DK1971361T3 - Forbedrede glycoformer af thyroidstimulerende hormonreceptor-polypeptidagonist til behandling af metabolisk syndrom - Google Patents
Forbedrede glycoformer af thyroidstimulerende hormonreceptor-polypeptidagonist til behandling af metabolisk syndromInfo
- Publication number
- DK1971361T3 DK1971361T3 DK06847924.5T DK06847924T DK1971361T3 DK 1971361 T3 DK1971361 T3 DK 1971361T3 DK 06847924 T DK06847924 T DK 06847924T DK 1971361 T3 DK1971361 T3 DK 1971361T3
- Authority
- DK
- Denmark
- Prior art keywords
- glycoforms
- enhanced
- treatment
- metabolic syndrome
- stimulating hormone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75379805P | 2005-12-23 | 2005-12-23 | |
PCT/US2006/048820 WO2007075906A2 (en) | 2005-12-23 | 2006-12-21 | Improved thyroid-stimulating hormone receptor polypeptide agonist glycoforms to treat metabolic syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1971361T3 true DK1971361T3 (da) | 2014-09-08 |
Family
ID=38218620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06847924.5T DK1971361T3 (da) | 2005-12-23 | 2006-12-21 | Forbedrede glycoformer af thyroidstimulerende hormonreceptor-polypeptidagonist til behandling af metabolisk syndrom |
Country Status (7)
Country | Link |
---|---|
US (1) | US9333241B2 (da) |
EP (1) | EP1971361B1 (da) |
JP (1) | JP5727693B2 (da) |
AU (1) | AU2006331619B2 (da) |
CA (1) | CA2631948A1 (da) |
DK (1) | DK1971361T3 (da) |
WO (1) | WO2007075906A2 (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2631948A1 (en) | 2005-12-23 | 2007-07-05 | James D. Kelly | Improved thyroid-stimulating hormone receptor polypeptide agonist glycoforms to treat metabolic syndrome |
CA2741030A1 (en) | 2008-10-20 | 2010-04-29 | Marvin C. Gershengorn | Low molecular weight thyroid stimulating hormone receptor (tshr) agonists |
US9206154B2 (en) | 2010-04-08 | 2015-12-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inverse agonists and neutral antagonists for the TSH receptor |
KR101789509B1 (ko) * | 2015-11-05 | 2017-10-26 | 주식회사 프로젠 | 재조합 인간 갑상선 자극 호르몬을 포함하는 조성물 및 상기 재조합 인간 갑상선 자극 호르몬의 생산 방법 |
CN115975056B (zh) * | 2023-02-07 | 2023-12-01 | 徐州医科大学 | 利用天然蛋白tsh作为抗原结合位点构建靶向tshr的car-t细胞 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
EP0228604A3 (en) | 1985-12-11 | 1988-10-12 | Sloan-Kettering Institute For Cancer Research | Isolation of a gene encoding human thyrotropin beta subunit |
JP2001517445A (ja) | 1997-09-22 | 2001-10-09 | ユニヴァーシティ オブ メリーランド,ボルチモア | 甲状腺刺激ホルモンの突然変異体およびそれに基づく方法 |
EP2264177B1 (en) | 1998-12-09 | 2015-09-30 | Phyton Holdings, LLC | Glycoproteins having human-type glycosylation |
US7514239B2 (en) | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
US20030219786A1 (en) | 2000-08-11 | 2003-11-27 | Applied Research Systems Ars Holding N.V. | Novel glycoproteins and methods of use thereof |
JP2004521952A (ja) | 2001-07-13 | 2004-07-22 | ザイモジェネティクス,インコーポレイティド | 脂肪分解を誘発するためのコルチコトロフ−誘導の糖タンパク質ホルモンの使用 |
CA2487924A1 (en) | 2002-06-10 | 2003-12-18 | Zymogenetics, Inc. | Use of corticotroph-derived glycoprotein hormone to treat inflammation and potentiate glucocorticoid action |
US20040138116A1 (en) * | 2002-08-30 | 2004-07-15 | Vincent Geenen | Tolerogenic approach for type 1 diabetes |
US20050096264A1 (en) | 2003-02-25 | 2005-05-05 | Macdonald Lynn | Methods for treating obesity and related conditions with glycoprotein hormone beta family hormones |
CA2517896A1 (en) | 2003-03-05 | 2004-09-16 | Zymogenetics, Inc. | Use of thyroid-stimulating hormone to induce lipolysis |
EP1682576A1 (en) | 2003-11-06 | 2006-07-26 | Compugen Ltd. | Variants of human glycoprotein hormone alpha chain: compositions and uses thereof |
US20050171017A1 (en) | 2003-12-05 | 2005-08-04 | Kelly James D. | Methods for treating inflammation using thyroid stimulating hormone |
US20050250185A1 (en) | 2003-12-12 | 2005-11-10 | Murphy Andrew J | OGH fusion polypeptides and therapeutic uses thereof |
US8431355B2 (en) * | 2004-02-04 | 2013-04-30 | Universite De Provence Aix-Marseille 1 | Process for screening glycoform-specific antibodies |
EP1734990A1 (en) * | 2004-03-05 | 2006-12-27 | ZymoGenetics, Inc. | Use of corticotroph-derived glycoprotein hormone to treat liver steatosis |
CA2631948A1 (en) | 2005-12-23 | 2007-07-05 | James D. Kelly | Improved thyroid-stimulating hormone receptor polypeptide agonist glycoforms to treat metabolic syndrome |
-
2006
- 2006-12-21 CA CA002631948A patent/CA2631948A1/en not_active Abandoned
- 2006-12-21 AU AU2006331619A patent/AU2006331619B2/en active Active
- 2006-12-21 EP EP06847924.5A patent/EP1971361B1/en active Active
- 2006-12-21 JP JP2008547554A patent/JP5727693B2/ja active Active
- 2006-12-21 WO PCT/US2006/048820 patent/WO2007075906A2/en active Application Filing
- 2006-12-21 DK DK06847924.5T patent/DK1971361T3/da active
-
2010
- 2010-02-17 US US12/707,334 patent/US9333241B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9333241B2 (en) | 2016-05-10 |
WO2007075906A2 (en) | 2007-07-05 |
JP2009525264A (ja) | 2009-07-09 |
AU2006331619B2 (en) | 2012-12-20 |
EP1971361A2 (en) | 2008-09-24 |
EP1971361B1 (en) | 2014-06-04 |
CA2631948A1 (en) | 2007-07-05 |
US20100210512A1 (en) | 2010-08-19 |
WO2007075906A3 (en) | 2009-09-03 |
EP1971361A4 (en) | 2010-08-18 |
AU2006331619A1 (en) | 2007-07-05 |
JP5727693B2 (ja) | 2015-06-03 |
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