JP2001522274A - 電極および電極配列 - Google Patents
電極および電極配列Info
- Publication number
- JP2001522274A JP2001522274A JP54633698A JP54633698A JP2001522274A JP 2001522274 A JP2001522274 A JP 2001522274A JP 54633698 A JP54633698 A JP 54633698A JP 54633698 A JP54633698 A JP 54633698A JP 2001522274 A JP2001522274 A JP 2001522274A
- Authority
- JP
- Japan
- Prior art keywords
- electrodes
- electrode
- electrical
- array
- waveform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 238000011282 treatment Methods 0.000 claims description 34
- 238000004520 electroporation Methods 0.000 claims description 26
- 210000000170 cell membrane Anatomy 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 5
- 230000035699 permeability Effects 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 15
- 238000001727 in vivo Methods 0.000 abstract description 7
- 210000004027 cell Anatomy 0.000 description 50
- 210000001519 tissue Anatomy 0.000 description 47
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- 229940124597 therapeutic agent Drugs 0.000 description 19
- 230000004083 survival effect Effects 0.000 description 16
- 241001465754 Metazoa Species 0.000 description 13
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- 241000700159 Rattus Species 0.000 description 6
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- 210000000988 bone and bone Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
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- 238000012546 transfer Methods 0.000 description 5
- 108010006654 Bleomycin Proteins 0.000 description 4
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- 229960001561 bleomycin Drugs 0.000 description 4
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- 210000004556 brain Anatomy 0.000 description 4
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
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- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 2
- 208000003174 Brain Neoplasms Diseases 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 208000007660 Residual Neoplasm Diseases 0.000 description 2
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- 229910001220 stainless steel Inorganic materials 0.000 description 2
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- 230000001052 transient effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 2
- 229960001600 xylazine Drugs 0.000 description 2
- -1 (Trade name) Substances 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 229910000575 Ir alloy Inorganic materials 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 102100034784 Protein TANC2 Human genes 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
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- 230000037005 anaesthesia Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000003491 array Methods 0.000 description 1
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- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
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- 230000006037 cell lysis Effects 0.000 description 1
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- 238000002224 dissection Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
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- 239000012212 insulator Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
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- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/0424—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/845,553 | 1997-04-24 | ||
| US08/845,553 US5873849A (en) | 1997-04-24 | 1997-04-24 | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| PCT/US1998/008183 WO1998047562A1 (en) | 1997-04-24 | 1998-04-23 | Electrodes and electrode arrays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001522274A true JP2001522274A (ja) | 2001-11-13 |
| JP2001522274A5 JP2001522274A5 (OSRAM) | 2005-12-02 |
Family
ID=25295503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54633698A Ceased JP2001522274A (ja) | 1997-04-24 | 1998-04-23 | 電極および電極配列 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5873849A (OSRAM) |
| EP (1) | EP0973579A4 (OSRAM) |
| JP (1) | JP2001522274A (OSRAM) |
| AU (1) | AU734611B2 (OSRAM) |
| CA (1) | CA2287366A1 (OSRAM) |
| WO (1) | WO1998047562A1 (OSRAM) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010533023A (ja) * | 2007-07-10 | 2010-10-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 神経刺激システム |
| JP2024535582A (ja) * | 2021-10-22 | 2024-09-30 | 杭州維納安可医療科技有限責任公司 | 電場発生装置及びその制御方法、コンピュータ可読記憶媒体 |
| US12303459B2 (en) | 2008-08-06 | 2025-05-20 | Serendia, Llc | Method, system, and apparatus for dermatological treatment |
Families Citing this family (288)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US6041252A (en) * | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| US5873849A (en) * | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6216034B1 (en) | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
| WO1999011771A1 (en) * | 1997-09-04 | 1999-03-11 | Science Research Laboratory, Inc. | Cell separation using electric fields |
| AUPO907697A0 (en) * | 1997-09-09 | 1997-10-02 | Day, Robert Edward | Chemical supplementation of bone |
| US7456012B2 (en) * | 1997-11-06 | 2008-11-25 | Cellectricon Ab | Method and apparatus for spatially confined electroporation |
| US6778853B1 (en) | 1997-12-17 | 2004-08-17 | University Of South Florida | Electroporation device |
| US6135990A (en) * | 1997-12-17 | 2000-10-24 | University Of South Florida | Electroporation device and method |
| US6009347A (en) * | 1998-01-27 | 1999-12-28 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US6208893B1 (en) | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| CA2626830A1 (en) | 1998-02-24 | 1999-08-26 | Boston Scientific Limited | High flow rate dialysis catheters and related methods |
| US6027488A (en) * | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US20040229363A1 (en) * | 1998-06-24 | 2004-11-18 | Ed Nolan | High efficiency transfection based on low electric field strength, long pulse length |
| ATE369877T1 (de) * | 1998-06-26 | 2007-09-15 | Genetronics Inc | Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel |
| US6678556B1 (en) | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
| US7922709B2 (en) * | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
| WO2000002620A1 (en) | 1998-07-13 | 2000-01-20 | Genetronics, Inc. | Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications |
| EP2428250A1 (en) | 1998-07-13 | 2012-03-14 | Genetronics, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| EP1100580A1 (en) | 1998-07-20 | 2001-05-23 | Ichor Medical Systems, Inc. | Electroporation electrodes |
| US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| US6314316B1 (en) * | 1998-12-17 | 2001-11-06 | University Of South Florida | Nonpenetrating electroporation device and method |
| US6937890B2 (en) * | 1998-12-17 | 2005-08-30 | University Of South Florida | Nonpenetrating electroporation device |
| JP4499295B2 (ja) * | 1999-01-28 | 2010-07-07 | サイト パルス サイエンシズ、インコーポレイテッド | 細胞内への巨大分子の送達 |
| US6542776B1 (en) * | 1999-04-14 | 2003-04-01 | Transneuronix Inc. | Gastric stimulator apparatus and method for installing |
| US6684104B2 (en) | 1999-04-14 | 2004-01-27 | Transneuronix, Inc. | Gastric stimulator apparatus and method for installing |
| US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6300108B1 (en) * | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6912424B2 (en) * | 1999-12-01 | 2005-06-28 | Meagan, Medical, Inc. | Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient |
| US6904324B2 (en) * | 1999-12-01 | 2005-06-07 | Meagan Medical, Inc. | Method and apparatus for deploying a percutaneous probe |
| US6560491B1 (en) | 1999-12-01 | 2003-05-06 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system providing electrode axial support |
| US6549797B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Electrode remover for a percutaneous electrical therapy system |
| US6622051B1 (en) | 1999-12-01 | 2003-09-16 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode entry angle control |
| US6556869B1 (en) | 1999-12-01 | 2003-04-29 | Vertis Neuroscience, Inc. | Electrode introducer for a percutaneous electrical therapy system |
| US6529776B1 (en) * | 1999-12-01 | 2003-03-04 | Vertis Neuroscience, Inc. | Method and apparatus for repositioning a percutaneous probe |
| US6522927B1 (en) | 1999-12-01 | 2003-02-18 | Vertis Neuroscience, Inc. | Electrode assembly for a percutaneous electrical therapy system |
| US6493592B1 (en) | 1999-12-01 | 2002-12-10 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode position maintenance |
| US6549810B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode depth control |
| US6539264B1 (en) | 1999-12-01 | 2003-03-25 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with sharp point protection |
| US6516226B1 (en) | 1999-12-01 | 2003-02-04 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system for minimizing electrode insertion discomfort |
| CA2394020C (en) | 1999-12-15 | 2011-04-05 | University Of South Florida | Electroporation device and method |
| US6714816B1 (en) * | 2000-02-22 | 2004-03-30 | University Of South Florida | Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo |
| US8024048B2 (en) | 2000-03-13 | 2011-09-20 | Ionix Medical Inc. | Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
| US7742811B2 (en) | 2000-03-13 | 2010-06-22 | Onco Stim | Implantable device and method for the electrical treatment of cancer |
| US7756584B2 (en) * | 2000-07-13 | 2010-07-13 | Advanced Neuromodulation Systems, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
| JP2004520865A (ja) * | 2000-07-25 | 2004-07-15 | リタ メディカル システムズ インコーポレイテッド | 局在化インピーダンス測定を使用する腫瘍の検出および処置のための装置 |
| US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
| US6892099B2 (en) * | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
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| JP2010533023A (ja) * | 2007-07-10 | 2010-10-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 神経刺激システム |
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| US12303459B2 (en) | 2008-08-06 | 2025-05-20 | Serendia, Llc | Method, system, and apparatus for dermatological treatment |
| JP2024535582A (ja) * | 2021-10-22 | 2024-09-30 | 杭州維納安可医療科技有限責任公司 | 電場発生装置及びその制御方法、コンピュータ可読記憶媒体 |
| JP7783470B2 (ja) | 2021-10-22 | 2025-12-10 | 杭州維納安可医療科技有限責任公司 | 電場発生装置及びその制御方法、コンピュータ可読記憶媒体 |
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| AU7151598A (en) | 1998-11-13 |
| US6278895B1 (en) | 2001-08-21 |
| US5873849A (en) | 1999-02-23 |
| EP0973579A1 (en) | 2000-01-26 |
| WO1998047562A1 (en) | 1998-10-29 |
| CA2287366A1 (en) | 1998-10-29 |
| EP0973579A4 (en) | 2000-11-02 |
| AU734611B2 (en) | 2001-06-21 |
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