JP2001524526A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001524526A5 JP2001524526A5 JP2000522922A JP2000522922A JP2001524526A5 JP 2001524526 A5 JP2001524526 A5 JP 2001524526A5 JP 2000522922 A JP2000522922 A JP 2000522922A JP 2000522922 A JP2000522922 A JP 2000522922A JP 2001524526 A5 JP2001524526 A5 JP 2001524526A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- embedded image
- different
- same
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 18
- 150000003839 salts Chemical class 0.000 description 10
- 102000004127 Cytokines Human genes 0.000 description 9
- 108090000695 Cytokines Proteins 0.000 description 9
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 9
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 9
- 150000002148 esters Chemical class 0.000 description 9
- 125000000623 heterocyclic group Chemical group 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 8
- 125000005843 halogen group Chemical group 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 description 8
- 125000002887 hydroxy group Chemical class [H]O* 0.000 description 6
- 239000013543 active substance Substances 0.000 description 5
- 125000004430 oxygen atom Chemical group O* 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 239000013066 combination product Substances 0.000 description 3
- 229940127555 combination product Drugs 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 125000000751 azo group Chemical group [*]N=N[*] 0.000 description 2
- XOZUGNYVDXMRKW-AATRIKPKSA-N azodicarbonamide Chemical class NC(=O)\N=N\C(N)=O XOZUGNYVDXMRKW-AATRIKPKSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- USVVENVKYJZFMW-ONEGZZNKSA-N (e)-carboxyiminocarbamic acid Chemical compound OC(=O)\N=N\C(O)=O USVVENVKYJZFMW-ONEGZZNKSA-N 0.000 description 1
- GHSTWVSOBMTOQJ-UHFFFAOYSA-N 1-carbamimidoyliminoguanidine Chemical group NC(=N)N=NC(N)=N GHSTWVSOBMTOQJ-UHFFFAOYSA-N 0.000 description 1
- VKDSLCPOHMYLHR-UHFFFAOYSA-N CC(=O)NN=NN(C=O)C Chemical compound CC(=O)NN=NN(C=O)C VKDSLCPOHMYLHR-UHFFFAOYSA-N 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- OQJBFFCUFALWQL-UHFFFAOYSA-N n-(piperidine-1-carbonylimino)piperidine-1-carboxamide Chemical compound C1CCCCN1C(=O)N=NC(=O)N1CCCCC1 OQJBFFCUFALWQL-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE9700949 | 1997-11-26 | ||
| BE9700949A BE1011571A3 (fr) | 1997-11-26 | 1997-11-26 | Procede d'inhibition de la production cellulaire de cytokines. |
| PCT/BE1998/000183 WO1999027937A2 (fr) | 1997-11-26 | 1998-11-25 | Procede d'inhibition de la production cellulaire de cytokines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001524526A JP2001524526A (ja) | 2001-12-04 |
| JP2001524526A5 true JP2001524526A5 (enExample) | 2006-01-05 |
Family
ID=3890860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000522922A Pending JP2001524526A (ja) | 1997-11-26 | 1998-11-25 | サイトカインの細胞生産を阻害するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6407081B1 (enExample) |
| EP (1) | EP1032401B1 (enExample) |
| JP (1) | JP2001524526A (enExample) |
| AT (1) | ATE290870T1 (enExample) |
| AU (1) | AU757489B2 (enExample) |
| BE (1) | BE1011571A3 (enExample) |
| CA (1) | CA2312023A1 (enExample) |
| DE (1) | DE69829406T2 (enExample) |
| ES (1) | ES2241182T3 (enExample) |
| WO (1) | WO1999027937A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1011571A3 (fr) * | 1997-11-26 | 1999-11-09 | Hubriphar | Procede d'inhibition de la production cellulaire de cytokines. |
| AU4545301A (en) * | 2000-03-14 | 2001-09-24 | Nat Jewish Med & Res Center | Method and composition for treating airway hyperresponsiveness |
| AR058107A1 (es) * | 2005-10-26 | 2008-01-23 | Phar H | Azodicarbonamida micronizada, su preparacion y su utilizacion |
| EP2213299B1 (fr) | 2009-01-29 | 2015-09-09 | Michel Vandevelde | Composition vaccinale à base de virus exhibant une protéine à motif(s) en doigt de zinc, son procédé de préparation et son utilisation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3159704B2 (ja) * | 1990-04-19 | 2001-04-23 | プレヴィザン アクチェンゲゼルシャフト | アゾ系誘導体ならびにこれらの誘導体を含む薬剤及び抗エイズ剤としての使用 |
| US5585367A (en) | 1990-04-19 | 1996-12-17 | Previsan S.A. | Method of treating humans and animals infected with viruses of the retrovirus group |
| BE1011571A3 (fr) * | 1997-11-26 | 1999-11-09 | Hubriphar | Procede d'inhibition de la production cellulaire de cytokines. |
-
1997
- 1997-11-26 BE BE9700949A patent/BE1011571A3/fr not_active IP Right Cessation
-
1998
- 1998-11-25 CA CA002312023A patent/CA2312023A1/fr not_active Abandoned
- 1998-11-25 AU AU13276/99A patent/AU757489B2/en not_active Ceased
- 1998-11-25 DE DE69829406T patent/DE69829406T2/de not_active Expired - Lifetime
- 1998-11-25 EP EP98956724A patent/EP1032401B1/fr not_active Expired - Lifetime
- 1998-11-25 ES ES98956724T patent/ES2241182T3/es not_active Expired - Lifetime
- 1998-11-25 US US09/555,258 patent/US6407081B1/en not_active Expired - Fee Related
- 1998-11-25 JP JP2000522922A patent/JP2001524526A/ja active Pending
- 1998-11-25 WO PCT/BE1998/000183 patent/WO1999027937A2/fr not_active Ceased
- 1998-11-25 AT AT98956724T patent/ATE290870T1/de not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2004269903B2 (en) | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma | |
| JPH11222432A (ja) | インターフェロンを誘起するアミド誘導体を含有する外用剤 | |
| CN109734701B (zh) | Rock抑制剂-二氯乙酸复盐及其制备方法和用途 | |
| CN104010501B (zh) | 含src同源区2蛋白酪胺酸磷酸酶-1增效剂及其治疗方法 | |
| EA027476B1 (ru) | Применение n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида для лечения кастрационно-резистентного рака простаты и остеобластических метастазов в кости | |
| CA2675845A1 (en) | Positively charged water-soluble prodrugs of 1h-imidazo[4,5-c]quinolin-4-amines and related compounds with very high skin penetration rates | |
| JPH05163139A (ja) | 抗動脈硬化剤 | |
| EP0774257B1 (en) | Use of piperazine and homopiperazine compounds for the inhibition of cellular adhesion and infiltration | |
| JP2001524526A5 (enExample) | ||
| BG64456B1 (bg) | Фармацевтични продукти за лечение и предпазване от болести, свързани с дисфункцията на васкуларни ендотелиални клетки | |
| KR20070007783A (ko) | 암 및 건선 등의 혈관의존성 질환의 치료를 위한 약제제조시의 2,5-디히드록시벤젠 술폰산의 용도 | |
| EP0532553B1 (en) | Use of compounds for the treatment of age-related memory impairment and other cognitive disorders | |
| HRP20020178A2 (en) | Use of bis-sulphonamides for producing medicaments used for preventing or treating hyperlipidaemia | |
| ES2880444T3 (es) | Combinación de metotrexato y simvastatina para su uso en el tratamiento del osteosarcoma | |
| CN112125866A (zh) | 1,4-[二(1,2-苯并异硒唑-3(2h)-酮)]丁烷的晶型及其制备方法与应用 | |
| ES2241182T3 (es) | Procedimiento de inhibicion de la produccion de citocinas. | |
| EP2117552B1 (en) | Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases | |
| AU4424799A (en) | N-acetyl 3-chloroprocainamide, acid addition salts thereof, and methods of use | |
| ES2240564T3 (es) | Agentes antinflamatorios. | |
| CN102970986B (zh) | 含有吡罗昔康的骨架型贴剂以及局部治疗急性和慢性疼痛及其相关炎症的方法 | |
| JP2840337B2 (ja) | 腫瘍転移抑制剤 | |
| JPS56120683A (en) | Piperazine derivative of theophylline* its manufacture and therapeutic composition for respiratory disease | |
| CN104274455B (zh) | 含苄基哌嗪槲皮素衍生物制法及其对胃黏膜保护作用 | |
| JP7418502B2 (ja) | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 | |
| CN110433172B (zh) | 一种具有治疗非小细胞肺癌功效的药物及其用途 |