, Even without using other antibacterial agents and preservatives, it is possible to easily and efficiently impart antibacterial properties and preservative properties to cosmetics.

Continued on the front page F-term (reference) 4C083 AA122 AA161 AA162 AB332 AC022 AC072 AC092 AC102 AC122 AC132 AC172 AC242 AC422 AC642 AC692 AC782 AD222 AD512 AD532 BB48 CC04 CC05 CC25 CC37 DD21 DD23 FF01 4C087 AA02 AA04 BA02 NA1 ZB35 BB02

Claims (6)

[Claims] 1. An antibacterial agent comprising an aragonite extract as an active ingredient. 2. The antibacterial agent according to claim 1, wherein the extract is an extract obtained using a polar solvent as an extraction solvent. 3. The antibacterial agent according to claim 1, wherein the antibacterial agent is a cosmetic antibacterial agent. 4. A preservative comprising an aragonite extract as an active ingredient. 5. The preservative according to claim 4, wherein the extract is an extract obtained using a polar solvent as an extraction solvent. 6. The preservative according to claim 4, wherein the preservative is a preservative for cosmetics.