JP2001518477A5 - - Google Patents
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- Publication number
- JP2001518477A5 JP2001518477A5 JP2000513868A JP2000513868A JP2001518477A5 JP 2001518477 A5 JP2001518477 A5 JP 2001518477A5 JP 2000513868 A JP2000513868 A JP 2000513868A JP 2000513868 A JP2000513868 A JP 2000513868A JP 2001518477 A5 JP2001518477 A5 JP 2001518477A5
- Authority
- JP
- Japan
- Prior art keywords
- glucopyranosyl
- frost
- ene
- galactopyranoside
- triol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WQZGKKKJIJFFOK-SVZMEOIVSA-N D-galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
Description
本発明に従い、式ＩＩの好ましい化合物は、
（２５Ｓ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−ヒドロキシ−５β−フロスト−２β，３β，２６−トリオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→２）−β−Ｄ−ガラクトピラノシド、
（２５Ｓ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−メトキシ−５β−フロスト−２β，３β，２６−トリオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→２）−β−Ｄ−ガラクトピラノシド、
（２５Ｓ）−２６−Ｏ−β−Ｄ−グルコピラノシル−５β−フロスト−２０（２２）−エン−２β，３β，２６−トリオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→２）−β−ガラクトピラノシド、
（２５Ｒ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−ヒドロキシ−５−エン−フロスト−３β，２６−ジオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→４）−β−Ｄ−ガラクトピラノシド、
（２５Ｒ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−メトキシ−５−エン−フロスト−３β，２６−ジオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→４）−β−Ｄ−ガラクトピラノシド、
（２５Ｒ）−２６−Ｏ−β−Ｄ−グルコピラノシル−５−エン−フロスト−２０（２２）−エン−３β，２６−ジオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→４）−β−Ｄ−ガラクトピラノシド
より成る群から選択される。
（２５Ｓ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−ヒドロキシ−５β−フロスト−２β，３β，２６−トリオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→２）−β−Ｄ−ガラクトピラノシド、
（２５Ｓ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−メトキシ−５β−フロスト−２β，３β，２６−トリオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→２）−β−Ｄ−ガラクトピラノシド、
（２５Ｓ）−２６−Ｏ−β−Ｄ−グルコピラノシル−５β−フロスト−２０（２２）−エン−２β，３β，２６−トリオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→２）−β−ガラクトピラノシド、
（２５Ｒ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−ヒドロキシ−５−エン−フロスト−３β，２６−ジオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→４）−β−Ｄ−ガラクトピラノシド、
（２５Ｒ）−２６−Ｏ−β−Ｄ−グルコピラノシル−２２−メトキシ−５−エン−フロスト−３β，２６−ジオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→４）−β−Ｄ−ガラクトピラノシド、
（２５Ｒ）−２６−Ｏ−β−Ｄ−グルコピラノシル−５−エン−フロスト−２０（２２）−エン−３β，２６−ジオール−３−Ｏ−β−Ｄ−グルコピラノシル（１→４）−β−Ｄ−ガラクトピラノシド
より成る群から選択される。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97119680.X | 1997-09-26 | ||
| CN97119680A CN1131237C (zh) | 1997-09-26 | 1997-09-26 | 甾体皂甙防治老年性痴呆的用途及新的甾体皂甙 |
| PCT/CN1998/000204 WO1999016786A1 (fr) | 1997-09-26 | 1998-09-28 | Utilisation de composes de saponine et de steroides pour prevenir la senilite et nouveaux composes de saponine steroide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001518477A JP2001518477A (ja) | 2001-10-16 |
| JP2001518477A5 true JP2001518477A5 (ja) | 2009-06-18 |
| JP4338306B2 JP4338306B2 (ja) | 2009-10-07 |
Family
ID=5175496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000513868A Expired - Fee Related JP4338306B2 (ja) | 1997-09-26 | 1998-09-28 | 痴呆の予防または治療のためのステロイドサポニンの使用、及び新規なステロイドサポニン化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6593301B1 (ja) |
| EP (1) | EP1024146B1 (ja) |
| JP (1) | JP4338306B2 (ja) |
| KR (1) | KR100354826B1 (ja) |
| CN (1) | CN1131237C (ja) |
| AU (1) | AU9336098A (ja) |
| CA (1) | CA2304770C (ja) |
| DE (1) | DE69841421D1 (ja) |
| WO (1) | WO1999016786A1 (ja) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| US20030118673A1 (en) * | 1998-03-26 | 2003-06-26 | Zongqin Xia | Smilagenin and anzurogenin-D for the treatment of alzheimer's disease |
| JP3768100B2 (ja) | 1998-03-26 | 2006-04-19 | ファイトファーム・ピーエルシー | アルツハイマー病を治療するためのステロイドサポゲニンとその誘導体 |
| GB9905275D0 (en) | 1999-03-08 | 1999-04-28 | Phytopharm Ltd | Treatment of conditions associated with membrane-bound receptors and their function |
| GB2347676A (en) | 1999-03-08 | 2000-09-13 | Phytopharm Plc | Screening method |
| GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
| CN1422861A (zh) * | 2001-12-03 | 2003-06-11 | 张晓� | 皂甙化合物的用途 |
| CA2479249A1 (en) * | 2002-03-15 | 2003-09-25 | Samaritan Pharmaceuticals, Inc. | Neuroprotective spirostenol pharmaceutical compositions |
| US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
| NZ563183A (en) * | 2002-03-27 | 2009-03-31 | Phytopharm Plc | Therapeutic methods and uses of sapogenins and their derivatives |
| CN102727501A (zh) * | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
| KR20100093621A (ko) * | 2002-03-27 | 2010-08-25 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 용도 |
| AU2003229877B8 (en) * | 2002-03-27 | 2008-06-12 | Phytopharm Plc | Theraputic methods and uses of sapogenins and their derivatives |
| US20060009433A1 (en) * | 2003-03-14 | 2006-01-12 | Zhi-Xing Yao | Neuroprotective spirostenol pharmaceutical compositions |
| GB0513881D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| US20080182801A1 (en) * | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| CN100427500C (zh) * | 2004-04-29 | 2008-10-22 | 中国人民解放军军事医学科学院放射医学研究所 | 知母皂苷bⅱ的制备方法 |
| CN1692914B (zh) * | 2004-04-29 | 2010-05-26 | 中国人民解放军军事医学科学院放射医学研究所 | 知母皂苷bⅱ在制备用于防治脑卒中药物或产品中的用途 |
| CN1315866C (zh) * | 2004-05-09 | 2007-05-16 | 上海正祥天然药物科技有限公司 | 天冬总甾体皂苷提取物及其制备方法与应用 |
| CN1732955B (zh) * | 2004-08-03 | 2011-02-09 | 山东绿叶制药有限公司 | 以知母总皂苷元为活性成分的药物组合物及其制备方法和用途 |
| CN1754541A (zh) * | 2004-09-30 | 2006-04-05 | 成都地奥制药集团有限公司 | 甾体皂苷药物组合物及其制备方法和用途 |
| CA2584333A1 (en) * | 2004-10-14 | 2006-04-27 | Georgetown University | Neuroprotective spirostenol pharmaceutical compositions |
| KR20080036552A (ko) * | 2005-05-17 | 2008-04-28 | 사토리 파마슈티컬즈, 인코포레이티드 | 신경퇴행성 장애를 치료하는 데 유용한 화합물 |
| GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| JP5166272B2 (ja) * | 2005-10-28 | 2013-03-21 | キム・スンヨウ | ヤマノイモ科植物の抽出物、及びこれを含む末梢神経障害の予防用または治療用の組成物 |
| EP2274317A4 (en) * | 2008-04-30 | 2012-10-24 | Inst Radiation Med Amms Pla | SYNTHESIS OF TIMOSAPONINE BII |
| EP2389182A1 (en) | 2009-01-24 | 2011-11-30 | Phytopharm PLC | Treatment of neurotrophic factor mediated disorders |
| CN102311481B (zh) * | 2010-07-01 | 2012-12-05 | 中国科学院上海药物研究所 | 毛红椿酸甲酯及其制备方法和用途 |
| US20130210786A1 (en) | 2010-07-20 | 2013-08-15 | Patrick Alexander Howson | Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders |
| KR101341693B1 (ko) * | 2011-03-16 | 2013-12-16 | 동아에스티 주식회사 | 생약추출물을 함유하는 퇴행성 신경질환의 치료 및 예방을 위한 조성물 |
| WO2013149580A1 (en) * | 2012-04-03 | 2013-10-10 | Chiming Che | Timosaponin compounds |
| KR101777920B1 (ko) * | 2015-07-27 | 2017-09-14 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물 |
| CN105153266B (zh) * | 2015-07-30 | 2017-03-22 | 中国人民解放军第四军医大学 | 一种甾体皂苷类化合物及其在制备抗肿瘤药物中的应用 |
| US20190060341A1 (en) * | 2015-10-16 | 2019-02-28 | Instituto Tecnológico y de Estudios Superiores de Monterrey | Agavaceae extract comprising steroidal saponins to treat or prevent metabolic disorder related pathologies |
| CN105440098B (zh) * | 2015-12-31 | 2017-04-19 | 南京中医药大学 | 一种制备知母皂苷n的方法 |
| CN107488204A (zh) * | 2017-08-17 | 2017-12-19 | 烟台大学 | 达玛烷型人参皂苷（元）及其ocotillol型衍生物的抗炎用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1144136B (it) * | 1980-03-05 | 1986-10-29 | Zenyaku Kogyo Kk | Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione |
| JP2631686B2 (ja) * | 1988-03-01 | 1997-07-16 | 湧永製薬株式会社 | 新規ステロイドサポニンおよびその製造法ならびにこれらの誘導体の新規用途 |
| JPH02243631A (ja) * | 1989-03-15 | 1990-09-27 | Wakunaga Pharmaceut Co Ltd | 抗発癌プロモーター |
| JPH0454194A (ja) * | 1990-06-19 | 1992-02-21 | Wakunaga Pharmaceut Co Ltd | 新規ステロイド配糖体およびこの製造法ならびにこれを有効成分とする血糖降下剤 |
| CN1088748A (zh) * | 1993-01-01 | 1994-07-06 | 赵广才 | 荞麦保健食品 |
| DE4303214A1 (de) * | 1993-02-04 | 1994-08-11 | Wolfgang Marks | Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone |
| US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
| CN1102186A (zh) * | 1993-10-29 | 1995-05-03 | 沈阳医学院 | 中药薤白新成分的鉴定及用途 |
| JPH07267864A (ja) * | 1994-03-28 | 1995-10-17 | Tsumura & Co | 体温降下剤 |
| JPH0859476A (ja) * | 1994-08-22 | 1996-03-05 | Shiratori Seiyaku Kk | 肝炎治療剤 |
| CN1138984A (zh) * | 1995-06-26 | 1997-01-01 | 军事医学科学院放射医学研究所 | 新型甙类抗血栓药物 |
| KR0169536B1 (ko) * | 1996-02-27 | 1999-01-15 | 손경식 | 신규한 인삼 사포닌, 그의 제조방법 및 이를 유효성분으로 하는 항종양제 |
-
1997
- 1997-09-26 CN CN97119680A patent/CN1131237C/zh not_active Expired - Lifetime
-
1998
- 1998-09-28 DE DE69841421T patent/DE69841421D1/de not_active Expired - Lifetime
- 1998-09-28 WO PCT/CN1998/000204 patent/WO1999016786A1/zh active IP Right Grant
- 1998-09-28 KR KR1020007003288A patent/KR100354826B1/ko active IP Right Review Request
- 1998-09-28 EP EP98946213A patent/EP1024146B1/en not_active Expired - Lifetime
- 1998-09-28 JP JP2000513868A patent/JP4338306B2/ja not_active Expired - Fee Related
- 1998-09-28 US US09/509,287 patent/US6593301B1/en not_active Expired - Lifetime
- 1998-09-28 CA CA002304770A patent/CA2304770C/en not_active Expired - Lifetime
- 1998-09-28 AU AU93360/98A patent/AU9336098A/en not_active Abandoned
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