JP2004018492A - Histamine release inhibitor, antiallergic agent and cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new and safe histamine release inhibitor, an antiallergic agent and a cosmetic composition. <P>SOLUTION: The invention provides a histamine release inhibitor, an antiallergic agent and a cosmetic composition containing an extracted or pressed material of at least one kind of a plant of the family Orchidaceae selected from varieties of Epipactis papillosa Franch et Savat., Neottia nidus-avis (L.)L.C. Rich. var. manshurica Komar, Cephalanthera longibracteata Blume and Dacrylorhiza incarnata (L.) Soo. These components have excellent histamine release suppressing action and high safety and are usable as a histamine release suppressing agent, an antiallergic agent or a cosmetic composition for preventing and ameliorating allergic/atopic dermatitis and rough skin. <P>COPYRIGHT: (C)2004,JPO

Description

【０１３３】
（試験結果）
表１の通り、本願発明のアオスズラン、サカネラン、ササバギンラン及びハクサンチドリの変種のラン科植物抽出物を含有した化粧料組成物（乳液及びエモリエントクリーム、ヘアートニック）は、湿疹、カユミ、肌荒れやアトピー性皮膚炎等の皮膚・頭皮疾患に対して、改善効果が確認された。
【０１３４】
【発明の効果】
本願発明のアオスズラン、サカネラン、ササバギンラン及びハクサンチドリの変種から選ばれる少なくとも１種以上のラン科植物の抽出物又は圧搾物は、優れたヒスタミン遊離抑制作用を有し、かつ安全性も高いものであり、優れたヒスタミン遊離抑制剤として使用することができる。又、本願発明のヒスタミン遊離抑制剤を配合した抗アレルギー剤は湿疹、蕁麻疹、アトピー性皮膚炎、アレルギー性鼻炎、花粉症等の各種アレルギー性皮膚疾患の予防、治療に有効であり、又、皮膚の老化防止にも利用できる。従って、あらゆる形態の製剤（医薬品類、医薬部外品類、化粧品類、食品類）に応用することができ、更に本願発明の抗アレルギー剤を配合した化粧料組成物は、アレルギー・アトピー性の皮膚炎症疾患（例えば、発赤、湿疹、浮腫、腫脹等）や肌荒れ、カユミといったトラブルを有する皮膚・頭皮に対して、その予防及び改善に用いることができ、又、口腔用組成物や食品へ応用範囲を拡大することも可能である。
【図面の簡単な説明】
【図１】アオスズラン、サカネラン、ササバギンラン及びハクサンチドリの変種の各種抽出液のヒスタミン遊離抑制率を示す図である。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to the application of at least one or more orchid plant extracts or pressed products selected from a variety of Aosuzuran, Sakanelan, Sasabaginran, and Chinese Plover to a histamine release inhibitor, an antiallergic agent, and a cosmetic composition.
[0002]
[Prior art]
Today, allergic diseases such as hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria due to drugs, etc. are caused by the deterioration of environmental conditions, changes in lifestyles, increased stress due to the complication of social life, etc. More and more people suffer from rough skin, dry skin and the like. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, not only in children but also in a wide range of ages including adults.
[0003]
Essentially, in order to eliminate foreign substances (antigens such as bacteria, pollen, mites) that have entered the body, the body produces immunity that protects the body by producing biological components (antibodies, lymphocytes, etc.) Has functions. However, sometimes the reaction becomes too sensitive and harmful to the body, causing various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into immediate type and delayed type.
[0004]
Of allergic reactions, those with a high frequency of onset are immediate, mainly reactions involving immunoglobulin E (IgE) antibodies. This IgE is produced for an allergen that has entered the body and has a strong effector effect on mast cells and basophils. Mast cells and basophils (a type of leukocyte) are histamine and basophils. Cells having granules containing pharmacologically active amines such as serotonin, the former being present around blood vessels and connective tissues, and the latter being present in blood. On these cell membranes, receptors that bind IgE antibodies are present and have the property of strongly binding to IgE antibodies. When the same type of allergen binds again to IgE antibodies bound to mast cells or basophils. Many active substances such as histamine and serotonin described above are released from these cells with degranulation, causing various allergic symptoms, and itching and redness and blistering rash (urticaria) on the skin, nose and eyes Symptoms that cause inflammation and itching and increased secretion of nasal discharge and tears, or symptoms of choking of the trachea and causing attacks of dyspnea (bronchial asthma) are classified as allergic diseases of this type. ing.
[0005]
In immediate allergy, the process can be broadly divided into three stages, and each stage is classified according to its point of action, and attempts have been made to prevent, alleviate, or treat allergic diseases through drug administration and the like. . That is, when a foreign antigen invades the body, an IgE antibody is produced by an immunocompetent cell line, and the IgE antibody is distributed in mast cells distributed at sites where allergic reactions such as the respiratory tract, skin, and digestive organs occur, or in the blood. Sensitization is established by sticking to basophils. This is the reaction referred to as the first step.
[0006]
Next, when the sensitized cells are again contacted with an antigen, the cells undergo morphological changes such as vacuolation, swelling, and degranulation, and release chemical transmitters such as histamine, serotonin, and SRS-A. This is the second stage reaction.
[0007]
The released chemical mediators act on the contraction of smooth muscle such as bronchial muscle and gastrointestinal tract, increase of capillary permeability, neutrophil migration, platelet aggregation, etc., resulting in asthma, back pain and diarrhea. The process of developing allergic symptoms such as digestive allergy, nasal allergy and urticaria is the third stage reaction.
[0008]
Therefore, in a narrow sense, drugs acting on the first and second stages can be regarded as preventive agents against allergic reactions, and those acting on the third stage can be regarded as symptomatic therapeutic agents. Currently, the most active research on antiallergic drugs is the development of drugs that suppress this second stage.
[0009]
[Problems to be solved by the invention]
Many of the conventionally used antiallergic drugs are drugs relating to diseases caused by an immediate allergic reaction whose action point is relatively clear. Examples include antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines, all of which are contrasting therapeutic agents that act at the third stage. In addition, most of them are synthetic drugs, and have a problem in side effects.
[0010]
On the other hand, currently the most active research on antiallergic drugs involved in immediate-type allergic diseases, drugs that suppress the release of chemical mediators, drugs that antagonize the released chemical mediators, etc. As for the development of a drug that suppresses the second stage, no drug with sufficient efficacy has been found at present.
[0011]
[Means for Solving the Problems]
In view of such circumstances, the inventors of the present application have attempted to screen a substance which is excellent in histamine release inhibitory action and has no side effects and is relieved to the human body and skin from natural plants. As a result, it was confirmed that the extract or pressed product of orchids such as Aosuzuran, Sakaneran, Sasabaginran and Hakusanchidori varieties has an excellent histamine release inhibitory action, and is very safe for living bodies. . Therefore, provision of a histamine release inhibitor and an antiallergic agent containing an extract or a compressed product of orchidaceous plants such as Aosuzuran, Sakaneran, Sasabaginran and a varieties of Chinese plover, or an allergic skin inflammatory disease (for example, redness, edema) , Eczema, etc.), atopic dermatitis or rough skin, and a safe cosmetic composition excellent in prevention and improvement of skin and scalp troubles such as Kayumi, the present invention has been completed.
[0012]
BEST MODE FOR CARRYING OUT THE INVENTION
The orchid family (Orchidaceae) of the family Orchidaceae used in the present invention is Orchidaceae (Orchidaceae) and the genus Achisulane (Science: Epipactis papillosa Franch et Savat .; Alternative name: Epiactis hellvara. et @ Sav.) Hashimoto) flowers, spikes, pericarp, fruit, seeds, stems, leaves, branches, stems, bark, rhizomes, root bark, roots, root nodules or whole plants can be used.
[0013]
The orchid family Sakanelan used in the present invention includes orchids (Orchidaceae) and Sakanelan genus Sakaneran (scientific name: Neotia nidus-avis (L.) L.C. Rich. Var. Manshurica Komar.). Peel, fruit, seed, stem, leaf, branch, trunk, bark, rhizome, root bark, root, root nodule or whole plant can be used.
[0014]
The orchid plant Sasabagin orchid used in the present invention is Orchidaceae, orchid genus Sasabagin orchid (scientific name: Cephalanthera longibractateata Blume) or a plant of the same genus (Cephalanthera longifloria, L. fruit, L. fruit). , Seeds, stems, leaves, branches, trunks, bark, rhizomes, root bark, roots, root nodules or whole plants can be used.
[0015]
The orchid family of Orchidaceae used in the present invention is a variant of Orchidaceae, a species of the genus Haxanthidonia (scientific name: Dactylorhiza @ incarnata (L.) Soo) or a species of orchid that is the origin thereof. : Dactylorhiza (aristata)} flowers, spikes, pericarp, fruits, seeds, stems, leaves, branches, stems, bark, rhizomes, root bark, roots, nodules or whole plants can be used.
[0016]
In the present invention, various parts (flowers, spikelets, fruit ears, pericarp, fruits, stems, leaves, branches, branches and leaves, stems, bark, roots, rhizomes, root bark, seeds or whole plants of a variety of Aosuzuran, Sakaneran, Sasabaginran and Hakusanchidori ) Is used as it is, or after crushing and then squeezing, and then a pressed product or a residue thereof, or as it is or after crushing, an extract or a residue thereof obtained by extracting with a solvent.
[0017]
The extraction solvent for obtaining the orchid extract used in the present invention may be selected in consideration of the purpose of use of the product to be provided, the type, or the processing to be performed later, but usually, water, Lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or hydrated lower alcohols, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5 Polyhydric alcohols such as pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, and polyethylene glycol (molecular weight: 100 to 100,000) Or hydrous polyhydric alcohol, acetone, acetic acid Various organic solvents such as chill, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, and toluene, and acids (hydrochloric acid, sulfuric acid, nitric acid, phosphorus It is preferable to use one or a mixture of two or more selected from acids, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when the content of the solvent is not preferable depending on the application, use only water, or perform extraction using a highly volatile solvent that easily removes the solvent after the extraction, and dissolve in water or the like after removing the solvent. Such a method is also possible. Moreover, you may extract and extract suitably.
[0018]
Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can also be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably about 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. In addition, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, in the range of 4: 1 to 1:50, and the weight ratio of 1: 1 to 1:20 is particularly preferable.
[0019]
The orchid extract or pressed product used in the present invention can be further subjected to a purification operation as appropriate after solvent extraction or pressing. As the purification operation, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, Decomposition by addition of organic acids, etc.) or alkalis (sodium hydroxide, calcium hydroxide, ammonia, etc.), fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resins, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange) Fractionation using chromatography having hydrophilic adsorption, hydrophobic adsorption, size exclusion, ligand exchange, affinity, etc.), filtration using filter paper or a membrane filter, an ultrafiltration membrane, etc., pressurization or decompression, Heating or cooling, drying, pH adjustment, deodorization, decolorization, long-term storage, and the like can be exemplified, and it is possible to arbitrarily select and combine these.
[0020]
The form of the orchid extract used in the present invention may be in any form such as liquid, solid, powder, paste, and gel. Can be selected.
[0021]
The content of the Aos duran, Sakanelan, Sasabagin orchid, and the varieties of sasabagin orchids of the present invention with respect to the histamine release inhibitor of various orchid plant extracts or pressed products is not particularly defined, and the type, quality, and expectation of the histamine release inhibitor are not specified. Depending on the degree of action performed, it is usually 0.0001% by mass or more (hereinafter expressed as%), preferably 0.01 to 50.0%, in terms of solid content, in the total amount of the preparation. Similarly, the amount of the histamine release inhibitor of the present invention with respect to the antiallergic agent also slightly varies depending on the type, quality, and expected effect of the antiallergic agent. 0.0001% by mass or more (hereinafter represented by%), preferably 0.01 to 50.0%, and the amount of the antiallergic agent of the present invention in the cosmetic composition is also the same. The composition slightly varies depending on the type, quality and expected degree of action of the composition, and is usually 0.0001% by mass or more (hereinafter expressed as%), preferably 0.01 to 50%, in terms of solid content in the total amount of the preparation. 0.0% is preferred. When a bath composition is to be constituted, the formulation may be considered so that the concentration is almost the same as when the composition is poured into 200 to 300 L of bath water and blended into another type of cosmetic composition.
[0022]
Further, the dosage form and form of the histamine release inhibitor or antiallergic agent and the cosmetic composition of the present invention are arbitrary, and may be capsule, powder, granule, solid, liquid, gel, foam, and emulsion. , Cream, sheet and the like.
[0023]
The field of use can be used, for example, in various external preparations (including preparations used for animals) in general, and specifically, ampules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) quasi-drugs, 3) Topical or systemic skin cosmetics (eg, lotions, emulsions) in suitable forms for use such as air bubbles, emulsions, sheets, mist, sprays, etc. , Creams, ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, depilatory agents, shaving treatments, after-shave lotions, pre-show lotions, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfume, nail polish, nail enamel, nail Namel removers, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.) 4) Medicinal or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, Hair treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair tonic agents, hair restoration / hair restoration, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.) 5) Bath Bath agents used in hot water; 6) Others include axillary deodorants, deodorants, deodorants, antiperspirants, sanitary products, sanitary cotton, wet tissues, toothpastes, mouth fresheners, gargles, etc. Can be
[0024]
Incidentally, the histamine release inhibitor or antiallergic agent and the cosmetic composition of the present invention, if necessary, in addition to the above essential components, within the range not impairing the effects of the present invention, the components and additives exemplified below. It can be manufactured by optionally selecting and using in combination. The content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50% by mass.
[0025]
(1) Various fats and oils
Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, coconut oil, anise oil, mocro, palm Oils, beef tallow, lard, squalene, squalane, pristane, hydrogenated products of these fats and oils (hardened oils, etc.) and the like.
[0026]
(2) waxes
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.
[0027]
(3) Mineral oil
Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.
[0028]
(4) Fatty acids
Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acids, Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid.
[0029]
(5) alcohols
Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.
[0030]
(6) Polyhydric alcohols
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.
[0031]
(7) Esters
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.
[0032]
(8) Metal soaps
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.
[0033]
(9) Gum, sugar or water-soluble polymer compound
Gum arabic, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan, alkylene (C2-C4) oxide, such as ethylene oxide, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, potassium Boxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or a crosslinked polymer thereof, a carboxyvinyl polymer, polyethyleneimine and the like.
[0034]
(10) Surfactant
Anionic surfactants (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactants (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing nonionic surfactant), other surfactants (natural surfactant, protein) Derivatives of hydrolysates, polymeric surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0035]
(11) Various vitamins
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxerol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0036]
(12) Various amino acids
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And their amino acids such as sulfates, phosphates, nitrates, citrates, and pyrrolidone carboxylic acids.
[0037]
(13) Various additives derived from plant or animal raw materials
These are processed in a conventional manner according to the type and form of the product to be added (eg, pulverization, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization). , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., are arbitrarily selected and combined), and arbitrarily selected from various materials.
[0038]
The solvent used in the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but is usually selected from water, methanol, ethanol, propyl alcohol, isopropyl alcohol, and butanol. , One selected from lower alcohols such as isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone and ethyl acetate. Alternatively, it is desirable to use a mixture of two or more. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.
[0039]
In addition, when an additive derived from a plant or animal-based material is applied to a systemic or topical external preparation or cosmetics, the skin and hair are protected, the moisturizer is improved, the feel / feel is improved, flexibility is imparted, and stimulation is provided. Mitigation, alleviation of stress by aroma, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin and hair quality, prevention and improvement of rough skin, hair growth, hair growth, hair loss prevention, gloss imparting, cleaning effect, In addition to cosmetic effects such as alleviation of fatigue, promotion of blood flow, and warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.
[0040]
As a specific plant (crude) used as a raw material, for example, almond (amber peach), eye (aiba), blue moss (Seifu wisteria), blue oyster (Aoki), blue ash or Kenasia ogiri (Otogi), blue porphyra (Kimomi) , Aotema, acacia, red ginger (red maize), red crocodile "fruit", red clover, red grape, red akaminoki (logwood), red akameshiwa (red bud), red akamane or rape or madder (akane grass root), red pheasant or pheasant (land yellow), Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Omiten palm), Akebi (Kidori), Asa (Jinji), Malva Asagao or Asagao (Toshiboshi), Hydrangea (Hydrangea), Ashitaba (morning leaves), Azuki (red azuki bean), Asunaro, Acerola, Acene Ku (Asenyaku), Achilla (Shokuyoukanna), Anise, Abiu, Abiurana, Brassica, Abemaki "fruit", Avocado, Ama, Amacha (sweet tea), Amacadul, Amadokoro (Tamatake), Amana (Kojingi), Amaranth (Amaranthus, Balsam pear, Hymenoptera, Senninkoku, Sugimorigeito, Hosoaoigato, Aogaito, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Yurizisen), Arcana (Alcanabo), Alcana , Althea, Arnica, Alpinia or Katsumadai (Sou-zuku), Aloe (lux), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azuka), Yellow sapote, Igakouzolina , Epimedium or Epimedium (Indian kaku), Igusa (Water heart grass), Itadori (Tiger root), Yew (No. 1), Strawberry, Fig (Figurine "fruit, leaf"), Ichihatsu (Primary), Ichibi (Winter Aiko) ), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo "seed, leaves"), Itohimemegi (Enshi), Carob, Inosumanus (Teilexi), Inuyuyu (Honaguinubiyu), Rice "seed, seed coat", Inondo "seed", Ibukijakosou, Nettle, ylang-ylang, iwa tobacco (Iwagashi chi), iwahiba or iwamatsu (makikashi), kidney bean, oolong tea, fennel (feng scent), wheat (chibusanoki), ukiyagara (sanraku), squid "fruit", hime uikyo, turmeric Ukukushi), duckweed (floating), usubasaishin or keirinsaishin or cattle Hyacinthus (spicy), Usbania oyster, Usbenitachiaoi, Uchouran, Utsubogusa (summer hay), Udo or Shisiudo (Qanggai, Independent, Tang Dungyo), Unyadegato (Unkaria, Cat's Claw), Uba tea, Ume (Ume (seed, flesh) )), Vladimir, Elephant's walnut (Kusakomomo), Unshurikan (Chen skin), Eunboku, Estragon, Ezocogi (Ezo Goka), Ezo lily of the valley, Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (Enotake mushroom), Ebisugusa or Mise ), Elcampre, Elderberry "fruit", Elemi, Eryngii or Pre-Lotus Erinji, Enju (Gooseblossom, Sophora blossom rice), Pea, Ohgi or Kibanaohagi (Ascot radix), Narco lily or Kagikurumabanarukoyuri (Yoshisei), Ohisasanoyuki Is Sasanoyuki, Ouren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Public engineering incense), Ootsurafuji (Honshu), Oobako (Car forehead, Carmae grass), Obanana thistle (Keju Leak reed, Baekwanda), Toucan (Haruko), Toucan cactus, Obanana okera or Okera (white jujube), Obanassarsuberi (Banaba), Obanayashabushi "fruit", Oohoshigusa (Grain sperm), Oumia catechu, O hawthorn or Hawthorn (mountain sprout), Oomiyashi, Barley ), Oka, okazeri (snake bed), okra "fruit", oguruma (turnover), ocururihigotai (Ushu sashimi, indigo sashimi), panax ginseng or horseshoe ginseng (carrots), hypericum or lycopodium perforatum or periwinkle Younger cut grass), dragonfly (intermittent), Namomi (blue ears), onigurumi, onidokoro or tokoro or nagadokoro (hikai), oninoyagara (Tenma), onyuri or sasasayuri or hakatayuri (yuri), onoeran, ononis, ohio (hihayu), ominaeshi (soy sauce), oyuko , Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeybee, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp", caycaio (ripe yellow), cacao "fruit, pericarp, seed", oyster (Persimmon "leaf"), kagikazura (choujiku), kakidooshi or kantorisou (rensensou), kakiran, gaku hydrangea, cassia, casinoki (kozumi real "fruit"), gajutsu (shadowatsu), kashiwa (shiki, Shakuha), Kascarilla, Kascara sagrada, Gypsophila, Kasensou, Kanixa (Kin Sato), Kaniwa, Ka Nation, valerian root (valerian root), hippopotamus, birch or weeping birch (white birch), gerbera, pumpkin, kapok-no-ki (seed), kahoku sansho (pepper), gama (bamboo), chamomile or roman chamomile, chamitsude (tsukusa), camu cam (Duck), Karaguwa or Yamaguwa (mushroom), color, karaksakeman, crow squirrel or cinnamon cucurbite (roasted melon), crow sabisaku (midsummer), mussels, guarana "seed", karahoo (thick), karaya, galyu, karin ), Garcinia, Kawamidori, Kawara Psycho (Kelyo greens, white-leaved grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaranginjin (blue croak), Kawamuragi (in ??) Ko), Kansui (sweet), Licorice (licorice), Kantarasa, Kandelilla, Kanto, Canna, Kanran, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Maple strawberry, European strawberry), Kiwi "Fruits, leaves", Kikarasuuri (Kuroro root), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Shima kaniku, Daffodilium), Chrysanthemum, Catalpa (Azusa), Giant stalk (Yotei root), Pheasant (Komi), Kizuta, Kidachi aloe, Kidachiha, Kinna , Linden (shincona, red linden), quinoa (quinoa), yellowfin (huangbashi), pigeon pea, gymnema sylvesta, kimmenkaku, cabbage, cabbage "immature fruit", caraway, cucumber, goryuu (Nishikawayanagi, teriyaki), kiraja Saponaria, Kiraya, Kiranso Peanut grass), kumquat "fruit", kinkiju, ginsekai, kimbusen, betel, kinmizukiki (senkaku grass), quinran, ginran, kinryohen, guapeba vermelha, guava "fruit", guayule, quelux infectria (gallicate), kukuinuts , Kugenumaran, wolfberry (Gugi, gugi, gugi leaf, ground bone bark), Sugisugi Kazura (Tenmen Fuyu), Kuzu (Kakkon), camphor tree, gooseberry "fruit", Xining ginseng (Huanghuako), cutiti river, gardenia ( Gardenia), kunugi (bokusou), kupuasu, kubeba, kumazasa, kumamatsura (horse whip grass), clara (bitter scallop), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit " Fruits and leaves ", buckthorn, black stalk (rescue required) Kameba Hikioko or Kurobana Hikioko or Hikiokoshi (extended life grass), clove (clove, clove), gumbinazuna (sekimei, sekimeishi), kaigai (infestation, infestation spike), cadmium (corolla, cockscomb), gekkavidin, bayberry (laurel tree) Sartorii rose (Tokubukuryo, mountain return), gentian, genoshoko (Oirou grass), Kemponashi (Kigushi), Koukisekikoku, Kishumican (Koji, Tachibana, Obeninican, Fucremican, Sagamikouji, Ponkan, Santara (tachibana)), Koshinbara (Tachibana) Monthly flower), Kosui mentha, Kozo "fruit", Kocha (tea), Kouhone (river bone), Kouhon (straw and kara straw), Kouriang, Kourikyo (Korajang), Cilantro "fruit", Kouren (huohren), Scarabae (Yellow Gon), Cowberry (Koshibachi), coconut "fruit", goshuyu (goshuyu), goshoichigo (covered bunko), pepper (pepper), cosmos, copaiba balsam, coffee "seed, leaf", kobushi or magnolia (spice), burdock (burdock) Burdock, burdock, sesame seeds, sesame, sesame seeds, sesame seeds, sesame seeds, gomeshi, scallop or binankazura or pine bush, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata "Seeds", Cola Vera "Seeds", Colony Lilla, Fenugreek "Fruit", Colombo, Kondulango, Kombu, Konjac, Comfrey (Finbari grass), Sisal (Sisal Asa), Saihailan, Sakanelan (Ezosakaneran), Sakisima button or Sina Button pills or cinnamon grass (Sacred Heart), Sakura (Ooshimazakura, Mazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaves, flowers, fruits, bark (cherry bark)"), cherries, pomegranate, sasasa, sasabaginran, sasanokada Tachibana), sweet potato, sugar cane, sugar beet, sapling jujube (acid jujube), saffron (safflower, west safflower), sapodilla, sapotea mariyo, pomelo "fruit", saponso, salmon berry "fruit", sarasinashima (masuma), saranshito (Sand indigo sashimi), Salvia (sage), Sawagyoukyo (Yamakosai), Sawagumi (Yamawomo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (37 ginseng), Sanshuyu (Sanshuyu) ), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shitake), Shion (Shionen), Syria bean, Dikitaris, Shikunshi (Shikishi), Shiso or Aodiso or Chirimenzo or Catamenziso or Shimeniso (Shiso) (Leaves, perilla), rosewood, linden, Chinese pine, Chinese beetle (forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, oshiroishimeji, bunashishimeji, honjimesi, shirotamotaketake), shimokren (spicy), shimotsukuyakuya, yakumo-jamaku , Shajin (Sasan), Jasmine (Matsurika), Janohige (Marimon winter), Juroxa-sage, Syringa paniculata, Skushamitsu (Sandin, sand compaction), Juzudama, Shiro "fruit", Shunlan, Saw palmetto, Ginger ( Ginger), jade hydrangea (Tsuneyama), Shobu (iris, iris root), Shozuku "fruit", Shirakashi "seed", Silane (byakkyu), Shirogou butterfly "seed", White clover (clover), White adzuki (chicken bone grass), White iris (small iris), Shirobanatsuta "flower", Shirobanana lupine, Shirominanten (Minami Tenmi), Cinchona sacrifura, Jinkoge (Mizuka, Mizuka, Shencho flower), Cinnamon, Cinnammum cassia (Gui bark), Watermelon (watermelon), Honeysuckle (Gold and silver flower, Shinto winter) ), Sorrel (acid pattern), swim berry "fruit", star apple, stevia, strawberry "fruit", suzu psycho (Xu Chang Lord), horsetail (question thorn), purslane (horse dent, horse tooth kenko), plum "fruit" , Sulgaran (Oran), Pinus sylvestris "cone", larch, pine Plants, walnuts, walnuts, hawthorn, eucalypt, dandelion, horse chestnut (malonie), pear "fruits", snowy pears, seaweed berry (elder), sea breeds (juniper, pine wood), sea millet Rose of the valley, cornflower, mistletoe, mint or mint, squirrel, horseradish, iris (stone iris), seaweed (sakurasekoku, sukiseksoku, giant swordfish, suzuki ssug, ssinus ssssssssssss> ) (Dendrobium, Ishimura), Cedron (Bowshukuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Sengyu (River Kyu), Sengshinren Senshin, Sennin cactus, Senna "fruit, leaf", Senninsou (large tate), Senburi (drug), Senboku, Soka (grass), Zougechu, Soshinrowai, Buckwheat "seed seed", Somenimo, Broad bean, Rhubarb (daioh), radish, soybean, daidai (orange, kikomi), takasagorurihigotai (southeast indigo sashimi), takasaburo (dry lotus), takatodai (daigei), takawarabi (gull), dark sweet cherry " Fruits ”, hollyhock, hollyhock (thyme, Hyakurika), hollyhock (hikari), hollyhock, tamarind“ seed ”, onion, tamshiba (spicy), taro tree“ fruit, leaf, root bark ”, taroy (large leaf winter blue, one leaf tea, Bitter tea, bitter tea), dahlia (tenjikubotan), tarui, tanukirimame, tanshiuchiwa, tanjin (dansan), Dandelion (Gakukohide) or white dandelion or moko dandelion, dammar, cherry "fruit", japonica "fruit, root, bud", chisetsu carrot (bamboo ginseng), chicory, chancapiedra (kidachikomikansou), tulip, chocolate coco, Artichoke (Artichoke), Artichoke (Ohta), Artichoke (Wuyi), Artemisia (Aoba), Choreimaitake (Irei), Japanese cricket, Tsukimisou, Tsukushisakaneran, Tsukutake (mushroom), Tsuchiakebi, Camellia, Camellia Tsumekusa (lacquer lacustrine), Tsuyukusa (duckling grass), Tsuruazuki (red azuki bean), Tsurutsuchiakebi, Tsurudukudami (Hanshukara), Tsuruna (Banju), Tsurujin (four-leaf ginseng), Tsuruame, Tsuwabuki, Deiko, Teuchigurumi, Duberry "fruit" " Gussa, Tencha (Tencha), Tendai Yaku (Wakayaku), Pepper (Winter Gourd), Touoka Kazura, Pepper (Pan Pepper), Touki (Tokyo), Tokinsenka (Marigold), Tousakaika, Tounabena (River Cut), Corn Or corn hair (Southern barb hair), horned rice mochi (female child), eucalyptus or Korean gentian (dragon bile), horsetail (wood pirates), dokudami (jujutsu), konkon (spit root), sashimi or beetle or beetle or sardine, eucommia (tochu) "Bark, leaves, roots"), ash (qin bark), tomato, tragacanth, triacanthos "seed", turkey, tormentilla, dronoki, trollo aoi, tongue bean, Niseria berry "fruit", potato or yam (herbal medicine), squid (Butcher bloom), Naginata Kouju, Nazuna Rapeseed, rape bean or mandarin (sword bean), jujube, jujube (daijutsu), nanawaibara (gold cherry), avena (intermittent), shimeko, peanut (peanut), nanten (minamitenmi), nanbankarashi (ramie), odor Violets, bitter berries (bitter wood), sagebrush (bitter mite), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon bark) or keiseki (keishi), gnochus plover, leeks (nirako), elderberry (bone grafted "fruits, flowers" , Stalks, leaves "), garlic (garlic), nulde (fivefolds), leek, nemuki or neb or nebi or nemlinoki or digokubana (healing), nozami (daiji), eucalyptus (real fruit), wild kazura (ryohana), nogatei, Yarrow, Japanese oak (Maehu), Nobara, Nomomo, Pineapple "fruit", Hibiscus (Bussouge, Hurinbussouge, roselle), hayindow, hauchiwa, pau dosse, hakayamaraboshi (bone crushing), hakukayumatou, haksanchidori, haksen (ringworm skin), hakuruberry "fruit", hakobe (generic reed), hajibami (haruko), hasilidokoro Roth root, basil, lotus (lotus, lotus, lotus root), parsley (holland jelly), hadakamugi, batata, hachiku or madake (bamboo-boiled), patchouli, mint (lightly-loaded, lightly-loaded leaves), mustard bean, adlay (yokunin) , Hanasuge (chimbo), banana, hanamint, hanabishi (siturishi, shisitsuri), vanilla bins, papaya, scotch grass (mouse koji grass), pahalobobo, hub "whole grass, stem, leaf", paprika, oyster, hamago or mitsubahamago ( Vine thorn, hamasuge (katsuki), hamabishi (shikoriko), hama Su (maikai flower), Hamabofu (beach storm), hamamelis, palm, rose (rose), balata, balata gum tree, agaric (aratake, white-faced agaricus, usukimori no kasa), haran, pariurus (bamboo jujuba), pallietaria, harkanran, balsamina lus , Bitter melon, harunire (yu bark, yu white bark, yu leaf), barbasco, harindou, handaikai (beach large sea), breadfruit, giant goose (radish), lizard carrot (party party), pecan nut, giganbana (ishiru, vine) (Shuhua), Higulmadaria, Higotai, Hishi (Hisami), Pistachio, Beet, Aedes (Ishire), Aedes aegypti, Daisies (Daisy), Aedes Kozuchi (cow knees), Ayers persica, Hinoki, Hiba, Castor, Sunflower , Bell Pepper, Himeuzu (Heaven ), Himegama (incense buds), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta "fruit", juniper, beakyu, hiyu "fruit", chickpea, lentil, belodooi, hirohaokinagusa, biwa "fruit, fruit" , Stem ", betel nut (large clothing skin, betel nut), Puer tea (pu? Tea), spruce buds (southern rattan), butterflies, butterbur poppies (winter flowers, winter leaves), fujibakama (orchid grass), wisteria beans (flat beans), fujimodoki (butterfly clover, pine flowers), grapes "fruit, peel, seeds, leaves", beech , Fuyumushinatsukutake (Cordyceps sinensis), Brazilian liquorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry, Branjen, Plum "fruit", Flucellaria, Blueberry (Prunus avium), Prune , Floral Blanca, Blond Psyllium, Bundo (Mung Bean), Hazelnut, Loofah, Hetkaran, Safflower (Safflower), Henneken, Belladonna, Berry "Fruit", Persair, Perbianberg, Pereschia Grandifolia, Benkeiiso or Ikuxa (Keiten), Boy Berry “fruit”, squirrel or mulberry or gentian or squirrel or kokia (skin), spinach, balsam (blossoms, acute offspring, osteophyte), potteria sapota, potteria lukma, spinach, spinach, squirrel (toro root) ), Bonito (Japanese magnolia, magnolia), bokeh (gourd), hosoba aburagiku (bitter gourd), hosobaoguruma, hosobananaokera (sojutsu), hosobanokirinsou (Kageten Sanshichi), hosobabarengiku, bodaiju (bodice tree), button ( Peony "flower, leaf, stem, bark"), buttonpi (peony bark), hop, jojoba, borage (ruriichisha), bordeaux, white berry "fruit", hon-onik (meat porcelain, daigei), hon-sekko (iron skin) Stone mackerel, sparrow mountain stone mascara), mysurutennanshaw (Tennan star), maitake (maitake), ephedra (maoh), maca, Cademia nuts, Margaret (Mokshungiku), Macri (Martian grass), Magwa (Mulberry white bark "bark, leaves"), Magnolia splengeri, Masalampuba, Masaranzuba do Ceara, Masaira de Boi, Mashua (Tamanowen) Haren, Kyukonkinrenka, Matatabi (Kiten Tate), Matsukasa, Pine "leaves, bark, roots", Matta Oryo, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanahakka), Malvanozadin (Together), Mulberry "Fruit", quince, malein (belowed squid), mango, mangosteen, mansagna (andesukamitsure), manshugulumi, mandarin "fruit", Mannentake (reishi), pheasant (Komimi "fruit"), Mishimasaiko (Shibako) ), Water plantain or water morning glory ( Dragon tongue grass), mizokokushi (half-edge lotus), misohagi (senkakuna), beetle or elder willow (meditative), mitsugashiwa, honeywort, midori sapote, midorihakka, mimosa, myoga, miracle fruit "fruit", myrrh, mirobaran, mugiwaragiku , Mokuge (Mokugei), Mokumoki, Mokuuji (Extended life skin), Munya, Murasaki (purple root), Murasakisikibu or Omurasakikibu (purple bead), Murasaki maize, Murasaki natsufuji (Kunming chicken blood wisteria), Megakanza opuntica, Mehajiki ), Mebogi, Japanese primrose (Evening primrose), Melaleuca, Melissa, Melilot, Melon "fruit", Mokogomigi, Mosobuchiku, Mokukirin, Moje (Gingerbush), Mochinoki, Mokkou (tree incense), Momijibadaio, Peach (peach "leaf, Seeds, flowers, berries "), sprouts Morero cherry "fruit", moroheiya (burlap), yakawamurasakiimo, yakuchi (masuchi), cornflower (cornflower), cornflower mint, yacon, yashabushi (arrow car) or himeyashabushi or giant yashabushi "fruit, peel, fruit ear", yachiyanagi , Oysters (octagonal gold plate), mistletoe (willow parasitism), willows (river willows, tachiyanagi, weeping willow, akameanagi, cat willow, inukoryanagi, kinuyanagi, koryanagi, unryuyanagi, yamayanagi, palm, yamanagi, rye, rye, rye ), Willow leaf “leaves, stems”, scabbard, spar beetle (purple gold beef), squirrel tobacco (crane squirrel, Tenmeisei), pokeweed (commercial land), yamahanoki (yamaharu), yamamomo (yangpume skin), yamagomigi, eucalyptus, yukino Ta (tiger eargrass), yucca or flevifolia, yuzu "fruit", lily, yoraigusa, mugwort (Aiba), ligan (raimaru), lime "fruit", rye, lakanka "fruit", raspberry "leaf, fruit", Latania (Clameria), Rakkyo or Shallot (scallop), lavender, longan (longan meat), agave (Aono agave, fukurin agave), ryocha (green tea), apple "fruit, seeds, leaves, roots", gentian, rubus or suavisimus ( Sugar beet, Rurithama thistle (Urajirohigotai, Xinjiang indigo head), litchi (Lichi, Lichi nucleus), lettuce (Chisha), red currant "fruit", red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia (Forsythia), astragalus, waxby, wax palm, loco (Reeds), loganberry "fruits", rosemary (mannen wax), rose hips (nobara), wasabi, cotton wisteria (Mengmenhua), warmoko (chiyu) and the like.
[0041]
Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usbaaonori, Sujiaonori, Hiraaonori, Bowaonori, Hosoedaaonori), Anaausa (Aosa) and seaweed [Brown algae] (Macomb, Resiliconbu, Hosomebu, Mitsuikonbu), Wakame, Hirome, Aookame, Giant Kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys Luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa, Kiribano Sea Prickly Pear, Akabumi Prickly Pear, Konau Prickly Pear, Okinawa Prickly Pear, Usuki Prickly Pear, Ecchi Prickly Pear], Seaweed [Red Algae: Hijirimen, Maxa (Tengusa), Hiracusa, Onixa, Obaku ) Kainori, Yaleus Banori, Kagius Banori, Sujius Banori, Hyus Banori, Akamomininori] and the like.
[0042]
In addition, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Quwanomimo, Volvox: Ohigemawari, Volvox, Palmera, Yotsumemo, Aomidro: Hizaori, Spirogyra, Papilio spp., Hibimidro spp .: Hibimidro spp. Echinacea spp .: Echinacea spp., Iwata spp .: Husaiwata, Sricogulata, Helaiwata, Crocita, Janemo, Mir spp .: Mill, Cromil, Sakibuchimil, Nagamil, Hira Le, Casanori: Casanoli, Jusmo: Futozuzumo, Tamazuzumo, Mizojusmo, Mikazukimo, Korekaete, Tsuzumimo, Kikkogusa: Kikkougusa, Hitoexa Genus: Hitougusa, Hirohanohitengusa, Utsutoegumo, Genus Sumiremo: Sumiremo, Hoshimidoro, Fushinashimidoro etc.).
[0043]
Blue-green algae (Genus L .: L., L., L .: Kawatake, Ishikurage, Hassai, Juremo, L. (spirulina): Spirulina, Trichodesmium (Aiakashio), etc.).
[0044]
Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami spp., Isogrape spp .: Isogrape, Isogawara spp .: Isogawara spp. , Genus Sanadagusa: Sanadagusa, Fukurinamiji, common genus: common rush, terrestrial genus: Ezoyahazu, Yahuzugusa, Uraboshiyahazu, genus Genus: jigamigususa, Umiuchiwa genus: Genus genus, genus genus, genus Genus : Nabarimo, Chasoumen: Motsuchachasomen, Matsumo: Matsumo, Nagamatsumo: Nagamatsumo, Okinawamozuku: Okinawamozuku, fake Tomozuku genus: Nisefumozuku, Futomozuku genus: Futomozuku, Ishimozuku genus: Ishimozuku, Kuromo genus: Chromo, Nisemozuku genus: Nisemozuku, Mozuku genus: Mozuku, Ishige genus: Ishige, Irolo, Ichimegasa genus: Calligraphy Umibos, Urushigusa genus: Urushigusa, Keulushigusa, Tobacco moss, Kombmodoki: Kombudoki, Hambamodoki genus: Havamodoki, Habanori genus: Habanori, Hiranohabanori genus: Habanori, Commonbukuro genus: Commonbukuro, Ezobukurono, Ezobukurono, Ezobukuronozo, genus Genus: genus: genus: kagomenori: kagomenori, muralidori: murachidori, shakusugusa: sharksugusa, iwahige: iwahige, yokojimanori: yokojimanori, Genus: Cyperus, Fennel: Fennel, Turmo: Turmo, Anana: Aname, Sujime: Sujime, Miss kelp: Miss kelp, Atsuba Miss kelp, kelp: Gatsugara kelp, Kakisima kelp, Oni kelp, Gohei sorghum, Gohei kelp, Gohei sorghum Genus Oleoptera, Trolocomb: Trolocomb, Antokume: Antokume, Swordfish: Swordfish, Tsurarame, Kurome, Asterina: Asterine, Nesulecomb: Nesirecomb, Kuroshiome: Kuroshiome, Nekoashikame: Acerium, Araumenu Genus: Ainu-Wakame, Chigaiso, Oniwakamezo-Ezoishige: Ezoishige, Yabanemoku: Yabanmoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jo Lomoku, Hiemoku, Hondawara: Tamanamoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametara, Tatsukuri, Yasumatamoku, Umitoranoo, Oobamoku, Hashimomoku, Haikumokugi, Hawk Mokumoku , Genus genus: genus auricularia, genus bulumium: genus bulumium, genus kayamoris: kayamoris, etc.).
[0045]
Red algae (Coleoptera genus: genus oxenori, fenori no moss, Amanori genus: Asakusanori, Susabinori, Uppulinori, Oniamanori, Tasa, Filitasa, Benitasa, Rhodocorton genus: Milnoveni, Akebonomozuku, Agenidae, Genus: Sea elephant, Tsukumonori, Kamogashiranori, Benimozuku: Benimozuku, Hosobenimozuku, Kasamatsu: Casamatsu, Fusanori: Fusanori, Nisefusanori: Nisefusanori, Sodegarami: Sodegaramiragara, Gallaghera Genus: Tamaitadaki, swordfish: swordfish, swordfish, slimebrush: slimebrush, swordfish, oobusa, nambugu , Kohira, Yohira, Kinukusa, Hibiroudo: Hibiroudo, Himehibiroudo, Isomumedoki: Isomemodoki, Shimogaesou genus: Michigaesou, Ryumonsou genus: Ryumonsou, Herarumumon, Nisekareibagusa, Nisekarekawasuba, Nisekarekawagusa: Genus Naminohana: Hosobanaminohana, Naminohana, Coralthrum Genus: Garagaramodoki, Shiogosagoromo Genus: Shiogosagoromo, Iwanokawa Genus: Etsukiiwanokawa, Kainokawa Genus: Kainokawa, Kaninote Genus: Kaninote, Kanonomi, Genus, Sagomo, Dessertica Cyanophora, Sakuranori, Nikumukade, Tambanori, Smooth, Hudarak, Malbahudarak, Isonohana: Nuraksa Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hawk-throwing, Hunting genus: Chabokintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Suzukito, Kokuto, Kakutoto Genus Nagaobane: Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Kalexigusa: Kalexigusa, Tosakamokuki: Hosobanotosakamodo, Hirohanotosakamoki, Yatsudegatatosakamoki, Kurotosakanotoka, Japanese moss Tosakamomodo, Nankaitosakamoki, Himetosakamoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Gatacarimenia, genus genus: hornworm, lycaenoid genus: lycaenoid, Usuginu, genus genus: nikhounoo, venicenago genus: venicenago, ssukakebeni genus: sukakebeni, okagamusa genus: yamadagusa, mirin genus: mirin, scorpionus , Isomocca: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Rhinoceros, Tachiibara, Kagiibaranori, Kizinoo: Kijinoo, Isosanthus: Isodantsuu, Atsubanori: Atsubanori, Ogononori, Ogonotori, Ogonotori, Mizo-Okonori, Kabanori, Beniogonori, Fukuroshinori, Murasaki Kabanori, Shinkaikabanori, Togekabanori, Katagonori, Ryukyuogo Li, Sorbus americana, Cyperus sylvestris, Ligustrum serrata, Lily of the valley, Genus sylvestris, L. Genus: crocodile, saimi, crocodile, lotus spp .: lotus spp. Genus genus goats: genus goatsou, hanasakura, shirotsunagi: fukurotsunagi, sujikonori, hananoeda genus: hananoeda, hirataogoya: hiratagoat, dal Genus: Darus, Masagoshibari, Anadarus, Webagusa Genus: Webugsa, Benifukuronori Genus: Benifukuronori, Fushitsunagi Genus: Fushitsunagi, Himefushinagi, Hirohafushinagi, Watsunagisou Genus: Hirawagnagisougi, Usuwagigisui, Kagegisugi Amixa, Egonori Genus: Egonori, Futogigi, Saeda Genus: Saeda, Chrysanthemum Genus: Chirimomiji, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usveni Genus: Usveni, Genus Genus: Hashijinginu, Nagakonosuginu, Genus Genus: The genus Hyusbanori: Kagiusbanori, Yaleusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki: Usubanolimodoki, Ayanishiki: Ayani Shiki, Ayaginu: Ayaginu, Dadia: Enashidadia, Shimadada: Isohagi, Shimadadia, Dazimodoki: Dazimomodoki, Itogusa: Moletogusa, Toigugusa, Makuri: Makuri, Sanaginori: Hanayanagigina, Yuna, Nayaginagori , Sasabayanaginori, Sozogenus: Kurosozo, Kobusozo, Hanesozo, Sozonohana, Hanegusa: Hanegusa, Kehanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Genus: Himegoke, Kurohoshigoshi, Hioudoogoshigu Isomegusa, Suginashigusa: Suginashigusa, Isobasho: Isobasho, Fujimatsumo: Fujimatsumo, Sawwort: Hakesakinokihiba, Kawamozuku : Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku, Itogusa genus, Chinorimo genera: Chinorimo, Chisujinori genera: Chisujinori, etc.).
[0046]
Axle algae (Erythra spp., Echinacea spp., Hoshiturimo genus: Hoshiturimo, Lichnotamus genus, Phalaenopsis genus: Himejirabamo, Chaboflavidium, Tripella genus, etc.), yellow algae (Hikarimo genus: Hikarimo etc.) and the like.
[0047]
In addition, as a material derived from animal-based raw materials, a cockscomb extract, a cow or pig, a human placenta extract, a cow or pig stomach, a duodenum, an intestine, an extract of a spleen or a decomposition product thereof, a cow or pig brain tissue Extract, collagen hydrolyzate (acid, alkali, enzyme, etc.) hydrolyzate of bovine / pork or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin or elastin hydrolyzate of bovine / pork / fish (acid, Alkali or enzyme) or water-soluble elastin derivative, keratin and its degradation product or their derivative, silk protein and its degradation product or their derivative, pig or bovine blood cell protein degradation product (globin peptide), cow or pig hemoglobin Decomposition products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its decomposition products or derivatives thereof, skim milk powder and its decomposition products or it Derivatives, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0048]
In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, or the like derived from a genetically modified product or a cell fusion can be used. Furthermore, for example, undifferentiated cells or cells undergoing differentiation, which are obtained by culturing cells at any site, cell, tissue, organ, or the like, can also be used.
[0049]
(14) Marine components
Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salt obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fungo), for example , Italian fango, German fango, Eifelfango, Freiburgfango, etc. sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide , Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintokushi, black pearl stone, etc.
[0050]
(15) Microbial culture metabolite
Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red bran, white bran) ) Fermented extract, Euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermentation of raw milk or skim milk powder, lactic acid fermentation of legumes, lactic acid fermentation of coconut genus plants, and the like.
[0051]
(16) α-hydroxy acids
Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0052]
(17) Inorganic pigment
Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0053]
(18) UV absorber / blocker
Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Sodium acid, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.) , Methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, paramethoxycinnamate 2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, etc., salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, Myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives , Dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative , Vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, Talc, kaolin, etc.
[0054]
(19) Whitening agent
Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives , Nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein , Berberine, placenta extract, ellagic acid, lucinol, etc.
[0055]
(20) Tyrosinase activity inhibitor
Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or its derivative, N-acetyltyrosine or its derivative , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, Admiral, bolet, hops, hawthorn, eucalyptus, yarrow, Altea, calyx, mankei, hammeris, caragua or yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, mahuang, senkyu, dokkatsu, psycho, Ufuu, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0056]
(21) Melanin pigment reduction / decomposition substance
Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether) and the like.
[0057]
(22) Turnover promoting action / cell activator
Hydroquinone, lactic acid bacterium extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, ogon, horsetail, gentian, burdock, sicon, carrot, Hamamelis, hops, okinin, edulis, assembly, touki, balsam, amacha, hypericum, cucumber, scotch, mannenrou, parsley) and the like.
[0058]
(23) Astringent
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds) and the like.
[0059]
(24) Active oxygen scavenger
Superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or its derivatives, gallic acid or its salts and their derivatives, curcumin or its salts and their derivatives, transferrin, ceruloplasmin, Coenzyme Q (Q6-Q10), uric acid, bilirubin, metallothionein, stilbengalloyl glycoside, chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester and derivatives thereof, chlorogenic acid glycolipid ester, chlorogenic acid sugar ester, chlorogenic acid sterol ester , Thiazole derivatives or salts thereof, hydroxymatairesinol, allohydroxymatairesinol, hydantoin derivatives and the like.
[0060]
(25) Antioxidant
Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaseletenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamolin, gossypol, propolis etc.
[0061]
(26) Lipid peroxide production inhibitor
β-carotene, plant extracts (sesame cultured cells, amacha, Hypericum perforatum, hamamelis, clove, melissa, emisoso, birch, salvia, mannenrou, Nantenmi, Eijitsu, Ginkgo, green tea) and the like.
[0062]
(27) Anti-inflammatory agent
Icutamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof Salt, licorice extract, sicon extract, age extract, propolis and the like.
[0063]
(28) Antibacterial, disinfectant, disinfectant
Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine compound, iodoform, sorbin Acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophen, chlorohexidi , Ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether , Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benza chloride) Ruconium, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, Star Le violet, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.
[0064]
(29) Moisturizer
Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative , Pyrrolidonecarboxylic acid or a salt thereof, sodium lactate, urea, sorbitol, amino acid or a derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, Tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates, Acid, nitrate, citrate, or pyrrolidone carboxylic acid), oils and fats such as avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, Cucumber oil, beef tallow fatty acid, quince seed oil, kukuinut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, Peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, coconut oil, eucalyptus oil, tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (hardened) Oil) ", waxes (bee wax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin) , Hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax), natto metabolite, natto extract, silk fiber extract, plant extract (Akamatsu sap, aloe, kakkon, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assemblage, mulberry bark, biwa leaf, loofah, peony, penguin) and the like.
[0065]
(30) Elastase activity inhibitor
Diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, Mulberry leaf, Calyx, Gennoshoko, Comfrey, Salvia, Agaricus japonicus, Bodaiju, Botanpi), seaweed extract and the like.
[0066]
(31) Hair agent
Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0067]
(32) Antiandrogen agent
Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone, etc.
[0068]
(33) Peripheral vascular blood flow promoter
Vitamin E or its derivatives, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.
[0069]
(34) Stimulant
Pepper tincture, nonyl acid vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.
[0070]
(35) Metabolic activator
Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate, and the like.
[0071]
(36) Antiseborrheic
Pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.
[0072]
(37) Keratolytic agent
Resorcinol, salicylic acid, lactic acid, urea, etc.
[0073]
(38) Oxidizing agent
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.
[0074]
(39) Hair remover
Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide and calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0075]
(40) Hair swelling agent
Ethanolamine, urea, guanidine, etc.
[0076]
(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol P-nitroorthophenylenediamine, p-phenylenediamine, p-methylaminophenol, picramic acid, sodium piclamate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- ( 2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, sulfuric acid Orthochloroparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitrophenol sulfate Tophenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcinol , Tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.
[0077]
(42) Fragrance
Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black character Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, large fragrance essential oil, Tuberose essential oil, T-shaped essential oil, orange flower essential oil, winter green essential oil, Truval sam essential oil, baturi essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil, sandalwood essential oil, petitgren essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, perl Vegetable flavors such as balsam essential oil, boad rose essential oil, camphor essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannen wax) essential oil, Japanese mint essential oil, etc. Synthetic fragrances, etc.
[0078]
(43) Dyes / colorants
Red cabbage pigment, red rice pigment, Akane pigment, anato pigment, squid pigment, turmeric pigment, endju pigment, krill pigment, persimmon pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, Buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.
[0079]
(44) Other
Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / antibiotics, cooling agents, stabilizers, emulsifiers, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products , Animal and plant glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters) Etc.), oral agents, deodorants / deodorants, bittering agents, etc., and when used in combination therewith, an additive or synergistic improvement in the effects of the present invention or other cosmetic effects can be expected.
[0080]
The method for adding the histamine release inhibitor or antiallergic agent of the present invention to the cosmetic composition may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability. Good.
[0081]
【Example】
Hereinafter, the present invention will be described with reference to Production Examples, Test Examples, and Formulation Examples, but the present invention is not limited thereto.
[0082]
(Production Example 1)
After crushing 2.5 kg of dried roots of Aos duran, adding 4.0 kg of a 45 w / v% 1,3-butylene glycol solution, and immersing at room temperature (about 24 to 28 ° C.) for 10 to 12 days, The solution was filtered using a filter paper and a membrane filter, and the extraction solvent was distilled off. Then, the mixture was adjusted with a 45 w / v% 1,3-butylene glycol solution to obtain 3.0 kg of a 5.0% by mass aosuzuran extract.
[0083]
(Production Example 2)
After crushing 2.5 kg of dried root of Sakanelan, adding 4.0 kg of a 45 w / v% 1,3-butylene glycol solution, and immersing at room temperature (about 24 to 28 ° C.) for 10 to 12 days, The solution was filtered using a filter paper and a membrane filter, and the extraction solvent was distilled off. Then, the mixture was adjusted with a 45 w / v% 1,3-butylene glycol solution to obtain 3.0 kg of a 5.0% by mass sakaneran extract.
[0084]
(Production Example 3)
After crushing 2.5 kg of dried root of Sasabagin orchid, adding 4.0 kg of a 45 w / v% 1,3-butylene glycol solution, and immersing it at room temperature (about 24 to 28 ° C.) for 10 to 12 days, The solution was filtered using a filter paper and a membrane filter, and the extraction solvent was distilled off. Then, the mixture was adjusted with a 45 w / v% 1,3-butylene glycol solution to obtain 3.0 kg of a 5.0 mass% sasabagin orchid extract.
[0085]
(Production Example 4)
2.5 kg of dried roots of the varieties of Chinese plovers are crushed, 4.0 kg of a 45 w / v% 1,3-butylene glycol solution is added, and immersed at room temperature (about 24-28 ° C.) for 10-12 days After that, the mixture was filtered using a filter paper and a membrane filter, and the extraction solvent was distilled off. Then, the mixture was adjusted with a 45 w / v% 1,3-butylene glycol solution to obtain 3.0 kg of a 5.0 mass% varieties extract of Chinese lantern.
[0086]
(Production Example 5)
2.5 kg of dried Aozudran root and 2.5 kg of dried Sakaneran root were each crushed and mixed, and 8.0 kg of a 45 w / v% ethanol solution was added thereto, and then room temperature (about 24-28 ° C.) After immersion for 10 to 12 days, the mixture was filtered using filter paper and a membrane filter, and the extraction solvent was distilled off. Then, the mixture was adjusted with a 45 w / v% ethanol solution to obtain 6.0 kg of a 5.0% by mass mixed orchid extract.
[0087]
(Production Example 6)
2.5 kg of dried root of Sasabagin orchid and 2.5 kg of dried root of varieties of Chinese lantern were crushed and mixed, and 8.0 kg of a 45 w / v% ethanol solution was added thereto. (About ° C) for 10 to 12 days, and then filtered using a filter paper and a membrane filter to distill off the extraction solvent. Then, the mixture was adjusted with a 45 w / v% ethanol solution to obtain 6.0 kg of a 5.0% by mass mixed orchid extract.
[0088]
(Production Example 7)
12. 2.5 kg of dried Aozudran root, 2.5 kg of dried Sakaneran root and 2.5 kg of dried Sasabagin orchid root were each crushed and mixed, and a 45 w / v% 1,3-butylene glycol solution was used. After adding 0 kg and soaking at room temperature (about 24 to 28 ° C.) for 10 to 12 days, the mixture was filtered using a filter paper and a membrane filter to distill off the extraction solvent. The mixture was adjusted with a 45 w / v% 1,3-butylene glycol solution to obtain 9.0 kg of a 5.0 mass% mixed extract of three orchids.
[0089]
(Production Example 8)
2.5 kg of dried Aozudran root, 2.5 kg of dried Sakaneran root, 2.5 kg of dried Sasabagin orchid and 2.5 kg of dried root of a variety of Chinese plover / V% of a 1,3-butylene glycol solution, and immersed at room temperature (about 24 to 28 ° C.) for 10 to 12 days, followed by filtration using a filter paper and a membrane filter to distill off the extraction solvent. I left. Then, the mixture was adjusted with a 45 w / v% 1,3-butylene glycol solution to obtain 12.0 kg of a 5.0 mass% extract of four orchids mixed with four orchids.
[0090]
(Test 1) Histamine release inhibition test
In the immediate allergic reaction, chemical mediators such as histamine are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, a production method using a test method for releasing histamine from rat mast cells with histamine releasing reagent compound 48/80 (J. Soc. Cosmet. Japan, Vol. 25, No. 4, P246 (1992)) was used. The extracts obtained in 1 to 8 were examined.
[0091]
"Test method and evaluation method"
A 1.2 mL sample of mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: male Wister rat, about 4 to 9 weeks old) was prepared by adding 0.2 mL of the sample and compound48 / 80 to a final concentration of 1.0 μg / mL. And incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, and the histamine released from the supernatant was extracted and purified, color was developed with o-phthaldialdehyde, and the fluorescence absorbance at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm was measured. The histamine release inhibition rate was determined from Equation 1 and the results are shown in FIG.
"sample"
In addition, the sample of the histamine release inhibition test was used for the test using the extract obtained in Production Examples 1 to 8 of the present invention. As a comparative sample, 5.0 w / v% cromolyn (manufactured by Sigma) was used.
[0092]
(Equation 1)
Histamine release inhibition rate (%) = {1- (AC / BC)} × 100
A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample in mast cells
B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells
C: Fluorescence intensity of histamine spontaneously released from mast cells (A, B, and C are measured values minus blind values)
[0093]
(Test results)
As shown in FIG. 1, the extracts of the variants of Aosuzuran, Sakanelan, Sasabaginran and Hakusanchidori of the present invention showed an effect of significantly suppressing the release of histamine. Furthermore, the mixed extract of the orchid species showed a particularly strong histamine release inhibitory action, and the extract of the four species showed the greatest histamine release inhibitory action. In addition, it was confirmed that the compound had a very strong histamine release inhibitory effect as a whole, as compared with cromolyn, which is a comparative sample, and was found to be useful as a histamine release inhibitor and an antiallergic agent.
[0094]
(Test 2) Safety test
(1) Skin primary irritation test
Japanese white rabbits (female, 3 per group, females of the present invention obtained in Production Examples 1 to 8) were adjusted with purified water so that the dry solid content was about 1.0%, and the back was shaved. (Approximately 2.3 kg body weight). Judgment was made 24, 48, and 72 hours after application by primary irritation scoring using erythema and edema as indices. The results were negative in all animals without any erythema and edema.
[0095]
(Test 3) Safety test
(2) Skin irritation test
Similarly, the product of the present invention obtained in Production Examples 1 to 8 was adjusted with purified water so as to have a dry solid concentration of about 1.0%, and a Hartley-type guinea pig (female, 3 per group) with shaved flanks was used. 0.5 mL / animal was applied to the skin once a day, 5 times a week. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day following each application day and the day after the last application day by using the primary irritancy scoring method as an index of erythema and edema. The results were negative for all animals without any erythema and edema over 2 weeks.
[0096]
(Test 4) Safety test
(3) Acute toxicity test
Similarly, a ddy mouse (male and female, 5 mice per group, 5 weeks old), which was obtained by subjecting the product of the present invention obtained in Production Examples 1 to 8 to concentration and drying under reduced pressure and fasting for 4 hours before the test, ) Was orally administered at a dose of 2,000 mg / kg, and the appearance and extent of toxic symptoms were observed over time. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, LD50 was determined to be 2,000 mg / kg or more.
[0097]
(Test results)
As a result of Tests 2 to 4, it was confirmed that the extracts of the variants of Aozuzuran, Sakanelan, Sasabaginran and Hakusanchidori of the present invention and their mixed extracts were very safe for living organisms.
[0098]
(Prescription example) Production of histamine release inhibitor, antiallergic agent, cosmetic composition
According to the above evaluation results, formulation examples are shown below. Each formulation example may be one manufactured by a usual method for manufacturing each product, and only the compounding amount is shown. Further, the present invention is not limited to these.
[0099]
(Prescription example 1) Emulsion mass%
1. Squalane $ 5.0
2. Olive oil ¥ 5.0
3. Jojoba oil $ 5.0
4. Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6. Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-butylene glycol 1.0
9. Glycerin 2.0
10. Four-mixed extract of Production Example 8 10.0
11. Preservative (p-hydroxybenzoate) appropriate amount
12. Perfume appropriate amount
13. Purified water 100 residue
[0100]
(Formulation Example 2) Emulsion mass%
1. Squalane $ 8.0
2. Jojoba oil 7.0
3. Glyceryl paraaminobenzoate 1.0
4. Ethyl urocanate 1.0
5. Vitamin C phosphate ester magnesium salt エ ス テ ル 1.0
6. Cetyl alcohol 1.5
7. Glycerin monostearate 2.0
8. Polyoxyethylene (20) cetyl ether 3.0
9. Polyoxyethylene (20) soorbitan monooleate 2.0
10.1,3-butylene glycol 1.0
11. Glycerin 2.0
12.1,2-Pentanediol @ 3.0
13. Three-mixed extract of Production Example 7 $ 8.0
14． St. John's wort ethanol aqueous solution extract 1.0
15. Honoki propylene glycol aqueous solution extract 1.0
16. Swine placenta water extract 1.0
17. Preservative (p-hydroxybenzoate) appropriate amount
18. Purified water 100 residue
[0101]
(Prescription example 3) cosmetic oil mass%
1. Liquid paraffin 30.0
2. Squalane 20.0
3. Olive oil ¥ 20.0
4. Isopropyl palmitate 10.0
5. Two-mixed extract of Production Example 6 5.0
6. Grapefruit fruit or leaf hot water extract 1.0
7. Grape leaf ethanol aqueous solution extract 1.0
8. Soybean seed hot water extract 種子 1.0
9. Olive oil 1.0
10. Shea fat 1.0
11. Butyl hydroxyanisole 0.1
12. Vitamin E derivative 0.1
13. Preservative (benzalkonium chloride) appropriate amount
14． Fragrance (Tokisui) appropriate amount
15. Purified water 100 residue
[0102]
(Formulation Example 4) Flexible lotion% by mass
1. Glycerin 5.0
2.1,3-butylene glycol @ 5.0
3. Polyoxyethylene sorbitan monolaurate (20EO) 1.0
4. Ethanol $ 15.0
5. Two-mixed extract of Production Example 5 5.0
6. Chamomile 1,2-pentanediol aqueous solution extract 1.0
7. Chlorella ethanol aqueous solution extract 1.0
8. Pepper peel or fruit 1,2-pentanediol aqueous solution extract 1.0
9. Birch extract 1.0
10. Antibacterial and preservative (lactoferrin solution) appropriate amount
11. Fragrance (Western thin water) appropriate amount
12. Purified water 100 residue
[0103]
(Formulation Example 5) Astringent lotion mass%
1. Sorbit $ 2.0
2. POE (20) Oleyl alcohol ¥ 1.0
3. Ethanol $ 15.0
4. Extract of Production Example 1 5.0
5. Extract of Production Example 3 5.0
6. Extract of whole plant 1,3-butylene glycol aqueous solution 2.0
7. Hamamelis whole plant ethanol aqueous solution extract 2.0
8. Sage whole plant ethanol aqueous solution extract 2.0
9. Yeast 1,3-butylene glycol aqueous solution extract 1.0
10. Allantoin 0.2
11. Astringent (zinc sulfocarbonate) 炭 酸 0.2
12. Antibacterial and preservative (thiamine lauryl sulfate)
13. Fragrance (lavender water) appropriate amount
14． Purified water 100 residue
[0104]
(Formulation Example 6) Two-layer lotion (liquid-liquid type) mass%
1. Squalane $ 8.0
2. POE sorbitan tetraoleate 0.3
3. Sorbit $ 1.0
4. Ethanol $ 15.0
5. Extract of Production Example 2 5.0
6. Aloe ethanol aqueous solution extract 1.0
7. Marigold ethanol aqueous extract 1.0
8. Magnesium ascorbate 0.2
9. Astringent (calamine) 0.1
10. Preservative (phenoxyethanol) appropriate amount
11. Flavor (lemon water) appropriate amount
12. Purified water 100 residue
[0105]
(Formulation Example 7) Carmine lotion (liquid-solid) mass%
1. Glycerin @ 3.0
2.1,3-butylene glycol @ 5.0
3. Ethanol $ 15.0
4. Iron oxide (Bengara) 0.2
5. Zinc oxide 0.5
6. Kaolin 2.0
7. Extract of Production Example 4 6.0
8. Spiraea flower propylene glycol aqueous solution extract 2.0
9. Shakuyane root propylene glycol aqueous solution extract 2.0
10. Usbania propylene glycol aqueous solution extract 2.0
11. Chamomile flower propylene glycol aqueous solution extract 2.0
12. Swine placenta enzyme decomposition solution ¥ 1.0
13. Camphor 0.2
14． Phenol 0.03
15. Preservative (photosensitive element 201 & 401) appropriate amount
16. Fragrance (bodhi tree water) appropriate amount
17． Purified water 100 residue
[0106]
(Formulation Example 8) Pack mass%
1. Polyvinyl alcohol $ 15.0
2. Sodium carboxymethylcellulose @ 5.0
3. Propylene glycol @ 3.0
4. Ethanol 10.0
5. Extract of Production Example 4 2.0
6. Extract of Production Example 2 2.0
7. Raspberry fruit diglycerin aqueous solution extract 1.0
8. Ginger root 1,2-pentanediol aqueous solution extract 1.0
9. Preservative (p-hydroxybenzoate) appropriate amount
10. Fragrance (rose water) appropriate amount
11. Purified water 100 residue
[0107]
(Formulation Example 9) Peel-off pack mass%
1. Glycerin 5.0
2. Propylene glycol @ 4.0
3. Polyvinyl alcohol $ 15.0
4. Ethanol $ 8.0
5. Polyoxyethylene glycol 1.0
6. Pantothenyl ethyl ether 1.0
7. Mixed extract of Production Example 8 # 5.0
8. Safflower ethanol aqueous extract 2.0
9. Dutch jelly ethanol aqueous extract 2.0
10. Royal jelly ethanol aqueous solution extract 1.0
11. Trehalose solution 1.0
12. Preservative (p-hydroxybenzoate) appropriate amount
13. Fragrance (chamomile water) appropriate amount
14． Purified water 100 residue
[0108]
(Formulation Example 10) Cold cream mass%
1. Salami beeswax $ 11.0
2. Liquid paraffin 22.0
3. Lanolin 10.0
4. Olive oil ¥ 5.0
5. Chamomile oil ¥ 5.0
6. Palm oil $ 5.0
7. Borax 0.5
8. Three-mixed extract of Production Example 7 5.0
9. Yaba Santa ethanol aqueous solution extract 2.0
10. Birch bark 1,3-butylene glycol aqueous solution extract 2.0
11. Panax ginseng root propylene glycol aqueous solution extract 2.0
12. Matsufodo sclerotium 1,2-butylene glycol aqueous solution extract 1.0
13. Soybean seed water extract 1.0
14． Liquid shea butter 1.0
15. Dipotassium glycyrrhizinate 0.1
16. Preservative (acrinol) ¥ 0.1
17. Fragrance (sage water) appropriate amount
18. Purified water 100 residue
[0109]
(Formulation Example 11) Emollient cream mass%
1. Stearic acid 2.0
2. Stearyl alcohol $ 7.0
3. Reduced lanolin 2.0
4. Squalane $ 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25EO) ．3.0
7. Lipophilic glyceryl monostearate 2.0
8. Propylene glycol 2.0
9.1,2-pentanediol @ 2.0
10. Four-mixed extract of Production Example 8 10.0
11. Dokudami leaf hot water extract 2.0
12. Shiso leaf propylene glycol aqueous solution extract 2.0
13. Orange propylene glycol aqueous solution extract 1.0
14． Fermented soybean natto fermented liquid ¥ 1.0
15. Tocopherol acetate 0.1
16. Sea bream extract collagen hydrolyzate ¥ 1.0
17. Preservative (paraben) appropriate amount
18. Fragrance (clove water) appropriate amount
19. Purified water 100 residue
[0110]
(Formulation Example 12) Face wash cream weight%
1. Stearic acid 10.0
2. Palmitic acid 10.0
3. Myristic acid 12.0
4. Lauric acid $ 4.0
5. Oleyl alcohol 1.5
6. Lanolin derivative (EO adduct) $ 1.0
7. Glycerin $ 18.0
8. Potassium hydroxide 6.0
9. Two-mixed extract of Production Example 6 5.0
10. Glycyrrhetinic acid 1.0
11. Preservative (salicylic acid) 0.1
12. Fragrance (Tokisui) appropriate amount
13. Purified water 100 residue
[0111]
(Formulation Example 13) Face wash cream mass%
1. Stearic acid 10.0
2. Palmitic acid 10.0
3. Myristic acid 12.0
4. Lauric acid $ 4.0
5. Oleyl alcohol 1.5
6. Lanolin derivative (EO adduct) $ 1.0
7. Glycerin $ 18.0
8. Potassium hydroxide 6.0
9. Two-mixed extract of Production Example 5 5.0
10. Green tea 1,3-butylene glycol aqueous solution extract 2.0
11. Royal jelly 1,3-butylene glycol aqueous solution extract 1.0
12. ε-aminocaproic acid 0.5
13. Preservative (salicylic acid) 0.1
14． Fragrance (Mugwort water) appropriate amount
15. Purified water 100 residue
[0112]
(Formulation Example 14) Body soap mass%
1. Potassium laurate 15.0
2. Potassium myristate 5.0
3. Propylene glycol 5.0
4. Extract of Production Example 4 4.0
5. Oolong tea leaf 1,3-butylene glycol aqueous solution extract 1.0
6. Toki 2,3-butylene glycol aqueous solution extract 0.5
7. Wakame 1,3-butylene glycol aqueous solution extract 0.5
8. Melilot 1,3-butylene glycol aqueous solution extract 0.5
9. Fermented soybean natto fermented liquid 0.5
10. Polyethylene powder 0.5
11. Hydroxypropyl chitosan solution 0.5
12. Amino acids (arginine, glycine, glutamine, etc.) 0.5
13. Monoammonium glycyrrhizinate 0.1
14． Preservative (undecylenic acid, phenol) appropriate amount
15. pH adjuster appropriate amount
16. Fragrance (lavender water) appropriate amount
17． Purified water 100 residue
[0113]
(Formulation Example 15) Sunscreen cosmetics (O / W type) mass%
1. Oxybenzone 2.0
2. Octyl paramethoxycinnamate 5.0
3. Squalane ¥ 10.0
4. Vaseline $ 5.0
5. Stearyl alcohol @ 3.0
6. Stearic acid $ 3.0
7. Glyceryl monostearate 2.0
8. Ethyl polyacrylate 1.0
9.1 1,3-butylene glycol 6.0
10. Disodium edetate 0.1
11. Triethanolamine 1.0
12. Titanium dioxide 5.0
13. Extract of Production Example 2 0.5
14． Kakkon propylene glycol aqueous solution extract 0.5
15. Cornflower leaf propylene glycol aqueous solution extract 0.5
16. Barley seed propylene glycol aqueous solution extract 0.5
17. Citrus fruit dipropylene glycol aqueous solution extract 0.5
18. Preservative (benzyl parahydroxybenzoate) appropriate amount
19. Fragrance (apple water) appropriate amount
20. Purified water 100 residue
[0114]
(Formulation Example 16) Sunscreen cosmetics (oil type) mass%
1. Liquid paraffin 70.0
2. Ethyl paraaminobenzoate 1.0
3. Tetrahydroxybenzophenone 1.0
4. Cetyl octanoate $ 22.0
5. Extract of Production Example 3 3.0
6. Roman chamomile flowers
1,3-butylene glycol aqueous solution extract 1.0
7. Burdock root hot water extract 0.5
8. Horse chestnut whole grass
1,3-butylene glycol aqueous solution extract 0.5
9. Mallow flower or leaf propyl alcohol aqueous solution extract 0.5
10. Adlay whole grass
1,3-butylene glycol aqueous solution extract 0.5
11. Antioxidant (butylhydroxytoluene) appropriate amount
12. Perfume (cornflower water)
[0115]
(Formulation Example 17) Cream foundation (O / W type) mass%
1. Stearic acid $ 4.0
2. Glycerin monostearate 3.0
3. Cetanol 1.5
4. Isopropyl myristate@7.0
5. Liquid paraffin 10.0
6. Sarah beeswax $ 3.00
7. Triethanolamine 1.5
8. Glycerin @ 3.0
9. Bentonite 1.0
10. Titanium oxide 8.0
11.2,4-Dihydroxybenzophenone @ 8.0
12. Kaolin 3.0
13. Talc $ 3.0
14． Color pigment (iron iron oxide) 1.0
15. Extract of Preparation Example 4 # 2.5
16. Dokudami leaf hot water extract dry powder 0.2
17. Satsuma mandarin peel hot water extract dry powder 0.2
18. Saxifrage whole plant hot water extract dry powder 0.2
19. Kelp algae ethanol aqueous extract 0.2
20. T-shaped bud diglycerin aqueous solution extract 0.2
21. Preservative (phenoxyethanol) 0.1
22. Fragrance (rose water) appropriate amount
23. Purified water 100 residue
[0116]
(Formulation Example 18) Shampoo mass%
1. Triethanolamine lauryl sulfate 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-butylene glycol @ 4.0
4. Lauric acid diethanolamide 2.0
5. Disodium edetate 0.1
6. Two-mixed extract of Production Example 5 6.0
7. Hamamelis bark hot water extract 2.0
8. Iris flower or rhizome
1,3-butylene glycol aqueous solution extract 2.0
9. Toukine 1,3-butylene glycol aqueous solution extract 1.0
10. Hydroxypropyl chitosan solution 1.0
11. Mucopolysaccharide solution 1.0
12. Dipotassium glycyrrhizinate 0.1
13. Antibacterial and preservative (photosensitive element No. 101) appropriate amount
14． pH adjuster appropriate amount
15. Fragrance (sandalwood water)
16. Purified water 100 residue
[0117]
(Formulation Example 19) Rinse mass%
1. Stearyl trimethyl ammonium chloride 2.0
2. Cetostearyl alcohol 2.0
3. Polyoxyethylene lanolin ether 3.0
4. Propylene glycol 5.0
5. Two-mixed extract of Production Example 6 $ 8.0
6. Assembly leaf or stem
1,2-butylene glycol aqueous solution extract 1.0
7. Calendula flower
1,3-butylene glycol aqueous solution extract 1.0
8. Orchid Rhizome 1,3-butylene glycol aqueous solution extract 1.0
9. Comfrey leaf or stem
1,3-butylene glycol extract 1.0
10. Fermented soybean natto fermented liquid 0.5
11. Hydroxyethyl chitosan solution 0.5
12. Trehalose solution 0.5
13. Hydrolyzed silk solution 0.5
14． Antibacterial and preservative (benzalkonium chloride) appropriate amount
15. Fragrance (grape water) appropriate amount
16. Purified water 100 residue
[0118]
(Formulation Example 20) Rinse mass%
1. Stearyl trimethyl ammonium chloride 2.0
2. Cetostearyl alcohol 2.0
3. Polyoxyethylene lanolin ether 3.0
4. Propylene glycol 5.0
5. Ethylene glycol @ 3.0
6. Preparation 3 mixed extract of 1.0
7. Polylysine 1.0
8. Green tea leaf hot water extract 1.0
9. Matsufodo sclerotium 1,2-butylene glycol aqueous solution extract 1.0
10. Loquat leaf ethanol aqueous extract 抽出 1.0
11. Trehalose solution 1.0
12. Hydrolyzed keratin solution 1.0
13. Antibacterial and preservative (benzalkonium chloride) appropriate amount
14． Fragrance (chamomile water) appropriate amount
15. Purified water 100 residue
[0119]
(Formulation Example 21) Hair liquid mass%
1. Ethanol $ 29.0
2. Polyoxypropylene butyl ether phosphoric acid 10.0
3. Polyoxypropylene monobutyl ether 5.0
4. Triethanolamine 1.0
5. Four-mixed extract of Production Example 8 $ 3.0
6. Hop female spike ethanol aqueous solution extract 1.0
7. Melissa whole plant ethanol aqueous solution extract 1.0
8. Usubasaicin rhizome ethanol aqueous extract 1.0
9. Birch sap 1.0
10. Carpronium chloride 0.3
11. Hinokitiol 0.5
12. Keratin decomposition solution 0.5
13. Stearyl glycyrrhetinate 0.1
14． Antibacterial and preservative (paraben, benzalkonium chloride)
15. Fragrance (Rosehip water)
16. Purified water 100 residue
[0120]
(Formulation Example 22) Hair liquid mass%
1. Ethanol $ 29.0
2. Polyoxypropylene butyl ether phosphoric acid 10.0
3. Polyoxypropylene monobutyl ether 5.0
4. Triethanolamine 1.0
5. Trimethylene glycol @ 5.0
6. Extract of Production Example 1 1.0
7. Assembly leaf or stem
1,2-butylene glycol aqueous solution extract 1.0
8. Panax ginseng root hot water extract 1.0
9. Lemon fruit 1,3-butylene glycol aqueous solution extract 0.5
10. Apple fruit ethanol aqueous solution extract 1.0
11. Birch sap 1.0
12. Azulene 1.0
13. Antibacterial and preservative (paraben, benzalkonium chloride)
14． Fragrance (orange water) appropriate amount
15. Purified water 100 residue
[0121]
(Formulation Example 23) Hair liquid mass%
1. Ethanol $ 40.0
2. Ethyl oleate 1.0
3. Polyoxyethylene (40) hydrogenated castor oil $ 2.0
4. Extract of Production Example 2 3.0
5. Comfrey leaf or stem ethanol aqueous solution extract 3.0
6. Citrus leaf or fruit ethanol aqueous solution extract 3.0
7. Fermented soybean natto fermented liquid ¥ 1.0
8. Hamamelis leaf or bark hot water extract 1.0
9. Preservative (phenoxyethanol) 0.1
10. Fragrance (chamomile water) appropriate amount
11. Purified water 100 residue
[0122]
(Formulation Example 24) Hair tonic mass%
1. Ethanol $ 40.0
2. Ethyl oleate 1.0
3. Polyoxyethylene (40) hydrogenated castor oil $ 2.0
4. Four-mixed extract of Production Example 8 10.0
5. Preservative (paraben) appropriate amount
6. Residue to make purified water $ 100
7. Purified water 100 residue
[0123]
(Prescription example 25) Hair tonic mass%
1. l-menthol 0.2
2. Ethanol $ 32.5
3. Polyoxyethylene hydrogenated castor oil 0.5
4. Propylene glycol 5.0
5. Diphenhydramine hydrochloride 0.3
6. Extract of Production Example 3 3.0
7. Lavender flower or spike hot water extract 1.0
8. Aqueous Rhizome or root bark ethanol aqueous extract 1.0
9. Aqueous rhizome or root bark ethanol aqueous solution extract 1.0
10. Ethanol aqueous solution extract of Rhizoma rhizome or root bark 1.0
11. Soybean seed hot water extract 種子 1.0
12. Carboxymethyl chitin solution 1.0
13. Vitamin E derivative 0.5
14． Antibacterial and preservative (paraben) ¥ 0.1
15. Fragrance (sage water) appropriate amount
16. Purified water 100 residue
[0124]
(Formulation Example 26) Hair restorer / hair restorer 　 　　 　 mass%
1. Ethanol $ 60.0
2. Extract of Production Example 4 1.0
3. Watermelon extract of whole plant propylene glycol aqueous solution 2.0
4. Vitamin E derivative 0.5
5. Pepper tincture 0.5
6. Resorcinol 0.5
7. Dipotassium glycyrrhizinate 0.5
8. Carboxymethyl chitin solution 0.5
9. Porcine hematin solution 0.5
10. Porcine mucin solution 0.5
11. Amino acids (arginine, glycine, glutamine, etc.) 0.5
12. Antibacterial and preservative (paraben) ¥ 0.1
13. Fragrance (rosemary water)
14． Purified water 100 residue
[0125]
(Formulation Example 27) Hair restorer / hair restorer mass%
1. Ethanol $ 60.0
2. Two-mixed extract of Production Example 5 9.0
3. Assembly whole plant ethanol aqueous solution extract 1.0
4. Peony rhizome or root bark ethanol aqueous solution extract 1.0
5. Artemisia leaf or stem 1,3-butylene glycol aqueous solution extract 1.0
6. Fermented soybean natto fermented liquid ¥ 1.0
7. Cantaris tincture 0.5
8. Pantothenic acid derivative 0.2
9. β-glycyrrhetinic acid 0.2
10. Resorcin 0.2
11. Salicylic acid 0.2
12. Hydroxyethyl chitosan solution 0.2
13. Elastin hydrolysis solution 0.2
14． Antibacterial and preservative (paraben) ¥ 0.1
15. Fragrance (lavender water) appropriate amount
16. Purified water 100 residue
[0126]
(Formulation Example 28) Granule bath agent mass%
1. Sodium bicarbonate @ 58.0
2. Anhydrous sodium sulfate 30.0
3. Borax 2.0
4. 3-week mixed extract of Production Example 7 $ 4.0
5. Eucalyptus hot water extract dry powder 水 3.0
6. Natsume whole plant hot water extract dry powder ¥ 3.0
7. Dye (Gunjo green)
[0127]
(Formulation Example 29) Granule bath agent mass%
1. Sodium bicarbonate 50.0
2. Anhydrous sodium sulfate 30.0
3. Borax ¥ 3.0
4. Dry powder of the mixture of two extracts of Production Example 6 7.0
5. Dried flower of the elderberry flower or berry hot water extract dry powder 抽出 1.0
6. Dry mugwort leaf or stem hot water extract dry powder 1.0
7. Satsuma mandarin peel ethanol aqueous solution extract dry powder 1.0
8. Peach leaf ethanol aqueous solution extract dry powder 1.0
9. Iris leaf or root ethanol aqueous solution extract dry powder 1.0
10. Apple juice powder 1.0
11. Dye (Gunjo, chromium hydroxide) appropriate amount
12. Perfume (grape water)
[0128]
(Formulation Example 30) Coating protective agent
A gauze or liniment cloth is impregnated with a prescription liquid prepared by mixing an appropriate amount of the four-mixed extract of Production Example 8, an antibiotic, an anti-inflammatory agent, etc., and attached to the wound. Alternatively, the four-type mixed extract of Production Example 8 may be directly applied locally and covered with gauze or the like.
[0129]
(Formulation Example 31) Oral freshener mass%
1. Ethanol 20.0
2. Glycerin $ 15.0
3. Polyoxyethylene hydrogenated castor oil 1.0
4. Saccharin 0.2
5. Chlorohexidine 0.01
6. Dry powder of four-mixed extract of Production Example 8 5.0
7. Green tea leaf hot water extract 0.1
8. Pigment (Gunjo green) appropriate amount
9. Purified water 100 residue
[0130]
(Test 5) Use effect test
The effect when the cosmetic composition of the present invention was actually used was examined. The test used was a 20-year-old panelist of 20 to 30 years old who suffers from skin diseases such as eczema, skin kayumi, rough skin and atopic dermatitis. The test was carried out by applying an appropriate amount of the emollient cream of Example 11 to the face over a period of 4 months. Also, for 20 people (30-50 years old) who have the same skin disease on the scalp and hairline, apply the appropriate amount of the hair tonic of Formulation Example 24 to the scalp for 4 months after daily hair washing. A use test was performed by the subject, and a response was obtained from the subject regarding the effect. As a control, a milky lotion, an emollient cream, and a hair tonic prepared by removing the orchid extract of the present invention from the present invention by the same method were used. The evaluation was performed according to the following criteria. The results are shown in Table 1 and the numbers in the table represent the number of persons. No one complained of abnormalities in the skin or scalp during the use period.
[0131]
"Skin (scalp) disease improvement effect"
Effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis have been improved.
Slightly effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were slightly improved.
No effect: No change from before use.
[0132]
[Table 1]

[0133]
(Test results)
As shown in Table 1, the cosmetic compositions (emulsion and emollient cream, heart tonic) containing the orchid plant extracts of the variants of Aozudran, Sakaneran, Sasabaginran and Swanbird's var. The improvement effect was confirmed for skin and scalp diseases such as dermatitis.
[0134]
【The invention's effect】
The extract or pressed product of at least one orchid plant selected from the varieties of Aosuzuran, Sakaneran, Sasabagin orchid and the Chinese plover of the present invention has an excellent histamine release inhibitory action and is highly safe. , Can be used as an excellent histamine release inhibitor. The antiallergic agent containing the histamine release inhibitor of the present invention is effective for the prevention and treatment of various allergic skin diseases such as eczema, hives, atopic dermatitis, allergic rhinitis, hay fever, It can also be used to prevent skin aging. Therefore, it can be applied to all forms of preparations (medicines, quasi-drugs, cosmetics, foods), and furthermore, the cosmetic composition containing the antiallergic agent of the present invention can be used for allergic and atopic skin. It can be used for the prevention and improvement of inflammatory diseases (for example, redness, eczema, edema, swelling, etc.), skin and scalp having troubles such as rough skin and Kayumi, and is applicable to oral compositions and foods. It is also possible to enlarge.
[Brief description of the drawings]
BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a diagram showing the histamine release inhibition rates of various extracts of a variety of Aosuzuran, Sakaneran, Sasabaginran, and Chinese lantern.

Claims (3)

A histamine release inhibitor comprising an extract or pressed product of at least one orchid plant selected from a variety of Aozuraran, Sakanelan, Sasabaginran and Hakusanchidori. An antiallergic agent comprising the histamine release inhibitor according to claim 1. A cosmetic composition comprising the antiallergic agent according to claim 2.

Images