JP2001517445A - 甲状腺刺激ホルモンの突然変異体およびそれに基づく方法 - Google Patents
甲状腺刺激ホルモンの突然変異体およびそれに基づく方法Info
- Publication number
- JP2001517445A JP2001517445A JP2000512957A JP2000512957A JP2001517445A JP 2001517445 A JP2001517445 A JP 2001517445A JP 2000512957 A JP2000512957 A JP 2000512957A JP 2000512957 A JP2000512957 A JP 2000512957A JP 2001517445 A JP2001517445 A JP 2001517445A
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- mutant
- tsh
- subunit
- amino acid
- heterodimer
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93947297A | 1997-09-22 | 1997-09-22 | |
| US08/939,472 | 1997-09-22 | ||
| PCT/US1998/019772 WO1999015665A2 (en) | 1997-09-22 | 1998-09-22 | Mutants of thyroid stimulating hormone and methods based thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001517445A true JP2001517445A (ja) | 2001-10-09 |
| JP2001517445A5 JP2001517445A5 (https=) | 2006-01-05 |
Family
ID=25473237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000512957A Pending JP2001517445A (ja) | 1997-09-22 | 1998-09-22 | 甲状腺刺激ホルモンの突然変異体およびそれに基づく方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040266665A1 (https=) |
| EP (2) | EP1017817B1 (https=) |
| JP (1) | JP2001517445A (https=) |
| KR (4) | KR100642592B1 (https=) |
| CN (1) | CN1277633A (https=) |
| AT (1) | ATE356209T1 (https=) |
| AU (1) | AU758156B2 (https=) |
| CA (1) | CA2302993A1 (https=) |
| DE (1) | DE69837271T2 (https=) |
| WO (1) | WO1999015665A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530974A (ja) * | 2004-03-31 | 2007-11-01 | トロフォゲン，インコーポレイテッド | ヒト糖タンパク質ホルモンのスーパーアゴニストおよびその使用 |
| JP2010503689A (ja) * | 2006-09-19 | 2010-02-04 | ジェンザイム コーポレーション | 甲状腺刺激ホルモン（ｔｓｈ）の治療的投与のための配合物 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2344277A1 (en) * | 1998-09-22 | 2000-03-30 | University Of Maryland, Baltimore | Cystine knot growth factor mutants |
| KR100423735B1 (ko) * | 2000-11-13 | 2004-03-20 | 학교법인 포항공과대학교 | 그레이브스 질환에 길항작용을 하는 펩타이드 및 그의 용도 |
| JP2007513191A (ja) * | 2003-12-05 | 2007-05-24 | ザイモジェネティクス，インコーポレイティド | 甲状腺刺激ホルモンを用いての炎症の処理方法 |
| DK1971361T3 (da) | 2005-12-23 | 2014-09-08 | James D Kelly | Forbedrede glycoformer af thyroidstimulerende hormonreceptor-polypeptidagonist til behandling af metabolisk syndrom |
| GB0725201D0 (en) * | 2007-12-24 | 2008-01-30 | Asterion Ltd | Peptide fusion proteins |
| GB0808402D0 (en) * | 2008-05-09 | 2008-06-18 | Asterion Ltd | Tsh |
| US20110052591A1 (en) * | 2009-08-28 | 2011-03-03 | Board Of Regents Of The University Of Texas System | Variants of Thyroid Stimulating Hormone Beta |
| US10358574B2 (en) | 2016-07-01 | 2019-07-23 | Hercules Llc | Coating compositions containing lactam-functionalized polymer |
| US20230220026A1 (en) * | 2022-01-12 | 2023-07-13 | National Yang Ming Chiao Tung University | Nucleic acid carrier for producing the single-chain vegf fusion protein with high physiological stability and dimeric efficiency, preparation method thereof, and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| ES2098261T3 (es) * | 1989-02-21 | 1997-05-01 | Univ Washington | Formas modificadas de hormonas reproductoras. |
| PT725795E (pt) * | 1994-08-12 | 2004-05-31 | Univ Washington | Formas de cadeia simples do quarteto de hormonas glicoproteicas |
| US6361992B1 (en) * | 1996-05-08 | 2002-03-26 | The United States Of America As Represented By The Department Of Health And Human Services | Thyroid stimulating hormone superagonists |
-
1998
- 1998-09-22 CN CN98810542A patent/CN1277633A/zh active Pending
- 1998-09-22 KR KR1020057013108A patent/KR100642592B1/ko not_active Expired - Fee Related
- 1998-09-22 EP EP98948422A patent/EP1017817B1/en not_active Expired - Lifetime
- 1998-09-22 EP EP07004548A patent/EP1816199A1/en not_active Withdrawn
- 1998-09-22 JP JP2000512957A patent/JP2001517445A/ja active Pending
- 1998-09-22 AU AU94998/98A patent/AU758156B2/en not_active Ceased
- 1998-09-22 AT AT98948422T patent/ATE356209T1/de not_active IP Right Cessation
- 1998-09-22 DE DE69837271T patent/DE69837271T2/de not_active Expired - Fee Related
- 1998-09-22 CA CA002302993A patent/CA2302993A1/en not_active Abandoned
- 1998-09-22 WO PCT/US1998/019772 patent/WO1999015665A2/en not_active Ceased
- 1998-09-22 KR KR1020057013106A patent/KR100642599B1/ko not_active Expired - Fee Related
- 1998-09-22 KR KR1020057013107A patent/KR100642586B1/ko not_active Expired - Fee Related
- 1998-09-22 KR KR1020007003012A patent/KR100642602B1/ko not_active Expired - Fee Related
-
2004
- 2004-03-01 US US10/788,383 patent/US20040266665A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530974A (ja) * | 2004-03-31 | 2007-11-01 | トロフォゲン，インコーポレイテッド | ヒト糖タンパク質ホルモンのスーパーアゴニストおよびその使用 |
| JP2010503689A (ja) * | 2006-09-19 | 2010-02-04 | ジェンザイム コーポレーション | 甲状腺刺激ホルモン（ｔｓｈ）の治療的投与のための配合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100642602B1 (ko) | 2006-11-10 |
| KR20050085970A (ko) | 2005-08-29 |
| EP1816199A1 (en) | 2007-08-08 |
| CA2302993A1 (en) | 1999-04-01 |
| EP1017817A2 (en) | 2000-07-12 |
| WO1999015665A2 (en) | 1999-04-01 |
| KR20010030661A (ko) | 2001-04-16 |
| KR20050085969A (ko) | 2005-08-29 |
| KR100642592B1 (ko) | 2006-11-13 |
| WO1999015665A3 (en) | 1999-05-20 |
| DE69837271T2 (de) | 2007-11-22 |
| DE69837271D1 (de) | 2007-04-19 |
| KR20050085968A (ko) | 2005-08-29 |
| US20040266665A1 (en) | 2004-12-30 |
| EP1017817B1 (en) | 2007-03-07 |
| AU758156B2 (en) | 2003-03-13 |
| AU9499898A (en) | 1999-04-12 |
| CN1277633A (zh) | 2000-12-20 |
| KR100642586B1 (ko) | 2006-11-10 |
| KR100642599B1 (ko) | 2006-11-10 |
| ATE356209T1 (de) | 2007-03-15 |
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