CN1277633A - 促甲状腺激素的突变体及其制备方法 - Google Patents

促甲状腺激素的突变体及其制备方法 Download PDF

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Publication number
CN1277633A
CN1277633A CN98810542A CN98810542A CN1277633A CN 1277633 A CN1277633 A CN 1277633A CN 98810542 A CN98810542 A CN 98810542A CN 98810542 A CN98810542 A CN 98810542A CN 1277633 A CN1277633 A CN 1277633A
Authority
CN
China
Prior art keywords
tsh
subunit
heterodimer
mutant
mutation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98810542A
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English (en)
Chinese (zh)
Inventor
布鲁斯·D·温特劳布
马里乌什·W·斯库德林斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland Baltimore
Original Assignee
University of Maryland Baltimore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Maryland Baltimore filed Critical University of Maryland Baltimore
Publication of CN1277633A publication Critical patent/CN1277633A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN98810542A 1997-09-22 1998-09-22 促甲状腺激素的突变体及其制备方法 Pending CN1277633A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93947297A 1997-09-22 1997-09-22
US08/939,472 1997-09-22

Publications (1)

Publication Number Publication Date
CN1277633A true CN1277633A (zh) 2000-12-20

Family

ID=25473237

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98810542A Pending CN1277633A (zh) 1997-09-22 1998-09-22 促甲状腺激素的突变体及其制备方法

Country Status (10)

Country Link
US (1) US20040266665A1 (https=)
EP (2) EP1017817B1 (https=)
JP (1) JP2001517445A (https=)
KR (4) KR100642592B1 (https=)
CN (1) CN1277633A (https=)
AT (1) ATE356209T1 (https=)
AU (1) AU758156B2 (https=)
CA (1) CA2302993A1 (https=)
DE (1) DE69837271T2 (https=)
WO (1) WO1999015665A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2344277A1 (en) * 1998-09-22 2000-03-30 University Of Maryland, Baltimore Cystine knot growth factor mutants
KR100423735B1 (ko) * 2000-11-13 2004-03-20 학교법인 포항공과대학교 그레이브스 질환에 길항작용을 하는 펩타이드 및 그의 용도
JP2007513191A (ja) * 2003-12-05 2007-05-24 ザイモジェネティクス，インコーポレイティド 甲状腺刺激ホルモンを用いての炎症の処理方法
RU2006138235A (ru) * 2004-03-31 2008-05-10 Трофоджен, Инк. (Us) Суперагонисты человеческих гликопротеиновых гормонов и способы их применения
DK1971361T3 (da) 2005-12-23 2014-09-08 James D Kelly Forbedrede glycoformer af thyroidstimulerende hormonreceptor-polypeptidagonist til behandling af metabolisk syndrom
DK2063909T3 (da) * 2006-09-19 2013-01-02 Genzyme Corp Formuleringer til terapeutisk administration af thyroid-stimuleringshormon (TSH)
GB0725201D0 (en) * 2007-12-24 2008-01-30 Asterion Ltd Peptide fusion proteins
GB0808402D0 (en) * 2008-05-09 2008-06-18 Asterion Ltd Tsh
US20110052591A1 (en) * 2009-08-28 2011-03-03 Board Of Regents Of The University Of Texas System Variants of Thyroid Stimulating Hormone Beta
US10358574B2 (en) 2016-07-01 2019-07-23 Hercules Llc Coating compositions containing lactam-functionalized polymer
US20230220026A1 (en) * 2022-01-12 2023-07-13 National Yang Ming Chiao Tung University Nucleic acid carrier for producing the single-chain vegf fusion protein with high physiological stability and dimeric efficiency, preparation method thereof, and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980286A (en) * 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
PT725795E (pt) * 1994-08-12 2004-05-31 Univ Washington Formas de cadeia simples do quarteto de hormonas glicoproteicas
US6361992B1 (en) * 1996-05-08 2002-03-26 The United States Of America As Represented By The Department Of Health And Human Services Thyroid stimulating hormone superagonists

Also Published As

Publication number Publication date
KR100642602B1 (ko) 2006-11-10
KR20050085970A (ko) 2005-08-29
EP1816199A1 (en) 2007-08-08
CA2302993A1 (en) 1999-04-01
EP1017817A2 (en) 2000-07-12
WO1999015665A2 (en) 1999-04-01
KR20010030661A (ko) 2001-04-16
KR20050085969A (ko) 2005-08-29
KR100642592B1 (ko) 2006-11-13
WO1999015665A3 (en) 1999-05-20
JP2001517445A (ja) 2001-10-09
DE69837271T2 (de) 2007-11-22
DE69837271D1 (de) 2007-04-19
KR20050085968A (ko) 2005-08-29
US20040266665A1 (en) 2004-12-30
EP1017817B1 (en) 2007-03-07
AU758156B2 (en) 2003-03-13
AU9499898A (en) 1999-04-12
KR100642586B1 (ko) 2006-11-10
KR100642599B1 (ko) 2006-11-10
ATE356209T1 (de) 2007-03-15

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