JP2001517445A5 - - Google Patents
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- Publication number
- JP2001517445A5 JP2001517445A5 JP2000512957A JP2000512957A JP2001517445A5 JP 2001517445 A5 JP2001517445 A5 JP 2001517445A5 JP 2000512957 A JP2000512957 A JP 2000512957A JP 2000512957 A JP2000512957 A JP 2000512957A JP 2001517445 A5 JP2001517445 A5 JP 2001517445A5
- Authority
- JP
- Japan
- Prior art keywords
- tsh
- subunit
- mutant
- chain
- heterodimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000011923 Thyrotropin Human genes 0.000 description 239
- 108010061174 Thyrotropin Proteins 0.000 description 239
- 239000000833 heterodimer Substances 0.000 description 89
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 67
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 67
- 229940015047 chorionic gonadotropin Drugs 0.000 description 67
- 238000006467 substitution reaction Methods 0.000 description 58
- 150000001413 amino acids Chemical group 0.000 description 56
- 108090000765 processed proteins & peptides Proteins 0.000 description 52
- 208000024770 Thyroid neoplasm Diseases 0.000 description 42
- 201000002510 thyroid cancer Diseases 0.000 description 42
- 238000000034 method Methods 0.000 description 37
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 31
- 229910052740 iodine Inorganic materials 0.000 description 31
- 239000011630 iodine Substances 0.000 description 31
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 229940088597 hormone Drugs 0.000 description 14
- 239000005556 hormone Substances 0.000 description 14
- 102000009843 Thyroglobulin Human genes 0.000 description 12
- 108010034949 Thyroglobulin Proteins 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 229960002175 thyroglobulin Drugs 0.000 description 12
- 238000001727 in vivo Methods 0.000 description 11
- 102220227246 rs143025648 Human genes 0.000 description 11
- 102200058937 rs45581936 Human genes 0.000 description 11
- 102220496301 Trace amine-associated receptor 9_A17R_mutation Human genes 0.000 description 10
- 102220482854 Tyrosine-protein kinase receptor UFO_E63R_mutation Human genes 0.000 description 10
- 102220319049 rs1032793565 Human genes 0.000 description 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 9
- 102220071758 rs794728545 Human genes 0.000 description 9
- 102220622672 Ferroxidase HEPHL1_R14E_mutation Human genes 0.000 description 8
- 230000004071 biological effect Effects 0.000 description 8
- 210000004899 c-terminal region Anatomy 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
- 239000004475 Arginine Substances 0.000 description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 7
- 239000004472 Lysine Substances 0.000 description 7
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 7
- 102220539945 Ileal sodium/bile acid cotransporter_T11K_mutation Human genes 0.000 description 6
- 239000003937 drug carrier Substances 0.000 description 6
- 208000003532 hypothyroidism Diseases 0.000 description 6
- 230000002989 hypothyroidism Effects 0.000 description 6
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 4
- 208000023328 Basedow disease Diseases 0.000 description 3
- 208000015023 Graves' disease Diseases 0.000 description 3
- 208000024799 Thyroid disease Diseases 0.000 description 3
- 102000003911 Thyrotropin Receptors Human genes 0.000 description 3
- 108090000253 Thyrotropin Receptors Proteins 0.000 description 3
- 210000004748 cultured cell Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 210000001685 thyroid gland Anatomy 0.000 description 3
- 208000021510 thyroid gland disease Diseases 0.000 description 3
- 208000033781 Thyroid carcinoma Diseases 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000013077 thyroid gland carcinoma Diseases 0.000 description 2
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93947297A | 1997-09-22 | 1997-09-22 | |
| US08/939,472 | 1997-09-22 | ||
| PCT/US1998/019772 WO1999015665A2 (en) | 1997-09-22 | 1998-09-22 | Mutants of thyroid stimulating hormone and methods based thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001517445A JP2001517445A (ja) | 2001-10-09 |
| JP2001517445A5 true JP2001517445A5 (https=) | 2006-01-05 |
Family
ID=25473237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000512957A Pending JP2001517445A (ja) | 1997-09-22 | 1998-09-22 | 甲状腺刺激ホルモンの突然変異体およびそれに基づく方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040266665A1 (https=) |
| EP (2) | EP1017817B1 (https=) |
| JP (1) | JP2001517445A (https=) |
| KR (4) | KR100642592B1 (https=) |
| CN (1) | CN1277633A (https=) |
| AT (1) | ATE356209T1 (https=) |
| AU (1) | AU758156B2 (https=) |
| CA (1) | CA2302993A1 (https=) |
| DE (1) | DE69837271T2 (https=) |
| WO (1) | WO1999015665A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2344277A1 (en) * | 1998-09-22 | 2000-03-30 | University Of Maryland, Baltimore | Cystine knot growth factor mutants |
| KR100423735B1 (ko) * | 2000-11-13 | 2004-03-20 | 학교법인 포항공과대학교 | 그레이브스 질환에 길항작용을 하는 펩타이드 및 그의 용도 |
| JP2007513191A (ja) * | 2003-12-05 | 2007-05-24 | ザイモジェネティクス，インコーポレイティド | 甲状腺刺激ホルモンを用いての炎症の処理方法 |
| RU2006138235A (ru) * | 2004-03-31 | 2008-05-10 | Трофоджен, Инк. (Us) | Суперагонисты человеческих гликопротеиновых гормонов и способы их применения |
| DK1971361T3 (da) | 2005-12-23 | 2014-09-08 | James D Kelly | Forbedrede glycoformer af thyroidstimulerende hormonreceptor-polypeptidagonist til behandling af metabolisk syndrom |
| DK2063909T3 (da) * | 2006-09-19 | 2013-01-02 | Genzyme Corp | Formuleringer til terapeutisk administration af thyroid-stimuleringshormon (TSH) |
| GB0725201D0 (en) * | 2007-12-24 | 2008-01-30 | Asterion Ltd | Peptide fusion proteins |
| GB0808402D0 (en) * | 2008-05-09 | 2008-06-18 | Asterion Ltd | Tsh |
| US20110052591A1 (en) * | 2009-08-28 | 2011-03-03 | Board Of Regents Of The University Of Texas System | Variants of Thyroid Stimulating Hormone Beta |
| US10358574B2 (en) | 2016-07-01 | 2019-07-23 | Hercules Llc | Coating compositions containing lactam-functionalized polymer |
| US20230220026A1 (en) * | 2022-01-12 | 2023-07-13 | National Yang Ming Chiao Tung University | Nucleic acid carrier for producing the single-chain vegf fusion protein with high physiological stability and dimeric efficiency, preparation method thereof, and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| ES2098261T3 (es) * | 1989-02-21 | 1997-05-01 | Univ Washington | Formas modificadas de hormonas reproductoras. |
| PT725795E (pt) * | 1994-08-12 | 2004-05-31 | Univ Washington | Formas de cadeia simples do quarteto de hormonas glicoproteicas |
| US6361992B1 (en) * | 1996-05-08 | 2002-03-26 | The United States Of America As Represented By The Department Of Health And Human Services | Thyroid stimulating hormone superagonists |
-
1998
- 1998-09-22 CN CN98810542A patent/CN1277633A/zh active Pending
- 1998-09-22 KR KR1020057013108A patent/KR100642592B1/ko not_active Expired - Fee Related
- 1998-09-22 EP EP98948422A patent/EP1017817B1/en not_active Expired - Lifetime
- 1998-09-22 EP EP07004548A patent/EP1816199A1/en not_active Withdrawn
- 1998-09-22 JP JP2000512957A patent/JP2001517445A/ja active Pending
- 1998-09-22 AU AU94998/98A patent/AU758156B2/en not_active Ceased
- 1998-09-22 AT AT98948422T patent/ATE356209T1/de not_active IP Right Cessation
- 1998-09-22 DE DE69837271T patent/DE69837271T2/de not_active Expired - Fee Related
- 1998-09-22 CA CA002302993A patent/CA2302993A1/en not_active Abandoned
- 1998-09-22 WO PCT/US1998/019772 patent/WO1999015665A2/en not_active Ceased
- 1998-09-22 KR KR1020057013106A patent/KR100642599B1/ko not_active Expired - Fee Related
- 1998-09-22 KR KR1020057013107A patent/KR100642586B1/ko not_active Expired - Fee Related
- 1998-09-22 KR KR1020007003012A patent/KR100642602B1/ko not_active Expired - Fee Related
-
2004
- 2004-03-01 US US10/788,383 patent/US20040266665A1/en not_active Abandoned
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