AU743777B2 - Reverse-turn mimetics and methods relating thereto - Google Patents

Reverse-turn mimetics and methods relating thereto Download PDF

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Publication number
AU743777B2
AU743777B2 AU71679/98A AU7167998A AU743777B2 AU 743777 B2 AU743777 B2 AU 743777B2 AU 71679/98 A AU71679/98 A AU 71679/98A AU 7167998 A AU7167998 A AU 7167998A AU 743777 B2 AU743777 B2 AU 743777B2
Authority
AU
Australia
Prior art keywords
compound
reverse
pct
turn
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU71679/98A
Other languages
English (en)
Other versions
AU7167998A (en
Inventor
Masakatsu Eguchi
Michael S. Kahn
Hwa-Ok Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myriad Genetics Inc
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Publication of AU7167998A publication Critical patent/AU7167998A/en
Application granted granted Critical
Publication of AU743777B2 publication Critical patent/AU743777B2/en
Assigned to MYRIAD GENETICS, INC. reassignment MYRIAD GENETICS, INC. Alteration of Name(s) in Register under S187 Assignors: MOLECUMETICS, LTD.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU71679/98A 1997-04-30 1998-04-28 Reverse-turn mimetics and methods relating thereto Ceased AU743777B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/846,432 US6013458A (en) 1995-10-27 1997-04-30 Reverse-turn mimetics and methods relating thereto
US08/846432 1997-04-30
PCT/US1998/008542 WO1998049168A1 (en) 1997-04-30 1998-04-28 Reverse-turn mimetics and methods relating thereto

Publications (2)

Publication Number Publication Date
AU7167998A AU7167998A (en) 1998-11-24
AU743777B2 true AU743777B2 (en) 2002-02-07

Family

ID=25297917

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71679/98A Ceased AU743777B2 (en) 1997-04-30 1998-04-28 Reverse-turn mimetics and methods relating thereto

Country Status (7)

Country Link
US (1) US6013458A (enExample)
EP (1) EP0980373A1 (enExample)
JP (1) JP2001526651A (enExample)
KR (1) KR20010020416A (enExample)
AU (1) AU743777B2 (enExample)
CA (1) CA2286733C (enExample)
WO (1) WO1998049168A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184223B1 (en) * 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
AUPP254898A0 (en) * 1998-03-24 1998-04-23 University Of Queensland, The Peptide turn mimetics
DE60020366T2 (de) * 1999-06-14 2006-02-02 Genentech Inc., San Francisco Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage
US20030166003A1 (en) * 1999-06-14 2003-09-04 Cochran Andrea G. Structured peptide scaffold for displaying turn libraries on phage
US6294525B1 (en) 1999-09-01 2001-09-25 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US6872825B2 (en) 1999-12-21 2005-03-29 The Procter & Gamble Company Peptide β-turn mimetic compounds and processes for making them
PE20010955A1 (es) * 1999-12-21 2001-10-11 Procter & Gamble Compuestos mimeticos de peptidos de giros beta y procesos para su fabricacion
US6914123B2 (en) * 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
US7662960B2 (en) * 2001-04-26 2010-02-16 Choongwae Pharma Corporation Beta-strand mimetics and method relating thereto
WO2002090314A1 (en) * 2001-05-03 2002-11-14 Galileo Laboratories, Inc. Pyruvate derivatives
WO2002092010A2 (en) * 2001-05-16 2002-11-21 Molecumetics, Ltd. Reverse-turn mimetics and methods relating thereto
WO2003030907A1 (en) * 2001-10-09 2003-04-17 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
US8080657B2 (en) * 2001-10-12 2011-12-20 Choongwae Pharma Corporation Compounds of reverse turn mimetics and the use thereof
US7232822B2 (en) * 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7566711B2 (en) * 2001-10-12 2009-07-28 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7671054B1 (en) 2001-10-12 2010-03-02 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US20040072831A1 (en) * 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7576084B2 (en) * 2001-10-12 2009-08-18 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
AU2002348649B9 (en) * 2001-10-12 2008-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US6762185B1 (en) 2002-03-01 2004-07-13 Choongwae Pharma Corporation Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
US7606403B2 (en) 2002-10-17 2009-10-20 Intel Corporation Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures
WO2004035587A1 (en) * 2002-10-17 2004-04-29 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
DE10305885A1 (de) * 2003-02-13 2004-08-26 Aventis Pharma Deutschland Gmbh Substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2004268647B2 (en) 2003-08-28 2010-07-01 Choongwae Pharma Corporation Modulation of beta-catenin/TCF activated transcription
US20050222158A1 (en) * 2004-03-19 2005-10-06 Andres Charles J Jr Method of treating migraine headaches using calcitonin gene related peptide mimetics
US20050209256A1 (en) * 2004-03-19 2005-09-22 Andres Charles J Jr Novel beta-turn mimetics as calcitonin gene related peptide receptor antagonists
US20080009500A1 (en) * 2005-11-08 2008-01-10 Michael Kahn Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders
US8114844B2 (en) * 2006-03-30 2012-02-14 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptidomimetics
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
US7964181B2 (en) * 2006-03-30 2011-06-21 Palatin Technologies, Inc. Amino acid surrogates for peptidic constructs
JP2009040696A (ja) * 2007-08-07 2009-02-26 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド
AU2009255042B2 (en) * 2008-06-06 2014-05-15 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
WO2010044485A1 (en) 2008-10-14 2010-04-22 Prism Biolab Corporation Alpha helix mimetics in the treatment of cancer
JP5657642B2 (ja) * 2009-04-15 2015-01-21 ジェイダブリュ ファーマセウティカル コーポレーション リバースターン類似体の新規な化合物およびその製造方法と用途
US9040531B2 (en) 2009-05-07 2015-05-26 Prism BioLab Co., Ltd. Alpha helix mimetics and methods relating thereto
CN102906566A (zh) 2010-02-03 2013-01-30 株式会社棱镜生物实验室 与天然变性蛋白质结合的化合物及其筛选方法
EP2628741B1 (en) 2010-10-14 2015-10-07 JW Pharmaceutical Corporation Novel compound of a reverse-turn mimetic and a production method and use therefor
EP2678341A1 (en) 2011-02-25 2014-01-01 PRISM Pharma Co., Ltd. Alpha helix mimetics and methods relating thereto
EP2739302A2 (en) 2011-08-01 2014-06-11 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Novel sequences for the control of reproduction in fish
EP3057590B1 (en) 2013-10-18 2019-11-27 PRISM BioLab Co., Ltd. Treatment of hepatic fibrosis using an inhibitor of cbp/catenin
WO2022158610A1 (en) * 2021-01-20 2022-07-28 Prism BioLab Co., Ltd. Novel bicyclic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1570292A (en) * 1991-02-07 1992-09-07 Board Of Trustees Of The University Of Illinois, The Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
CA2141447A1 (en) * 1992-08-06 1994-02-17 Michael Kahn Conformationally restricted mimetics of reverse turns and peptides containing the same
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5886186A (en) * 1995-10-25 1999-03-23 Versicor, Inc. Synthesis of substituted N-heteroaromatic compounds and methods of use thereof

Also Published As

Publication number Publication date
WO1998049168A1 (en) 1998-11-05
CA2286733A1 (en) 1998-11-05
US6013458A (en) 2000-01-11
EP0980373A1 (en) 2000-02-23
JP2001526651A (ja) 2001-12-18
CA2286733C (en) 2004-07-20
KR20010020416A (ko) 2001-03-15
AU7167998A (en) 1998-11-24

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: MYRIAD GENETICS, INC.

Free format text: FORMER OWNER WAS: MOLECUMETICS, LTD.