JP2001526651A - 逆ターン擬態物およびそれに関連した方法 - Google Patents

逆ターン擬態物およびそれに関連した方法

Info

Publication number
JP2001526651A
JP2001526651A JP54729198A JP54729198A JP2001526651A JP 2001526651 A JP2001526651 A JP 2001526651A JP 54729198 A JP54729198 A JP 54729198A JP 54729198 A JP54729198 A JP 54729198A JP 2001526651 A JP2001526651 A JP 2001526651A
Authority
JP
Japan
Prior art keywords
compound
reverse
following structure
turn
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP54729198A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001526651A5 (enExample
Inventor
エス． カーン，マイケル
エグチ，マサカツ
キム，ワ−オク
Original Assignee
モレキュメティックス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by モレキュメティックス リミテッド filed Critical モレキュメティックス リミテッド
Publication of JP2001526651A publication Critical patent/JP2001526651A/ja
Publication of JP2001526651A5 publication Critical patent/JP2001526651A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP54729198A 1997-04-30 1998-04-28 逆ターン擬態物およびそれに関連した方法 Pending JP2001526651A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/846,432 1997-04-30
US08/846,432 US6013458A (en) 1995-10-27 1997-04-30 Reverse-turn mimetics and methods relating thereto
PCT/US1998/008542 WO1998049168A1 (en) 1997-04-30 1998-04-28 Reverse-turn mimetics and methods relating thereto

Publications (2)

Publication Number Publication Date
JP2001526651A true JP2001526651A (ja) 2001-12-18
JP2001526651A5 JP2001526651A5 (enExample) 2005-12-02

Family

ID=25297917

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54729198A Pending JP2001526651A (ja) 1997-04-30 1998-04-28 逆ターン擬態物およびそれに関連した方法

Country Status (7)

Country Link
US (1) US6013458A (enExample)
EP (1) EP0980373A1 (enExample)
JP (1) JP2001526651A (enExample)
KR (1) KR20010020416A (enExample)
AU (1) AU743777B2 (enExample)
CA (1) CA2286733C (enExample)
WO (1) WO1998049168A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006523680A (ja) * 2003-04-09 2006-10-19 チョンウェ ファーマ コーポレーション リバースターンミメティックおよびそれに関連した方法
JP2007532674A (ja) * 2004-04-16 2007-11-15 チョンウェ ファーマ コーポレーション リバースターンミメティックおよびそれに関連した方法
JP2009040696A (ja) * 2007-08-07 2009-02-26 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184223B1 (en) * 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
AUPP254898A0 (en) * 1998-03-24 1998-04-23 University Of Queensland, The Peptide turn mimetics
DE60020366T2 (de) * 1999-06-14 2006-02-02 Genentech Inc., San Francisco Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage
US20030166003A1 (en) * 1999-06-14 2003-09-04 Cochran Andrea G. Structured peptide scaffold for displaying turn libraries on phage
US6294525B1 (en) * 1999-09-01 2001-09-25 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
PE20010955A1 (es) * 1999-12-21 2001-10-11 Procter & Gamble Compuestos mimeticos de peptidos de giros beta y procesos para su fabricacion
US6872825B2 (en) 1999-12-21 2005-03-29 The Procter & Gamble Company Peptide β-turn mimetic compounds and processes for making them
US6914123B2 (en) * 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
US7662960B2 (en) * 2001-04-26 2010-02-16 Choongwae Pharma Corporation Beta-strand mimetics and method relating thereto
US20030013846A1 (en) * 2001-05-03 2003-01-16 Bing Wang Pyruvate derivatives
US7008941B2 (en) * 2001-05-16 2006-03-07 Myriad Genetics, Inc. Reverse-turn mimetics and methods relating thereto
WO2003030907A1 (en) * 2001-10-09 2003-04-17 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
US8080657B2 (en) * 2001-10-12 2011-12-20 Choongwae Pharma Corporation Compounds of reverse turn mimetics and the use thereof
EP1444235B1 (en) * 2001-10-12 2008-06-11 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7671054B1 (en) * 2001-10-12 2010-03-02 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7566711B2 (en) * 2001-10-12 2009-07-28 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7232822B2 (en) * 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US6762185B1 (en) 2002-03-01 2004-07-13 Choongwae Pharma Corporation Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
CA2502644A1 (en) * 2002-10-17 2004-04-29 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
US7606403B2 (en) 2002-10-17 2009-10-20 Intel Corporation Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures
DE10305885A1 (de) * 2003-02-13 2004-08-26 Aventis Pharma Deutschland Gmbh Substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
RU2383547C2 (ru) 2003-08-28 2010-03-10 Чоонгвае Фарма Корпорейшн Модуляция бета-катенин/tcf-активируемой транскрипции
US20050209256A1 (en) * 2004-03-19 2005-09-22 Andres Charles J Jr Novel beta-turn mimetics as calcitonin gene related peptide receptor antagonists
US20050222158A1 (en) * 2004-03-19 2005-10-06 Andres Charles J Jr Method of treating migraine headaches using calcitonin gene related peptide mimetics
US20080009500A1 (en) * 2005-11-08 2008-01-10 Michael Kahn Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders
US7964181B2 (en) * 2006-03-30 2011-06-21 Palatin Technologies, Inc. Amino acid surrogates for peptidic constructs
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
US8114844B2 (en) * 2006-03-30 2012-02-14 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptidomimetics
US8455488B2 (en) 2008-06-06 2013-06-04 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
EP2346871A1 (en) 2008-10-14 2011-07-27 PRISM BioLab Corporation Alpha helix mimetics in the treatment of cancer
KR101692921B1 (ko) * 2009-04-15 2017-01-05 제이더블유중외제약 주식회사 리버스턴 유사체의 신규한 화합물 및 그 제조방법과 용도
JP5768239B2 (ja) 2009-05-07 2015-08-26 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ アルファへリックスミメティック及び関連の方法
US20120296067A1 (en) 2010-02-03 2012-11-22 Prism BioLab Co., Ltd. Compound capable of binding to naturally occurring denatured protein, and method for screening for the compound
ES2552462T3 (es) 2010-10-14 2015-11-30 Jw Pharmaceutical Corporation Nuevo compuesto de un mimético de giro inverso y un procedimiento de producción y uso del mismo
WO2012115286A1 (en) 2011-02-25 2012-08-30 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
EP2739302A2 (en) 2011-08-01 2014-06-11 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Novel sequences for the control of reproduction in fish
JP6507336B2 (ja) * 2013-10-18 2019-05-08 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ Ｃｂｐ／カテニン阻害剤を用いる肝線維症の治療
US20240309006A1 (en) * 2021-01-20 2024-09-19 Prism BioLab Co., Ltd. Novel bicyclic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505486A (ja) * 1991-02-07 1994-06-23 モレキュメティクス，リミティド βターンおよびβバルジのコンフォメーション的に制限された模倣物およびそれらを含有するペプチド
JPH07509723A (ja) * 1992-08-06 1995-10-26 モレキュメティクス，リミティド 反転型ターンの立体配座的に拘束されたミメティックスと前者を含有するペプチド
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5886186A (en) * 1995-10-25 1999-03-23 Versicor, Inc. Synthesis of substituted N-heteroaromatic compounds and methods of use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006523680A (ja) * 2003-04-09 2006-10-19 チョンウェ ファーマ コーポレーション リバースターンミメティックおよびそれに関連した方法
JP2007532674A (ja) * 2004-04-16 2007-11-15 チョンウェ ファーマ コーポレーション リバースターンミメティックおよびそれに関連した方法
JP2009040696A (ja) * 2007-08-07 2009-02-26 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド

Also Published As

Publication number Publication date
WO1998049168A1 (en) 1998-11-05
CA2286733A1 (en) 1998-11-05
EP0980373A1 (en) 2000-02-23
US6013458A (en) 2000-01-11
AU743777B2 (en) 2002-02-07
AU7167998A (en) 1998-11-24
KR20010020416A (ko) 2001-03-15
CA2286733C (en) 2004-07-20

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