JP2001523729A5 - - Google Patents
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- Publication number
- JP2001523729A5 JP2001523729A5 JP2000521855A JP2000521855A JP2001523729A5 JP 2001523729 A5 JP2001523729 A5 JP 2001523729A5 JP 2000521855 A JP2000521855 A JP 2000521855A JP 2000521855 A JP2000521855 A JP 2000521855A JP 2001523729 A5 JP2001523729 A5 JP 2001523729A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogen
- subunit
- ltb
- holotoxin
- adjuvanted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002163 immunogen Effects 0.000 description 17
- 229960005486 vaccine Drugs 0.000 description 7
- 101710146739 Enterotoxin Proteins 0.000 description 5
- 239000000147 enterotoxin Substances 0.000 description 5
- 231100000655 enterotoxin Toxicity 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 230000001939 inductive effect Effects 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 241000424103 Parapercis colias Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 229930186900 holotoxin Natural products 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000016379 mucosal immune response Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 206010065764 Mucosal infection Diseases 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97203671.9 | 1997-11-25 | ||
| EP97203671A EP0919243A1 (en) | 1997-11-25 | 1997-11-25 | Vaccine containing B subunits of heat-labile enterotoxin (LTB) of Escherichia coli as an adjuvant |
| PCT/EP1998/007553 WO1999026654A1 (en) | 1997-11-25 | 1998-11-24 | Vaccines with an ltb adjuvant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001523729A JP2001523729A (ja) | 2001-11-27 |
| JP2001523729A5 true JP2001523729A5 (https=) | 2005-12-22 |
| JP4235359B2 JP4235359B2 (ja) | 2009-03-11 |
Family
ID=8228966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000521855A Expired - Fee Related JP4235359B2 (ja) | 1997-11-25 | 1998-11-24 | Ｌｔｂアジュバントを含むワクチン |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6793928B1 (https=) |
| EP (2) | EP0919243A1 (https=) |
| JP (1) | JP4235359B2 (https=) |
| KR (1) | KR100575019B1 (https=) |
| CN (1) | CN1227032C (https=) |
| AT (1) | ATE238809T1 (https=) |
| AU (1) | AU747061C (https=) |
| BR (1) | BR9815413A (https=) |
| CA (1) | CA2311492C (https=) |
| CZ (1) | CZ299770B6 (https=) |
| DE (1) | DE69814177T2 (https=) |
| DK (1) | DK1071456T3 (https=) |
| ES (1) | ES2198089T3 (https=) |
| HU (1) | HU226214B1 (https=) |
| IL (2) | IL135905A0 (https=) |
| NO (1) | NO324690B1 (https=) |
| NZ (1) | NZ504396A (https=) |
| PL (1) | PL190925B1 (https=) |
| PT (1) | PT1071456E (https=) |
| RU (1) | RU2211050C2 (https=) |
| SK (1) | SK284572B6 (https=) |
| TR (1) | TR200001485T2 (https=) |
| UA (1) | UA72199C2 (https=) |
| WO (1) | WO1999026654A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| AU2003261492B2 (en) * | 1998-05-08 | 2006-09-07 | Trident Pharmaceuticals, Inc. | Vaccine |
| KR20010043441A (ko) | 1998-05-08 | 2001-05-25 | 더 유니버시티 오브 브리스톨 | 백신용 면역조절제 |
| KR20070067719A (ko) * | 1998-05-08 | 2007-06-28 | 유니버시티 오브 브리스톨 | 백신용 면역조절제 |
| CA2388054C (en) * | 1999-10-18 | 2012-12-11 | Chiron Corporation | Compositions and methods for stimulating an immune response against infectious agents |
| RU2223783C1 (ru) * | 2002-07-05 | 2004-02-20 | Российская медицинская академия последипломного образования | Способ профилактики гриппа и острых респираторных заболеваний у часто болеющих детей |
| IL158140A0 (en) * | 2003-09-25 | 2004-03-28 | Hadasit Med Res Service | Multiepitope polypeptides for cancer immunotherapy |
| US20060002960A1 (en) * | 2003-12-09 | 2006-01-05 | Paul Zoeteweij | GM1 binding deficient exotoxins for use as immunoadjuvants |
| EP1930025B1 (en) | 2005-08-05 | 2013-05-01 | The University of Tokushima | ANTIGEN-AND-DRUG VEHICLE WHICH ENABLES THE CHANGEOVER FROM THE SELECTIVE PRODUCTION OF IgA ANTIBODY TO THE PRODUCTION OF BOTH OF IgA AND IgG ANTIBODIES, AND TRANSNASAL/TRANSMUCOSAL VACCINE USING THE VEHICLE |
| TWI397419B (zh) * | 2006-03-22 | 2013-06-01 | Abbott Biologicals Bv | 病毒顆粒的鼻內或吸入給藥 |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| EP2076531B1 (en) * | 2006-10-12 | 2011-11-23 | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. | Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| AU2008293504B2 (en) | 2007-08-27 | 2012-04-12 | Longhorn Vaccines & Diagnostics, Llc | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| CA2861667C (en) | 2007-10-01 | 2017-06-13 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system and methods of use |
| WO2013112916A1 (en) | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| EP2865390B1 (en) * | 2012-06-20 | 2019-08-21 | The University of Tokyo | Mucosal immunity-stimulating agent, and oral pharmaceutical composition for treating hpv infection |
| US10208093B2 (en) | 2013-12-16 | 2019-02-19 | Agricultural Technology Research Institute | Plasmid, method and kit thereof for producing heat labile enterotoxin B-subunit |
| WO2016183292A1 (en) | 2015-05-14 | 2016-11-17 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the extraction of nucleic acids from biological samples |
| MX2020004434A (es) * | 2017-11-01 | 2020-08-06 | Merck Sharp & Dohme | Formulaciones estables de citomegalovirus. |
| CA3087569A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| WO2019183208A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| KR20220005560A (ko) | 2019-05-06 | 2022-01-13 | 신세틱 바이오로직스, 인코퍼레이티드 | 알칼리성 포스페이트-기반 종양학 치료제 |
| US12485166B2 (en) | 2020-02-06 | 2025-12-02 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
| CN113616783B (zh) * | 2020-05-08 | 2025-08-08 | 昱厚生技股份有限公司 | 使用免疫调节剂和包含所述免疫调节剂的疫苗组合物预防或治疗冠状病毒感染的方法 |
| KR20230091978A (ko) | 2020-10-20 | 2023-06-23 | 롱혼 백신즈 앤드 다이어그나스틱스, 엘엘씨 | 면역원성 항원 |
| TWI896302B (zh) * | 2024-08-22 | 2025-09-01 | 國立清華大學 | 重組蛋白及其製備方法、包含重組蛋白的疫苗蛋白質佐劑及重組蛋白用於預防呼吸道疾病的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH589453A5 (https=) | 1974-01-14 | 1977-07-15 | Sandoz Ag | |
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| WO1990006366A1 (en) * | 1988-12-07 | 1990-06-14 | University Of Leicester | Heat-labile toxin b subunit fusion proteins |
| US5241053A (en) * | 1990-09-05 | 1993-08-31 | Takeda Chemical Industries, Ltd. | Fused proteins comprising glycoprotein gD of HSV-1 and LTB |
| GB9513733D0 (en) * | 1995-07-05 | 1995-09-06 | Univ Bristol | Therapeutic agents |
-
1997
- 1997-11-25 EP EP97203671A patent/EP0919243A1/en not_active Withdrawn
-
1998
- 1998-11-24 CA CA2311492A patent/CA2311492C/en not_active Expired - Fee Related
- 1998-11-24 AT AT98963503T patent/ATE238809T1/de active
- 1998-11-24 CN CNB988115492A patent/CN1227032C/zh not_active Expired - Fee Related
- 1998-11-24 CZ CZ20001895A patent/CZ299770B6/cs not_active IP Right Cessation
- 1998-11-24 US US09/555,139 patent/US6793928B1/en not_active Expired - Fee Related
- 1998-11-24 TR TR2000/01485T patent/TR200001485T2/xx unknown
- 1998-11-24 EP EP98963503A patent/EP1071456B1/en not_active Expired - Lifetime
- 1998-11-24 JP JP2000521855A patent/JP4235359B2/ja not_active Expired - Fee Related
- 1998-11-24 HU HU0100058A patent/HU226214B1/hu not_active IP Right Cessation
- 1998-11-24 NZ NZ504396A patent/NZ504396A/en not_active IP Right Cessation
- 1998-11-24 RU RU2000116260/14A patent/RU2211050C2/ru not_active IP Right Cessation
- 1998-11-24 KR KR1020007005665A patent/KR100575019B1/ko not_active Expired - Fee Related
- 1998-11-24 ES ES98963503T patent/ES2198089T3/es not_active Expired - Lifetime
- 1998-11-24 UA UA2000063620A patent/UA72199C2/uk unknown
- 1998-11-24 IL IL13590598A patent/IL135905A0/xx active IP Right Grant
- 1998-11-24 WO PCT/EP1998/007553 patent/WO1999026654A1/en not_active Ceased
- 1998-11-24 DK DK98963503T patent/DK1071456T3/da active
- 1998-11-24 AU AU18750/99A patent/AU747061C/en not_active Ceased
- 1998-11-24 DE DE69814177T patent/DE69814177T2/de not_active Expired - Lifetime
- 1998-11-24 BR BR9815413-3A patent/BR9815413A/pt not_active IP Right Cessation
- 1998-11-24 PT PT98963503T patent/PT1071456E/pt unknown
- 1998-11-24 PL PL340635A patent/PL190925B1/pl unknown
- 1998-11-24 SK SK776-2000A patent/SK284572B6/sk not_active IP Right Cessation
-
2000
- 2000-05-01 IL IL135905A patent/IL135905A/en not_active IP Right Cessation
- 2000-05-22 NO NO20002613A patent/NO324690B1/no not_active IP Right Cessation
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