JP2001516764A5 - - Google Patents
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- Publication number
- JP2001516764A5 JP2001516764A5 JP2000511783A JP2000511783A JP2001516764A5 JP 2001516764 A5 JP2001516764 A5 JP 2001516764A5 JP 2000511783 A JP2000511783 A JP 2000511783A JP 2000511783 A JP2000511783 A JP 2000511783A JP 2001516764 A5 JP2001516764 A5 JP 2001516764A5
- Authority
- JP
- Japan
- Prior art keywords
- array number
- growth factor
- purified
- isolated
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003102 growth factor Substances 0.000 description 17
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 239000002157 polynucleotide Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 102100036660 Persephin Human genes 0.000 description 5
- 108091033319 polynucleotide Proteins 0.000 description 5
- 102000040430 polynucleotide Human genes 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 108010070453 persephin Proteins 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 230000010558 Gene Alterations Effects 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000001259 mesencephalon Anatomy 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- 241000839309 Thesea Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/931,858 US6222022B1 (en) | 1996-03-14 | 1997-09-16 | Persephin and related growth factors |
| US08/931,858 | 1997-09-16 | ||
| PCT/US1998/019163 WO1999014235A1 (en) | 1997-09-16 | 1998-09-15 | Persephin and related growth factors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001516764A JP2001516764A (ja) | 2001-10-02 |
| JP2001516764A5 true JP2001516764A5 (https=) | 2006-01-05 |
Family
ID=25461462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000511783A Withdrawn JP2001516764A (ja) | 1997-09-16 | 1998-09-15 | ペルセフィン及び関連成長因子 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6222022B1 (https=) |
| EP (1) | EP1009768B1 (https=) |
| JP (1) | JP2001516764A (https=) |
| AT (1) | ATE315581T1 (https=) |
| AU (1) | AU758011B2 (https=) |
| CA (1) | CA2296045A1 (https=) |
| DE (1) | DE69833211T2 (https=) |
| ES (1) | ES2259458T3 (https=) |
| IL (1) | IL133834A0 (https=) |
| NZ (1) | NZ502090A (https=) |
| PT (1) | PT1009768E (https=) |
| WO (1) | WO1999014235A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716600B1 (en) * | 1996-03-14 | 2004-04-06 | Washington University | Persephin and related growth factors |
| WO2000006731A2 (en) * | 1998-07-31 | 2000-02-10 | Washington University | PERSEPHIN ARF, A PROTEIN ENCODED BY UNSPLICED PERSEPHIN mRNA |
| GB9915200D0 (en) | 1999-06-29 | 1999-09-01 | Janssen Pharmaceutica Nv | Neurotrophic factor receptor |
| AU7263300A (en) * | 1999-09-16 | 2001-04-17 | Neurotrophic Bioscience, Inc. | Opaminergic neuronal survival-promoting factors and uses thereof |
| DE60137414D1 (de) | 2000-05-05 | 2009-03-05 | Univ City | Zusammensetzungen zur stimulierung der regeneration und der wiederherstellung des nervensystems durch regulierung der arginase 1- und polyamin-synthese |
| AUPQ974900A0 (en) * | 2000-08-29 | 2000-09-21 | Macquarie Research Limited | Degenerate oligonucleotide gene-shuffling |
| GB0024550D0 (https=) | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
| US6376640B1 (en) * | 2001-01-12 | 2002-04-23 | General Electric Company | Melt polycarbonate catalyst systems |
| WO2003053476A1 (en) * | 2001-12-19 | 2003-07-03 | Lijun Wang | Adeno-associated virus-mediated delivery of gdnf to skeletal muscles |
| AU2003238178A1 (en) | 2002-05-29 | 2003-12-12 | Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung | Pancreas-specific proteins |
| US20060239966A1 (en) * | 2003-10-20 | 2006-10-26 | Tornoee Jens | In vivo gene therapy of parkinson's disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141856A (en) | 1989-01-05 | 1992-08-25 | Synergen, Inc. | Expression of purified ciliary neurotrophic factor |
| US5011914A (en) | 1989-01-05 | 1991-04-30 | Collins Franklin D | Purified ciliary neurotrophic factor |
| US5260417A (en) | 1989-04-03 | 1993-11-09 | Genetics Institute, Inc. | Megakaryocyte growth promoting activity protein |
| US5235043A (en) | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
| MX9205293A (es) | 1991-09-20 | 1993-05-01 | Syntex Sinergen Neuroscience J | Factores neurotrofico derivado del glial |
| WO1995006662A1 (en) | 1993-09-01 | 1995-03-09 | Start Technology Partnership | Neuron regulatory factor for promoting neuron survival |
| WO1995017203A1 (en) | 1993-12-22 | 1995-06-29 | The University Of Medicine And Dentistry Of New Jersey | Novel nucleic acid sequences isolated from glial cells |
| US5739307A (en) | 1995-08-28 | 1998-04-14 | Washington University | Polynucleotide encoding neurturin neurotrophic factor |
| NZ329482A (en) * | 1996-03-14 | 2000-05-26 | Univ Washington | A growth factor persephin related to the GDNF/neurturin family of growth factors Methods of treating conditions related to persephin deficiency detecting gene alterations and identifying other members of the family are included |
| WO2000006731A2 (en) * | 1998-07-31 | 2000-02-10 | Washington University | PERSEPHIN ARF, A PROTEIN ENCODED BY UNSPLICED PERSEPHIN mRNA |
-
1997
- 1997-09-16 US US08/931,858 patent/US6222022B1/en not_active Expired - Fee Related
-
1998
- 1998-09-15 DE DE69833211T patent/DE69833211T2/de not_active Expired - Lifetime
- 1998-09-15 NZ NZ502090A patent/NZ502090A/xx not_active IP Right Cessation
- 1998-09-15 EP EP98948217A patent/EP1009768B1/en not_active Expired - Lifetime
- 1998-09-15 ES ES98948217T patent/ES2259458T3/es not_active Expired - Lifetime
- 1998-09-15 PT PT98948217T patent/PT1009768E/pt unknown
- 1998-09-15 WO PCT/US1998/019163 patent/WO1999014235A1/en not_active Ceased
- 1998-09-15 JP JP2000511783A patent/JP2001516764A/ja not_active Withdrawn
- 1998-09-15 IL IL13383498A patent/IL133834A0/xx unknown
- 1998-09-15 CA CA002296045A patent/CA2296045A1/en not_active Abandoned
- 1998-09-15 AT AT98948217T patent/ATE315581T1/de active
- 1998-09-15 AU AU94838/98A patent/AU758011B2/en not_active Ceased
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